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2016 Capabilities and Experience Instant Access to 27,000+ US and 1,200+ Canadian Investigators 1 Table of Contents Scope of Services 3 Process: Simple Steps 4 Contact Information 4 Investigator Resources - US 5 Investigator Resources – Canada 6 Therapeutic Experience 7 Sponsors & CROs Using ILS 10 Management 12 Summary 12 2 Scope of Services We do one thing and one thing only: recruit experienced and motivated investigators for sponsors and CROs. Instant Access to 27,000+ US & 1,200+ Canadian Investigators ILS has built a comprehensive, proprietary database of 27,000+ experienced and motivated U.S. and 1,200+ experienced and motivated Canadian investigators in all medical specialties and practice settings. Based on your specifications, we instantly target and email appropriate investigators to determine interest in your study. Your company is not identified and investigators, who are interested and have the current capacity for your study, sign up to have their CV submitted to you. You review the CV and decide who to contact. Finding experienced investigators for clinical trials remains one of the greatest obstacles to rapidly launching studies. ILS is an informatics driven company whose proprietary system and expanded investigator database now contains over 27,000 experienced U.S. and Canadian investigators in all medical specialties and practice settings. Investigators are targeted by multiple criteria including medical specialty, research experience, practice setting and location. Instant email broadcasts rapidly identify interested investigators with current capacity for additional trials matching client specifications. Site Questionnaires are sent to further qualify investigators. Save Time and Effort ILS eliminates weeks and months of frustrating work by your project teams playing phone tag with investigators only to find them unable to take your project due to other commitments. Free to CROs and Sponsors Investigators pay our fees if you use them and our services are free to CROs and Sponsors. Experienced & Motivated Investigators The key to ILS’s success and repeat business from sponsors and CROs is that investigators who sign up through ILS are experienced and extra motivated to perform. Investigators who sign up through ILS typically have 10-15 years of experience and are extra motivated to perform for you since they have agreed to pay ILS our fee when the study starts. Our study gets top priority at the site. Sponsors & CROs Using ILS Since 2001, 414 Sponsors and CROs have used ILS to recruit over 10,000 investigators for 987 protocols including difficult to place projects. Remember, you review the CVs of experienced and motivated investigators interested in your project and decide who to contact. No cost, risk FREE. 3 Process 4 Simple Steps 1. 2. 3. 