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Programme Wednesday 03rd April 2013 08.00–09.15 Registration 09.15-10.00 Welcome Prof. Nicolae Victor Zamfir, General Director IFIN-HH Dr. Ioan Ursu, Scientific Secretary IFIN-HH 10.00-10.30 CCR - Radiopharmaceuticals Research Centre Dana Niculae, Department of Radioisotopes and Radiation Metrology, IFIN-HH 10.30-11.00 The new TR19 Cyclotron for PET radioisotopes production and Applied Research in IFIN-HH Liviu Craciun, Department of Applied Nuclear Physics, IFIN-HH 11.00-11.20 Cofee break Radiopharmacy – a multidisciplinary approach Chairmen Dana Niculae and Stefano Boschi 11.20-12.20 Invited lecture - The Role of PET in Molecular Oncology Prof. John Mercer Oncologic Imaging, Faculty of Medicine and Dentistry, University of Alberta / Cross Cancer Institute, Edmonton 12.20-13.00 Invited lecture – Radiopharmaceutical legislation in Europe Prof. Clemens Decristoforo, Department of Nuclear Medicine, Medical University, Innsbruck 13.00-13.20 The Role of the PET/CT Investigation in the Radiotherapy of Malignant Tumors Prof. Christian Chiricuta, Amethyst Radiotherapy Center, Bucharest-Otopeni 13.20-13.40 Compared Oncology as Discipline of Medical Sciences Prof. Nicolae Manolescu, Institute for Compared Oncology, Translational Medicine, University of Veterinary Medicine, Bucharest 13.40-14.30 14.30-15.00 Lunch break Visits at Radiopharmaceutical Research Centre and Radioisotopes Production Centre Planning and running a medical radioisotopes production facility Chairmen Ioan Ursu and Liviu Craciun 15.00-15.30 The Debrecen Experience in PET Radiochemistry Dr. Pal Mickecz, Department of Nuclear Medicine, MHSC, University of Debrecen 15.30-16.30 Metrological traceability assurance in production and use of radiopharmaceuticals for PET imaging and targeted radiotherapy Dr. Maria Sahagia, Department of Radioisotopes and Radiation Metrology, IFINHH 16.30-17.00 Establishing a PET Production Facility; Seven Alternative PET Radiopharmaceutical Production Centers Ayfer Asiye Soylu, Eczacıbaşı-Monrol Nuclear Products Company, Turkey 17.00-17.30 Radiation protection at radiopharmaceutical production sites Dr. Radu A. Vasilache, Canberra Packard GmbH Thuesday 04th April 2013 PET radioisotopes - clinical radiopharmacy Chairmen Doina Draganescu and Clemens Decristoforo 09.15-10.00 Invited lecture – Fluorine-18 Radiopharmaceuticals for cancer imaging - 18F-FDG and beyond. Prof. John Mercer Oncologic Imaging, Faculty of Medicine and Dentistry, University of Alberta / Cross Cancer Institute, Edmonton, Canada 10.00-10.45 Invited lecture - 11C Radiopharmaceuticals in clinical radiopharmacy: a ten years' experience Prof. Stefano Boschi, PET radiopharmacy, Department of Nuclear Medicine, University Hospital, Bologna, Italy 10.45-11.05 Review of FDG PET-CT Application in Oncology Mirela Gherghe, Euromedic Romania, Department of PET-CT 11.05-11.20 Cofee break PET radioisotopes - chemistry Chairmen Adriana Rimbu and Pal Mickecz 11.20-11.50 Development and application of chiral nickel complexes for the preparation of carbon-11 and fluorine-18 labelled amino acids Prof. Alexander Popkov, Department of Cognitive Research and Tomographic Imaging Methods, Samo University, Pardubice, Czech Republic 11.50-12.20 Non-HPLC methods for the production of F-18, C-11 and Ga-68 PET tracers Dr. Alexander Yordanov, Ezcacibasi-Monrol Nuclear Products, Turkey (Monrol Bulgaria) 12.20-12.50 Development of high power Ni target for production of Cu 64 by a biomedical cyclotron Dr. Lidia Matei, Best Theratronics, Radiochemistry Division, Ottawa Canada; 12.50-13.10 Sponsor presentation - PET/CT in monitoring the patient response to oncological treatment Daniela Stanoi, GE Healthcare, GE Medical Systems Romania 