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Structural brain MRI studies in eye diseases: are they clinically
Structural brain MRI studies in eye diseases: are they clinically

... Because of the well-defined retinotopic organization of the connections of the visual pathways, this may affect specific parts of the visual pathways and cortex, as a result of either deprivation or transsynaptic degeneration. For this reason, over the past several years, numerous structural magnetic r ...
A Symmetric Approach Elucidates Multisensory Information Integration
A Symmetric Approach Elucidates Multisensory Information Integration

... the mental and its relation to the physical. Multisensory neurons (we will also term them “heteromodal” or “multimodal”) receiving convergent inputs from multiple sensory modalities (independent sources of information called “cues”) integrate information from the five different senses [1]. When cues ...
Non-human primates in neuroscience research: The case against its
Non-human primates in neuroscience research: The case against its

... beyond doubt and, indeed, “the only way to successfully cope with devastating disorders and reduce the invasive character of many clinical procedures applied for their diagnosis and treatment” (17) — has been questioned by many (e.g. 18). This is acknowledged by Recommendation 4 of the Bateson Revie ...
Dynamics of Spontaneous Activity in Neocortical Slices
Dynamics of Spontaneous Activity in Neocortical Slices

... neocortical brain slices can sustain spontaneous activity. In the past, slices have been used to study the responses of neurons to electrical or pharmacological stimulations. At the same time, EPSPs and IPSPs are routinely recorded intracellularly from neurons in slices even under conditions in whic ...
BrainFacts.org A   P R I M E R  ...
BrainFacts.org A P R I M E R ...

... are using remarkable new tools and technologies to learn how the brain controls and responds to the body, drives behavior, and forms the foundation for the mind. Research is also essential for the development of therapies for more than 1,000 nervous system disorders that affect more than 1 billion p ...
a Primer on the Brain and Nervous System
a Primer on the Brain and Nervous System

... are using remarkable new tools and technologies to learn how the brain controls and responds to the body, drives behavior, and forms the foundation for the mind. Research is also essential for the development of therapies for more than 1,000 nervous system disorders that affect more than 1 billion p ...
P312Ch02_Nervous System, Neurons Lecture
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... Release of others causes inhibition - resulting in decrease in likelihood of action potentials of neurons whose dendrites are nearby. Primary among these is the amino acid GABA (gammaaminobutyric acid). A given neurotransmitter may have one function in one part of brain and a completely different fu ...
No Slide Title
No Slide Title

... tissues including, _______, _______, _______, _____ & _________. The non-immune component’s responses are inhibition of __________, increase of _________ _________ from a.a. and fats. Immune response is _________________ and ...
primer on brain facts - Chicago Society of Neuroscience
primer on brain facts - Chicago Society of Neuroscience

... are using remarkable new tools and technologies to learn how the brain controls and responds to the body, drives behavior, and forms the foundation for the mind. Research is also essential for the development of therapies for more than 1,000 nervous system disorders that affect more than 1 billion p ...
Remembering or Forgetting: The Lifetime of Memories
Remembering or Forgetting: The Lifetime of Memories

... by showing fear even if the danger is no longer present (the same way we fear the street even if cannot see the dog). If the mice are placed in a different, “safe” location, they show no fear. Some time ago, it was discovered that this fear memory is created in a certain part of the brain called the ...
Neurotic Overview
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Aneuploidy and DNA Replication in the Normal Human Brain and
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Cell type-specific pharmacology of NMDA receptors using masked
Cell type-specific pharmacology of NMDA receptors using masked

... when it is processed by an enzyme that is normally produced in pigs’ livers. Next, living mouse brain cells, including some that were engineered to express the pig enzyme, were exposed to the drug in the laboratory. The drug blocked the NMDA receptors on brain cells that expressed the enzyme, but no ...
Molecular Mechanisms of Appetite Regulation
Molecular Mechanisms of Appetite Regulation

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... ways bionic technologies can be deployed not only to restore lost sensory-motor functions, but also to discover brain mechanisms. ...
Inferring functional connections between neurons
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8 pages - Science for Monks
8 pages - Science for Monks

... person who knows they are dreaming —or, if not, when they wake they are able to narrate their dream sequence by sequence. So what happens during sleep? There are no external stimuli. The brain is by itself with its own intrinsic activity, and this intrinsic activity is largely dependent on how my ne ...
Restraining influence of A2 neurons in chronic control of arterial
Restraining influence of A2 neurons in chronic control of arterial

... Our approach was to avoid some of these limitations and electrically “silence”, rather than destroy, A2 neurons. In NEergic neurons the transcription factor Phox2 is highly active. This feature is exploited by an artificial Phox2dependent promoter [21], PRSx8, which we used to express a human inward ...
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Gaze effects in the cerebral cortex: reference frames for

... Zipser and Andersen 1988); the other combines movement preparatory signals with eye position for movement representation in a higher order coordinate system. ...
Drug-activation of brain reward pathways
Drug-activation of brain reward pathways

... caffeine acts at adenosine receptors ŽSnyder et al., 1981.. Some drugs do not act at neurotransmitter receptors per se, but nonetheless have actions selective for particular transmitter systems. For example, cocaine blocks reuptake ŽHeikkila et al., 1975a. of dopamine, norepinephrine, and serotonin ...
Huntington disease models and human neuropathology: similarities
Huntington disease models and human neuropathology: similarities

... constellation of changes characteristically seen in the human HD brain. This phenotypic deWcit is in part due to the limitation of the usual methods that are conventionally applied in a clinical setting to evaluate neuropathologically human brains. Nonetheless, that the dedicated scientiWc publicati ...
Cortico-Basal Ganglia Interactions in Huntington`s Disease
Cortico-Basal Ganglia Interactions in Huntington`s Disease

... Pattern of cortical degeneration in Huntington’s disease (HD): Due to the complex pathology and variable symptomatology of HD, the hypothesis proposing that the striatum is the main site of pathology in HD has been challenged by several studies. The critical involvement of the cerebral cortex in bot ...
Temporary inhibition of AMPA receptors induces a prolonged improvement
Temporary inhibition of AMPA receptors induces a prolonged improvement

... The Cln3-knockout (Cln3Dex1e6) mouse model of JNCL exhibits many characteristic features of the human disorder, including a deficit in cerebellar motor coordination (Kovacs et al., 2006; Mitchison et al., 1999; Weimer et al., 2009). Exploring the possible cause(s) of the functional impairment of the ...
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Haemodynamic response



In haemodynamics, the body must respond to physical activities, external temperature, and other factors by homeostatically adjusting its blood flow to deliver nutrients such as oxygen and glucose to stressed tissues and allow them to function. Haemodynamic response (HR) allows the rapid delivery of blood to active neuronal tissues. Since higher processes in the brain occur almost constantly, cerebral blood flow is essential for the maintenance of neurons, astrocytes, and other cells of the brain.
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