4. Call ILS and describe your study. ILS emails appropriate investigators about your study (you are not identified). ILS sends you the CVs of interested & motivated investigators. You decide who to contact and deal directly with the investigator. It’s that simple. And it’s FREE. Investigators pay our fees. Call ILS today! Contact Information Joe A. Bollert, PhD President Investigator Location Services, Inc. 70 S.W. Century Dr. Suite 100-247 Bend, OR 97702 Phone (541)633-7540 jbollert@invlocate.com www.invlocate.com 4 Investigator Resources-US 27,000+ experienced and motivated US investigators to accelerate your clinical trials Adolescent Medicine 85 Aerospace Medicine 27 Allergy 851 Anesthesiology 131 Cardiology 1984 Cardiac Electrophysiology 200 Clinical Pharmacology 129 Critical Care 476 Dentist 110 Dermatology 611 Dermatological Immunology 57 Emergency Medicine 210 Endocrinology 989 Family Practice 704 Gastroenterology 1247 General Practice 164 Geriatric Medicine 431 Gynecologic Oncology 686 Hematology 1467 Immunology Clinical 185 Infectious Disease 985 Internal Medicine 686 Maternal and Fetal Medicine 76 Medical Oncology 1800 Neonatal-Perinatal Medicine 158 Nephrology 484 Neurology 1335 Neurology Child 32 Neurophysiology Clinical 156 Nuclear Medicine 50 ObGyn 708 Occupational Medicine 55 Ophthalmology 635 Orthopedic Surgery 452 Osteopathy 84 Otolaryngology 272 Pain Management 511 Physical Medicine & Rehabilitation 119 Pediatrics 719 Pediatric Cardiology 112 Pediatric Critical Care 41 Pediatric Emergency Medicine 47 Pediatric Endocrinology 103 Pediatric Gastroenterology 54 Pediatric Hematology-Oncology 112 Pediatric Infectious Disease 172 Pediatric Nephrology 40 Pediatric Otolaryngology 37 Pediatric Pulmonology 96 Pediatric Radiology 21 Pediatric Rheumatology 49 Pediatric Sports 25 Plastic Surgery 134 Podiatry 109 Psychiatry 815 Psychiatry Addiction 130 Psychiatry Child 197 Psychiatry Geriatric 163 Pulmonary Disease 1052 Radiology 171 Radiation Oncology 115 Reproductive Endocrinology 104 Rheumatology 985 Sleep Medicine 194 Sports Medicine 118 Surgery 413 Surgery Colorectal 64 Surgery Critical Care 82 Surgery General Vascular 323 Surgery Hand 26 Surgery Neurological 154 Surgery Pediatric 35 Surgery Thoracic 145 Urology 647 What specialty do you need for your next study? 5 Investigator Resources-Canada 1,200 + experienced and motivated Canadian investigators to accelerate your clinical trials Adolescent Medicine 0 Aerospace Medicine 0 Allergy 37 Anesthesiology 3 Cardiology 114 Cardiac Electrophysiology 5 Clinical Pharmacology 5 Critical Care 37 Dentist 3 Dermatology 30 Dermatological Immunology 0 Emergency Medicine 6 Endocrinology 42 Family Practice 33 Gastroenterology 37 General Practice 35 Geriatric Medicine 15 Gynecologic Oncology 6 Hematology 64 Immunology Clinical 12 Infectious Disease 53 Internal Medicine 20 Maternal and Fetal Medicine 1 Medical Oncology 152 Neonatal-Perinatal Medicine 2 Nephrology 27 Neurology 46 Neurology Child 1 Neurophysiology Clinical 1 Nuclear Medicine 2 ObGyn 30 Occupational Medicine 2 Ophthalmology 13 Orthopedic Surgery 44 Osteopathy 0 Otolaryngology 2 Pain Management 24 Physical Medicine & Rehabilitation 10 Pediatrics 13 Pediatric Cardiology 2 Pediatric Critical Care 1 Pediatric Emergency Medicine 5 Pediatric Endocrinology 7 Pediatric Gastroenterology 2 Pediatric Hematology-Oncology 2 Pediatric Infectious Disease 8 Pediatric Nephrology 1 Pediatric Otolaryngology 0 Pediatric Pulmonology 5 Pediatric Radiology 0 Pediatric Rheumatology 0 Pediatric Sports 1 Plastic Surgery 1 Podiatry 3 Psychiatry 32 Psychiatry Addiction 6 Psychiatry Child 4 Psychiatry Geriatric 4 Pulmonary Disease 49 Radiology 3 Radiation Oncology 4 Reproductive Endocrinology 5 Rheumatology 30 Sleep Medicine 8 Sports Medicine 11 Surgery 11 Surgery Colorectal 1 Surgery Critical Care 1 Surgery General Vascular 16 Surgery Hand 0 Surgery Neurological 10 Surgery Pediatric 3 Surgery Thoracic 75 Urology 54 What specialty do you need for your next study? 