Bone Marrow-derived Mesenchymal Stromal Cells Are
... ability to undergo tri-lineage differentiation. The finding that the majority of passage 2-4 MSCs in this study were positive for MHC II expression has not been previously described. Equine studies examining MHC II expression and immunogenic properties of MSCs to date have largely focused on later p ...
... ability to undergo tri-lineage differentiation. The finding that the majority of passage 2-4 MSCs in this study were positive for MHC II expression has not been previously described. Equine studies examining MHC II expression and immunogenic properties of MSCs to date have largely focused on later p ...
Basic Components: Structure and Function
... and cellular responses. Humoral responses result in the generation of antibody reactive with a particular antigen. Antibodies are proteins with similar structures, known collectively as immunoglobulins (Ig). They can be transferred passively to another individual by injection of serum. In contrast, ...
... and cellular responses. Humoral responses result in the generation of antibody reactive with a particular antigen. Antibodies are proteins with similar structures, known collectively as immunoglobulins (Ig). They can be transferred passively to another individual by injection of serum. In contrast, ...
Antibody Feedback Regulation
... Our immune system is composed of a complex network of specialized cells and soluble mediators, which protects us against potentially pathogenic organisms such as viruses and bacteria. The immune system can be roughly divided into two parts, the innate and the adaptive immune system. The innate immun ...
... Our immune system is composed of a complex network of specialized cells and soluble mediators, which protects us against potentially pathogenic organisms such as viruses and bacteria. The immune system can be roughly divided into two parts, the innate and the adaptive immune system. The innate immun ...
Role of Estrogen nuclear receptor (ER) in T helper cells
... such as bacteria and viruses breach the physical barrier, then the innate immune system orchestrates immediate non-specific response. Macrophages and neutrophils provide the first line of defense against different microorganisms. If pathogens evade the first line of defense, the lymphocytes of adapt ...
... such as bacteria and viruses breach the physical barrier, then the innate immune system orchestrates immediate non-specific response. Macrophages and neutrophils provide the first line of defense against different microorganisms. If pathogens evade the first line of defense, the lymphocytes of adapt ...
The testis in immune privilege
... and its integrity is maintained by the time the first preleptotene spermatocytes move through the junctional complex by a coordinated opening and closing of the barrier (74). Interestingly, as JAMs play a crucial role in leukocyte transmigration (75), it is tempting to speculate that they perform a ...
... and its integrity is maintained by the time the first preleptotene spermatocytes move through the junctional complex by a coordinated opening and closing of the barrier (74). Interestingly, as JAMs play a crucial role in leukocyte transmigration (75), it is tempting to speculate that they perform a ...
Downloaded - The Journal of Immunology
... seem to be primarily responsible for control of disease progression and resolution observed in wild-type mice, as B cell deficiency resulted in more severe disease, whereas T cell deficiency had little impact on arthritis resolution and the development of other inflammatory disease manifestations in ...
... seem to be primarily responsible for control of disease progression and resolution observed in wild-type mice, as B cell deficiency resulted in more severe disease, whereas T cell deficiency had little impact on arthritis resolution and the development of other inflammatory disease manifestations in ...
Can We Translate Vitamin D Immunomodulating Effect on Innate
... and effector molecules working together against invading foreign antigens in the daily battle with microorganisms and pathogens. Those cellular components are bone marrow derived B-cells and thymus derived T-lymphocytes that form part of the adaptive immune system; and macrophages, dendritic cells ( ...
... and effector molecules working together against invading foreign antigens in the daily battle with microorganisms and pathogens. Those cellular components are bone marrow derived B-cells and thymus derived T-lymphocytes that form part of the adaptive immune system; and macrophages, dendritic cells ( ...
Regulation of memory B-cell survival by the BH3
... anti-Puma antibody was found to produce a concentrated signal inside the germinal centers (Figure 2Aii), where it was colocalized with staining for the pro-survival Bcl-2 family member Mcl-1 (Figure 2Aiii), which has recently been reported to be essential for the survival of germinal center B cells. ...
... anti-Puma antibody was found to produce a concentrated signal inside the germinal centers (Figure 2Aii), where it was colocalized with staining for the pro-survival Bcl-2 family member Mcl-1 (Figure 2Aiii), which has recently been reported to be essential for the survival of germinal center B cells. ...
