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Peripheral Nerves and Arteries Information IN Sensory or “afferent” neurons carry information into the CNS from receptors located throughout the body. Information OUT Motor or “efferent neurons” carry electrical impulses away from the CNS to innervate “effector organs,” like muscles and glands. Sensory Receptors in Skin •They detect sensory input and convert them into electrical impulses that will travel up neurons along the spinal cord. •Sensory input about touch, pain, heat, cold, pressure. Proprioceptors •Sensory receptors that report on internal events in your muscles and joints. •They report on muscle stretch and joint position. •They generate electrical impulses that will travel up neurons to the CNS. The Reflex Arc Dorsal root ganglia contain cell bodies of sensory neurons Upper and Lower Motor Neurons  Of course, the signal to initiate motor movement does not begin at the neuron cell body in the spinal cord; it begins in the brain.  The motor neuron whose cell body is in the brain is called an upper motor neuron.  It relays the signal to the motor neuron whose cell body is in the spinal cord, called the lower motor neuron.  The lower motor neuron synapses on a muscle, causing contraction. Lower Motor Neurons “Innervate” Muscle Cells at the Neuromuscular Junction Motor Neurons “Innervate” Muscle Cells Neuron “innervates” muscle and triggers it to contract by the release of a chemical neurotransmitter. Order of Nerves Firing  To pick up an object, you wrap your hand around the object. This gives you a sensory input as you feel the object.  The sensory neuron sends the impulse to the spinal cord where it synapses on an interneuron.  The interneuron synapses on a motor neuron  The motor neuron tells your muscles to contract so you can pick up the object. Upper and Lower Motor Neuron Diseases  Some diseases only effect the UMN, and some only effect the LMN.  Lower motor neuron disorders:   Multiple Sclerosis Polio  Upper motor neuron disorder:  Cerebral palsy Autonomic Neuropathy  Autonomic neuropathy is damage to autonomic nerves.  The autonomic nerves are those that supply involuntary body functions, including heart rate, blood pressure, perspiration and digestion.  A common symptom in autonomic neuropathy is dizziness. Muscle twitches and lack of sensation are NOT symptoms, since they are not supplied by autonomic nerves. XS of the Spinal Cord Dorsal median sulcus Roots Rami Ventral median fissure Spinal Nerve Spinal Nerve Plexi  A network of ventral rami  Interlacing network  Each branch carries fibers from several spinal nerves  Gives redundancy in case of nerve damage C1-C4- Cervical plexus C5-T1- Brachial plexus L1-L4- Lumbar Plexus L4-S4- Sacral Plexus Cervical Plexus Nerves innervate skin of neck, back of head and upper shoulder. Phrenic nerve (important for breathing!) from C3, C4, C5. Carries afferent and efferent fibers to the respiratory diaphragm. Brachial Plexus ROOTS TRUNKS DIVISIONS CORDS NERVES Brachial Plexus Brachial Plexus  Damage to Brachial Plexus   Klumpke’s paralysis (brachial plexus damaged during birth) Acquired Brachial Plexus injuries  Crutch paralysis (total upper extremity paralysis)  Claw Hand / Ape hand  Hand of benediction  Wrist Drop (Waiter’s Hand) Peripheral damage to the Brachial Plexus “Funny Bone” damage Carpal Tunnel Axillary Musculocutaneus Major Nerves of the Upper Extremity Axillary Nerve  Deltoid  Teres minor Musculocutaneus Nerve  Supplies anterior muscles of the arm Median Nerve  Supplies no muscles of the arm  Supplies anterior forearm (except flexor carpi ulnaris)  Carpal Tunnel Syndrome  Hand of benediction Ulnar Nerve  Supplies flexor carpi ulnaris  “Funny Bone”  Damage can cause claw/ape hand Radial Nerve  Supplies muscles on the posterior arm and forearm    Triceps brachii Extensor carpi radialis Extensor digitorum communis  Damage can cause wrist drop Lumbo-Sacral Plexus • Lumbar: – Femoral nerve • Sacral: – Sciatic nerve Obturator Femoral Nerves of the Lower Extremity Obturator Nerve  Supplies adductor muscles Sciatic Nerve  Supplies back of thigh    Biceps femoris Semimembranosis Semitendonosis  Supplies leg and foot Femoral Nerve  Anterior Thigh  Quadriceps femoris Tibial Nerve  Posterior leg and foot    Gastrocnemius Soleus Tibialis Posterior Common Peroneal Nerve  Superficial branch   Lateral side of leg Supplies peroneal muscles  Deep branch   Supplies anterior leg muscles Injury causes “Foot Drop” Dermatomes  The area of skin innervated by a cutaneous branch of a spinal nerve at a particular level. Arteries of the Upper Extremity Arteries of the Upper Extremity  Subclavian (becomes axillary artery in armpit)  Axillary (becomes brachial artery in arm)  Supplies triceps brachii  Brachial (divides into radial and ulnar arteries when it reaches the elbow)  Supplies arm muscles except triceps brachii  Radial  Ulnar External Iliac artery Arteries of the Lower Extremity Arteries of the Lower Extremity  External iliac (becomes femoral artery)  Femoral (becomes popliteal artery at knee)  Femoral artery supplies muscles of thigh (including adductor muscles)  Popliteal (becomes tibial artery in leg)  Tibal  Leg muscles Peripheral Vascular Disease (PVD)  Refers to the obstruction of large arteries, frequently in the lower extremity. Usually caused from atherosclerosis (fatty plaques).  Symptoms  Claudication: pain, weakness, numbness, or cramping in muscles due to decreased blood flow  Sores, wounds, or ulcers that heal slowly or not at all  Change in color (blueness or paleness) or temperature (coolness) when compared to the other limb  Diminished hair and nail growth on affected limb and digits (shiny, hairless skin)