Predictive, Preventive and Personalized Medicine
... Autoimmune diseases are the third leading cause of morbidity and mortality in the industrialized world! Most of the autoimmune diseases follow a chronic course that can be compared with a lengthy train ride. And a substantial need does exist for developing and validating a range of biomarkers that w ...
... Autoimmune diseases are the third leading cause of morbidity and mortality in the industrialized world! Most of the autoimmune diseases follow a chronic course that can be compared with a lengthy train ride. And a substantial need does exist for developing and validating a range of biomarkers that w ...
HS435 Immunisation Guideline: Tetanus
... of appetite, severe headaches and photophobia. There is often evidence of hepatitis and sometimes pneumonia. The illness lasts up to 3 weeks if untreated. Acute Q fever leads to a protracted post Q fever fatigue syndrome lasting several months in about 10% of cases, leading to several weeks off work ...
... of appetite, severe headaches and photophobia. There is often evidence of hepatitis and sometimes pneumonia. The illness lasts up to 3 weeks if untreated. Acute Q fever leads to a protracted post Q fever fatigue syndrome lasting several months in about 10% of cases, leading to several weeks off work ...
Prognostic benefits of heart rate reduction in cardiovascular disease
... of 80 years, humans are already an exception to the equation for heart rate and life expectancy in mammals. The explanation is provided by a fundamental metabolic theory based on heat loss and production, the ratio of which increases as body size decreases. However, it is true that in the general po ...
... of 80 years, humans are already an exception to the equation for heart rate and life expectancy in mammals. The explanation is provided by a fundamental metabolic theory based on heat loss and production, the ratio of which increases as body size decreases. However, it is true that in the general po ...
the heart - Cloudfront.net
... – Valvular stenosis (narrowing): • The valve flaps become stiff (typically because of scar tissue formation following endocarditis or calcium salt deposit) and constrict then opening • This stiffness compels the heart to contract more forcibly than normal • Heart’s work load increases • Heart may be ...
... – Valvular stenosis (narrowing): • The valve flaps become stiff (typically because of scar tissue formation following endocarditis or calcium salt deposit) and constrict then opening • This stiffness compels the heart to contract more forcibly than normal • Heart’s work load increases • Heart may be ...
Phagocyte-specific S100 proteins are released from affected
... amounts that mix with other secretions and gut contents, which ultimately appear in the patients’ stool. Therefore, assays which determine intestinal inflammation by detecting neutrophil-derived DAMPs in stool bear a great diagnostic potential [7]. Among the factors released by infiltrating neutroph ...
... amounts that mix with other secretions and gut contents, which ultimately appear in the patients’ stool. Therefore, assays which determine intestinal inflammation by detecting neutrophil-derived DAMPs in stool bear a great diagnostic potential [7]. Among the factors released by infiltrating neutroph ...
Acute heart failure in the intensive care unit - Area
... common precipitant (10% of cases in the New York registry), and poorly controlled blood pressure (13% with presenting systolic blood pressure ⬎200 mm Hg) and poor compliance with medication for hypertension or heart failure (13%) were common (11). Length of Stay and Mortality. The median length of s ...
... common precipitant (10% of cases in the New York registry), and poorly controlled blood pressure (13% with presenting systolic blood pressure ⬎200 mm Hg) and poor compliance with medication for hypertension or heart failure (13%) were common (11). Length of Stay and Mortality. The median length of s ...
Ischemic Mitral Valve Disease: Repair, Replace or Ignore?
... • Mitral valve replacement achieved an average 14% lower riskadjusted survival over 15 years, as compared to valve repair ...
... • Mitral valve replacement achieved an average 14% lower riskadjusted survival over 15 years, as compared to valve repair ...
Peds Respiratory Emergencies
... “Corticosteroid medications should not be used routinely in the management of bronchiolitis” Level B ...
... “Corticosteroid medications should not be used routinely in the management of bronchiolitis” Level B ...
Autoimmune Disorders in Pregnancy
... • Hx of thrombosis and APS- Heparin(prophylactic + aspirin (81mg) • Any of the co-morbidities present with antibodies- prophylactic heparin indicated antepartum and postpartum • Tx: Low molecular weight heparin preferred- less side effects • Antibodies without any clinical history- anticoagulation ...
... • Hx of thrombosis and APS- Heparin(prophylactic + aspirin (81mg) • Any of the co-morbidities present with antibodies- prophylactic heparin indicated antepartum and postpartum • Tx: Low molecular weight heparin preferred- less side effects • Antibodies without any clinical history- anticoagulation ...