6 Therapeutic Experience ILS has recruited clinical investigators in the following therapeutic areas: Abdominal Infection Abdominal Pain Abdominal Surgical Pain Abdominal Wound Healing Acne Acromegaly Actinic Keratosis Acute Asthma Acute Coronary Syndrome Acute MI Acute Respiratory Distress Acute Sinusitis Acute Stroke Acute Urinary Retention Adolescent Ankle Sprain Adolescent Panic Adolescent Psoriasis Adolescent Schizophrenia Advanced Breast Cancer Agitation & Bipolar Disorder Agitation & Schizophrenia Allergy Alzheimer’s Disease Acute Myelogenous Leukemia Anemia in Chemotherapy Anemia & COPD Anesthesia Angina Ankle Sprain Ascites Asthma Atherosclerosis Athlete’s Foot Atopic Dermatitis Atrial Fibrillation Autism AV Fistula AV Graft Hemostasis B-cell Lymphoblastic Leukemia Bipolar Disorder Bladder CA Bone Loss BPH Diabetic Neuropathy Dialysis Diarrhea Down Syndrome Dry Eye Dx Acute MI Dx Colon Cancer Dx HIV Dx Pul. Embolism & DVT Dyskinesia Early Renal Insufficiency Encephalitis Endocarditis Endometriosis Epilepsy ED Eosiniophilic Asthma Esophageal Cancer FSAD Femur Fracture Fibrocystic Breast Disease Flu Gastroparesis Gaucher’s Disease Genital Herpes GERD Glucose Monitor Gout Graft vs. Host Disease Gynecologic Adhesions Gynecologic Cancer Head Lice Head & Neck Cancer Hemodialysis Hemostasis Hepatic Surgery Hepatitis A Vaccine Hepatitis B Vaccine Hepatitis C Hepatocellular Cancer Hereditary Antithrombin Deficit Herpes Labialis Hip Arthroplasty 7 Opioid Bowel Dysfunction Oral Contraceptive Orthopedic Pain Orthostatic Hypotension Osteoarthritis Otolaryngology Surgical Pain Ovarian Cancer Pancreatic Cancer Parkinson’s Disease Pediatric Allergy Pediatric Asthma Pediatric Atopic Dermatitis Pediatric Bipolar Disorder Pediatric Bronchiolitis Pediatric Depression Pediatric Diabetes Pediatric Emergency Asthma Pediatric Epilepsy Pediatric GERD Pediatric Chemo Nausea Pediatric HIV Pediatric Hypertension Pediatric Migraine Pediatric Neurogenic Bladder Pediatric Otitis Media Pediatric Post Op Nausea Pediatric RSV Pediatric Ulcerative Colitis Pediatric Vaccine Peripheral Artery Bypass Peripheral Artery Disease Peripheral Artery Hemostasis PMS Pneumonia Post Herpetic Pain Post Hysterectomy Pain Post Op Ileus Post Op Nausea Post Op Pain Post Renal Transplant Pressure Ulcer Pre-Surgical Sedation Primary Biliary Cirrhosis Brain Cancer Break Thru Pain Breast Augmentation Breast Cancer Bronchiectasis Bronchiolitis Bunion Pain CABG Cachexia Cancer Pain Cancer PK Cardiac Electrophysiology Catheter Infection Cartilage Repair C dif. Colitis Cellulitis Cervical Ripening Chemo Nausea Chemo Protection Breast CA Chronic Back Pain Chronic Kidney Disease Hip Fracture HIV Hot Flashes HPV Assay Humerus Fracture Hyperlipidemia Hypertension Hypertension/Hyperlipidemia Hyponatremia Hysterectomy Pain IBS ICU sedation Interstitial Cystitis Itradialytic Hypotension Invasive Fungal Infection Iron Deficiency Ischemic Stroke Knee Cartilage Repair Knee OA Knee Replacement Leukemia Prostate Cancer Psoriasis Psychotic Depression Pul. Arterial Hypertension Radial Fracture Renal Cell Carcinoma Rheumatoid Arthritis Sarcopenia Schizophrenia Sciatica Scleroderma Sepsis