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... o vs. MDMA – “ecstasy”, not a stimulant (dopamine receptor), actually a hallucinogen (serotonin) o vs. Cocaine – same mechanism, but amphetamines last longer, and enable dopamine release Schedule II Drug – legal, but under strict control Types – include Adderal, Dexedrine, Desoxyn can be given ...
... o vs. MDMA – “ecstasy”, not a stimulant (dopamine receptor), actually a hallucinogen (serotonin) o vs. Cocaine – same mechanism, but amphetamines last longer, and enable dopamine release Schedule II Drug – legal, but under strict control Types – include Adderal, Dexedrine, Desoxyn can be given ...
3rd year antidepressant part 2a2011-09-11 10
... 5-HT1-receptors are predominantly inhibitory in their effects. 5-HT1A-receptors are expressed as autoreceptors by the 5-HT neurons in the raphe nuclei, and their autoinhibitory effect tends to limit the rate of firing of these cells. They are also widely distributed in the limbic system and are bel ...
... 5-HT1-receptors are predominantly inhibitory in their effects. 5-HT1A-receptors are expressed as autoreceptors by the 5-HT neurons in the raphe nuclei, and their autoinhibitory effect tends to limit the rate of firing of these cells. They are also widely distributed in the limbic system and are bel ...
Opioids OD fact sheet
... Pethidine: stronger kappa; some 5-HT (can cause SS); 50% BA; 60% protein bound; DOA 3hrs; more euphoria and addiction, seizures Fentanyl: rapid onset of action; DOA 30-40mins; serotonin syndrome Remifentanyl: rapid onset; assoc with muscle rigidity; HL 3-10mins; DOA 5-10mins Codeine: 66% BA Methadon ...
... Pethidine: stronger kappa; some 5-HT (can cause SS); 50% BA; 60% protein bound; DOA 3hrs; more euphoria and addiction, seizures Fentanyl: rapid onset of action; DOA 30-40mins; serotonin syndrome Remifentanyl: rapid onset; assoc with muscle rigidity; HL 3-10mins; DOA 5-10mins Codeine: 66% BA Methadon ...
181lec5
... Nicotinic acetylcholine receptor coupled to sodium channel drugs: nicotine, curare ...
... Nicotinic acetylcholine receptor coupled to sodium channel drugs: nicotine, curare ...
Sample question
... G protein-coupled receptors Two classes: G protein directly coupled to ion channel effector is ion channel G protein coupled to 2nd messenger system effector is enzyme that promotes formation of intracellular “second messenger” ...
... G protein-coupled receptors Two classes: G protein directly coupled to ion channel effector is ion channel G protein coupled to 2nd messenger system effector is enzyme that promotes formation of intracellular “second messenger” ...
Metoprolol (Lopressor) 5 mg IV slow May repeat X 2 every 5 min.
... (may repeat X 1 after 5 minutes if no relief) If chest pain persists and SBP >100 Morphine 2 mg IV May repeat every 5 min. up to 20 mg If heart rate >75 and SBP >100 Metoprolol (Lopressor) 5 mg IV slow ...
... (may repeat X 1 after 5 minutes if no relief) If chest pain persists and SBP >100 Morphine 2 mg IV May repeat every 5 min. up to 20 mg If heart rate >75 and SBP >100 Metoprolol (Lopressor) 5 mg IV slow ...
H2-receptor antagonists proton pump inhibitors
... resolves spontaneously within a week; more severe or protracted cases may necessitate drug discontinuation. Misoprostol can cause clinical exacerbations of inflammatory bowel disease and should be avoided in patients with this disorder. Misoprostol is contraindicated during pregnancy because it can ...
... resolves spontaneously within a week; more severe or protracted cases may necessitate drug discontinuation. Misoprostol can cause clinical exacerbations of inflammatory bowel disease and should be avoided in patients with this disorder. Misoprostol is contraindicated during pregnancy because it can ...
Comparison of ramosetron and ondansetron for
... of PONV is advantageous The two Antiemetics RAMOSETRON and ONDANSETRON are compared in laparoscopic procedures ...
... of PONV is advantageous The two Antiemetics RAMOSETRON and ONDANSETRON are compared in laparoscopic procedures ...
Comparison of ramosetron and ondansetron for
... of PONV is advantageous The two Antiemetics RAMOSETRON and ONDANSETRON are compared in laparoscopic procedures ...
... of PONV is advantageous The two Antiemetics RAMOSETRON and ONDANSETRON are compared in laparoscopic procedures ...
Demographic Differences in the Misuse and Abuse of Oxycodone
... Mountain Poison & Drug Center - Denver Health, Denver, CO 2University of Colorado Anschutz School of Medicine – Aurora, CO ...
... Mountain Poison & Drug Center - Denver Health, Denver, CO 2University of Colorado Anschutz School of Medicine – Aurora, CO ...
Autonomic Nervous System
... mood inappropriation, paranoia (persecution mania) and hallucinations (voices) and Negative symptoms: withdrawal from society, flattened emotional responses, defect in selective attention (can’t distinguish between important and insignificant) Affects up to 1% of population, high suicide rate (10%) ...
... mood inappropriation, paranoia (persecution mania) and hallucinations (voices) and Negative symptoms: withdrawal from society, flattened emotional responses, defect in selective attention (can’t distinguish between important and insignificant) Affects up to 1% of population, high suicide rate (10%) ...
