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Insulin Signaling
Insulin Signaling

Chapter 8: Fibrous Proteins
Chapter 8: Fibrous Proteins

... -keratin is rich in Cys residues and disulfide bridges One of the difference between the many -keratin proteins is their Cys content The mechanical strength of horns, nails and skin depends upon the content of Cys residues and the number of disulfide bridges The more disulfide bridges the more rig ...
Membrane
Membrane

... a fluid state to a solid state • The temperature at which a membrane solidifies depends on the types of lipids • Membranes rich in unsaturated fatty acids are more fluid that those rich in saturated fatty acids • Membranes must be fluid to work properly; they are usually about as fluid as salad oil ...
Molecule Pages - Berkeley Database Group
Molecule Pages - Berkeley Database Group

...  A collaboration with the research community through the Alliance for Cellular Signaling  An experiment in the next generation of online, database-driven scientific publications ...
Document
Document

... To label target proteins with Se-Met, PASM-5052 auto-inducing medium is inoculated with a fresh overnight culture grown in PA-0.5G. Growth at 37C from a thousand-fold dilution into PASM-5052 typically reaches saturation in 14-16 hours. Growth at 20C is much slower and a culture can take 3 days or ...
Characterization of the binding properties of the Avian Coronavirus
Characterization of the binding properties of the Avian Coronavirus

... List of figures ............................................................................................................. I List of tables ............................................................................................................... II List of Abbreviations .................... ...
Acyl-CoA
Acyl-CoA

... - Being small and water-soluble, ketone bodies serve as important metabolic fuels for tissues such as the: (1) Heart (virtually no glycogen reserves)—since heart primarily relies on fatty acids for energy production, ketone bodies serve as an alternative source of fuel that can be readily “burned” v ...
CMBI
CMBI

... – How do the proteins encoded in genomes interact with each other to produce cells and phenotypes ? – To predict such functional interactions between proteins as there exist e.g. in metabolic pathways, signalling pathways or protein complexes ...
Plasma Membrane Transporter Protein Mutations
Plasma Membrane Transporter Protein Mutations

... were present in kidney and gut epithelium. SGLT1 is shared by the kidney and gut, whereas SGLT2 functions predominantly in the kidney alone and causes renal glycosuria without glucose-galactose malabsorption (see Table 216-4 ). An insulin-responsive, facilitative glucose transporter (GLUT4) is not ...
GFP is the way to glow: bioimaging of the plant endomembrane
GFP is the way to glow: bioimaging of the plant endomembrane

... The first report on the visualization of the Golgi apparatus in living plant cells with GFP dates back to 1998 (Boevink et al., 1998), whereas the mammalian counterpart dates back to 2 years earlier (Cole et al., 1996). The Golgi apparatus in living plant cells has been first visualized with two dif ...
Roles of phosphatidate phosphatase enzymes in lipid metabolism
Roles of phosphatidate phosphatase enzymes in lipid metabolism

ribosome binding site Prokaryotic mRNAs have a ribosome binding
ribosome binding site Prokaryotic mRNAs have a ribosome binding

... • Although the expression of most genes is regulated at the level of mRNA transcription, it is more effective for the cell to regulate gene expression at the level of translation. • As with other types of regulation, translational control typically functions at the level of initiation. ...
Viral Antigens Recombinant Proteins
Viral Antigens Recombinant Proteins

... Meridian Life Science offers live viruses for your pre-clinical or research needs The World Health Organization (WHO) published a media release on a Measles (Rubeola) outbreak. Thirty countries in the European Union have reported a total of 6,500 Measles cases in the first four months of 2011. The c ...
Improving muscle mass: response of muscle metabolism to exercise
Improving muscle mass: response of muscle metabolism to exercise

... Muscle mass is critical for human health, physical activity and function, as well as for athletic performance [1]. Improvement of muscle mass is of great interest to many varied populations. Athletes and body builders desire to increase muscle mass and strength for competitive reasons. Others, such ...
Structures of nucleotide-bound and free aIF2γ from Sulfolobus
Structures of nucleotide-bound and free aIF2γ from Sulfolobus

... The α- and β-phosphates of GDP are located in the cavity limited by the main chain amide groups of the P-loop (residues 18-23), switch 2 (residues 96-97), hydroxyl group of Thr23 and the side chain of strictly conserved Lys22. It is interesting to note that most of the main chain amide groups of th ...
Pyropheophytin a accompanies pheophytin a in darkened light
Pyropheophytin a accompanies pheophytin a in darkened light

... Bony Fishes Vascular Specialization in Fish, but No Evidence for Lymphatics ...
- Free Documents
- Free Documents

... enterokinase. The major proteolytic enzyme in the stomach is pepsin. while carboxypeptidase B cleaves Cterminal arginine or lysine residues. and proelastase. Pepsin preferentially attacks peptide bonds involving residues of aromatic amino acids. which is secreted by the chief cells of the gastric mu ...
A fluorophore ligase for site-specific protein labeling inside living cells
A fluorophore ligase for site-specific protein labeling inside living cells

... explore the biology of nuclear actin. Cytosolic β-actin has a wellrecognized role in controlling cell migration and morphology, but biochemical studies have also suggested several roles for β-actin in the nucleus, including involvement in transcriptional regulation (24) and chromatin remodeling (25) ...
O - Portland State University
O - Portland State University

... if each step occurs in low yield, or if the concentrations of precursors is low, then the overall yield is in danger of being so small as to be negligible ...
LecturesPart07
LecturesPart07

... and X17254 (human) erythroid transcription factors using Entrez  Do Pustell Protein Matrix Analysis ...
Strain in Protein Structures as Viewed Through Nonrotameric Side
Strain in Protein Structures as Viewed Through Nonrotameric Side

... nonrotameric residues cannot be attributed to structural resolution, because the rotamericity (fraction of all side chains in a protein structure found rotameric) does not increase with crystallographic resolutions ⬍1.9 Å. Schrauber et al. suggested that nonrotamericity is often a result of functio ...
Protein-protein interactions: mechanisms and
Protein-protein interactions: mechanisms and

... The charge density varies from 0 to 12 charged groups per interface surface (Xu et al., 1997b). The distribution of the opposite charges in the interfaces of the contacting area showed that salt bridges across them are highly favourable (Drozdov-Tikhomirov et al., 2001; Xu et al., 1997a,b). The deso ...
Gluconeogenesis Glycogen metabolism
Gluconeogenesis Glycogen metabolism

... and to a lesser extent in the kidney, only these tissues can release free glucose into the blood. The dephosphorylation of glucose 6-phosphate takes place within the lumen of endoplasmic reticulum. ...
GFP - Bio-Rad
GFP - Bio-Rad

... the right conditions, these bacteria can make authentic human insulin. When allowed to multiply in gigantic vats (fermenters) these bacteria can be used to mass produce the human insulin protein. This genetically engineered insulin is purified using protein chromatography and used to treat patients ...
Examples from metabolism of xenobiotics
Examples from metabolism of xenobiotics

... 1. ENTRANCE TO THE BODY digestive tract → blood → LIVER lungs → blood skin → blood Xenobiotics are metabolized at the place of „their entrance or exit“ ...
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Proteolysis



Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Low pH or high temperatures can also cause proteolysis non-enzymatically.Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of a polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes, as well as preventing the accumulation of unwanted or abnormal proteins in cells. Consequently, dis-regulation of proteolysis can cause diseases, and is used in some venoms to damage their prey.Proteolysis is important as an analytical tool for studying proteins in the laboratory, as well as industrially, for example in food processing and stain removal.
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