Septic Shock Skin & Soft Tissue Infection Small Pox Vaccine Solid Tumor Spinal Fusion Spinal Surgery Staph Infection STEMI Stroke Prevention Chronic Lymphocytic Leukemia Chronic Myelogenous Leukemia Chronic Rhinosinusitis Surgery Chronic Sinusitis Chronic Stable Angina Cisplatin Nausea Clozapine Agranulocytosis Cognitive Rehab Colorectal Cancer Colorectal Cancer Pain Community Acquired Pneumonia Comp. SST Infection Comp. Urinary Tract Inf. Conjunctivitis Congestive Heart Failure Constipation COPD Coronary Artery Disease Crohn’s Disease Cushing’s Disease Cutaneous Lymphoma Dental Pain Deep Vein Thrombosis Depression Dermatitis Liver Disease Low Back Pain Lumbar Joint Replacement Lupus Lymphoma Lyme’s Disease Mad Cow Disease Male Hot Flash Melanoma Meningitis Metabolic Syndrome Metastatic Breast Cancer Migraine Headache MRSA Infection Mucositis Multiple Sclerosis Myasthenia Gravis Mycosis Narcolepsy Neonatal Candidiasis Neutropenia Non Hodgkin’s Lymphoma Noonan Syndrome Nosocomial Pneumonia NSCLC Surgical Hemostasis Surgical Infections T-cell Leukemia Thrombocythemia Thrombocytopenia Tibial Fracture Total Knee Replacement Ulcerative Colitis Uterine Adhesions Vaginal Atrophy Vaginitis Varicose Veins Venous Catheter Venous Ulcer Viral Conjunctivitis Venous Leg Ulcer VTE VTI Induction Women’s Health Wound Care Xerostomia Healthy Volunteer 8 Diabetes Type I & II Diabetic Foot Ulcer Diabetic Neuropathy Nutrition Obstructive Sleep Apnea Opioid Addiction ILS recruits clinical investigators for routine as well as difficult to place clinical trials. 9 Partial List of Sponsors and CROs Using ILS 3M Pharmaceuticals Aastrom Healthcare Products HealthPoint Health Decisions Helsinn MTRA Myriad Genetics Naurex Neurobiologic Tech Sanguine Abbott Abt Associates Ceregenics Ceregene Chiltern Chelsea Therapeutics Acadia Acambis Acell Accentia Accera Actavis Chugai Biosciences Ciba Vision ClinDatrix Clinimetrics Clin R&D Clin Res Mngt Hill Top Hollis Eden Hospira I3innovus IBSA ICON Neurocrine NeurogesX New World Niveus Nova Bay NovaRx Scirex Schiff Seattle Genetics Sequenom SeraCare Serenity Actelion Advanced Biologics Adventrx Aeterna Laboratories Afecta Pharm. Affymax ClinStat CNS Response Coaxia Coloplast Constella Group Convatech ICOS IDDS Ikaria IMeds Immune Network Impath Novartis Novella NovoNordisk Nuron Biotech NW Biotherapeutics Nymox Serono Sirion SIRO Clinipharm Skye Pharma Smith & Nephew Solvay Alba Corcept Cortendo Covalent Group Covance CROfessionals CROMedica INC Inclinix Incyte Inflabloc Inflamax Infoquest Ockham Omeros Omnicare Omrix Ono Optum Sonus Spectrum SPRIM Strategic Science Statking Sucampo CTMS Cubist Cumberland Cyberonics Cylene Cytokine Innoclin INO Therapeutics Insmed Integra Life Science Integrated Qual Res Integrium Orion Ortec Ortho Biotech Orthologic Otic Otonomy Symbion Symbollon Synergy Synteract Synthetic Blood Systems Med Daiichi Dainippon Delcath DePuy DermSci DermTech Intranasal Therapeutics Intrinsic Group Inveresk IOR Ischemia Care Isis Otsuka Ovation Oxford Pacira Palatin Paragon TAB Takeda Targagen Targeted Med Taris Tasly Apotex Research AP Pharma Arkios Armethion Ash Medical Systems Asterand Diagnostic Onc. Dimension Discovery Labs Diverse Lynx Dow Pharmaceuticals Draximage J&J Javelin Kendle Kensey Nash KeraCure KV Parexel Perrigo Perlegen Pfizer Pharmacyclics