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IDENTIFYING A SINGLE LOCUS IN THE POLYGENIC COMPLEX
IDENTIFYING A SINGLE LOCUS IN THE POLYGENIC COMPLEX

... allele CaH for higher excretion is q, then the Hardy-Weinberg equation states that the three phenotypes expected, low, intermediate and high (hypercalciuric) excretors, will occur in the population in the proportions (p2 + 2pq + q2 = 1). Satisfaction of this relationship is no less significant than ...
Case study I: DNA copy number changes
Case study I: DNA copy number changes

... Copy number variations (CNVs) Approx. 12% of the human genome consists of copy number variations ...
Molecular evolution of swine vesicular disease virus
Molecular evolution of swine vesicular disease virus

... carried out on virus isolates from Asia, where SVDV strains have been isolated almost continually since 1970, and from countries in Europe, where no long-term continuous series of stored isolates was available because either the virus was eliminated or virus isolates were not retained. Phylogenetic ...
Word - NIEHS SNPs Program
Word - NIEHS SNPs Program

... will see a section called Color-Coding for LD Plot. To simplify the view change the Min value from 0.1 to 0.5. Let’s try to display LD again and when the ‘Select Display Type’ window emerges, click the ‘open graphical display of linkage disequilibrium.’ What we have done is to get rid of all the low ...
Tumor cell metabolism: the marriage of molecular genetics and
Tumor cell metabolism: the marriage of molecular genetics and

... are then extrapolated to cellular metabolic events. The weakness of this group is the absence of training in and understanding of the principles of enzymology, the factors that effect cellular enzyme activity, and the relationships of sequential enzyme activities in metabolic pathways. This is the e ...
Rapid detection of multidrug-resistant tuberculosis
Rapid detection of multidrug-resistant tuberculosis

... eye, and stored using any simple word-processing programme. Strain-typing itself does not provide direct information about drug susceptibility, but a register of spoligotypes from known MDR isolates may be particularly useful in providing early warning of possible infection with these strains. Whils ...
01 - cloudfront.net
01 - cloudfront.net

... phenotype. He then allowed the F1 generation offspring to self-pollinate. This resulted in an F2 generation with dominant phenotypes only / both dominant and recessive phenotypes. 9. Mendel concluded that traits are inherited as “discrete units.” Today, we call these discrete units gametes / genes. ...
Pedigree Chart Activity - Anderson School District One
Pedigree Chart Activity - Anderson School District One

... appearance (phenotype) of a particular genetic trait, as it is passed from one generation to the next in a given family. From this information, along with an understanding of inheritance, genotypes of individuals can often be determined. Follow the story and use your INVITAE app to make the appropri ...
embj201490542-sup-0013
embj201490542-sup-0013

... target genes. To define genes that become induced upon Scl expression, SclhCD4 reporter ES cells (Chung et al, 2002) were used to identify genes that become up-regulated in day 4 Scl-expressing mesoderm (Flk1+Scl+) as compared to Flk1+Scl- mesodermal precursors that give rise to other mesodermal lin ...
The Rate and Tract Length of Gene Conversion between
The Rate and Tract Length of Gene Conversion between

... technical problem is that, in a simple experimental design with a single selected marker, an estimated rate may include both gene conversion and unequal crossing-over because they have an identical outcome. Such a rate cannot be fairly compared with an estimate from a more sophisticated experiment, ...
1. Telomeres 2. Centromeric Repeats 3. Retrotransposons (Class I
1. Telomeres 2. Centromeric Repeats 3. Retrotransposons (Class I

... Three of the Tos family (Tos10, Tos17, Tos19) have been shown to be active under tissue culture conditions Tos17 was found to only have two copies in the Nipponbare genome Tos17, when activated, has a preference for insertion into low copy sequences in the rice genome Tos17 activation leads to a gra ...
Searching for fossil genes
Searching for fossil genes

... Most mammals, such as mice, can produce their own vitamin C and therefore do not need a source of vitamin C in their diet. The GULO gene codes for an enzyme, Lgulonolactone oxidase, involved in vitamin C synthesis. The GULO gene is present in mice and most other mammals, but is either missing, or is ...
unit 4 revision
unit 4 revision