Medicinal Chemistry (MDCH) 5220
... alcohols with these properties (that may be used as drugs). Barbiturates: (1) Know the structure of barbituric acid. Why is this not an effective sedative/hypnotic? [hint: this is not due to toxicity]. How can we modify it to make it better? (2) Know the basic SAR of the barbiturates. Why are barbit ...
... alcohols with these properties (that may be used as drugs). Barbiturates: (1) Know the structure of barbituric acid. Why is this not an effective sedative/hypnotic? [hint: this is not due to toxicity]. How can we modify it to make it better? (2) Know the basic SAR of the barbiturates. Why are barbit ...
2 receptor
... 间羟胺) (2) Hypotension due to drug poisoning • especially for chlorpromazine (3) Hemorrhage in upper alimentary tract • orally given after dilution ...
... 间羟胺) (2) Hypotension due to drug poisoning • especially for chlorpromazine (3) Hemorrhage in upper alimentary tract • orally given after dilution ...
87 - VCU
... sentences) a cellular and/or tissue site of action, the effect that the drug produces (relating to nausea and vomiting, gastric acid secretion, or GI motility), and a resultant clinical application. (For example: Drug type acts on the Nucleus/Cell in the Tissue/ organ where it mediates Effect; becau ...
... sentences) a cellular and/or tissue site of action, the effect that the drug produces (relating to nausea and vomiting, gastric acid secretion, or GI motility), and a resultant clinical application. (For example: Drug type acts on the Nucleus/Cell in the Tissue/ organ where it mediates Effect; becau ...
Cannabinoids
... Can develop after a few daily doses, but sensitivity returns after a few drug free days. May be due to receptor down regulation. Cross-tolerance develops between LSD, mescaline and psilocin not between LSD and amphetamines or cocaine not between LSD and cannabinoids Flashbacks: recurrence of drug ef ...
... Can develop after a few daily doses, but sensitivity returns after a few drug free days. May be due to receptor down regulation. Cross-tolerance develops between LSD, mescaline and psilocin not between LSD and amphetamines or cocaine not between LSD and cannabinoids Flashbacks: recurrence of drug ef ...
Adrenergic System Adrenoceptor Blocking Drugs
... If Beta-blockers or diuretics fail to control hypertension, Prazosin or other SELECTIVE alpha1-blockers may be added. B) Secondary Hypertension: The alpha Adrenoceptor antagonists are most useful when increased blood pressure reflects excess circulating concentration of catecholamines which may resu ...
... If Beta-blockers or diuretics fail to control hypertension, Prazosin or other SELECTIVE alpha1-blockers may be added. B) Secondary Hypertension: The alpha Adrenoceptor antagonists are most useful when increased blood pressure reflects excess circulating concentration of catecholamines which may resu ...
PPT
... Their major adverse effect is orthostatic hypotension, which may be severe after the first few doses but is otherwise uncommon (First-Dose Phenomenon). ...
... Their major adverse effect is orthostatic hypotension, which may be severe after the first few doses but is otherwise uncommon (First-Dose Phenomenon). ...
Pharmacology Objectives 2
... 3. Give evidence for the existence of drug receptors. i. Drug potency indicates sites of interactions, e.g. LSD. ii. Similar molecules produce similar effects, e.g. norepinephrine & epinephrine. iii. Difference in action of stereoisomers, e.g. dextrophan(-) and levophranol(+). iv. Competitive antago ...
... 3. Give evidence for the existence of drug receptors. i. Drug potency indicates sites of interactions, e.g. LSD. ii. Similar molecules produce similar effects, e.g. norepinephrine & epinephrine. iii. Difference in action of stereoisomers, e.g. dextrophan(-) and levophranol(+). iv. Competitive antago ...
Antidepressant drugs - Dr Lynch
... Murray & Lopez eds. The Global Burden of Disease. Harvard University Press, 1996 ...
... Murray & Lopez eds. The Global Burden of Disease. Harvard University Press, 1996 ...
Depression and Suicide
... Murray & Lopez eds. The Global Burden of Disease. Harvard University Press, 1996 ...
... Murray & Lopez eds. The Global Burden of Disease. Harvard University Press, 1996 ...
Antidepressant Drugs
... *Selective serotonin re-uptake inhibitors(SSRIs) -300-3000 fold greater selective for serotonin transporter than for norepinephrine transporter(in contrast to TCAs that nonselectively inhibit uptake of norepinephrine and serotonin). -SSRIs have little blocking activity at muscarinic, adrenoceptors, ...
... *Selective serotonin re-uptake inhibitors(SSRIs) -300-3000 fold greater selective for serotonin transporter than for norepinephrine transporter(in contrast to TCAs that nonselectively inhibit uptake of norepinephrine and serotonin). -SSRIs have little blocking activity at muscarinic, adrenoceptors, ...
5-HT3 antagonist
The 5-HT3 antagonists, informally known as ""setrons"", are a class of drugs that act as receptor antagonists at the 5-HT3 receptor, a subtype of serotonin receptor found in terminals of the vagus nerve and in certain areas of the brain.With the notable exception of alosetron and cilansetron, which are used in the treatment of irritable bowel syndrome, all 5-HT3 antagonists are antiemetics, used in the prevention and treatment of nausea and vomiting. They are particularly effective in controlling the nausea and vomiting produced by cancer chemotherapy and are considered the gold standard for this purpose.The 5-HT3 antagonists may be identified by the suffix –setron, and are classified under code A04AA of the WHO's Anatomical Therapeutic Chemical Classification System.