Severe Aplastic Anaemia - Women`s and Children`s Hospital
... Severe Aplastic Anaemia affects 2- 6 people per million worldwide. It is more common in Asia than in the western world and most cases occur in adults. What causes Severe Aplastic Anaemia? The cause of the disease is usually unknown and is often termed “idiopathic”. It is thought that most cases of S ...
... Severe Aplastic Anaemia affects 2- 6 people per million worldwide. It is more common in Asia than in the western world and most cases occur in adults. What causes Severe Aplastic Anaemia? The cause of the disease is usually unknown and is often termed “idiopathic”. It is thought that most cases of S ...
Page 1 Biology 3
... Iron is needed to produce haemoglobin. If there is a shortage of iron a person won’t have enough red blood cells, this is called anaemia, less oxygen will be carried around the body. ...
... Iron is needed to produce haemoglobin. If there is a shortage of iron a person won’t have enough red blood cells, this is called anaemia, less oxygen will be carried around the body. ...
Bombay Blood A Rare Entity
... However what is not generally known is that all these groups have an antigen H in the blood as well. There are very few people who do not have this antigen H also in their blood. Instead they have antibody H because of which no other blood can be given to them. Such people are believed to have the B ...
... However what is not generally known is that all these groups have an antigen H in the blood as well. There are very few people who do not have this antigen H also in their blood. Instead they have antibody H because of which no other blood can be given to them. Such people are believed to have the B ...
Improved algorithms for the analysis and classification of HbF
... Figure 2. A Probability State Model (PSM) uses a set of expression profiles for one or more listmode parameters to assign events to states and cell types probabilistically. A PSM can be designed to minimize subjective decisions in FMH analysis. The operator visually examines intensity and line sprea ...
... Figure 2. A Probability State Model (PSM) uses a set of expression profiles for one or more listmode parameters to assign events to states and cell types probabilistically. A PSM can be designed to minimize subjective decisions in FMH analysis. The operator visually examines intensity and line sprea ...
Glomerulonephritis
... Neutrophil / macrophage recruitment and activation Activation of coagulation system ...
... Neutrophil / macrophage recruitment and activation Activation of coagulation system ...
Immune System
... a. Numerous cells that die and calcify b. “2005 issue of Nature, researchers at The University of Texas M. D. Anderson Cancer Center found that Hassall's corpuscles produce chemical signals that instruct dendritic cells in the thymus to induce development of these regulatory T cells - the critically ...
... a. Numerous cells that die and calcify b. “2005 issue of Nature, researchers at The University of Texas M. D. Anderson Cancer Center found that Hassall's corpuscles produce chemical signals that instruct dendritic cells in the thymus to induce development of these regulatory T cells - the critically ...
Complications and Troubleshooting
... • All drugs except Vinca alkaloids, etoposide, and catecholamines…apply ICE for 15-20 minutes (minimum of QID) for 48 hrs • For vinca alkaloids, etoposide and catecholamines…apply heat for 15-20 minutes (minimum of QID) for 48 hours ...
... • All drugs except Vinca alkaloids, etoposide, and catecholamines…apply ICE for 15-20 minutes (minimum of QID) for 48 hrs • For vinca alkaloids, etoposide and catecholamines…apply heat for 15-20 minutes (minimum of QID) for 48 hours ...
Alternative macrophage differentiation is altered in - HAL
... on intrahepatic and adipose tissue immune cell function 3. However, these inflammatory cells derive mainly from circulating precursors, such as peripheral blood mononuclear cells (PBMC), whose function in obesity-associated immune and inflammatory defects has been less studied. Circulating PBMC, are ...
... on intrahepatic and adipose tissue immune cell function 3. However, these inflammatory cells derive mainly from circulating precursors, such as peripheral blood mononuclear cells (PBMC), whose function in obesity-associated immune and inflammatory defects has been less studied. Circulating PBMC, are ...
lymphoid tissue and the immune response
... Medullary cords contain primarily B-lymphocytes, macrophages, plasma cells, and reticular cells. Major site of phagocytosis and immunoglobulin synthesis. Lymph node function Main function is to filter lymph before it returns to the circulatory system. Phagocytic cells within the lymph node will ...
... Medullary cords contain primarily B-lymphocytes, macrophages, plasma cells, and reticular cells. Major site of phagocytosis and immunoglobulin synthesis. Lymph node function Main function is to filter lymph before it returns to the circulatory system. Phagocytic cells within the lymph node will ...
Blood Group Incompatibility
... Incompatibility in the context of blood groups is due to the binding of plasma antibody with red cell antigen, thereby causing a reaction. In laboratory tests this reaction is most commonly visualized by agglutination of the red cells. In the body, an antigen–antibody reaction can occur as an advers ...
... Incompatibility in the context of blood groups is due to the binding of plasma antibody with red cell antigen, thereby causing a reaction. In laboratory tests this reaction is most commonly visualized by agglutination of the red cells. In the body, an antigen–antibody reaction can occur as an advers ...
