WO 2012/149481 Al
... one or more reactive groups on the peptide have been derivatized with a substituent group. Examples of peptide derivatives include peptides in which an amino acid side chain, a peptide backbone, or an amino- or carboxy-terminus has been modified (e.g., methylation, Nacylation, etc.). The peptide can ...
... one or more reactive groups on the peptide have been derivatized with a substituent group. Examples of peptide derivatives include peptides in which an amino acid side chain, a peptide backbone, or an amino- or carboxy-terminus has been modified (e.g., methylation, Nacylation, etc.). The peptide can ...
Chapter 1
... • Allosteric enzymes are the basis for feedback inhibition • With feedback inhibition, a product late in a series of enzyme-catalyzed reactions serves as an inhibitor for a previous allosteric enzyme earlier in the series • In this example, product F serves to inhibit the activity of enzyme E1 – Pro ...
... • Allosteric enzymes are the basis for feedback inhibition • With feedback inhibition, a product late in a series of enzyme-catalyzed reactions serves as an inhibitor for a previous allosteric enzyme earlier in the series • In this example, product F serves to inhibit the activity of enzyme E1 – Pro ...
Solubility of recombinant Src homology 2 domains expressed in E
... SH2 domain sequence (S90-R188) revealed that the βC strand of the human TSAd SH2 domain (Figure 1) harbours a nine aa sequence (SAVTFVLTY) with near 100% propensity for intermolecular beta-sheet aggregation (Figure 3A). Similar results were obtained for the murine and rat sequences, whereas no beta- ...
... SH2 domain sequence (S90-R188) revealed that the βC strand of the human TSAd SH2 domain (Figure 1) harbours a nine aa sequence (SAVTFVLTY) with near 100% propensity for intermolecular beta-sheet aggregation (Figure 3A). Similar results were obtained for the murine and rat sequences, whereas no beta- ...
Safety assessment - Food Standards Australia New Zealand
... information to consumers. In fulfilling these objectives, FSANZ also had regard for the need for standards to be based on risk analysis using the best available scientific evidence and the desirability of an efficient and internationally competitive food industry. ...
... information to consumers. In fulfilling these objectives, FSANZ also had regard for the need for standards to be based on risk analysis using the best available scientific evidence and the desirability of an efficient and internationally competitive food industry. ...
Powerpoint Presentation: Translation
... same direction 5’ to 3’ (the same way as transcription and replication) The polypeptide chain is constructed from the amino end to the carboxyl end ...
... same direction 5’ to 3’ (the same way as transcription and replication) The polypeptide chain is constructed from the amino end to the carboxyl end ...
Structural Characterization of Humanized Nanobodies with
... CyaA is synthesized as an inactive precursor which requires a palmitoyl group be added at Lys983 by CyaC acyltransferase [7,13,14]. The CyaA-RTX subdomain is involved in toxin binding to target cells through the αM β2 -integrin receptor (also known as CD11b/CD18) expressed on the surface of cells in ...
... CyaA is synthesized as an inactive precursor which requires a palmitoyl group be added at Lys983 by CyaC acyltransferase [7,13,14]. The CyaA-RTX subdomain is involved in toxin binding to target cells through the αM β2 -integrin receptor (also known as CD11b/CD18) expressed on the surface of cells in ...
الشريحة 1
... 6- Citric acid loses water and CO on treatment with H2SO4 giving acetone dicarboxylic acid which on strong heating decomposes into acetone and CO2. ...
... 6- Citric acid loses water and CO on treatment with H2SO4 giving acetone dicarboxylic acid which on strong heating decomposes into acetone and CO2. ...
PDF - Walter Lab
... elongation (Walter and Blobel, 1981; Siegel and Walter, 1985). Second, targeting to the ER is mediated through direct interaction of the SRP bound to the ribosome with an integral membrane protein, the SRP receptor or docking protein (Gilmore et al., 1982; Meyer et al., 1982), of the ER membrane (Ho ...
... elongation (Walter and Blobel, 1981; Siegel and Walter, 1985). Second, targeting to the ER is mediated through direct interaction of the SRP bound to the ribosome with an integral membrane protein, the SRP receptor or docking protein (Gilmore et al., 1982; Meyer et al., 1982), of the ER membrane (Ho ...
Regulation of the heat stress response in Arabidopsis by
... It was shown that the transcriptional activity of mammalian Hsf1 is regulated by phosphorylation (Knauf et al., 1996; Kline & Morimoto, 1997; Holmberg et al., 2001). So far, 5 phosphorylation sites have been characterized for mammalian Hsf1: S230, S303, S307, S326 and S363 (Chu et al., 1996). During ...
... It was shown that the transcriptional activity of mammalian Hsf1 is regulated by phosphorylation (Knauf et al., 1996; Kline & Morimoto, 1997; Holmberg et al., 2001). So far, 5 phosphorylation sites have been characterized for mammalian Hsf1: S230, S303, S307, S326 and S363 (Chu et al., 1996). During ...
الشريحة 1
... 6- Citric acid loses water and CO on treatment with H2SO4 giving acetone dicarboxylic acid which on strong heating decomposes into acetone and CO2. ...
... 6- Citric acid loses water and CO on treatment with H2SO4 giving acetone dicarboxylic acid which on strong heating decomposes into acetone and CO2. ...
