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Structure & Function Animals Overview: Diverse Forms, Common Challenges • Anatomy is the study of the biological form of an organism • Physiology is the study of the biological functions an organism performs • The comparative study of animals reveals that form and function are closely correlated Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Fig. 40-3 Mouth Gastrovascular cavity Exchange Exchange Exchange 0.15 mm 1.5 mm (a) Single cell (b) Two layers of cells Fig. 40-4 External environment CO2 Food O2 Mouth Respiratory system 0.5 cm 50 µm Animal body Lung tissue Nutrients Heart Cells Circulatory system 10 µm Interstitial fluid Digestive system Excretory system Lining of small intestine Kidney tubules Anus Unabsorbed matter (feces) Metabolic waste products (nitrogenous waste) Tissue Structure and Function • Different tissues have different structures that are suited to their functions • Tissues are classified into four main categories: – Epithelial – Connective – Muscle – nervous Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Fig. 40-5a Epithelial Tissue Cuboidal epithelium Simple columnar epithelium Pseudostratified ciliated columnar epithelium Stratified squamous epithelium Simple squamous epithelium Fig. 40-5c Connective Tissue Loose connective tissue Chondrocytes Cartilage Elastic fiber Chondroitin sulfate Nuclei Fat droplets Adipose tissue Osteon 150 µm Fibrous connective tissue 30 µm 100 µm 120 µm Collagenous fiber White blood cells Blood 55 µm 700 µm Bone Central canal Plasma Red blood cells Fig. 40-5j Muscle Tissue Multiple nuclei Muscle fiber Sarcomere Skeletal muscle Nucleus 100 µm Intercalated disk 50 µm Cardiac muscle Nucleus Smooth muscle Muscle fibers 25 µm Fig. 40-5n Nervous Tissue 40 µm Dendrites Cell body Glial cells Axon Neuron Axons Blood vessel 15 µm 11 Body Systems 1. Nervous 2. Integumentary 3. Skeletal 4. Muscular 5. Circulatory 6. Respiratory 7. Digestive 8. Reproductive 9. Excretory 10. Endocrine 11. Immune & Lymphatic Table 40-1 Stimulus • Control and coordination within a body depend on the endocrine system and the nervous system Stimulus Endocrine cell Neuron Axon Signal Hormone Signal travels along axon to a specific location. Signal travels everywhere via the bloodstream. Blood vessel Signal Axons Response (a) Signaling by hormones Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Response (b) Signaling by neurons Regulating and Conforming 40 • A regulator uses internal control mechanisms to moderate internal change in the face of external, environmental fluctuation • A conformer allows its internal condition to vary with certain external changes Body temperature (°C) River otter (temperature regulator) 30 20 Largemouth bass (temperature conformer) 10 0 10 20 30 40 Ambient (environmental) temperature (ºC) Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Homeostasis • “Steady Internal State” Response: Heater turned off Room temperature decreases Stimulus: Control center (thermostat) reads too hot • In humans, Set point: 20ºC – body temperature – blood pH – glucose concentration Stimulus: Control center (thermostat) reads too cold Room temperature increases Response: Heater turned on • Endothermic animals generate heat by metabolism; birds and mammals are endotherms (a) A walrus, an endotherm • Ectothermic animals gain heat from external sources; ectotherms include most invertebrates, fishes, amphibians, and non-avian reptiles (b) A lizard, an ectotherm •Five general adaptations help animals thermoregulate: – Insulation – Circulatory adaptations • Countercurrent Exchange • Vasodilation • Vasoconstriction – Cooling by evaporative heat loss – Behavioral responses – Adjusting metabolic heat production (BMR) Fig. 40-12 Canada goose Bottlenose dolphin Blood flow Artery Vein Vein Artery 35ºC 33º 30º 27º 20º 18º 10º 9º Overview: The Need to Feed • Food is taken in, taken apart, and taken up in the process of animal nutrition • In general, animals fall into three categories: – Herbivores eat mainly autotrophs (plants and algae) – Carnivores eat other animals – Omnivores regularly consume animals as well as plants or algal matter Digestive System • Digestion is the process of breaking food down into molecules small enough to absorb – In chemical digestion, the process of enzymatic hydrolysis splits bonds in molecules with the addition of water • Absorption is uptake of nutrients by body cells • Elimination is the passage of undigested material out of the digestive compartment Fig. 41-7 Small molecules Pieces of food Mechanical digestion Chemical digestion Nutrient (enzymatic hydrolysis) molecules enter body cells Undigested material Food 1 Ingestion 2 Digestion 3 Absorption 4 Elimination Tentacles Extracellular vs Intracellular Digestion Mouth Epidermis Gastrodermis Food Gastrovascular cavity Fig. 41-9a Crop Esophagus Gizzard Intestine Pharynx Formation of Alimentary Canal Anus Mouth Typhlosole Lumen of intestine (a) Earthworm Digestive System • The digestive system includes the – Mouth – Pharynx – Esophagus – Stomach – small intestine – Liver – Gallbladder – Pancreas – large intestine – Rectum Mouth • Mechanical Digestion – Tongue and teeth work together to break down food mechanically – Type of teeth reflect dietary habits • Chemical Digestion – SalivaryAmylase enzyme in saliva that breaks the carbohydrates • chemical bonds between the sugar monomers in starches Esophagus, Pharynx, Epiglottis • Esophagus – No digestion – Food is directed from mouth, to pharynx, to esophagus. • Epiglottis – flap of cartilage – Ensures food travels to esophagus and not wind pipe (larynx) Stomach • Stomach - large muscular sac that continues the mechanical and chemical digestion of food – Acidic pH – 2-3 on the pH scale – (TOP) Cardiac sphincter – circular muscle that keeps materials down in the stomach. Stops acid and food from reentering the esophagus – (Bottom) Pyloric Sphincter – Mechanical Digestion • – Peristalsis Chemical Digestion – protein digestion begins here • HCL and Pepsin - The combination of pepsin (enzyme) and hydrochloric acid begins the complex process of protein digestion. Pepsin breaks proteins into smaller polypeptide fragments. – HCL changes inactive enzyme, pepsinogen active pepsin • Rennin – enzyme that aids in the digestion of the protein in milk • Chyme - mixture of stomach fluids and food produced in the stomach by Fig. 41-12 Esophagus Sphincter Stomach 5 µm Sphincter Interior surface of stomach Small intestine Folds of epithelial tissue Epithelium 3 Pepsinogen 1 Pepsinogen and HCl are secreted. Pepsin 2 HCl Gastric gland 2 HCl converts pepsinogen to pepsin. 1 Mucus cells Cl– 3 Pepsin activates more pepsinogen. H+ Chief cells Chief cell Parietal cells Parietal cell Ulcers – tissue erosion • Can occur in stomach, esophagus, or the duodenum (upper intestine.) – Bacteria Heliobacter pylori can lead to ulcers, but can be treated with antibiotics Small Intestine • Digestion is completed and nutrients are absorbed here. – pH – 8 and length of 6m – Digestion completed in Duodenum first 10 inches. – Digestion • • – Intestinal Enzymes – Lumen – Pancreatic amylases – starch – Peptidases (trypsin, chymotrypsin) – proteins amino acids – Nucleases – nucleic acids nucleotides – Lipases – break down fat Epithelium of small intestine – Maltase – Lactase Absorption – villi (villus-singular) – millions of fingerlike projections (latter portion of small intestine) • Increase surface area • Capillaries – absorb amino acids, vitamins, monosaccharides • Lacteal – absorbs fatty acid and glycerol lymphatic system • Each villus contain microvilli Villi and the Small Intestive •Absorption – villi (villus-singular) – millions of fingerlike projections (latter portion of small intestine) •Increase surface area •Capillaries – absorb amino acids, vitamins, monosaccharides •Lacteal – absorbs fatty acid and glycerol lymphatic system •Each villus contain microvilli Liver • Liver - large organ just above the stomach that produces bile, a fluid loaded with lipids and salts – Accessory gland – Produces bile that emulsifies fat – Bile mixed with Sodium Bicarbonate pH 11 (pancreas), neutralizes “chyme” coming from the stomach – Sends bile to gallbladder for storage – Other functions • Breaks down/recycles red blood cells • Detoxifies blood – removes alcohol & drugs • Produces cholesterol for cell membranes • Produces Urea (nitrogenous waste) from protein metabolism Gallbladder and Pancreas • Accessory glands • Gallbladder – Stores bile – Cholesterol Deposits (gallstones) • We can function without it • Pancreas – Secretes enzymes & bicarbonate Large Intestine or Colon • large intestine – No digestion – 3 major functions • Egestion – removal of undigested waste – Rectum – last 7-8inches stores feces for release • Vitamin Production – B, K, folic acid • Reabsorption – Constipation – Diarrhea Hormones that Regulate the Digestive System Hormone Site of Production Effect Gastrin Stomach wall Stimulate secretion of gastric Juice Secretin Duodenum Wall Stim. Pancreas to release bicarbonate Cholecystokinin Duodenum Wall Stim. Pancreas to release enzymes and gallbladder to release bile Fig. 41-18 Incisors Canines Premolars (a) Carnivore (b) Herbivore (c) Omnivore Molars Fig. 41-19 Small intestine Stomach Small intestine Cecum Colon (large intestine) Carnivore Herbivore Fig. 41-13 Carbohydrate digestion Oral cavity, pharynx, esophagus Protein digestion Nucleic acid digestion Fat digestion Polysaccharides Disaccharides (starch, glycogen) (sucrose, lactose) Salivary amylase Smaller polysaccharides, maltose Stomach Proteins Pepsin Small polypeptides Lumen of small intestine Polysaccharides Pancreatic amylases Polypeptides Pancreatic trypsin and chymotrypsin DNA, RNA Fat globules Pancreatic nucleases Bile salts Maltose and other disaccharides Nucleotides Fat droplets Smaller polypeptides Pancreatic lipase Pancreatic carboxypeptidase Glycerol, fatty acids, monoglycerides Amino acids Epithelium of small intestine (brush border) Small peptides Disaccharidases Monosaccharides Nucleotidases Nucleosides Dipeptidases, carboxypeptidase, and aminopeptidase Amino acids Nucleosidases and phosphatases Nitrogenous bases, sugars, phosphates