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Oncogenesis: abnormal developmental plasticity
Oncogenesis: abnormal developmental plasticity

... The major focus of our studies is to analyze gene function in normal and pathological conditions, e.g. in tumor development, using the mouse as a model organism. Specifically, the functions of AP-1 in regulating cell proliferation, differentiation and cell death are investigated. Our studies reveale ...
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C22 Cancer and the Immune System

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Programmed Cell Death(Apoptosis)
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Cell encapsulation



Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.
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