Review Non-ribosomal peptide synthetases: Identifying the cryptic
... data sets are being generated by several groups (Baranašić et al. 2014). Minowa et al. have proposed an alternate method for prediction of NRP/PK compounds, encoded from the microbial genomes (Minowa et al. 2007). Their method is based not only on the specific domain sequences/motifs corresponding t ...
... data sets are being generated by several groups (Baranašić et al. 2014). Minowa et al. have proposed an alternate method for prediction of NRP/PK compounds, encoded from the microbial genomes (Minowa et al. 2007). Their method is based not only on the specific domain sequences/motifs corresponding t ...
Simulation of Enzyme Reaction - diss.fu
... atoms of a molecular system are represented in detail. All electrostatic interactions between the corresponding point charges are then calculated explicitly, such that the electrostatic energy is given by Eq. 2.1. If also all solvent molecules are represented explicitly the dielectric constant can b ...
... atoms of a molecular system are represented in detail. All electrostatic interactions between the corresponding point charges are then calculated explicitly, such that the electrostatic energy is given by Eq. 2.1. If also all solvent molecules are represented explicitly the dielectric constant can b ...
Identity elements in tRNA-mediated transcription
... system. An uncharged tRNA can bind to the leader transcript, maintain the antiterminator conformation and thus promote the expression of the operon or gene. A tRNA that is charged with an amino acid on the acceptor arm, however, would not be able to bind and stabilize the antiterminator in the leade ...
... system. An uncharged tRNA can bind to the leader transcript, maintain the antiterminator conformation and thus promote the expression of the operon or gene. A tRNA that is charged with an amino acid on the acceptor arm, however, would not be able to bind and stabilize the antiterminator in the leade ...
The cytogenetics of homologous chromosome pairing in meiosis in
... tion (Siaud et al., 2004). These observations indicate that DMC1 is chiefly responsible for DSB repair using the homologous chromosome as a template. RAD51 predominantly repairs meiotic DSBs using a sister chromatid as template, instead of the homologous chromosome. Studies on yeast and mouse, show ...
... tion (Siaud et al., 2004). These observations indicate that DMC1 is chiefly responsible for DSB repair using the homologous chromosome as a template. RAD51 predominantly repairs meiotic DSBs using a sister chromatid as template, instead of the homologous chromosome. Studies on yeast and mouse, show ...
The cytogenetics of homologous chromosome pairing in meiosis in plants Meiosis
... tion (Siaud et al., 2004). These observations indicate that DMC1 is chiefly responsible for DSB repair using the homologous chromosome as a template. RAD51 predominantly repairs meiotic DSBs using a sister chromatid as template, instead of the homologous chromosome. Studies on yeast and mouse, show ...
... tion (Siaud et al., 2004). These observations indicate that DMC1 is chiefly responsible for DSB repair using the homologous chromosome as a template. RAD51 predominantly repairs meiotic DSBs using a sister chromatid as template, instead of the homologous chromosome. Studies on yeast and mouse, show ...
Life History Shapes Trait Heredity by Accumulation of
... A fundamental question in biology is whether variation in organisms primarily emerges as a function of adaptation or as a function of neutral genetic drift. Trait variation in the model organism baker’s yeast follows population bottlenecks rather than environmental boundaries suggesting that it prim ...
... A fundamental question in biology is whether variation in organisms primarily emerges as a function of adaptation or as a function of neutral genetic drift. Trait variation in the model organism baker’s yeast follows population bottlenecks rather than environmental boundaries suggesting that it prim ...
Structural And Functional Studies Of Nicotinamide Adenine
... Strep (GAS), results in approximately 600,000 deaths annually. With evidence of antibiotic-resistant strains of this bacterium on the rise, there is a need for the identification of new drug targets to control these infections. In our approach we target the quinolinatesalvage pathway (QSP) and the s ...
... Strep (GAS), results in approximately 600,000 deaths annually. With evidence of antibiotic-resistant strains of this bacterium on the rise, there is a need for the identification of new drug targets to control these infections. In our approach we target the quinolinatesalvage pathway (QSP) and the s ...
Mitochondrial protein acetylation regulates metabolism
... by mitochondrial protein acetylation, we used DAVID (database for annotation, visualization and integrated discovery) 6.7 [36]. First, we determined which mitochondrial pathways were enriched in protein acetylation. By assigning a single, primary GO term to each mitochondrial protein, we measured wh ...