The Effect of Dobutamine on the 8
... Only five out of the nine embryos tested gave reliable data. – One embryo was deformed. – One had a tumor on its heart. – Two of the embryos gave poor and inaccurate test results. ...
... Only five out of the nine embryos tested gave reliable data. – One embryo was deformed. – One had a tumor on its heart. – Two of the embryos gave poor and inaccurate test results. ...
Cardiovascular magnetic resonance imaging in valvular heart disease
... FIGURE 2: (a) Axial cine SSFP image through the aortic valve in diastole demonstrates a closed valve with three valve cusps: the right coronary cusp (RCC), the left coronary cusp (LCC) and non-coronary cusp (NCC). The left atrium (LA) and right atrium (RA) are also identified; (b) Axial cine SSFP im ...
... FIGURE 2: (a) Axial cine SSFP image through the aortic valve in diastole demonstrates a closed valve with three valve cusps: the right coronary cusp (RCC), the left coronary cusp (LCC) and non-coronary cusp (NCC). The left atrium (LA) and right atrium (RA) are also identified; (b) Axial cine SSFP im ...
Full-Text PDF
... hearts lack the sinu-ventricular ligament and posses a sinus cord. They show, however, dystopic PE-derived tissue bridges, which connect the sinus cord or the blocking membrane with the developing ventricles. The points of attachment of such dystopic cardiac ligaments to the ventricles usually lie c ...
... hearts lack the sinu-ventricular ligament and posses a sinus cord. They show, however, dystopic PE-derived tissue bridges, which connect the sinus cord or the blocking membrane with the developing ventricles. The points of attachment of such dystopic cardiac ligaments to the ventricles usually lie c ...
Arnold M. Katz and Michael R. Zile 2006;113:1922-1925 doi: 10.1161/CIRCULATIONAHA.106.620765
... strategies for DHF, however, attempt to alleviate congestive symptoms by reducing LV preload and afterload, attenuating such exacerbating factors as tachycardia and ischemia, and controlling blood pressure in hypertensive patients. It is clear, however, that strategies for DHF should also target the ...
... strategies for DHF, however, attempt to alleviate congestive symptoms by reducing LV preload and afterload, attenuating such exacerbating factors as tachycardia and ischemia, and controlling blood pressure in hypertensive patients. It is clear, however, that strategies for DHF should also target the ...
viding diagnostic insights into the pathophysiologic mechanisms under
... FIG 20. Comparison of timing of extra sounds and events. Note that S1 and P2 are accentuated with mitral stenosis. With constrictive pericarditis a pericardial knock sound (K) occurs later than the opening snap (OS) and S1 is not accentuated. (From Harvey WP. Cardiac pearls. Newton (NJ): Laennec; 1 ...
... FIG 20. Comparison of timing of extra sounds and events. Note that S1 and P2 are accentuated with mitral stenosis. With constrictive pericarditis a pericardial knock sound (K) occurs later than the opening snap (OS) and S1 is not accentuated. (From Harvey WP. Cardiac pearls. Newton (NJ): Laennec; 1 ...
this PDF file
... The WHO also reports that the incidence of dengue fever has grown dramatically around the world in recent decades.5 Jones et al. reports that 60-76% of the 400 emerging infectious diseases are zoonotic globally, and this indicates that zoonosis like leptospirosis is a major public health problem in ...
... The WHO also reports that the incidence of dengue fever has grown dramatically around the world in recent decades.5 Jones et al. reports that 60-76% of the 400 emerging infectious diseases are zoonotic globally, and this indicates that zoonosis like leptospirosis is a major public health problem in ...
Review series on helminths, immune modulation
... How might infection modulate the onset of type 1 diabetes? appeared to be compelling following the isolation of a virus from the pancreas of a diabetic patient and the ability of certain viral infections to initiate diabetes in mice or non-human primates.12–15 The apparent seasonal onset of T1D fur ...
... How might infection modulate the onset of type 1 diabetes? appeared to be compelling following the isolation of a virus from the pancreas of a diabetic patient and the ability of certain viral infections to initiate diabetes in mice or non-human primates.12–15 The apparent seasonal onset of T1D fur ...
Understanding your child`s heart Tricuspid atresia
... For more than half of these children, the heart disease is only a minor problem which either doesn’t need any treatment, or which can be successfully corrected with surgery. problem which either doesn’t need any treatment, or which can be successfully corrected with surgery. For others it is more se ...
... For more than half of these children, the heart disease is only a minor problem which either doesn’t need any treatment, or which can be successfully corrected with surgery. problem which either doesn’t need any treatment, or which can be successfully corrected with surgery. For others it is more se ...
