
In vivo contribution of amino acid sulfur to cartilage proteoglycan
... when extracellular sulfate concentration is low or when its transport is impaired such as in DTDST chondrodysplasias [13]. We have previously demonstrated that sulfate recruitment from sulfur-containing amino acids is active in cultured fibroblasts and chondrocytes from DTDST patients and this pathw ...
... when extracellular sulfate concentration is low or when its transport is impaired such as in DTDST chondrodysplasias [13]. We have previously demonstrated that sulfate recruitment from sulfur-containing amino acids is active in cultured fibroblasts and chondrocytes from DTDST patients and this pathw ...
REDESIGN OF CARNITINE ACETYLTRANSFERASE SPECIFICITY BY PROTEIN ENGINEERING UNIVERSIDAD DE BARCELONA
... A novel compound, the fatty acid synthase (FAS) inhibitor C75, has been proposed to pharmacologically regulate CPT I activity (Price, 2001). Structurally, C75 is a cell-permeable α-methylene-γ-butyrolactone designed to be less reactive and potentially safer than cerulenin, a natural product obtained ...
... A novel compound, the fatty acid synthase (FAS) inhibitor C75, has been proposed to pharmacologically regulate CPT I activity (Price, 2001). Structurally, C75 is a cell-permeable α-methylene-γ-butyrolactone designed to be less reactive and potentially safer than cerulenin, a natural product obtained ...
THE COLLAGENS
... Nearly one residue out of three is Gly Proline content is unusually high Unusual amino acids found: ◦ 4-hydroxyproline ◦ 3-hydroxyproline ◦ 5-hydroxylysine ◦ Pro and HyPro together make 30% of res. ...
... Nearly one residue out of three is Gly Proline content is unusually high Unusual amino acids found: ◦ 4-hydroxyproline ◦ 3-hydroxyproline ◦ 5-hydroxylysine ◦ Pro and HyPro together make 30% of res. ...
Biosynthesis of theanine (g-ethylamino-L
... have been published (Takeo, 1974; Konishi et al., 1978; Chu et al., 1997) compared with biomedical research. In the present paper we examined the biosynthesis of theanine in different parts of tea seedlings, using 15N- and 14C-precursors. Transcript levels of theanine synthetase genes (TS1 and TS2) ...
... have been published (Takeo, 1974; Konishi et al., 1978; Chu et al., 1997) compared with biomedical research. In the present paper we examined the biosynthesis of theanine in different parts of tea seedlings, using 15N- and 14C-precursors. Transcript levels of theanine synthetase genes (TS1 and TS2) ...
Lipid and fatty acid metabolism in Ralstonia eutropha: relevance for
... Genome sequencing of R. eutropha strain H16 has indicated the presence of several genes that could potentially be involved in specific steps of the process of fatty acid degradation (Pohlmann et al. 2006). More recently, whole genome transcriptome analysis has shown that two putative operons, both ...
... Genome sequencing of R. eutropha strain H16 has indicated the presence of several genes that could potentially be involved in specific steps of the process of fatty acid degradation (Pohlmann et al. 2006). More recently, whole genome transcriptome analysis has shown that two putative operons, both ...
The first page should show the paper title, names and addresses of
... mapping did not confirm the pericentric inversion proposed earlier based on G-banding analysis and comparative FISH-mapping on metaphase chromosomes. What other chromosomal rearrangements that might have occurred during karyotype evolution in Galliformes could be resolved using the FISH on lampbrush ...
... mapping did not confirm the pericentric inversion proposed earlier based on G-banding analysis and comparative FISH-mapping on metaphase chromosomes. What other chromosomal rearrangements that might have occurred during karyotype evolution in Galliformes could be resolved using the FISH on lampbrush ...
arXiv:0708.2724v1 [cond-mat.other] 20 Aug 2007
... FIG. 3 (Color in online edition) The atomistic structure of the nucleic acid backbones. (a) Two repeat units of the deoxyribonucleic acid backbone. The phosphate groups have a negative charge in solution, which is shared between the two oxygens solely bound to the phosphorous atom. Also shown is the ...
... FIG. 3 (Color in online edition) The atomistic structure of the nucleic acid backbones. (a) Two repeat units of the deoxyribonucleic acid backbone. The phosphate groups have a negative charge in solution, which is shared between the two oxygens solely bound to the phosphorous atom. Also shown is the ...
BIOLOGY 3 Lab Manual - Los Angeles Mission College
... such an experiment is not so straightforward. There are many different types of cars (sedans, vans, pickups, SUVs) and they may not all give the same result. Plus some cars have 4 adjustable windows and others only 2, and windows can be partially open as well. To keep the experiment simple you might ...