... by mitochondrial protein acetylation, we used DAVID (database for annotation, visualization and integrated discovery) 6.7 [36]. First, we determined which mitochondrial pathways were enriched in protein acetylation. By assigning a single, primary GO term to each mitochondrial protein, we measured wh ...
Origin and Distribution of Calvin Cycle Fructose and
... (1) including those of diatoms, Amphidinium, Emiliania, and Euglena. However, this ensemble does not contain the cryptophycean sequence of Guillardia and its phylogeny is inconsistent with the accepted organismal relationships. In particular, the grouping of Euglena and the haptophyte Emiliania is s ...
... (1) including those of diatoms, Amphidinium, Emiliania, and Euglena. However, this ensemble does not contain the cryptophycean sequence of Guillardia and its phylogeny is inconsistent with the accepted organismal relationships. In particular, the grouping of Euglena and the haptophyte Emiliania is s ...
GhMYB25-like: a key regulator of early cotton fiber development.
... The full length GhMYB25-like gene driven by its own promoter was introduced into cotton and 13 T0 lines were produced (OX25L plants). Segregating T1 plants from independent transformants OX25L-11, OX25L-18, OX25L-59 and OX25L-78 each with a single additional copy of the GhMyb25 gene were passaged th ...
... The full length GhMYB25-like gene driven by its own promoter was introduced into cotton and 13 T0 lines were produced (OX25L plants). Segregating T1 plants from independent transformants OX25L-11, OX25L-18, OX25L-59 and OX25L-78 each with a single additional copy of the GhMyb25 gene were passaged th ...
Full-Text PDF
... Pollen from different species of monocotyledonic or and dicotyledonic plants is regarded to be the most frequent and active allergen source. Pollen allergens are low molecular weight proteins or glycoproteins and are located intracellular in the pollen grains. Their physiological activation starts a ...
... Pollen from different species of monocotyledonic or and dicotyledonic plants is regarded to be the most frequent and active allergen source. Pollen allergens are low molecular weight proteins or glycoproteins and are located intracellular in the pollen grains. Their physiological activation starts a ...
A fluorophore ligase for site-specific protein labeling inside living cells
... Third, we characterized the sequence specificity of both coumarin ligases. It was unclear if remodeling of the lipoic acid binding pocket would affect LplA’s recognition of peptide and protein substrates. In addition, mammalian cells express protein substrates for their own mitochondrial lipoic acid ...
... Third, we characterized the sequence specificity of both coumarin ligases. It was unclear if remodeling of the lipoic acid binding pocket would affect LplA’s recognition of peptide and protein substrates. In addition, mammalian cells express protein substrates for their own mitochondrial lipoic acid ...
Structure-Function of the Glucagon Receptor Family of G Protein
... Boushey et al. 2000). Following clinical and experimental ob- 1993). Consistent with the very high degree of sequence conserservations linking intestinal growth, injury, and gut adaptation vation found for GLP-1 in most mammalian species, the GLPto increased levels of circulating PGDPs (Drucker 1999 ...
... Boushey et al. 2000). Following clinical and experimental ob- 1993). Consistent with the very high degree of sequence conserservations linking intestinal growth, injury, and gut adaptation vation found for GLP-1 in most mammalian species, the GLPto increased levels of circulating PGDPs (Drucker 1999 ...
manuscript pdf
... stamens until the completion of flower development. However, low levels of transcript of some of the class B genes have been detected in first-whorl (DEF and AP3) and fourthwhorl (DEF) organs of flowers in later stages of development. Class B proteins become detectable in the second- and third-whorl ...
... stamens until the completion of flower development. However, low levels of transcript of some of the class B genes have been detected in first-whorl (DEF and AP3) and fourthwhorl (DEF) organs of flowers in later stages of development. Class B proteins become detectable in the second- and third-whorl ...
Modular Stitching To Image Single
... Urbana, Illinois 61801, United States S Supporting Information ...
... Urbana, Illinois 61801, United States S Supporting Information ...
Programmed Ribosomal Frameshifting Generates a Copper
... (Jacks et al., 1988a; Sharma et al., 2014). These observations, combined with our experimental data, offer a straightforward explanation for the generation of the CopA(Z) polypeptide ending with a Gly residue. First, ribosomes translating the copA ORF undergo !1 PRF within the SS and incorporate a G ...
... (Jacks et al., 1988a; Sharma et al., 2014). These observations, combined with our experimental data, offer a straightforward explanation for the generation of the CopA(Z) polypeptide ending with a Gly residue. First, ribosomes translating the copA ORF undergo !1 PRF within the SS and incorporate a G ...
