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... to form and retrieve memories. c. When administered to middle-age rats, one ampakine was able to reverse their age-related decline in the cellular mechanism of memory. ...
The Effect of Ischemia on Biogenic Amine Concentrations in
The Effect of Ischemia on Biogenic Amine Concentrations in

... such methods, the results are subject to criticism because the distribution of damage is not reliably reproducible in any of the currently known cerebral stroke models. Since the brain is so complex morphologically and neurotransmitter concentrations differ substantially from region to region, compa ...
A review of alpha activity in integrative brain function: Fundamental
A review of alpha activity in integrative brain function: Fundamental

... introduced by using brain oscillations has become one of the most important conceptual and analytic tools for the understanding of cognitive processes. He proposes that a major task for neuroscience is to devise ways to study and analyze the activity of distributed systems in waking brains, in parti ...
Chapter 14: Integration of Nervous System Functions
Chapter 14: Integration of Nervous System Functions

... Which transmitter substance has been implicated in Parkinson's disease? A) norepinephrine B) dopamine C) serotonin D) GABA E) acetylcholine Answer: b Level: 1 ...
View PDF - CiteSeerX
View PDF - CiteSeerX

Topography of Visual Cortex Connections with Frontal Eye Field in
Topography of Visual Cortex Connections with Frontal Eye Field in

... and Mishkin, 1982; Morel and Bullier, IWO; Baizer et al., I99 I ; Young, 1992). How information from the various cortical areas is combined to generate perception and action is not known. The investigation of visually guided eye movements may be a domain in which this issue can be examined effective ...
PDF
PDF

... of the direction of movement required to reach the posture. Stimulation of other cortical sites evoked different postures. Postures that involved the arm were arranged across cortex to form a map of hand positions around the body. This stimulation-evoked map encompassed both primary motor and the ad ...
Basal ganglia contributions to motor control: a - Research
Basal ganglia contributions to motor control: a - Research

... projects to the frontal cortex including parts of the premotor and primary motor cortex. (b) Internal connectivity of the BG motor circuit (front subpanel) showing principal pathways only. Direct and indirect pathways start in projection neurons of the putamen (part of the striatum) that express D1- ...
Transcranial Magnetic Stimulation: A Neuroscientific Probe of
Transcranial Magnetic Stimulation: A Neuroscientific Probe of

... currents and result in scalp burn, unless appropriate electrode materials (e.g., plastic) or shapes (e.g., slotted) are used (14). A particularly appealing aspect of combining TMS with other imaging techniques is that it becomes possible to obtain physiological, objective measures of TMS effects, ra ...
Chapter 5 - Wake Forest University
Chapter 5 - Wake Forest University

... • The discovery of cell-body stains made it possible to identify nuclear masses in the brain. • Figure 5.8 shows a frontal section of a cat brain stained with cresyl violet. Note that you can observe fiber bundles by their lighter appearance; they do not take up the stain. (See Figure 5.8.) • The st ...
Alpha-beta and Gamma Rhythms Subserve Feedback and
Alpha-beta and Gamma Rhythms Subserve Feedback and

... pair (MT-TEO; 4.76%) and not significantly different in another 7 (33.33%), i.e. it was more frequently significantly stronger in the feedback than in the feedforward direction (p=0.0018, sign test here and for the following tests). In the right hemisphere, alpha-beta GC was stronger in the feedback ...
BRAIN - ESPN.com
BRAIN - ESPN.com

Hedonic Hotspots Regulate Cingulate-driven
Hedonic Hotspots Regulate Cingulate-driven

... Positive hedonic states are known to attenuate the impact of demanding events on our body and brain, supporting adaptive behavior in response to changes in the environment. We used functional magnetic resonance imaging to examine the neural mechanism of this hedonic regulation. The effect of hedonic ...
Somatosensory System Organization and Texture Sensation in Rats
Somatosensory System Organization and Texture Sensation in Rats

... own cortical barrel was extended from mice to rats and confirmed by many physiological studies.46–49 Thus, the receptive fields of the neurons in barrel D3 are centered on the socalled principal whisker, D3. Whiskers surrounding the principal whisker may also excite cells to a lesser degree. Neurons ...
A forward genetic screen with a thalamocortical emx2
A forward genetic screen with a thalamocortical emx2

... neatly organized array of TCAs grown from the dorsal thalamus (dTh) through the ventral telencephalon (vTel) into cortex (ctx). The hippocampus (hip) fills the lateral ventricle. (C) A fuddle mutant brain shows hollow lateral ventricles (v) due to hippocampal hypoplasia, and a partial TCA defect in ...
Divergent Projections from the Anterior Inferotemporal Area TE to
Divergent Projections from the Anterior Inferotemporal Area TE to

... Figure 3. Cytoarchitecture of TEav, the caudal part of area 36 (36c), area 35, and area 28. A, Nissl-stained section. There is a separation between layers V and VI in TEav but not in 36c. Layer IV is present in area 36 but absent in areas 35 and 28. The presence of intensely stained large neurons in ...
Basal Forebrain Cholinergic System Is Involved in Rapid Nerve
Basal Forebrain Cholinergic System Is Involved in Rapid Nerve