... such an experiment is not so straightforward. There are many different types of cars (sedans, vans, pickups, SUVs) and they may not all give the same result. Plus some cars have 4 adjustable windows and others only 2, and windows can be partially open as well. To keep the experiment simple you might ...
Abundant RNA editing sites of chloroplast protein
... and is involved in primordial error correction, such as repairing UV damage at the transcript level. Others argue that the editing system produces additional mutations to adapt to different physiological functions. However, this does not explain why RNA editing did not occur in some ancient predatin ...
... and is involved in primordial error correction, such as repairing UV damage at the transcript level. Others argue that the editing system produces additional mutations to adapt to different physiological functions. However, this does not explain why RNA editing did not occur in some ancient predatin ...
A novel role for the floral homeotic gene APETALA2
... Fig. 2. m413 mutation rescues replum development in rpl ful. (A,B,D,E,G,H) SEM micrographs of ful (A,B), rpl ful (D,E) and rpl ful m413 (G,H). (B,E,H) Higher magnification views of the medial region of the fruits in A, D and G, respectively. In ful, the replum adopts a typical zigzag configuration ( ...
... Fig. 2. m413 mutation rescues replum development in rpl ful. (A,B,D,E,G,H) SEM micrographs of ful (A,B), rpl ful (D,E) and rpl ful m413 (G,H). (B,E,H) Higher magnification views of the medial region of the fruits in A, D and G, respectively. In ful, the replum adopts a typical zigzag configuration ( ...
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... About Genova Diagnostics Headquartered in Asheville, N.C., Genova Diagnostics is a global specialty clinical laboratory, pioneering a systems approach that supports healthcare providers in the personalized treatment and prevention of chronic disease. Chronic diseases are often complex and Genova’s s ...
... About Genova Diagnostics Headquartered in Asheville, N.C., Genova Diagnostics is a global specialty clinical laboratory, pioneering a systems approach that supports healthcare providers in the personalized treatment and prevention of chronic disease. Chronic diseases are often complex and Genova’s s ...
Gene Section FST (follistatin) Atlas of Genetics and Cytogenetics
... bound activin is unable to initiate signal transduction and consequently follistatin is a potent antagonist of physiological activin signals. Of the three follistatin domains present in all follistatin isoforms, (Shimasaki et al., 1988) the first two, but not the third, are necessary for activin A b ...
... bound activin is unable to initiate signal transduction and consequently follistatin is a potent antagonist of physiological activin signals. Of the three follistatin domains present in all follistatin isoforms, (Shimasaki et al., 1988) the first two, but not the third, are necessary for activin A b ...
Introduction to Nutrition and Metabolism, Third Edition
... An understanding of the way in which nutrients are metabolized, and hence of the principles of biochemistry, is essential for an understanding of the scientific basis of what we would call a prudent or healthy diet. My aim in the following pages is to explain both the conclusions of the many expert ...
... An understanding of the way in which nutrients are metabolized, and hence of the principles of biochemistry, is essential for an understanding of the scientific basis of what we would call a prudent or healthy diet. My aim in the following pages is to explain both the conclusions of the many expert ...
Complete genome sequence of the thermophilic Thermus sp
... and rod-shaped thermophilic bacteria. Thermus aquaticus was the first bacterium of the genus Thermus that was discovered in several of the hot springs in Yellowstone National Park, United States [1]. A few years later, two strains of Thermus thermophilus (HB27 and HB8) were successfully isolated fro ...
... and rod-shaped thermophilic bacteria. Thermus aquaticus was the first bacterium of the genus Thermus that was discovered in several of the hot springs in Yellowstone National Park, United States [1]. A few years later, two strains of Thermus thermophilus (HB27 and HB8) were successfully isolated fro ...
BACILLUS SPHAERICUS TOXINS: Molecular Biology and Mode of
... The mode of action of B.sphaericus crystal toxin has only been studied in mosquito larvae. However, in one report, the toxin was active in adults of C.pipiens quinquefasciatus, but not in A.aegypti adults, after introduced enema into the midgut (74). Investigations into the mode of action of the B. ...
... The mode of action of B.sphaericus crystal toxin has only been studied in mosquito larvae. However, in one report, the toxin was active in adults of C.pipiens quinquefasciatus, but not in A.aegypti adults, after introduced enema into the midgut (74). Investigations into the mode of action of the B. ...
PROTEIN PHOSPHORYLATION AND CELLULAR REGULATION, I by
... viewed simply as unexplained phenomenology. Indeed for several years Carl Cori advised against my publishing these findings unless I could explain them. Eventually, after Neil Madsen found that protamine could physically bind to phosphorylase, which was at least a step in the direction of how it mig ...
