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Killing of human immunodeficiency virus-infected primary T-cell blasts by autologous natural killer cells is dependent on the ability of the virus to alter the expression of major histocompatibility complex class I molecules by Matthew I. Bonaparte, and Edward Barker Blood Volume 104(7):2087-2094 October 1, 2004 ©2004 by American Society of Hematology NK cells lacking CD158a, CD158b, and CD159a have greater ability to kill HIV-infected cells. Matthew I. Bonaparte, and Edward Barker Blood 2004;104:2087-2094 ©2004 by American Society of Hematology NK cells lacking CD158a, CD158b, and CD94 or CD159a kill autologous T-cell blasts infected with an HIV strain that decreases MHC class I molecules but not T-cell blasts infected with an HIV strain that does not alter MHC class I molecules. Matthew I. Bonaparte, and Edward Barker Blood 2004;104:2087-2094 ©2004 by American Society of Hematology Expression of CD4, HIV p24 antigen, and MHC class I molecules on HIV-infected primary CD4- Tcell blasts. Matthew I. Bonaparte, and Edward Barker Blood 2004;104:2087-2094 ©2004 by American Society of Hematology Blocking the interaction between CD158a, CD158b, and CD159a on NK cells and HLA-C and -E molecules on infected cells increases the ability of NK cells to destroy HIV-infected autologous primary T cells. Matthew I. Bonaparte, and Edward Barker Blood 2004;104:2087-2094 ©2004 by American Society of Hematology Expression of MHC class I molecules on primary T-cell blasts after infection with various strains of HIV. PHA-stimulated primary CD4+ T cells from HIV-uninfected donors were infected with HIV1SF162 (A, C), HIV-1SF33 (A), HIV-1SF128A (B), HIV-1SF2 (B), or H... Matthew I. Bonaparte, and Edward Barker Blood 2004;104:2087-2094 ©2004 by American Society of Hematology Expression of various types of MHC class I molecules on T-cell blasts infected with different HIV strains. Matthew I. Bonaparte, and Edward Barker Blood 2004;104:2087-2094 ©2004 by American Society of Hematology
