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131 Learning Objectives Chapter 11: Intro to Organic Molecules & Functional Groups  Difference between organic and inorganic molecules  Name characteristic features of organic compounds  Draw organic compounds, including skeletal structures  Identify common bond types, angles, and molecule shapes  Name functional groups  Understand polarity and its effect on solubility and boiling point  Explain the difference between fat and water soluble vitamins Chapter 12: Alkanes  Describe alkane characteristics  Draw alkanes as full, condensed, and skeletal structures  Bond angle around alkane carbons  Draw constitutional isomers and ID longest carbon chain  ID 1°, 2°, 3°, 4° carbons  Name simple alkanes and cycloalkanes  Predict products of combustion & balance reaction equations Chapter 13: Unsaturated Hydrocarbons  Identify unsaturated hydrocarbons: alkenes, alkynes, aromatic compounds  Alkene, Alkyne, Aromatic nomenclature  Stereoisomers  Addition Reactions  Polymers  Substitution Reactions Chapter 14: Oxygen, Halogens, Sulfur  Name organic compounds with carbon-heteroatom single bonds (oxygen, halogens, sulfur)  Identify 1°, 2°, 3° alcohols and alkyl halides  Predict the products or reactants for following reactions: Alcohol dehydration Alcohol oxidation Sulfur oxidation Sulfur reduction Chapter 15: The 3-D Shape of Molecules  Understand the difference between Chiral and Achiral molecules  Identify chiral centers  Draw the enantiomers & diastereomers of a chiral molecule (using dashes & wedges to show geometry)  Draw fischer projections of chiral molecules  Explain the relevance of chiral centers in Biochemistry Chapter 16: Aldehydes & Ketones  Nomenclature for aldehydes & ketones  Identify structure and describe bonding of aldehydes & ketones  Aldehyde oxidation without alcohol oxidation  Addition reactions at C – O double bond  Hemiacetal & acetal formation  Identify cyclic hemiacetals Chapter 17: Carboxylic Acids, Esters, Amides  Nomenclature for carboxylic acids, esters, & amides  Identify and describe structure of carboxylic acids, esters & amides  Acid-base chemistry of carboxylic acids (think soap!)  Substitution reactions of carboxylic acids o Formation of esters o Formation of amides  Hydrolysis of acyl compounds o Ester hydrolysis o Amide hydrolysis  Structure & formation of polyamides & polyesters Chapter 18: Amines  Identify amines and describe bonding & structure (1°, 2°, 3°)  Nomenclature for amines  Amine hydrogen bonding  Alkaloids & Nitrogen heterocycles  Acid-base chemistry of amines  Neurotransmitter amines  Amines and common drugs Chapter 19: Lipids  Describe lipids o Properties o Hydrolyzable & nonhydrolyzable  Identify fatty acids o Properties o Saturated & unsaturated  Wax chemical structure  Identify triglycerides & describe properties o Triglyceride hydrolysis  Identify Phospholipids and Phyosphoacylglycerols  Describe the structure & transport across cell membranes  Identify & describe steroid hormones & their properties  Identify prostaglandins & leukotrines o Describe role in asthma Chapter 20: Carbohydrates  Identify carbohydrates o Describe properties and types (monosaccarides to polysaccharides)  Draw Fischer projections of carbohydrates o Classify as D or L o ID multiple chiral center and draw enantiomers  Draw common monosaccharieds: glucose, galactose, fructose  Draw cyclic monosaccarides & identify hemiacetal o  &  isomers o draw Haworth projections  Draw ketohexose  Reduction & oxidation of monosaccharides  Describe & draw disaccharides  Polysaccharides: types and structures  Describe blood types Chapter 21: Amino Acids, Proteins, Enzymes  The 20 common, naturally occurring Amino Acids  stereochemistry  acid/base chemistry  Peptides  Formation  N & C terminals  Proteins  Primary, Secondary, Tertiary, Quaternary structure  Hydrolysis and denaturation  Enzymes  Catalysis  Inhibitors  Zymogens Chapter 22: Nucleic Acids & Protein Synthesis  Nucleosides & Nucleotides: structure  DNA & RNA base pairs: names & structures  Phosphate addition  Nucleic Acids  Formation & primary structure  DNA double helix structure, hydrogen bonding  Replication, Transcription, Translation  RNA  rRNA, mRNA, tRNA  Genetic Code: codon & anticodon  Protein Synthesis: initiation, elongation, termination  Mutations  Recombinant DNA: formation & use  PCR: polymerase chain reaction: technique & application Chapter 23: Metabolism & Energy Production  Stages of Metabolism  ATP: structure, hydrolysis, & formation  Coupling reactions  Coenzymes  NAD+ & NADH  FAD & FADH2  Coenzyme A  Citric Acid Cycle: all 8 steps  Electron Transport Chain  ATP synthesis by Oxidative Phosphorylation Chapter 24: Carbohydrate, Lipid, Protein Metabolism  Role in Metabolism of fatty acid oxidation, glycolysis, & Amino acid catabolism  Reactions catalyzed by: kinase, isomerase, dehydrogenase, decarboxylase, carboxylase  Glycolysis: steps & net reaction  Pyruvate conversion to acetyl Coenzyme A  Gluconeogenesis: steps in synthesis of glucose  Catabolism of Triacylglycerols: beta-oxidation  Synthesis of ketone bodies: ketogenesis  Catabolism of Amino acids:  transamination & oxidative deamination  Ketogenic vs glucogenic amino acid catabolism