Crosstalk between Red Blood Cells and the Immune System and Its
... atherosclerotic disease progression, via activation or attenuation of inflammatory responses. However, the mechanisms underlying macrophage polarization and activation within the plaque remain unclear [68, 69]. The interactions between macrophages and RBCs are important for RBC clearance and homeost ...
... atherosclerotic disease progression, via activation or attenuation of inflammatory responses. However, the mechanisms underlying macrophage polarization and activation within the plaque remain unclear [68, 69]. The interactions between macrophages and RBCs are important for RBC clearance and homeost ...
Mathematical Models of Immune Responses Following Vaccination
... supportive functions. T h1 cells secrete pro-inflammatory cytokines [24] such as Interferonγ (IFN-γ) and tumor necrosis factor α (TNF-α) which cause reactions in infected cells, that lead to their destruction. They also support macrophage activation and CD8 T cell differentiation [31]. For these rea ...
... supportive functions. T h1 cells secrete pro-inflammatory cytokines [24] such as Interferonγ (IFN-γ) and tumor necrosis factor α (TNF-α) which cause reactions in infected cells, that lead to their destruction. They also support macrophage activation and CD8 T cell differentiation [31]. For these rea ...
The race between infection and immunity
... In fast infections, the rapid growth of pathogens and cytotoxic T lymphocytes (CTL) often leads to the number of CTL significantly 'overshooting' the number required for pathogen containment, and thus there is a high ratio of T cells to pathogen later in infection facilitating pathogen clearance. In ...
... In fast infections, the rapid growth of pathogens and cytotoxic T lymphocytes (CTL) often leads to the number of CTL significantly 'overshooting' the number required for pathogen containment, and thus there is a high ratio of T cells to pathogen later in infection facilitating pathogen clearance. In ...
Gene Expression Measurement of Immuno
... ranging between 0.96 to 0.99 shown for HTG EdgeSeq Immuno-Oncology Assay). High reproducibility was observed across technical replicates and across platforms (r ≥ 0.94) and days (median r > 0.93; data not shown) for both assays. In two melanoma tumors, the lymphocyte infiltrates appear to be similar ...
... ranging between 0.96 to 0.99 shown for HTG EdgeSeq Immuno-Oncology Assay). High reproducibility was observed across technical replicates and across platforms (r ≥ 0.94) and days (median r > 0.93; data not shown) for both assays. In two melanoma tumors, the lymphocyte infiltrates appear to be similar ...
Microglial Phagocytosis of FibrillarЯ
... accelerates the disease process. Paradoxically, despite the presence of abundant activated microglia in the brain of AD patients, these cells fail to mount a phagocytic response to A deposits but can efficiently phagocytose A fibrils and plaques in vitro. We report that exposure of microglia to fA ...
... accelerates the disease process. Paradoxically, despite the presence of abundant activated microglia in the brain of AD patients, these cells fail to mount a phagocytic response to A deposits but can efficiently phagocytose A fibrils and plaques in vitro. We report that exposure of microglia to fA ...
lymphatic - Ruhr-Universität Bochum
... Topic 3: Immune response to infection (Prof. Bufe) - 22.06.16 1. Phases of infection (Janeway 430, 11.1); Role of innate immune response for adaptive response (Janeway 432; 11.2); Cytokines and different T-cell subsets in response to different pathogens (Janeway 434-439; 11.3-11.5) ...
... Topic 3: Immune response to infection (Prof. Bufe) - 22.06.16 1. Phases of infection (Janeway 430, 11.1); Role of innate immune response for adaptive response (Janeway 432; 11.2); Cytokines and different T-cell subsets in response to different pathogens (Janeway 434-439; 11.3-11.5) ...
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... TCR␥␦ T cells (see Table 4).18,19 NK cells represent a third class of lymphocytes distinct from B and T cells and do not express a clonally distributed antigen receptor that is subject to somatic diversification. Mouse liver lymphocytes contain about 10% NK cells, whereas rat and human liver lymphocy ...
... TCR␥␦ T cells (see Table 4).18,19 NK cells represent a third class of lymphocytes distinct from B and T cells and do not express a clonally distributed antigen receptor that is subject to somatic diversification. Mouse liver lymphocytes contain about 10% NK cells, whereas rat and human liver lymphocy ...
Lung cancer-initiating cells: a novel target for cancer therapy
... Stem cells and the role of CICs in tumorigenesis Normal somatic stem cells have the following attributes: (1) they are capable of self-renewal and repair in adult tissues; (2) they have the capacity for differentiation and the ability to generate a large number of multi-lineage progeny; (3) they are ...
