An Introduction to Energy, Enzymes, and Metabolism
... ave you ever taken aspirin or ibuprofen to relieve a headache or reduce a fever? Do you know how it works? If you answered “no” to the second question, you’re not alone. Over 2,000 years ago, humans began treating pain with powder from the bark and leaves of the willow tree, which contains a compoun ...
... ave you ever taken aspirin or ibuprofen to relieve a headache or reduce a fever? Do you know how it works? If you answered “no” to the second question, you’re not alone. Over 2,000 years ago, humans began treating pain with powder from the bark and leaves of the willow tree, which contains a compoun ...
The Cyclin-Dependent Kinase Inhibitor KRP6 Induces Mitosis and
... Different types of CDK/CYC complexes account for the correct temporal and unidirectional ordering of cell cycle events (Inzé and De Veylder, 2006). The model plant species Arabidopsis encodes up to 12 CDKs and 49 CYCs that have been categorized into different classes according to their sequence simi ...
... Different types of CDK/CYC complexes account for the correct temporal and unidirectional ordering of cell cycle events (Inzé and De Veylder, 2006). The model plant species Arabidopsis encodes up to 12 CDKs and 49 CYCs that have been categorized into different classes according to their sequence simi ...
The Dictyostelium LvsA Protein is Localized on the Contractile
... phenotypic characteristics, suggesting that they may participate in the same membrane traffic pathway (2,9). When both mutants attempt cytokinesis they are able to initiate cleavage furrow formation. However, the furrow is not successful and the cells end up with a double furrow morphology that ulti ...
... phenotypic characteristics, suggesting that they may participate in the same membrane traffic pathway (2,9). When both mutants attempt cytokinesis they are able to initiate cleavage furrow formation. However, the furrow is not successful and the cells end up with a double furrow morphology that ulti ...
Ch 9 (primary ppt) - Phillips Scientific Methods
... Pyruvate Ethanol + CO2 Pyruvate Lactate Ex. bacteria, yeast Ex. fungi, bacteria, human Used in brewing, muscle cells winemaking, baking Used to make cheese, yogurt, acetone, methanol Note: Lactate build-up does NOT causes muscle fatigue and pain (old idea) ...
... Pyruvate Ethanol + CO2 Pyruvate Lactate Ex. bacteria, yeast Ex. fungi, bacteria, human Used in brewing, muscle cells winemaking, baking Used to make cheese, yogurt, acetone, methanol Note: Lactate build-up does NOT causes muscle fatigue and pain (old idea) ...
The role of cytoplasmic streaming in symplastic transport
... Any cytosolic convection arising from the action of molecular motors moving along cytoskeletal cables. This definition emphasizes the active metabolically driven nature of the process. and the low Reynolds number environment mandates that streaming stop dead in its tracks when motor activity ceases. ...
... Any cytosolic convection arising from the action of molecular motors moving along cytoskeletal cables. This definition emphasizes the active metabolically driven nature of the process. and the low Reynolds number environment mandates that streaming stop dead in its tracks when motor activity ceases. ...
The Nervous System
... • Nervous system communication can be conceptualized as working through a twostep process: 1. signal movement down a neuron’s axon 2. signal movement from this axon to a second cell across a structure known as a synapse ...
... • Nervous system communication can be conceptualized as working through a twostep process: 1. signal movement down a neuron’s axon 2. signal movement from this axon to a second cell across a structure known as a synapse ...
Doubly Selective Antimicrobial Polymers: How Do They Differentiate
... mimics of antimicrobial peptides (SMAMPs) are becoming increasingly important for a wide range of applications, including medical devices and healthcare products. SMAMPs are polymers designed to capture the essential features of antimicrobial peptides (AMPs). They contain cationic hydrophilic groups ...
... mimics of antimicrobial peptides (SMAMPs) are becoming increasingly important for a wide range of applications, including medical devices and healthcare products. SMAMPs are polymers designed to capture the essential features of antimicrobial peptides (AMPs). They contain cationic hydrophilic groups ...
Brief rapid pacing depresses contractile function via Ca
... respectively, with photomultiplier tubes. Changes of the intracellular Ca2⫹ concentration ([Ca2⫹]i) are expressed as changes in the ratio (R ⫽ F405/F485). Analysis of PKC isoenzyme expression by Western blotting. Acutely isolated cat ventricular myocytes were centrifuged (1,000 g for 10 min) and res ...
... respectively, with photomultiplier tubes. Changes of the intracellular Ca2⫹ concentration ([Ca2⫹]i) are expressed as changes in the ratio (R ⫽ F405/F485). Analysis of PKC isoenzyme expression by Western blotting. Acutely isolated cat ventricular myocytes were centrifuged (1,000 g for 10 min) and res ...
ANALYSIS OF A BACTERIAL SERINE/THREONINE KINASE
... sensor kinase, responds to the periplasmic concentration of divalent cations such as magnesium and calcium. Millimolar amounts of magnesium repress the PhoPQ system while micromolar concentrations activate the system. It is thought that magnesium binds directly to PhoQ’s periplasmic domain so that ...