4 Titration Curve of an Amino Acid
... A few amino acids are classified as triprotic. This is because, in addition to the ionizable protons of the α-COOH and α-NH3 groups, they also have a dissociable proton in their R group. Although triprotic amino acids can exist as zwitterions, under physiological conditions these amino acids will be ...
... A few amino acids are classified as triprotic. This is because, in addition to the ionizable protons of the α-COOH and α-NH3 groups, they also have a dissociable proton in their R group. Although triprotic amino acids can exist as zwitterions, under physiological conditions these amino acids will be ...
Catalytic Strategies
... acceleration from formation of covalent bonds between enzyme and substrate • Amino acids side chains offer variety of nucleophilic centers for catalysis • These groups readily attack electrophilic centers of substrates, forming covalent enzyme-substrate complexes • The covalent intermediate can be a ...
... acceleration from formation of covalent bonds between enzyme and substrate • Amino acids side chains offer variety of nucleophilic centers for catalysis • These groups readily attack electrophilic centers of substrates, forming covalent enzyme-substrate complexes • The covalent intermediate can be a ...
Biogenesis of proteins of the mitochondrial intermembrane space
... genomes and phylogenetic studies supported the idea of an α-proteobacterium inhabiting the cytosol of the first eukaryotes as the ancestor of mitochondria (Gray, Burger et al. 1999; Kurland and Andersson 2000; Herrmann 2003). Following the change from the endosymbiont to an organelle, a large fracti ...
... genomes and phylogenetic studies supported the idea of an α-proteobacterium inhabiting the cytosol of the first eukaryotes as the ancestor of mitochondria (Gray, Burger et al. 1999; Kurland and Andersson 2000; Herrmann 2003). Following the change from the endosymbiont to an organelle, a large fracti ...
Lecture 9-Mycology
... C. both sexual (meiotic) and asexual (mitotic) spores may be produced, depending on the species and conditions D. typically not motile, although a few (e.g. Chytrids) have a motile phase. E. like plants, may have a stable haploid & diploid states ...
... C. both sexual (meiotic) and asexual (mitotic) spores may be produced, depending on the species and conditions D. typically not motile, although a few (e.g. Chytrids) have a motile phase. E. like plants, may have a stable haploid & diploid states ...
Molecular Characterization of a Hamster Oviduct
... of the mature form of the HOGP region. The amino acid sequence of HOGP appeared to have eight potential N-glycosylation sites. Northern blot analysis revealed that a single message of approximately 2.5 kb was present inoviductal RNA but not inthe RNA of several other hamster tissues. The HOGP showed ...
... of the mature form of the HOGP region. The amino acid sequence of HOGP appeared to have eight potential N-glycosylation sites. Northern blot analysis revealed that a single message of approximately 2.5 kb was present inoviductal RNA but not inthe RNA of several other hamster tissues. The HOGP showed ...
Summary of Chapter 24
... • Ser • Phe → Tyr by phenylalanine-4-monooxygenase. • Glutamine synthetase is a central control point in the nitrogen metabolism, since Gln is an amino group donor and a storage of ammonia. 1. Feedback inhibition: His, Tyr, carbamoyl phosphate, AMP, CTP, glucosamine-6phosphate (all end ...
... • Ser • Phe → Tyr by phenylalanine-4-monooxygenase. • Glutamine synthetase is a central control point in the nitrogen metabolism, since Gln is an amino group donor and a storage of ammonia. 1. Feedback inhibition: His, Tyr, carbamoyl phosphate, AMP, CTP, glucosamine-6phosphate (all end ...
Energy Cycle in Vertebrates - Jean
... Figure 1 Food enters the body as a mixture of lipids, carbohydrates and proteins. These compounds are digested, assimilated and stored as triacylglycerol and glycogen, mainly in adipose tissue, liver and muscle. Over 90% of total energy reserves are in the form of triacylglycerol for long-term, main ...
... Figure 1 Food enters the body as a mixture of lipids, carbohydrates and proteins. These compounds are digested, assimilated and stored as triacylglycerol and glycogen, mainly in adipose tissue, liver and muscle. Over 90% of total energy reserves are in the form of triacylglycerol for long-term, main ...
enzymes lecture 1
... 1- Enzymes increase the rate of reaction by decreasing the activation energy of reaction. 2- The activation energy is the energy barrier between reactants and products. ...
... 1- Enzymes increase the rate of reaction by decreasing the activation energy of reaction. 2- The activation energy is the energy barrier between reactants and products. ...
Chapter 10. Delivering Oxygen.
... Under conditions of chronic, long-term O2 deprivation, more capillaries form. This can happen when living for a long time at high altitudes and some people living at high altitude in the Andes have this condition. Formation of more capillaries may also occur in people who are suffering from a weaken ...
... Under conditions of chronic, long-term O2 deprivation, more capillaries form. This can happen when living for a long time at high altitudes and some people living at high altitude in the Andes have this condition. Formation of more capillaries may also occur in people who are suffering from a weaken ...
Human Physiology
... Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. ...
... Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. ...
Proteolysis
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Low pH or high temperatures can also cause proteolysis non-enzymatically.Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of a polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes, as well as preventing the accumulation of unwanted or abnormal proteins in cells. Consequently, dis-regulation of proteolysis can cause diseases, and is used in some venoms to damage their prey.Proteolysis is important as an analytical tool for studying proteins in the laboratory, as well as industrially, for example in food processing and stain removal.