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Nervous System
Nervous System

... The cranial meninges are continuous with the spinal meninges and are named the dura mater, arachnoid and pia mater. The brain contains cavities called ventricles which communicate with one another, with the central canal of the spinal cord, and with the subarachnoid space. Cerebrospinal fluid is for ...
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Chapter 12 The Nervous System

... y Caused by deposits of a protein called amyloid in the brain that disrupts communication between brain cells y Levels of acetylcholine drop, further breaking down brain cell communication. y Patients start out not being able to remember things, have difficulty learning. y Eventually old memories ar ...
Chapter 1 A Perspective on Human Genetics
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... • Minimizes possibility that harmful blood-borne substances might reach central nervous tissue • Prevents certain circulating hormones that could also act as neurotransmitters from reaching brain • Limits use of drugs for treatment of brain and spinal cord disorders – Many drugs cannot penetrate BBB ...
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Chapter 12 The Nervous System
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... Metabolic pathways in the brain show some striking particularities mainly due to the blood-brain barrier (BBB) that blocks the free diffusion of polar solutes from the blood to the brain. The BBB is formed by endothelial cells with continuous tight junctions that exhibit very low pinocytotic activit ...
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Blood–brain barrier



The blood–brain barrier (BBB) is a highly selective permeability barrier that separates the circulating blood from the brain extracellular fluid (BECF) in the central nervous system (CNS). The blood–brain barrier is formed by brain endothelial cells, which are connected by tight junctions with an extremely high electrical resistivity of at least 0.1 Ω⋅m. The blood–brain barrier allows the passage of water, some gases, and lipid-soluble molecules by passive diffusion, as well as the selective transport of molecules such as glucose and amino acids that are crucial to neural function. On the other hand, the blood–brain barrier may prevent the entry of lipophilic, potential neurotoxins by way of an active transport mechanism mediated by P-glycoprotein. Astrocytes are necessary to create the blood–brain barrier. A small number of regions in the brain, including the circumventricular organs (CVOs), do not have a blood–brain barrier.The blood–brain barrier occurs along all capillaries and consists of tight junctions around the capillaries that do not exist in normal circulation. Endothelial cells restrict the diffusion of microscopic objects (e.g., bacteria) and large or hydrophilic molecules into the cerebrospinal fluid (CSF), while allowing the diffusion of small hydrophobic molecules (O2, CO2, hormones). Cells of the barrier actively transport metabolic products such as glucose across the barrier with specific proteins. This barrier also includes a thick basement membrane and astrocytic endfeet.
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