PharmaLink Teva Teva Neuroscience The Medicines Co. Theorem Theradex Theratech Astra Zeneca Asuragen Atlantic Attenuon Draxis Duramed DURECT Effective Research Labopharm Lexicor LifeTime Lineberry Pharmaxis Pharm-Olam Pharm. Research Pharmanet Titan TolerRx Topstone Transport Pharma Alcon AlgoRx Allergan Allocure Allos Altana Pharma Altea Therapeutics Altura Amarex Amazon Biotech. Amgen Anaclim Analytica Intl Angion Angiotech Angstrom Anosys 10 Sanofi Schering SciClone Auxilium Avanir Elan Eleison Lorus Luitpold PharmEast PhereSys Trine Pharm. Trius Aventis Averion Barrier Therapeutics Battelle Bausch & Lomb Bayer Bayhill Therapeutics BBCI Beardsworth Berlex Berman Beyond Innovation Biocryst Biokeys Biomedicines Biomet BioNumerik BioSante Biovex BoehringerIngelheim Brainsgate Bristol-Myers Squibb Cadence Pharma Cardium CareStat Catalyst Cato CE3 Celldex Celgene Cell Diagnostics Cell Therapeutics Cephalon Emissary Emmes Encorium Endoceutics Essential Group Eurand Exoxemis Facet Solutions Femme Pharma Ferring FeRx Fibrogen FlowMedic Forest Labs Galderma Genaissance Genentech Genervon Genetic Collaborative Genetronics Macrogenics Mallinkrodt MannKind Marshall Edwards MDS Pharma Mead Johnson Medarex Medifacts Medimmune Medinox Medpace MedSearch Medtronic Melante Mentor Metabasis Metaphore Methylgene Merck Metropolitan Research Physical Thera Posit Science Pozen PPD PRA Praeger Premier Proctor & Gamble Promedica Promethius Proneuron Protherics PSI-CRO Purdue Pharma QLT Quigley Quintiles Reg Affiars Renovis RepliGen UBC UCB Pharma Unigen Unipath United Therapeutics US Biotest USHIFU US Micron US World Meds Vascular Pharm Ventana Ventria Ventrus Bioscience Veroscience Vical Vicuron ViroPharm ViTech Vivus Warner Chilcott Genomics Inc. GenMAB Gentiae GenVec Genzyme GlaxoSmithKline Global Max Global Research Globus Grifols GTC GTx Guilford Microvention Millenix MonitorForce Lifetime Pharma MCRS Medicines Company MedSource Methylgene MicroPoint Millenix Mitsubishi Pharma Momentum Moximed Repros Research Point ResponseBio RhoWorld Robarts Roche Roche Diagnostics Romark RPS RS Medical RTL Rx Development Sangamo Watson Winston Laboratories Wyeth YM Bioscience Xbiotech Ximedica Xmedia Xoma Zarix Zeptometrix ZS Pharma Zymogenetics BOLD = top 50 11 Management Joe A. Bollert, PhD, President Dr. Bollert, has over forty years of clinical research experience, first with the Upjohn Company and then as a leader for 20 years in the CRO industry with the Institute for Biological Research Development (IBRD). He founded the innovative investigator recruiting service known as ILS in 2001 and since then ILS has worked with 414 pharmaceutical, biotech, medical device, diagnostic and CRO companies to recruit investigators. Noemi Suazo, Director of Operations Mrs. Suazo has 15 years of medical and clinical research experience working in physician offices and in site recruitment with ILS since 2004. Her responsibilities include managing the recruiting relationship between investigators and sponsors and CROs. Summary Free and instant access to 27,000+ US and 1,200+ Canadian investigators in all medical specialties and practice settings can accelerate investigator recruiting on your next project. Contact ILS today to rapidly recruit outstanding investigators for your next clinical trial. (541) 633-7540 or jbollert@invlocate.com 12