... Stem cells and the role of CICs in tumorigenesis Normal somatic stem cells have the following attributes: (1) they are capable of self-renewal and repair in adult tissues; (2) they have the capacity for differentiation and the ability to generate a large number of multi-lineage progeny; (3) they are ...
Immunometabolism governs dendritic cell and macrophage function
... cytokines. Metabolites such as succinate and citrate have a direct impact on the functioning of macrophages. Immunogenicity and tolerogenicity of DCs is also determined by anabolic and catabolic processes, respectively. These findings provide new prospects for therapeutic manipulation in inflammator ...
... cytokines. Metabolites such as succinate and citrate have a direct impact on the functioning of macrophages. Immunogenicity and tolerogenicity of DCs is also determined by anabolic and catabolic processes, respectively. These findings provide new prospects for therapeutic manipulation in inflammator ...
Immunometabolism governs dendritic cell and macrophage function
... cytokines. Metabolites such as succinate and citrate have a direct impact on the functioning of macrophages. Immunogenicity and tolerogenicity of DCs is also determined by anabolic and catabolic processes, respectively. These findings provide new prospects for therapeutic manipulation in inflammator ...
... cytokines. Metabolites such as succinate and citrate have a direct impact on the functioning of macrophages. Immunogenicity and tolerogenicity of DCs is also determined by anabolic and catabolic processes, respectively. These findings provide new prospects for therapeutic manipulation in inflammator ...
Role of dopamine in the physiology of T
... 2008). The Th1 phenotype is favoured by the secretion of IL-12 by DCs. In contrast, Th2 phenotype is induced in the absence of IL-12 secretion during Ag recognition (Watford et al., 2003). Th1 cells predominantly secrete IFN-γ to promote cellular immunity against intracellular pathogens and tumor ce ...
... 2008). The Th1 phenotype is favoured by the secretion of IL-12 by DCs. In contrast, Th2 phenotype is induced in the absence of IL-12 secretion during Ag recognition (Watford et al., 2003). Th1 cells predominantly secrete IFN-γ to promote cellular immunity against intracellular pathogens and tumor ce ...
Indirect involvement of allergen-captured mast cells
... fluorescent OVA was observed in mast cells pretreated with anti-DNP IgE, as measured by flow cytometry. However, in BMMCs pretreated with anti-OVA IgE, a 5- to 10-fold increase in OVA uptake was seen after a 1-hour (Figure 1B,D) or 24-hour (Figure 1C) incubation with fluorescent OVA. The increase in ...
... fluorescent OVA was observed in mast cells pretreated with anti-DNP IgE, as measured by flow cytometry. However, in BMMCs pretreated with anti-OVA IgE, a 5- to 10-fold increase in OVA uptake was seen after a 1-hour (Figure 1B,D) or 24-hour (Figure 1C) incubation with fluorescent OVA. The increase in ...
Klin immunology_1
... A. The incidence of autoimmune disese is increased. B. The reduced number of IgA-bearing B cells accounts for the reduced serum IgA levels. C. Bone marrow transplantation is needed D. Secretory IgA levels usually are normal. E. Nothing above ANSWER:A 15. Chemically induced tumors have tumor-associat ...
... A. The incidence of autoimmune disese is increased. B. The reduced number of IgA-bearing B cells accounts for the reduced serum IgA levels. C. Bone marrow transplantation is needed D. Secretory IgA levels usually are normal. E. Nothing above ANSWER:A 15. Chemically induced tumors have tumor-associat ...
Preventing Infection at Mucosal Surfaces
... In every mucosal tissue, a layer of epithelial cells joined by tight junctions separates the outside environment from the inside of the body. The epithelial layer provides a formidable barrier that prevents commensal and pathogenic organisms from gaining access to the internal issues. Adding to this ...
... In every mucosal tissue, a layer of epithelial cells joined by tight junctions separates the outside environment from the inside of the body. The epithelial layer provides a formidable barrier that prevents commensal and pathogenic organisms from gaining access to the internal issues. Adding to this ...
The Role of Th-17 Cells and γδ T-Cells in Modulating the Systemic
... and γδ T-cell-deficient mice to thermal injury have demonstrated a causative relationship between γδ T-cell activation, chemokine production and the post-burn inflammatory response [13]. In peripheral lymphoid tissues such as the spleen where αβ T-cells predominate, γδ T-cells are only present at lo ...
... and γδ T-cell-deficient mice to thermal injury have demonstrated a causative relationship between γδ T-cell activation, chemokine production and the post-burn inflammatory response [13]. In peripheral lymphoid tissues such as the spleen where αβ T-cells predominate, γδ T-cells are only present at lo ...
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC). It is more formally known as lymphoid hematopoiesis.Pathosis in lymphopoiesis leads to any of various lymphoproliferative disorders, such as the lymphomas and lymphoid leukemias.