Inflammation plays a key role at all stages of the
... role of Th1 immunity in atherosclerosis were based on induction of disease by hypercholesterolemia suggests that the relevant autoantigen is a lipoprotein or possibly a protein modified by lipids. Most attention has focused on the role of oxidized LDL in these processes. Antibodies against oxidized ...
... role of Th1 immunity in atherosclerosis were based on induction of disease by hypercholesterolemia suggests that the relevant autoantigen is a lipoprotein or possibly a protein modified by lipids. Most attention has focused on the role of oxidized LDL in these processes. Antibodies against oxidized ...
T-regulatory cells in ischemic injury.
... Furthermore, histopathological analyses showed that there was a pronounced incidence of necrosis for both PC61 treated and IgG in IR 24 hours experiments. On the other hand, in IR 72 hours experiments we observed a regeneration pattern in both PC61 and IgG treated animals, but in the PC61 treated gr ...
... Furthermore, histopathological analyses showed that there was a pronounced incidence of necrosis for both PC61 treated and IgG in IR 24 hours experiments. On the other hand, in IR 72 hours experiments we observed a regeneration pattern in both PC61 and IgG treated animals, but in the PC61 treated gr ...
Organs from the endoderm
... tcron. Ills. IIIesohlastie soinites. N. Notochord. Ns. Nelll'al crest. IlL. :Òlediillary tube. PR. Pronephros. SN. Siihnotochordal l'od. So, Sr. Soinatie and splandinie mesoderm. (After IIIarshal!.) ...
... tcron. Ills. IIIesohlastie soinites. N. Notochord. Ns. Nelll'al crest. IlL. :Òlediillary tube. PR. Pronephros. SN. Siihnotochordal l'od. So, Sr. Soinatie and splandinie mesoderm. (After IIIarshal!.) ...
Moderate Physical Exercise and Purinergic Signaling: The Impact of
... The aim of this letter is to summarize the impact of ectonucleotidases activities on platelets and lymphocytes in a model of moderate physical exercise: rats submitted to swimming training. A vast body of evidence during the last few decades has shown the clear benefits of moderate physical exercise ...
... The aim of this letter is to summarize the impact of ectonucleotidases activities on platelets and lymphocytes in a model of moderate physical exercise: rats submitted to swimming training. A vast body of evidence during the last few decades has shown the clear benefits of moderate physical exercise ...
Th17 Cells Coordinate with Th22 Cells in Maintaining Homeostasis
... are preferentially depleted in the gastrointestinal (GI) tracts of HIVinfected humans and SIV-infected rhesus macaques (RMs) [5-7]. In contrast, Th17 cells are maintained at relatively normal levels in the GI tract of SIV-infected natural host species, HIV-infected long-term nonprogressors, as well ...
... are preferentially depleted in the gastrointestinal (GI) tracts of HIVinfected humans and SIV-infected rhesus macaques (RMs) [5-7]. In contrast, Th17 cells are maintained at relatively normal levels in the GI tract of SIV-infected natural host species, HIV-infected long-term nonprogressors, as well ...
Human endometrial regenerative cells alleviate carbon tetrachloride
... liver diseases are required. Recent development in stem cell-based therapeutic strategies have already garnered extensive attention and been introduced to regenerative medicine for hepatic diseases [3–5]. It has been demonstrated that infused mesenchymal stem cells (MSCs) engrafting in the liver fac ...
... liver diseases are required. Recent development in stem cell-based therapeutic strategies have already garnered extensive attention and been introduced to regenerative medicine for hepatic diseases [3–5]. It has been demonstrated that infused mesenchymal stem cells (MSCs) engrafting in the liver fac ...
Characterization of Pax3-expressing cells from adult blood vessels
... muscle-like cells located immediately adjacent to vascular endothelial cells, as well as cells described as myoendothelial cells, also show multipotency (Dellavalle et al., 2007; Kirillova et al., 2007; Zheng et al., 2007), with spontaneous differentiation into skeletal muscle. Myogenic reprogrammin ...
... muscle-like cells located immediately adjacent to vascular endothelial cells, as well as cells described as myoendothelial cells, also show multipotency (Dellavalle et al., 2007; Kirillova et al., 2007; Zheng et al., 2007), with spontaneous differentiation into skeletal muscle. Myogenic reprogrammin ...
The presence of cytotoxic autoantibody to lacrimal gland cells
... in humans.4-5'8'9 The predominant immunologic feature of NZB/W mice is the presence of hyperactive B-cells early in life. This results in the abundant production of various autoantibodies such as antinuclear antibody6'7 and antithymocyte antibody. 1314 Besides these well-known autoantibodies, three ...