... sensor kinase, responds to the periplasmic concentration of divalent cations such as magnesium and calcium. Millimolar amounts of magnesium repress the PhoPQ system while micromolar concentrations activate the system. It is thought that magnesium binds directly to PhoQ’s periplasmic domain so that ...
Brief rapid pacing depresses contractile function via Ca - AJP
... respectively, with photomultiplier tubes. Changes of the intracellular Ca2⫹ concentration ([Ca2⫹]i) are expressed as changes in the ratio (R ⫽ F405/F485). Analysis of PKC isoenzyme expression by Western blotting. Acutely isolated cat ventricular myocytes were centrifuged (1,000 g for 10 min) and res ...
... respectively, with photomultiplier tubes. Changes of the intracellular Ca2⫹ concentration ([Ca2⫹]i) are expressed as changes in the ratio (R ⫽ F405/F485). Analysis of PKC isoenzyme expression by Western blotting. Acutely isolated cat ventricular myocytes were centrifuged (1,000 g for 10 min) and res ...
Electrophoretic Extraction and Proteomic Characterization of
... amide bonds as found in proteins [2–4]. Protein building blocks, such as total hydrolysable amino acids (THAAs, total amino acids that can be extracted using 6 N HCl), are found to account for up to 30%–40% of particulate nitrogen in marine sediments [5–8]. In addition to proteins representing the l ...
... amide bonds as found in proteins [2–4]. Protein building blocks, such as total hydrolysable amino acids (THAAs, total amino acids that can be extracted using 6 N HCl), are found to account for up to 30%–40% of particulate nitrogen in marine sediments [5–8]. In addition to proteins representing the l ...
Study of the role of estrogen receptor variant, ER36, in non genomic
... best with his wife and kid, and many other kids to come. I wish to thank Lucie Malbeteau for always being present to ease out our stress, don’t worry the cells will grow and I’m confident you will do a great thesis. I wish to thank Hanine Lattouf, our other Lebanese student, for all the fun times we ...
... best with his wife and kid, and many other kids to come. I wish to thank Lucie Malbeteau for always being present to ease out our stress, don’t worry the cells will grow and I’m confident you will do a great thesis. I wish to thank Hanine Lattouf, our other Lebanese student, for all the fun times we ...
RBM3 regulates temperature sensitive miR-142–5p and miR
... Specific genes and miRNAs associated with the febrile response may impact patient outcomes after infection (9,10). The effects of isolated temperature elevation however have not been examined at a molecular level. Our in silico analysis showed decreased levels of mRNA encoding a coldshock protein, R ...
... Specific genes and miRNAs associated with the febrile response may impact patient outcomes after infection (9,10). The effects of isolated temperature elevation however have not been examined at a molecular level. Our in silico analysis showed decreased levels of mRNA encoding a coldshock protein, R ...
Dissecting the function of Atg1 complex in Dictyostelium autophagy
... generates a PtdIns3P-enriched region at the level of the endoplasmic reticulum (ER) to which the complex formed by Atg2 and Atg18/WIPI is recruited. Concomitantly, Atg12 is covalently bound to Atg5, and the Atg12–Atg5 conjugate form a ternary complex with Atg16L1, which is required for the subsequen ...
... generates a PtdIns3P-enriched region at the level of the endoplasmic reticulum (ER) to which the complex formed by Atg2 and Atg18/WIPI is recruited. Concomitantly, Atg12 is covalently bound to Atg5, and the Atg12–Atg5 conjugate form a ternary complex with Atg16L1, which is required for the subsequen ...
Cell wall synthesis is necessary for membrane dynamics during
... lipid-bounded compartment that is distinct from the membrane. This event rarely occurs spontaneously and is dependent upon enzymes that facilitate this process. Proteins that polymerize into filaments, such as actin and tubulin, convert the chemical energy of polymerization into mechanical work (The ...
... lipid-bounded compartment that is distinct from the membrane. This event rarely occurs spontaneously and is dependent upon enzymes that facilitate this process. Proteins that polymerize into filaments, such as actin and tubulin, convert the chemical energy of polymerization into mechanical work (The ...
The Drosophila F-box protein Fbxl7 binds to the protocadherin Fat
... size and shape at the end of their development. The Hippo signaling pathway has emerged as a key regulator of organ size (reviewed by Pan, 2010; Halder and Johnson, 2011; Tapon and Harvey, 2012). While most components of this pathway were originally discovered using genetic screens in Drosophila, ma ...
... size and shape at the end of their development. The Hippo signaling pathway has emerged as a key regulator of organ size (reviewed by Pan, 2010; Halder and Johnson, 2011; Tapon and Harvey, 2012). While most components of this pathway were originally discovered using genetic screens in Drosophila, ma ...