Two-Component System of Mycobacterium Tuberculosis
... the histidine protein kinase (HK) PhoR, are involved in the induction of Pho-regulon genes including the phoPR operon and genes encoding the major vegetative alkaline phosphatases, phoA and phoB. The PhoP protein belongs to OmpR/PhoB subfamily, which is considered as the largest of the response regu ...
... the histidine protein kinase (HK) PhoR, are involved in the induction of Pho-regulon genes including the phoPR operon and genes encoding the major vegetative alkaline phosphatases, phoA and phoB. The PhoP protein belongs to OmpR/PhoB subfamily, which is considered as the largest of the response regu ...
Divergent Evolution and Evolution by the Birth-and
... the evolution of the immunoglobulin heavy-chain variable-region (Vu) genes (Hood et al. 1975; Ohta 1980, 1983). Gojobori and Nei ( 1984), however, showed that Vu gene (often called “gene segment”) family in the mouse and human undergoes a very slow rate of concerted evolution, if any; that the exten ...
... the evolution of the immunoglobulin heavy-chain variable-region (Vu) genes (Hood et al. 1975; Ohta 1980, 1983). Gojobori and Nei ( 1984), however, showed that Vu gene (often called “gene segment”) family in the mouse and human undergoes a very slow rate of concerted evolution, if any; that the exten ...
htp Pseudomonas aeruginosa AMANDA SWANEPOEL
... opportunistic pathogen of humans, causing infections in immunocompromised patients such as those with cancer or AIDS and those suffering from cystic fibrosis and burns (Van Delden and Iglewski, 1998; Ramsey and Wozniak, 2005), but it has also been shown to infect plants and insects (Schroth et al., ...
... opportunistic pathogen of humans, causing infections in immunocompromised patients such as those with cancer or AIDS and those suffering from cystic fibrosis and burns (Van Delden and Iglewski, 1998; Ramsey and Wozniak, 2005), but it has also been shown to infect plants and insects (Schroth et al., ...
39 Synthesis and Degradation of Amino Acids
... incorporated into proteins during the process of protein synthesis. Modifications to these amino acids occur after they are incorporated into proteins (such as the synthesis of hydroxyproline in collagen). The major exception to this rule is selenocysteine, which is an essential component of enzymes ...
... incorporated into proteins during the process of protein synthesis. Modifications to these amino acids occur after they are incorporated into proteins (such as the synthesis of hydroxyproline in collagen). The major exception to this rule is selenocysteine, which is an essential component of enzymes ...
Branched chain aldehydes: production and breakdown pathways
... An initial step in leucine conversion of leucine towards 3methyl butanal is the formation of α-keto isocaproic acid. Reaction 3 in Fig. 1 yields this important intermediate and can be catalysed by transaminases and leucine dehydrogenase. In food systems, the transaminases play a major role (Yvon et ...
... An initial step in leucine conversion of leucine towards 3methyl butanal is the formation of α-keto isocaproic acid. Reaction 3 in Fig. 1 yields this important intermediate and can be catalysed by transaminases and leucine dehydrogenase. In food systems, the transaminases play a major role (Yvon et ...
Article A Distinct Mitochondrial Genome with DUI
... Arctica islandica (Linnaeus 1767) belongs to the Heterodonta, order Veneroida and is the sole living representative of the Arcticidae family (Morton 2011). This species, known as the longest-lived non colonial species with a maximum reported life span of 507 years, is of great interest for studies o ...
... Arctica islandica (Linnaeus 1767) belongs to the Heterodonta, order Veneroida and is the sole living representative of the Arcticidae family (Morton 2011). This species, known as the longest-lived non colonial species with a maximum reported life span of 507 years, is of great interest for studies o ...
eg1
... that includes multiple forms of all three classes when grown on crystalline cellulose (Cai et al. 1994, 1999). In addition to EG1, four other CMC-hydrolysing proteins were separated in lower yields from culture fluids of V. volvacea grown on crystalline cellulose using a combination of hydrophobic i ...
... that includes multiple forms of all three classes when grown on crystalline cellulose (Cai et al. 1994, 1999). In addition to EG1, four other CMC-hydrolysing proteins were separated in lower yields from culture fluids of V. volvacea grown on crystalline cellulose using a combination of hydrophobic i ...
Point mutation
A point mutation, or single base modification, is a type of mutation that causes a single nucleotide base change, insertion, or deletion of the genetic material, DNA or RNA. The term frameshift mutation indicates the addition or deletion of a base pair. A point mutant is an individual that is affected by a point mutation.Repeat induced point mutations are recurring point mutations, discussed below.