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SuccFind: a novel succinylation sites online
SuccFind: a novel succinylation sites online

... 3 Results and discussion Based on the succinylation data sets, we firstly generated the graphical sequence logo (P < 0.01; t-test) and detected a statistically significant differences in position-specific symbol compositions and biochemical environment (Fig. 1a, Supplementary Fig. S1). We then calcu ...
wrzaczek_ptms
wrzaczek_ptms

... University of Helsinki, Finland Helsinki, August 18th, 2016 ...
PutidaNET : Interactome database service and network analysis of
PutidaNET : Interactome database service and network analysis of

... • To provide valuable insights into biological functions and processes in cells. • To provide important clues about how to interpret metabolic pathways of enzymes. ...
Genome-Scale Modeling of the Protein Secretory Machinery
Genome-Scale Modeling of the Protein Secretory Machinery

... There are two main mechanisms for cargo detection at the ER transition site: direct binding of the cargo to the coat subunits and adaptor depended mechanism. Most of the transmembrane cargos are supposed to interact directly with the core subunits of the COPII coat complex. On the other hand, most o ...
C, H, O - Cloudfront.net
C, H, O - Cloudfront.net

... Proteins (C,H,O,N) sometimes (C,H,O,N,S) Proteins are macromolecules that contain nitrogen, carbon, hydrogen, and oxygen.  Proteins are large molecules (polymers) made up of monomers called amino acids.  Biuret Solution is an indicator solution for proteins. It turns blue-violet in the presence ...
Enzymatic properties of the N- and C
Enzymatic properties of the N- and C

... N-terminal and Δ18N constructs show higher affinity for ATP than the C-terminal half. Many lines of evidence suggest that GST or the GST-domains of fusion proteins have the potential to mediate oligomerization both in vitro and in vivo (23, 24). In particular, Tudyka and Skerra mentioned that when c ...
Proteins - New Age International
Proteins - New Age International

... structure, referred to as its conformation. Depending on their conformation, proteins are classified as Fibrous and Globular Proteins. Fibrous proteins consist of polypeptide chains arranged in parallel along a single axis to yield long fibers or sheets. Fibrous proteins are insoluble in water or di ...
How to make a Biomolecules booklet
How to make a Biomolecules booklet

... nitrogen, carbon, hydrogen, and oxygen.  Proteins are large molecules (polymers) made up of monomers called amino acids.  Biuret Solution is an indicator solution for proteins. It turns blue-violet in the presence of proteins. ...
Lecture PPT (updated)
Lecture PPT (updated)

... cyclin-dep kinases (CDK) phosphorylate to inactivate; reversed by auto-dephosphorylation 5. Toxins - microcystin, okadaic acid, calyculin A bind at active site (3D structures) ...
Copper perchlorate: Efficient acetylation catalyst
Copper perchlorate: Efficient acetylation catalyst

... Protected alcohols such as isopropylidene glycerol and 4(tert-butyldimethylsilyloxy)benzyl alcohol are successfully acylated to (2,2-dimethyl-1,3-dioxolan-4-yl)methyl acetate and 4(tert-butyldimethylsilyloxy)benzyl acetate (Scheme 5) respectively without losing the protective groups, being also a po ...
Isolation and Purification of RP2-L, a Nuclear Protein Fraction of the
Isolation and Purification of RP2-L, a Nuclear Protein Fraction of the

... amino acids, and molecular weight. In early stud ies on the proteins of the nucleus of tumor cells, it was found that each gram of tumor (wet weight) contained approximately 13 mg. of acid-soluble nuclear proteins and that RP2-L comprised ap proximately 14 per cent of the total weight. Since studies ...
The Cytoskeleton
The Cytoskeleton

... Summary: actin associated proteins • Different associated p proteins serve a broad range g of functions. • Proteins with multiple functional domains can have multiple functions. • Some but not all of them are essential. • Most of the proteins have functional overlap. ...
Carbon Compounds 2-3 Foldable Instructions
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... nitrogen, carbon, hydrogen, and oxygen.  Proteins are large molecules (polymers) made up of monomers called amino acids.  Biuret Solution is an indicator solution for proteins. It turns blue-violet in the presence of proteins. ...
Ribosome binding site Polysomes (多聚核糖体)
Ribosome binding site Polysomes (多聚核糖体)