Correlations Between Redox-State Potential Changes in Different
... a chemical or biological system. Redox potential exists only in a system at equilibrium. Living systems are open or non-equilibrium systems in which any measurement of Eh is a steady-state approximation. Hence, with biological objects we prefer to speak of "redox-state" or "redox-state potential". S ...
... a chemical or biological system. Redox potential exists only in a system at equilibrium. Living systems are open or non-equilibrium systems in which any measurement of Eh is a steady-state approximation. Hence, with biological objects we prefer to speak of "redox-state" or "redox-state potential". S ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... Lahore. Majority of patients were seen as a direct visit to the UCH Dengue clinic, and many were received as a referral from other hospitals. Keywords: Dengue Virus, Dengue Fever. ...
... Lahore. Majority of patients were seen as a direct visit to the UCH Dengue clinic, and many were received as a referral from other hospitals. Keywords: Dengue Virus, Dengue Fever. ...
How Periodontal Disease Can Be Transmitted
... infection was found 26 times more often in children younger than three years of age if the mother tested positive for this infection. (1) In another study researchers found periodontal infection in the children of one-third of families whose parents tested positive for periodontal infection, whereas ...
... infection was found 26 times more often in children younger than three years of age if the mother tested positive for this infection. (1) In another study researchers found periodontal infection in the children of one-third of families whose parents tested positive for periodontal infection, whereas ...
Vaccination in autoimmune diseases
... responsible for educating our immune system, thereby maintaining the balance between activation and suppression. Among others, important factors in maintaining this balance are regulatory T cells and heat-shock proteins. Several studies have focused on disease activity and antibody formation after i ...
... responsible for educating our immune system, thereby maintaining the balance between activation and suppression. Among others, important factors in maintaining this balance are regulatory T cells and heat-shock proteins. Several studies have focused on disease activity and antibody formation after i ...
Novel pebbles in the mosaic of autoimmunity Open Access Carlo Perricone
... antibodies, provoked deficiencies in olfactory capabilities and depression in mice [31,32]. Likewise, the 16/16 antibody bound to similar areas in the olfactory machinery as those to which anti-P ribosomal antibodies bind. Kivity et al. [33] identified another weapon at the armory of the 16/6 idioty ...
... antibodies, provoked deficiencies in olfactory capabilities and depression in mice [31,32]. Likewise, the 16/16 antibody bound to similar areas in the olfactory machinery as those to which anti-P ribosomal antibodies bind. Kivity et al. [33] identified another weapon at the armory of the 16/6 idioty ...
Rheumatic fever
Rheumatic fever, also known as acute rheumatic fever (ARF), is an inflammatory disease that can involve the heart, joints, skin, and brain. The disease typically develops two to four weeks after a throat infection. Signs and symptoms include fever, multiple painful joints, involuntary muscle movements, and a characteristic but uncommon non itchy rash known as erythema marginatum. The heart is involved in about half of cases. Permanent damage to the heart valves, known as rheumatic heart disease (RHD), usually only occurs after multiple attacks but may occasionally occur after a single case of ARF. The damaged valves may result in heart failure. The abnormal valves also increase the risk of the person developing atrial fibrillation and infection of the valves.Acute rheumatic fever may occur following an infection of the throat by the bacteria Streptococcus pyogenes. If it is untreated ARF occurs in up to three percent of people. The underlying mechanism is believed to involve the production of antibodies against a person's own tissues. Some people due to their genetics are more likely to get the disease when exposed to the bacteria than others. Other risk factors include malnutrition and poverty. Diagnosis of ARF is often based on the presence of signs and symptoms in combination with evidence of a recent streptococcal infection.Treating people who have strep throat with antibiotics, such as penicillin, decreases their risk of getting ARF. This often involves testing people with sore throats for the infection, which may not be available in the developing world. Other preventative measures include improved sanitation. In those with ARF and RHD prolonged periods of antibiotics are sometimes recommended. Gradual return to normal activities may occur following an attack. Once RHD develops, treatment is more difficult. Occasionally valve replacement surgery or repair is required. Otherwise complications are treated as per normal.Acute rheumatic fever occurs in about 325,000 children each year and about 18 million people currently have rheumatic heart disease. Those who get ARF are most often between the ages of 5 and 14, with 20% of first-time attacks occurring in adults. The disease is most common in the developing world and among indigenous peoples in the developed world. In 2013 it resulted in 275,000 deaths down from 374,000 deaths in 1990. Most deaths occur in the developing world where as many as 12.5% of people affected may die each year. Descriptions of the condition are believed to date back to at least the 5th century BCE in the writings of Hippocrates. The disease is so named because its symptoms are similar to those of some rheumatic disorders.