... viewed simply as unexplained phenomenology. Indeed for several years Carl Cori advised against my publishing these findings unless I could explain them. Eventually, after Neil Madsen found that protamine could physically bind to phosphorylase, which was at least a step in the direction of how it mig ...
Genetic interactions between scribbler, Atrophin and
... is the cause of an inherited neuronal degenerative disease, dentatorubral-pallidoluysian atrophy (KOIDE et al. 1994; NAGAFUCHI et al. 1994). Atro mutants in Drosophila have a range of defects, including aberrant segmentation, neurogenesis and dorsoventral-patterning that are associated with derepres ...
... is the cause of an inherited neuronal degenerative disease, dentatorubral-pallidoluysian atrophy (KOIDE et al. 1994; NAGAFUCHI et al. 1994). Atro mutants in Drosophila have a range of defects, including aberrant segmentation, neurogenesis and dorsoventral-patterning that are associated with derepres ...
David Rittenberg - National Academy of Sciences
... was instead assigned to H. T. Clarke, chair of the Department of Biochemistry at P&S to promote biological uses of 2H. At that time one interest of Clarke’s was the possibility of demonstrating optical activity for a compound, Cab1H2H. Clarke also suggested to Rittenberg a “roving commission” to tal ...
... was instead assigned to H. T. Clarke, chair of the Department of Biochemistry at P&S to promote biological uses of 2H. At that time one interest of Clarke’s was the possibility of demonstrating optical activity for a compound, Cab1H2H. Clarke also suggested to Rittenberg a “roving commission” to tal ...
METABOLIC CUES AND REGULATORY PROTEINS
... Figure 2.3. A strain containing a threonine-to-methionine substitution four residues from the proposed autophosphorylation site of LetS exhibits either WT or letS null phenotypes. .................................................50 Figure 2.4. A strain containing a threonine-to-methionine substituti ...
... Figure 2.3. A strain containing a threonine-to-methionine substitution four residues from the proposed autophosphorylation site of LetS exhibits either WT or letS null phenotypes. .................................................50 Figure 2.4. A strain containing a threonine-to-methionine substituti ...
A proteomic study of African elephant milk: Inter
... which contains the base uracil instead of thiamine in DNA. The mRNA which is now the blueprint for the protein and determines the amino acid sequence of the protein it codes for moves to the cytosol and the endoplasmic reticulum (ER) where translation occurs to form a polypeptide with the aid of tRN ...
... which contains the base uracil instead of thiamine in DNA. The mRNA which is now the blueprint for the protein and determines the amino acid sequence of the protein it codes for moves to the cytosol and the endoplasmic reticulum (ER) where translation occurs to form a polypeptide with the aid of tRN ...
Do universal codon-usage patterns minimize the effects of mutation
... each other codon that can be reached by a single-base substitution (see Materials and methods). The standard genetic code and all known variants resist error better (have a lower error value) than do random codes for a wide range of different amino-acid properties and models of random code generatio ...
... each other codon that can be reached by a single-base substitution (see Materials and methods). The standard genetic code and all known variants resist error better (have a lower error value) than do random codes for a wide range of different amino-acid properties and models of random code generatio ...
Cloning and Expression of Bovine Sodium/Glucose Cotransporter SGLT2* J. Dairy Sci. 88:2738–2748
... of SGLT2 in the cDNA library of bovine mammary tissues, indicating its expression in bovine mammary gland. To facilitate study of the mechanism of glucose reabsorption in bovine kidneys in maintenance of glucose homeostasis of lactating cows and the potential role of SGLT2 in the mammary gland, we c ...
... of SGLT2 in the cDNA library of bovine mammary tissues, indicating its expression in bovine mammary gland. To facilitate study of the mechanism of glucose reabsorption in bovine kidneys in maintenance of glucose homeostasis of lactating cows and the potential role of SGLT2 in the mammary gland, we c ...
Transcription factor Sp3 is silenced through - IMT
... On many reporter constructs containing multiple Spbinding sites, Sp3, unlike Sp1, is inactive or acts only as a weak activator (Hagen et al., 1994). The molecular basis for the inactivity of Sp3 under these conditions has been mapped to an inhibitory domain (ID) located between the second glutamine- ...
... On many reporter constructs containing multiple Spbinding sites, Sp3, unlike Sp1, is inactive or acts only as a weak activator (Hagen et al., 1994). The molecular basis for the inactivity of Sp3 under these conditions has been mapped to an inhibitory domain (ID) located between the second glutamine- ...
Point mutation

A point mutation, or single base modification, is a type of mutation that causes a single nucleotide base change, insertion, or deletion of the genetic material, DNA or RNA. The term frameshift mutation indicates the addition or deletion of a base pair. A point mutant is an individual that is affected by a point mutation.Repeat induced point mutations are recurring point mutations, discussed below.