... Protein targeting • The ultimate cellular location of proteins is often determined by specific, relatively short amino acid sequence within the proteins themselves. These sequences can be responsible for proteins being secreted, imported into the nucleus or targeted to other organelles. ...
Poster
Poster

... For example, heart failure is linked to hyperphosphorylation by PKA of a receptor involved in Ca +2 transport into cardiac muscle. In addition, a correlation is shown to exist between the amount of phosphorylation of the receptor and the degree to which the heart is affected (Reiken, et al., ...
Domain fusion between SNF1-related kinase subunits during plant
Domain fusion between SNF1-related kinase subunits during plant

... bound AKIN11 with similar efficiency. This binding appears specific because the same KIS fragments do not bind another kinase, CK2α, in the same assay (data not shown). Together, these results suggest that both the SNF4-like and KIS domains of ZmAKINβγ-1 mediate interactions with plant SNF1-related ...
Lecture 12 Proteins Classification of protein Proteins are classified
Lecture 12 Proteins Classification of protein Proteins are classified

... b. Classification of proteins based on function Proteins are classified based on their functions as: Catalytic proteins – Enzymes  The most striking characteristic feature of these proteins is their ability to function within the living cells as biocatalysts.  These biocatalysts are called as enz ...
Heat Shock Proteins
Heat Shock Proteins

... Determination of the IC50 of FITC-labeled Geldanamycin (Cat. #50312) on HSP90α (Cat. #50290), measured with the HSP90α Assay Kit (Cat. #50293/50298). ...
Eight bacterial proteins, including UDP-N
Eight bacterial proteins, including UDP-N

... difficult to find any common functional denominator specific enough to give any clue why these proteins all resemble each other and have the long hexapeptide repeat regions with the common theme. No three-dimensional structures have yet been determined for any of these proteins. Besides LpxA, LacA, ...
Novel eukaryotic enzymes modifying cell
Novel eukaryotic enzymes modifying cell

... microbial eukaryotes, and cell walls and waxes of plants and fungi. Not only do these play a major structural role in both unicellular and multicellular eukaryotes, but they are also important in the defense against parasites or interactions of parasites with their hosts. The enzymatic components of ...
Novel Amycolatopsis balhimycina biochemical abilities
Novel Amycolatopsis balhimycina biochemical abilities

... intact proteins and nanoLC-ESI-LIT-MS/MS analysis of their tryptic digests was carried out. With this procedure, 206 additional new proteins such as very basic, hydrophobic or large species were identified. This analysis revealed either components whose expression was previously only inferred by gro ...
protein metabolism - cmb
protein metabolism - cmb

... Heat shock proteins assist in the recovery from stress either by repairing damaged proteins (protein refolding) or by degrading them, thus restoring protein homeostasis and promoting cell ...
Protein
Protein

... • Derived proteins are of two types, primarily derived proteins and secondary derived proteins. Primary derived proteins are derivatives of proteins, in which the size of the protein molecule is not altered materially, while in secondary derived proteins, hydrolysis occurs, as a result the molecules ...
The nucleosome
The nucleosome

... acetylate free histones, but as part of the SAGAcomplex it modifies also ...
How metabolites modulate metabolic flux
How metabolites modulate metabolic flux

... most important energy producing pathway under normoxia. The activity of the transcription factor hypoxia inducible factor 1 (HIF1) is modulated by oxygen availability. In the presence of oxygen, HIF1a becomes hydroxylated, which marks the protein for ubiquitination and proteasomal degradation [24]. ...
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Acetylation



Acetylation (or in IUPAC nomenclature ethanoylation) describes a reaction that introduces an acetyl functional group into a chemical compound. (Deacetylation is the removal of the acetyl group.)Acetylation refers to the process of introducing an acetyl group (resulting in an acetoxy group) into a compound, namely the substitution of an acetyl group for an active hydrogen atom. A reaction involving the replacement of the hydrogen atom of a hydroxyl group with an acetyl group (CH3 CO) yields a specific ester, the acetate. Acetic anhydride is commonly used as an acetylating agent reacting with free hydroxyl groups. For example, it is used in the synthesis of aspirin and heroin.
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