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• Zygote: fertilized cell created by the union of the egg and sperm • Zygote divides into Embryonic stem cells 23 chromosomes – Potential to become any type of cell Egg Cell • Average human: – 100 trillion cells – Over 200 types of human cells 23 chromosomes Embryonic Stem cells zygote Stem cell controversy • Stem cells are being used in research to help treat various diseases… so why is this controversial? If someone has brain damage… stem cells can be grown into new brain cells to help the person recover. Stem cell controversy • Stem cells are being used in research to help treat various diseases… so why is this controversial? If someone has muscle damage… stem cells can be grown into new muscle cells to help the person recover. Stem cell controversy • Stem cells are being used in research to help treat various diseases… so why is this controversial? If someone is blind… stem cells can be grown into new eye cells to help the person recover. Stem cell controversy • Stem cells are being used in research to help treat various diseases… so why is this controversial? • Where do stem cells come from? – When couples seek help to create a child, many eggs and sperm are collected and mixed together to create many embryos – Embryos are implanted into the woman, where hopefully they will grow into a baby – Stem cells are obtained from left over 4-5 day embryos • Why controversial? – Reason: Embryo is destroyed in the process of obtaining the stem cells – Argument: Some claim this kills a human life – Counter Argument: These leftover embryos will soon be discarded as medical waste • The Myth: – When a woman gets an abortion, she can donate the dead embryo to stem cell research. Determination • Determination – Few weeks into development – Genes program the stem cell to become a specific cell – Irreversible Lump of stem cells Differentiation • Differentiation – Cells acquire the structures & functions of a specialized cell – Specific genes activated Some stem cells become… Differentiation • Differentiation – Cells acquire the structures & functions of a specialized cell – Specific genes activated Other stem cells become… Differentiation • Differentiation – Cells acquire the structures & functions of a specialized cell – Specific genes activated And other stem cells become… Quick Questions • Do your muscle cells have the same DNA as your skin cells? Yes • Do your skin cells have the same DNA as your brain cells? Yes • Do your brain cells have the same DNA as your liver cells? Yes • So if all your cells have the same DNA, how do they know to do different jobs? Stay tuned for the answer Stem cell (soon to be muscle cell) Gene A Gene B Gene C Gene D Gene E Gene F Gene G These If theselight cellsswitches have theare same symbolic DNA, of how thewill genes the top inside celleach know to become stem cell. a muscle cell? Stem cell (soon to be nerve cell) Gene A Gene B Gene C Gene D Gene E Gene F Gene G Stem cell (soon to be muscle cell) Gene A ON ON Gene B Gene C ON Gene D Gene E Gene F Gene G The proteins created in the top cell will cause the stem cell to become a muscle cell…. During “differentiation”, certain genes are activated in What do genes direct cells to create? some cells,created but deactivated in others. The proteins in the bottom cell will cause the stem cell to become a nerve cell. Stem cell (soon to be nerve cell) ON ON Gene A Gene B Gene C ON Gene D Gene E Gene F Gene G Differentiation Brain cells • Differentiation – Cells acquire the structures & functions of a specialized cell – Specific genes activated Muscle cells Pancreas cells Skin cells Programmed cell death (apoptosis) between the fingers & toes Incomplete Apoptosis (Webbed Toes) • Cell: Basic unit • Cell: Basic unit • Tissue: Group of cells – 4 types Muscle Tissue • Contracting cells • Skeletal, cardiac cells • Cell: Basic unit • Tissue: Group of cells – 4 types Connective Tissue • Support the body • Bone, fat, tendons • Cell: Basic unit • Tissue: Group of cells – 4 types Ligaments connect your femur (thigh bone)… to your tibia (shin bone) Connective Tissue • Support the body • Bone, fat, tendons • Cell: Basic unit • Tissue: Group of cells – 4 types Connective Tissue • Support the body • Bone, fat, tendons • Cell: Basic unit • Tissue: Group of cells – 4 types Epithelial Tissue • protective sheet of cells • skin, stomach lining • Cell: Basic unit • Tissue: Group of cells – 4 types Nerve Tissue • Transmit electric signals • Brain & Spinal Cord • Cell: Basic unit • Tissue: Group of cells – 4 types • Organ: Groups of tissue – Ex: lung contains each tissue • Cell: Basic unit • Tissue: Group of cells – 4 types • Organ: Groups of tissue – Ex: lung contains each tissue • Organ System: Group of organs working together – Respiratory System • Cell: Basic unit • Tissue: Group of cells – 4 types • Organ: Groups of tissue – Ex: lung contains each tissue • Organ System: Group of organs working together – Respiratory System • Cell: Basic unit • Tissue: Group of cells – 4 types • Organ: Groups of tissue – Ex: lung contains each tissue • Organ System: Group of organs working together – Respiratory System • Cell: Basic unit • Tissue: Group of cells – 4 types • Organ: Groups of tissue – Ex: lung contains each tissue • Organ System: Group of organs working together – Respiratory System • Organism: all organ systems working together YouTube Review: Levels of Organization Review 1) 2) 3) 4) What is a zygote? What is the specific function of a stem cell? How does “determination” differ from “differentiation”? Cells are programmed to die during a process called ______. 5) From smallest to largest, name the 5 levels of organization. 6) Name the four types of tissues. 7) Which tissue is able to stretch and contract? 8) Which tissue transmits electric signals? 9) Which tissue covers and protects the body? 10) Which tissue connects the body?