Copyleft from Kunadian … Gibson ,JTT 2008 in press.
... autoimmunization and mortality from GvHD. • Transfused cells may act as a nitric oxide sink Copyleft from Kunadian … Gibson ,JTT 2008 in press. Zallen G et al. Am J Surg. 1999;178:570 –572, Williamson LM, Warwick RM. Blood Rev. 1995;9:251–261, McMahon TJ et al. Nat Med.2002;8:711-717, Welch HG.Ann I ...
... autoimmunization and mortality from GvHD. • Transfused cells may act as a nitric oxide sink Copyleft from Kunadian … Gibson ,JTT 2008 in press. Zallen G et al. Am J Surg. 1999;178:570 –572, Williamson LM, Warwick RM. Blood Rev. 1995;9:251–261, McMahon TJ et al. Nat Med.2002;8:711-717, Welch HG.Ann I ...
No Slide Title
... – Describe the structure and function of hemoglobin. – State and define some clinical measurements of RBC and hemoglobin quantities. – Describe the life cycle of erythrocytes. – Name and describe the types, causes, and effects of RBC excesses and deficiencies. ...
... – Describe the structure and function of hemoglobin. – State and define some clinical measurements of RBC and hemoglobin quantities. – Describe the life cycle of erythrocytes. – Name and describe the types, causes, and effects of RBC excesses and deficiencies. ...
Chapter 18 *Lecture PowerPoint The Circulatory System: Blood
... – Describe the structure and function of hemoglobin. – State and define some clinical measurements of RBC and hemoglobin quantities. – Describe the life cycle of erythrocytes. – Name and describe the types, causes, and effects of RBC excesses and deficiencies. ...
... – Describe the structure and function of hemoglobin. – State and define some clinical measurements of RBC and hemoglobin quantities. – Describe the life cycle of erythrocytes. – Name and describe the types, causes, and effects of RBC excesses and deficiencies. ...
To your Chair Based Exercise Leadership Course Tutor Simon Hanna
... Safety First… • This session will cover: ...
... Safety First… • This session will cover: ...
Citrus Sinensis
... world production. A large portion of this production is addressed to the industrial extraction of citrus juice which leads to huge amounts of residues, including peel and segment membranes. Peels represent between 50 to 65% of total weight of the fruits and remain as the primary byproduct. If not pr ...
... world production. A large portion of this production is addressed to the industrial extraction of citrus juice which leads to huge amounts of residues, including peel and segment membranes. Peels represent between 50 to 65% of total weight of the fruits and remain as the primary byproduct. If not pr ...
Illuminating Neonatal Sepsis as Age-Specific Systemic Inflammatory
... Despite enormous progress in the field of neonatology sepsis is still the leading cause of death. Preterm babies are especially at high risk for fatal courses that directly correspond to severe sepsis associated with so called cytokine storms in adults. Clinically, the hallmark of the neonatal patie ...
... Despite enormous progress in the field of neonatology sepsis is still the leading cause of death. Preterm babies are especially at high risk for fatal courses that directly correspond to severe sepsis associated with so called cytokine storms in adults. Clinically, the hallmark of the neonatal patie ...
GRANULOMATOUS INFLAMMATION Lecture1
... Microorganisms which are of low inherent pathogenicity but which ...
... Microorganisms which are of low inherent pathogenicity but which ...
Blood and Lymph Systems
... Cellular components suspended in the plasma: erythrocytes — red blood cells leukocytes — white blood cells platelets — cell fragments essential for blood clotting ...
... Cellular components suspended in the plasma: erythrocytes — red blood cells leukocytes — white blood cells platelets — cell fragments essential for blood clotting ...
Inflammatory Myopathies
... – Nasal regurgitation or choking when eating – Hoarseness, change in voice – *Ocular/facial muscle involvement is very uncommon ...
... – Nasal regurgitation or choking when eating – Hoarseness, change in voice – *Ocular/facial muscle involvement is very uncommon ...
Chapter 14: Blood
... 2. Albumins are the smallest of the plasma proteins and are synthesized in the liver. 3. Albumins function to help maintain the colloid osmotic pressure of blood. 4. Colloid pressure is the osmotic pressure produced by plasma proteins. 5. Globulins can be divided into the following three groups: alp ...
... 2. Albumins are the smallest of the plasma proteins and are synthesized in the liver. 3. Albumins function to help maintain the colloid osmotic pressure of blood. 4. Colloid pressure is the osmotic pressure produced by plasma proteins. 5. Globulins can be divided into the following three groups: alp ...
Chapter 18
... – Describe the structure and function of hemoglobin. – State and define some clinical measurements of RBC and hemoglobin quantities. – Describe the life cycle of erythrocytes. – Name and describe the types, causes, and effects of RBC excesses and deficiencies. ...
... – Describe the structure and function of hemoglobin. – State and define some clinical measurements of RBC and hemoglobin quantities. – Describe the life cycle of erythrocytes. – Name and describe the types, causes, and effects of RBC excesses and deficiencies. ...