13.10-14.15 Lunch break From research to clinical applications Chairmen Cristian Chiricuta and Stefano Boschi 14.15-15.00 Invited lecture - Peptide radiopharmaceuticals: The theranostic approach Prof. Clemens Decristoforo, Department of Nuclear Medicine, Medical University, Innsbruck 15.00-15.30 Evaluation of 177Lu - DOTA - NT and 177Lu – DOTA - SR48692 therapeutic efficacy in murine experimental model Dr. Iuliana Gruia, Institute of Oncology Prof Dr Al Trestioreanu, Bucharest 15.30-16.00 Radiolabelled peptide in diagnosis and therapy of neuroendocrine tumors Dr. Mirela Gherghe, Institute of Oncology Prof Dr Al Trestioreanu, Bucharest 16.00-16.30 Clinical applications of molecular neuroimaging SPECT/CT and PET/CT Dr. Adriana Rimbu, Nuclear Medicine Department, Clinical Hospital Colentina, Bucharest 16.30-17.10 Nuclear medicine, beyond images Dr. Doina Piciu, Dept. Nuclear Medicine and Endocrine Tumors “Ion Chiricuta” Institute of Oncology Cluj-Napoca 17.10-17.30 Visits at Radiopharmaceutical Research Centre and Radioisotopes Production Centre 18.30 Dinner at Crama Domneasca Friday 05th April 2013 A promising generator produced PET radioisotope: Gallium-68 Chairmen Dana Niculae and Rodica Anghel 09.15-10.00 Invited lecture – 68Ga in radiopharmacy Prof. Stefano Boschi, PET radiopharmacy, Department of Nuclear Medicine, University Hospital, Bologna, Italy 10.00-10.45 Invited lecture - 68Ga radiopharmaceuticals: recent advances Prof. Clemens Decristoforo, Department of Nuclear Medicie, Medical University, Innsbruck, Austria 10.45-11.05 Preclinical evaluation of 68Ga-cycloRGD dimers for imaging and therapy follow-up Ioana Esanu, Department of Radioisotopes and Radiation Metrology, IFIN-HH 11.05-11.25 Automation of Ga-68 radiosynthesis Filip Puicea, Department of Radioisotopes and Radiation Metrology, IFIN-HH 11.25-11.45 Cofee break Alternative methods for production of Mo-99 and Tc-99m Chairmen John Mercer and Lidia Matei 11.45-12.30 Invited lecture - Recent Developments on 99mTc Production by Cyclotron Lidia Matei, Best Theratronics, Radiochemistry Division, Ottawa Canada; 12.30-12.50 Production of 99Mo using LEU targets at INR Pitesti Ana Maria Ivan, Institute for Nuclear Research Pitesti, Mioveni-Arges, Romania 12.50-13.10 Manipulation of isotope decay rates using the intensity of applied X- ray lasers Nicolae Enaki, Institute of Applied Physics, Academy of Sciences of Moldova, Moldova 13.10-13.30 A feasibility study on direct Cyclotron production of Tc-99m at IFIN-HH Liviu Craciun, Department of Applied Nuclear Physics, IFIN-HH 13.30-14.00 Closing remarks Dana Niculae, Department of Radioisotopes and Radiation Metrology, IFIN-HH Poster presentations: P1 Methods for 99Mo/99mTc obtaining at IFIN-HH-DRMR C. Cimpeanu, C. Barna P2 Bioaffinity of 177Lu-DOTA-NT and 177Lu-DOTA-SR Bioconjugates to neurotensin receptors Diana Chiper, Valeria Lungu, Catalina Barna, Cristian Postolache, Viorel Fugaru, Simona Manea, George Bubueanu P3 Obtaining of 177Lu-DOTA-NT and 177Lu-DOTA-SR Bioconjugates Diana Chiper, Valeria Lungu, Catalina Barna, Tuta Catalin, Marina Iliescu P4 Oncology in canidae and felidae. A study case (2007 – 2012) at the University of Veterinary Medicine Bucharest Emilia Balint1,N.Manolescu2,G.Predoi3,C.Mateescu4 P5 F-18 SODIUM FLUORIDE PRODUCTION WITH TWO COMMERCIAL SYNTHESIS MODULES Hakan DEMİRCİ, Salim ÖZTÜRK, Hakan BAĞCI, Sinem ŞENSOY, Deniz KIVRAKDAL, Sait KÖKOĞLU, Arda UYANIK, Turgay DOĞAN, P6 [F-18]FLT PRODUCTION WITH TWO DIFFERENT PURIFICATION METHODS Salim Öztürk, Hakan Demirci, Hakan Bağcı, Deniz Kıvrakdal, Sinem Şensoy P7 IN HOUSE MAINTENANCE OF TWELVE CYCLOTRONS FROM DIFFERENT MANUFACTURERS – THIRTEEN YEARS EXPERIENCE Harun KÜÇÜKMİDİL, Volkan ÇAM, Merter UZUN, Akın AYDIN, Mustafa UZAL, Lütfiye GENCO