... in humans.4-5'8'9 The predominant immunologic feature of NZB/W mice is the presence of hyperactive B-cells early in life. This results in the abundant production of various autoantibodies such as antinuclear antibody6'7 and antithymocyte antibody. 1314 Besides these well-known autoantibodies, three ...
IFN-g from CD4 T Cells Is Essential for Host Survival and Enhances
... Gallegos et al. supports that CD4 T cells have IFN-g–independent mechanisms of controlling M. tuberculosis infection in vivo (10). Taken together, these data suggest that CD4 T cells have roles in addition to IFN-g production. These data lead to the hypotheses that IFN-g from sources other than CD4 ...
... Gallegos et al. supports that CD4 T cells have IFN-g–independent mechanisms of controlling M. tuberculosis infection in vivo (10). Taken together, these data suggest that CD4 T cells have roles in addition to IFN-g production. These data lead to the hypotheses that IFN-g from sources other than CD4 ...
About and Key Statistics - American Cancer Society
... Some can kill cancer cells by themselves. Others have radioactive molecules or cell poisons attached to them, which help kill cancer cells. An advantage of these drugs is that they seem to target lymphoma cells while having fewer side effects than standard chemo drugs. They may be used alone or comb ...
... Some can kill cancer cells by themselves. Others have radioactive molecules or cell poisons attached to them, which help kill cancer cells. An advantage of these drugs is that they seem to target lymphoma cells while having fewer side effects than standard chemo drugs. They may be used alone or comb ...
Review - International Federation of Cell Therapy Professionals
... human keratinocytes were shown to be 100-fold more efficient and 2-fold faster at generating iPSCs when compared with other human fibroblasts.46 Also, hematopoietic stem cells were found to be 300× more efficient at iPSC generation when compared with mature T/B cells.47 These results are in agreemen ...
... human keratinocytes were shown to be 100-fold more efficient and 2-fold faster at generating iPSCs when compared with other human fibroblasts.46 Also, hematopoietic stem cells were found to be 300× more efficient at iPSC generation when compared with mature T/B cells.47 These results are in agreemen ...
download--no narration
... organisms that normally in and on our body are part of it (we are more bacterial cells than human cells!) • During fetal/childhood/adolescent development, immune cells are exposed to body’s own cells and the proteins that they have on their surface. This happens mostly in the thymus and bone marrow. ...
... organisms that normally in and on our body are part of it (we are more bacterial cells than human cells!) • During fetal/childhood/adolescent development, immune cells are exposed to body’s own cells and the proteins that they have on their surface. This happens mostly in the thymus and bone marrow. ...
Lineage Commitment During T cell Development
... in gd T cells. Its KO, decreases gd development. Its over-expression in DN thymocytes impairs DN -> DP transition and ab T cell development. Bcl11b, a zinc finger transcription factor, is preferentially expressed in ab lineage T cells and is induced in DN2a-DN2b. It is low in the gd lineage. The KO ...
... in gd T cells. Its KO, decreases gd development. Its over-expression in DN thymocytes impairs DN -> DP transition and ab T cell development. Bcl11b, a zinc finger transcription factor, is preferentially expressed in ab lineage T cells and is induced in DN2a-DN2b. It is low in the gd lineage. The KO ...
Early Interferon-c Production in Human Lymphocyte Subsets
... intracellular bacteria and their ability to survive within cells is essential for virulence [14]. The high susceptibility of individuals with chronic granulomatous disease, who lack normal phagocyte oxidative burst function, to infection with Salmonellae [15,16] indicates the importance of cellular ...
... intracellular bacteria and their ability to survive within cells is essential for virulence [14]. The high susceptibility of individuals with chronic granulomatous disease, who lack normal phagocyte oxidative burst function, to infection with Salmonellae [15,16] indicates the importance of cellular ...
brain regeneration in physiology and pathology: the immune
... features such as unlimited capacity for self-renewal, indefinite ability to proliferate in response to mitogens, and multipotency for differentiation, characterized by the ability to give rise to different neuroectodermal lineages of the CNS; 2) multipotent progenitors of the adult brain, which are ...
... features such as unlimited capacity for self-renewal, indefinite ability to proliferate in response to mitogens, and multipotency for differentiation, characterized by the ability to give rise to different neuroectodermal lineages of the CNS; 2) multipotent progenitors of the adult brain, which are ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.