Membranoproliferative Glomerulonephritis
... excessive complement activation which may be caused by several mechanisms not involving antibodies. • Some patients have an autoantibody against C3 convertase called C3 nephritic factor, which is believed to stabilize the enzyme and lead to uncontrolled cleavage of C3 and activation of the alternati ...
... excessive complement activation which may be caused by several mechanisms not involving antibodies. • Some patients have an autoantibody against C3 convertase called C3 nephritic factor, which is believed to stabilize the enzyme and lead to uncontrolled cleavage of C3 and activation of the alternati ...
CD8 T cell activation predominate early immune
... Department of Clinical Sciences, Skane University Hospital Malmö, Lund University, Lund, Sweden Full list of author information is available at the end of the article ...
... Department of Clinical Sciences, Skane University Hospital Malmö, Lund University, Lund, Sweden Full list of author information is available at the end of the article ...
Ms. Costello`s and Dr. Gocke`s PowerPoint slides
... Peripheral monocytes infiltrate the CNS and secrete proinflammatory cytokines and toxic molecules, such as nitric oxide, IL-1, IL-6, and matrix metalloproteinases, that can directly damage oligodendrocytes and neurons. ...
... Peripheral monocytes infiltrate the CNS and secrete proinflammatory cytokines and toxic molecules, such as nitric oxide, IL-1, IL-6, and matrix metalloproteinases, that can directly damage oligodendrocytes and neurons. ...
Atherosclerosis
Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is a specific form of arteriosclerosis in which an artery wall thickens as a result of invasion and accumulation of white blood cells (WBCs) (foam cell) and proliferation of intimal smooth muscle cell creating a fibrofatty plaque.The accumulation of the WBCs is termed ""fatty streaks"" early on because of the appearance being similar to that of marbled steak. These accumulations contain both living, active WBCs (producing inflammation) and remnants of dead cells, including cholesterol and triglycerides. The remnants eventually include calcium and other crystallized materials within the outermost and oldest plaque. The ""fatty streaks"" reduce the elasticity of the artery walls. However, they do not affect blood flow for decades because the artery muscular wall enlarges at the locations of plaque. The wall stiffening may eventually increase pulse pressure; widened pulse pressure is one possible result of advanced disease within the major arteries.Atherosclerosis is therefore a syndrome affecting arterial blood vessels due to a chronic inflammatory response of WBCs in the walls of arteries. This is promoted by low-density lipoproteins (LDL, plasma proteins that carry cholesterol and triglycerides) without adequate removal of fats and cholesterol from the macrophages by functional high-density lipoproteins (HDL). It is commonly referred to as a ""hardening"" or furring of the arteries. It is caused by the formation of multiple atheromatous plaques within the arteries.The plaque is divided into three distinct components: The atheroma (""lump of gruel"", from Greek ἀθήρα (athera), meaning ""gruel""), which is the nodular accumulation of a soft, flaky, yellowish material at the center of large plaques, composed of macrophages nearest the lumen of the artery Underlying areas of cholesterol crystals Calcification at the outer base of older or more advanced lesions.Atherosclerosis is a chronic disease that remains asymptomatic for decades. Atherosclerotic lesions, or atherosclerotic plaques, are separated into two broad categories: Stable and unstable (also called vulnerable). The pathobiology of atherosclerotic lesions is very complicated, but generally, stable atherosclerotic plaques, which tend to be asymptomatic, are rich in extracellular matrix and smooth muscle cells. On the other hand, unstable plaques are rich in macrophages and foam cells, and the extracellular matrix separating the lesion from the arterial lumen (also known as the fibrous cap) is usually weak and prone to rupture. Ruptures of the fibrous cap expose thrombogenic material, such as collagen, to the circulation and eventually induce thrombus formation in the lumen. Upon formation, intraluminal thrombi can occlude arteries outright (e.g., coronary occlusion), but more often they detach, move into the circulation, and eventually occlude smaller downstream branches causing thromboembolism. Apart from thromboembolism, chronically expanding atherosclerotic lesions can cause complete closure of the lumen. Chronically expanding lesions are often asymptomatic until lumen stenosis is so severe (usually over 80%) that blood supply to downstream tissue(s) is insufficient, resulting in ischemia.These complications of advanced atherosclerosis are chronic, slowly progressive and cumulative. Most commonly, soft plaque suddenly ruptures (see vulnerable plaque), causing the formation of a thrombus that will rapidly slow or stop blood flow, leading to death of the tissues fed by the artery in approximately five minutes. This catastrophic event is called an infarction. One of the most common recognized scenarios is called coronary thrombosis of a coronary artery, causing myocardial infarction (a heart attack). The same process in an artery to the brain is commonly called stroke. Another common scenario in very advanced disease is claudication from insufficient blood supply to the legs. Atherosclerosis affects the entire artery tree, but mostly larger, high-pressure vessels such as the coronary, renal, femoral, cerebral, and carotid arteries. These are termed ""clinically silent"" because the person having the infarction does not notice the problem and does not seek medical help, or when they do, physicians do not recognize what has happened.