... where inherited from each parent and weren’t a blend of the parents (codominance not discovered then) but were discrete as dominant and recessive. The F1 generation carried the hidded recessive which revealed itself again in F2 Phenotype = Genotype + Environment Test Cross – To find out if an organi ...
Review of the reconstruction
Review of the reconstruction

... Figures 43, 44, 45, 46, 47, 49, 50 and 52 in Additional file 6). The regulation of the synthesis of di- and tri-phosphate nucleotides (NDP, NTP) from mono-phosphate nucleotides (NMP) remains an open question. ATP seems to be the main phosphate donor. The synthesis of NDP from NMP and ATP is catalyze ...
Virus on virus infects bacterium
Virus on virus infects bacterium

... other. For example, not all strains of V. cholerae that express TCP can form transferable bacteriophage particles. Perhaps most of the TcpA is incorporated into a colonization pilus, and the remainder is used to coat the DNA in infectious phage particles (but only in those strains that can produce t ...
Steroid hormone receptor homologs in development
Steroid hormone receptor homologs in development

... small invisible entities called genes and that expression of different sets of these genes gives rise to differences in the adult organism (Morgan, 1934). Indeed differential gene expression does appear to play an important part in normal development as many classes of transcriptional regulators hav ...
Figure 1 - York College of Pennsylvania
Figure 1 - York College of Pennsylvania

... • Isolate, clone, and investigate the expression of Ankyrin 3A and B in zebrafish embryo brain tissue • Complete an Ankyrin 3A and B knockdown ...
Homologous pigmentation mutations in human, mouse and other
Homologous pigmentation mutations in human, mouse and other

... DNA and in a second mutant allele ep 6J (22) (Table 3). The protein encoded by this gene has no obvious features to indicate its function, except for two potential transmembrane domains, suggesting that it is localised in the melanosomal or lysosomal membrane with both termini in the lumen and a cyt ...
Nucleotide Sequence of the Osmoregulatory proU Operon of
Nucleotide Sequence of the Osmoregulatory proU Operon of

... disrupt proV. ProV is predicted to be a 400-amino-acid-long polypeptide, relatively hydrophilic (Fig. 3), with an Mr of 44,162; interestingly, it is devoid of any tryptophanyl residues. The predicted proV coding sequence extends beyond the Sall site at position 1810 for another 26 codons; consistent ...
Avian Infectious Bronchitis Virus (IBV)
Avian Infectious Bronchitis Virus (IBV)

... The Cq value obtained with the internal control will vary significantly depending on the extraction efficiency, the quantity of RNA added to the RT and PCR reaction and the individual machine settings. Cq values of 28±3 are within the normal range. When amplifying a IBV sample with a high genome cop ...
2006a Tests of parallel molecular evolution in a long
2006a Tests of parallel molecular evolution in a long

... The 12 replicate populations all were founded by the same ancestral strain and grown in identical environments for 20,000 generations. They evolved similar, but not identical, changes in various aspects of their performance, morphology, and physiology (11, 13, 15, 18, 25, 27, 29, 31, 32). Also, four ...
MF011_fhs_lnt_002b_May11 - MF011 General Biology 2 (May
MF011_fhs_lnt_002b_May11 - MF011 General Biology 2 (May

... Polyploidy is common in plants, but not animals Polyploids are more normal in appearance than aneuploids ...
New techniques in plant biotechnology
New techniques in plant biotechnology

... 2. Legislation and regulations In the EU Directive 2001/18 “on the deliberate release into the environment of genetically modified organisms”2 a GMO is defined as: “an organism, with the exception of human beings, in which the genetic material has been altered in a way that does not occur naturally ...
Abstract
Abstract

... sequences homology comparison by computational tools and most of their functions have not been experimentally proved. For instance, in September 2004, only 41.6% [4332 annotated genes/ (10113 small gene models, partial genes and pseudogenes plus 312 published genes)] of BAC/PAC predictions on chromo ...
Successive Losses of Central Immune Genes
Successive Losses of Central Immune Genes

... that are distributed among four clusters in the genome (fig. 2) where one of them shares synteny with the Mx region in A. mexicanus. Moreover, we find that Lepisosteus oculatus shares synteny with another of the identified Mx regions in D. rerio. As the teleost outgroup L. oculatus share an Mx conta ...
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RNA-Seq



RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.
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