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Other Patterns of Inheritance (Chapter 11.3) Exceptions to Mendel’s Principles First, let’s review Mendel’s principles. Mendel’s Principles • The traits that you inherit depend on your genes (units of inheritance), which came from your parents. Mendel’s Principles • • If a gene has two or more alleles (forms) for a single trait, some alleles may be dominant and others may be recessive. This is called simple dominant/recessive inheritance. Mendel’s Principles • • In most sexually reproducing organisms, the organisms has two sets of a gene (one from each parent) for a trait. Note that they may not be the same form of the gene. (Why not?) Mendel’s Principles • • • These alleles separate randomly during gamete formation. This is Mendel’s law of segregation. Therefore, a heterozygous parent can give either the dominant or the recessive allele to its offspring Mendel’s Principles • • • Genes (alleles) for different traits separate independently during gamete formation. This is Mendel’s law of independent assortment. Therefore, having one trait does not necessarily mean that you also have another trait. These principles can also be referred to as the principles of “Mendelian genetics.” Next up, “non-Mendelian genetics” In other words, exceptions to the “rule”. Some alleles are neither dominant nor recessive. Incomplete dominance: • example – flower color in snapdragon plants (3 phenotypes: red, white and pink) • Which is the phenotype of the heterozygote? • How would you write the genotypes? Some alleles are neither dominant nor recessive. Codominance: • example – feather color in some chickens (3 phenotypes: black, white and blackand-white) • Which is the phenotype of the heterozygote? • How would you write the genotypes? Some genes have more than two alleles. Multiple Alleles: • example – human blood type has three alleles (A, B, and O), which results in four different phenotypes (Types A, B, AB, and O) • How many alleles would each individual have? • Which is the phenotype of the heterozygote? • How would you write the genotypes? Some traits are controlled by more than one gene. Polygenic traits: • example – three genes affect eye color in fruit flies; four (or more) genes affect human skin color • Example - HLA (human leukocyte antigen) system that recognizes foreign tissue in humans – because many alleles contribute to the phenotypes, there are many possible phenotypes (30 million for the HLA system!). Discuss: 1. How many phenotypes would you expect to see in a case of simple dominant/recessive inheritance? 2. Codominance? 3. Incomplete dominance? 4. Multiple allelic inheritance? 5. Polygenic inheritance? Genes and the Environment Phenotype does not depend entirely on genotype. Environmental conditions can affect gene expression and influence genetically determined traits. example – the western white butterfly: wing color depends on when they hatch (because of temp differences)