Forespore membrane assembly in yeast
... communication). Temperature-sensitive mutations in psy1 lead to defective FSM assembly even at the permissive temperature (Y. Maeda, personal communication). The membrane fusion process mediated by this SNARE complex thus seems to be necessary for correct FSM formation. GFP-Psy1 shows a localization ...
... communication). Temperature-sensitive mutations in psy1 lead to defective FSM assembly even at the permissive temperature (Y. Maeda, personal communication). The membrane fusion process mediated by this SNARE complex thus seems to be necessary for correct FSM formation. GFP-Psy1 shows a localization ...
TGFβ/activin/nodal signaling is necessary for the maintenance of
... previously shown that BIO is also capable of maintaining hESCs in the undifferentiated state, even in the absence of CM, through activation of canonical WNT signaling (Sato et al., 2004; Meijer et al., 2003). Accordingly, BIO maintained phosphorylation of SMAD2/3 above levels seen in hESCs grown in ...
... previously shown that BIO is also capable of maintaining hESCs in the undifferentiated state, even in the absence of CM, through activation of canonical WNT signaling (Sato et al., 2004; Meijer et al., 2003). Accordingly, BIO maintained phosphorylation of SMAD2/3 above levels seen in hESCs grown in ...
chapt06b_lecture
... similar ligands. In this model, the first ligand is assumed to induce conformational changes that are transmitted sequentially to other protomers in the enzyme. Neither model above fully explains all allosteric enzyme activity. 6P2-29 ...
... similar ligands. In this model, the first ligand is assumed to induce conformational changes that are transmitted sequentially to other protomers in the enzyme. Neither model above fully explains all allosteric enzyme activity. 6P2-29 ...
Multimodal imaging and the neural basis of EEG and fMRI
... creates an electrical potential (about -70 millivolt) between the inside and the outside of the cell. Neurotransmitter leads to the opening of ions channels through which some ions, such as sodium (Na+), chloride (Cl-), potassium (K+) and calcium (Ca2+) will diffuse. ...
... creates an electrical potential (about -70 millivolt) between the inside and the outside of the cell. Neurotransmitter leads to the opening of ions channels through which some ions, such as sodium (Na+), chloride (Cl-), potassium (K+) and calcium (Ca2+) will diffuse. ...
Rat maf related genes: specific expression in chondrocytes
... Figure 3 Maf expression in chondrocytes. (a and b): The speci®c antibodies of Maf-1 and Maf-2 were prepared as follows: Fragments of Maf-1 and Maf-2 proteins were produced in E coli as fusion proteins with maltose binding protein and glutathione Stransferase, respectively. maf-1 cDNA fragment corres ...
... Figure 3 Maf expression in chondrocytes. (a and b): The speci®c antibodies of Maf-1 and Maf-2 were prepared as follows: Fragments of Maf-1 and Maf-2 proteins were produced in E coli as fusion proteins with maltose binding protein and glutathione Stransferase, respectively. maf-1 cDNA fragment corres ...
Detection and localization of single molecular recognition
... and the dynamics of the interaction between individual ligands and receptors, either on isolated molecules or on cellular surfaces. These studies require attaching specific biomolecules or cells on AFM tips and on solid supports and measuring the unbinding forces between the modified surfaces using ...
... and the dynamics of the interaction between individual ligands and receptors, either on isolated molecules or on cellular surfaces. These studies require attaching specific biomolecules or cells on AFM tips and on solid supports and measuring the unbinding forces between the modified surfaces using ...
HELIX BIOPHARMA CORP. TO PRESENT CAR
... VEGFR2 has been accepted for presentation at the AACR Annual Meeting 2017 taking place on April 1 - 5, 2017 at the Walter E. Washington Convention Center Washington, D.C., USA. This poster reports Helix’s second study in applying camelid single domain antibody in making Chimeric Antigen Receptor T C ...
... VEGFR2 has been accepted for presentation at the AACR Annual Meeting 2017 taking place on April 1 - 5, 2017 at the Walter E. Washington Convention Center Washington, D.C., USA. This poster reports Helix’s second study in applying camelid single domain antibody in making Chimeric Antigen Receptor T C ...
autonomic nervous system
... The effects of sympathetic stimulation, which result primarily from the interactions of NE and E with adrenergic receptors in the target cell’s plasma membrane ...
... The effects of sympathetic stimulation, which result primarily from the interactions of NE and E with adrenergic receptors in the target cell’s plasma membrane ...
Classification and domain analysis of protein
... (Ser/Thr) and tyrosine kinases (Tyk)) in various groups/ families, while Table 3 shows the distribution of aPKs. Tables 2 and 3 reveal the classification and distribution of both ePKs and aPKs in hominids. In ePKs, the most populated kinase groups are AGC, CAMK, CMGC and STE, and all of them belong ...
... (Ser/Thr) and tyrosine kinases (Tyk)) in various groups/ families, while Table 3 shows the distribution of aPKs. Tables 2 and 3 reveal the classification and distribution of both ePKs and aPKs in hominids. In ePKs, the most populated kinase groups are AGC, CAMK, CMGC and STE, and all of them belong ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.