... that included BF projection fibers. They showed enhanced ACh release from these synaptosomes starting within 1 min after NGF application. Anti-NGF antibodies blocked the NGFinduced rapid release of ACh. The rapid induction of ACh release cannot be readily explained by NGF’s known role of regulating ...
the organization of behavioral repertoire in motor cortex
the organization of behavioral repertoire in motor cortex

... Yet both views are similar in that they involve a cortical hierarchy in which premotor areas control various high-order aspects of movement, primary motor cortex decomposes movement into simple components in a body map, and these simple movement components are then communicated to the spinal cord fo ...
Midbrain fMRI: Applications, Limitations and Challenges
Midbrain fMRI: Applications, Limitations and Challenges

... Emrah Düzel, Marc Guitart­Masip, Anne Maass, Dorothea Hämmerer,   Matthew J. Betts, Oliver Speck, Nikolaus Weiskopf and Martin Kanowski ...
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Current BCI Platforms

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Optical imaging combined with targeted electrical recordings

... Fig. 3. General view of the electrode positioner microdrive. Top: The X /Y positioner stage, with the glass slightly open (left) and fully closed (right). Bottom: Photograph of the positioner microdrive at an angle of  608 on its stand. (A) Transparent sliding window (simple glass/Perspex cover) w ...
Epilepsy - OMICS International
Epilepsy - OMICS International

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... 2-27. It is lunchtime and you anticipate a feast. Which component of the nervous system will control digestion of this feast? a) central b) somatic c) autonomic d) peripheral ANS: c, p. 44, F/D, Difficulty=1 2-28. Which physiological response results from activation of the sympathetic nervous system ...
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Mirror neurons and their clinical relevance

... we witness the actions of others, the information could initially be subjected to sensory processing and then be sent to higher order ‘association’ areas where it is elaborated on by sophisticated cognitive mechanisms and compared with previously stored data. At the end of this process, we would kno ...
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Human brain



The human brain is the main organ of the human nervous system. It is located in the head, protected by the skull. It has the same general structure as the brains of other mammals, but with a more developed cerebral cortex. Large animals such as whales and elephants have larger brains in absolute terms, but when measured using a measure of relative brain size, which compensates for body size, the quotient for the human brain is almost twice as large as that of a bottlenose dolphin, and three times as large as that of a chimpanzee. Much of the size of the human brain comes from the cerebral cortex, especially the frontal lobes, which are associated with executive functions such as self-control, planning, reasoning, and abstract thought. The area of the cerebral cortex devoted to vision, the visual cortex, is also greatly enlarged in humans compared to other animals.The human cerebral cortex is a thick layer of neural tissue that covers most of the brain. This layer is folded in a way that increases the amount of surface that can fit into the volume available. The pattern of folds is similar across individuals, although there are many small variations. The cortex is divided into four lobes – the frontal lobe, parietal lobe, temporal lobe, and occipital lobe. (Some classification systems also include a limbic lobe and treat the insular cortex as a lobe.) Within each lobe are numerous cortical areas, each associated with a particular function, including vision, motor control, and language. The left and right sides of the cortex are broadly similar in shape, and most cortical areas are replicated on both sides. Some areas, though, show strong lateralization, particularly areas that are involved in language. In most people, the left hemisphere is dominant for language, with the right hemisphere playing only a minor role. There are other functions, such as visual-spatial ability, for which the right hemisphere is usually dominant.Despite being protected by the thick bones of the skull, suspended in cerebrospinal fluid, and isolated from the bloodstream by the blood–brain barrier, the human brain is susceptible to damage and disease. The most common forms of physical damage are closed head injuries such as a blow to the head, a stroke, or poisoning by a variety of chemicals which can act as neurotoxins, such as ethanol alcohol. Infection of the brain, though serious, is rare because of the biological barriers which protect it. The human brain is also susceptible to degenerative disorders, such as Parkinson's disease, and Alzheimer's disease, (mostly as the result of aging) and multiple sclerosis. A number of psychiatric conditions, such as schizophrenia and clinical depression, are thought to be associated with brain dysfunctions, although the nature of these is not well understood. The brain can also be the site of brain tumors and these can be benign or malignant.There are some techniques for studying the brain that are used in other animals that are just not suitable for use in humans and vice versa. It is easier to obtain individual brain cells taken from other animals, for study. It is also possible to use invasive techniques in other animals such as inserting electrodes into the brain or disabling certains parts of the brain in order to examine the effects on behaviour – techniques that are not possible to be used in humans. However, only humans can respond to complex verbal instructions or be of use in the study of important brain functions such as language and other complex cognitive tasks, but studies from humans and from other animals, can be of mutual help. Medical imaging technologies such as functional neuroimaging and EEG recordings are important techniques in studying the brain. The complete functional understanding of the human brain is an ongoing challenge for neuroscience.
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