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Nervous system functions
Nervous system functions

... • Selective barrier that allows nutrients to pass freely • Is ineffective against substances that can diffuse through plasma membranes (ex. Ethanol, caffeine) • Absent in some areas: • Ex. - hormones generally do not penetrate the brain from the blood, so in order to control the rate of hormone secr ...
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Reverse Engineering the Brain - Biomedical Computation Review
Reverse Engineering the Brain - Biomedical Computation Review

... chosen a certain way and when you choose that, it becomes easier, not more difficult.” has chosen a certain way and when you choose that, it becomes easier, not more difficult.” Data for the Blue Brain project was gathered using a key innovation: the ability to record ion signals from many neurons a ...
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... issues instructions based on past experience. The PNS, consisting of cranial and spinal nerves and ganglia, provides the communication lines between the CNS and the body’s muscles, glands, and sensory receptors. The nervous system is also divided functionally in terms of motor activities into the so ...
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Brain Research - Dana Foundation

... brain diseases are usually polygenic — multiple genes contribute to increased risk. Over 100 genes have been associated with schizophrenia, for example. (Huntington’s disease is an exception: Mutation in a single gene is always responsible.) Beyond helping us understand the brain, genetic research ...
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Blood–brain barrier



The blood–brain barrier (BBB) is a highly selective permeability barrier that separates the circulating blood from the brain extracellular fluid (BECF) in the central nervous system (CNS). The blood–brain barrier is formed by brain endothelial cells, which are connected by tight junctions with an extremely high electrical resistivity of at least 0.1 Ω⋅m. The blood–brain barrier allows the passage of water, some gases, and lipid-soluble molecules by passive diffusion, as well as the selective transport of molecules such as glucose and amino acids that are crucial to neural function. On the other hand, the blood–brain barrier may prevent the entry of lipophilic, potential neurotoxins by way of an active transport mechanism mediated by P-glycoprotein. Astrocytes are necessary to create the blood–brain barrier. A small number of regions in the brain, including the circumventricular organs (CVOs), do not have a blood–brain barrier.The blood–brain barrier occurs along all capillaries and consists of tight junctions around the capillaries that do not exist in normal circulation. Endothelial cells restrict the diffusion of microscopic objects (e.g., bacteria) and large or hydrophilic molecules into the cerebrospinal fluid (CSF), while allowing the diffusion of small hydrophobic molecules (O2, CO2, hormones). Cells of the barrier actively transport metabolic products such as glucose across the barrier with specific proteins. This barrier also includes a thick basement membrane and astrocytic endfeet.
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