Nomination Letter for Dara L. Kraitchman
... tissue and tracking stem cells. Her doctoral thesis combined measurement of cardiac function by MRI with perfusion using gadolinium contrast agents shortly after these agents had been approved for clinical use (1,2,3,5). The imaging processing methods developed by Dr. Young and her for tracking tagg ...
... tissue and tracking stem cells. Her doctoral thesis combined measurement of cardiac function by MRI with perfusion using gadolinium contrast agents shortly after these agents had been approved for clinical use (1,2,3,5). The imaging processing methods developed by Dr. Young and her for tracking tagg ...
Growth of curved and helical bacterial cells
... are the bending energy. T ab is the mixed component of the stress resultant tensor. H and K are the mean curvature and Gaussian curvature, respectively. Here, we assume that the spontaneous curvature of the cell wall is zero. Two constants k1 ¼ h3(l + 2m)/ 12 and k2 ¼ h3m/6 are similar to the bendi ...
... are the bending energy. T ab is the mixed component of the stress resultant tensor. H and K are the mean curvature and Gaussian curvature, respectively. Here, we assume that the spontaneous curvature of the cell wall is zero. Two constants k1 ¼ h3(l + 2m)/ 12 and k2 ¼ h3m/6 are similar to the bendi ...
Functional Characterization of Two Human Olfactory Receptors
... this issue. Due to limitations in heterologous expression, very few mammal ORs have been characterized, and so far only one is from human origin. Consequently, OR function still remains poorly understood, especially in humans, whose genome encodes a restricted chemosensory repertoire compared with m ...
... this issue. Due to limitations in heterologous expression, very few mammal ORs have been characterized, and so far only one is from human origin. Consequently, OR function still remains poorly understood, especially in humans, whose genome encodes a restricted chemosensory repertoire compared with m ...
Understanding the cell cycle
... The replication of chromosomes in S phase and their segregation at mitosis are of particular importance because they ensure that each daughter cell receives a full complement of the hereditary material. The machinery that brings about these essential cell-cycle events is composed of macromolecular a ...
... The replication of chromosomes in S phase and their segregation at mitosis are of particular importance because they ensure that each daughter cell receives a full complement of the hereditary material. The machinery that brings about these essential cell-cycle events is composed of macromolecular a ...
Precise control of plant stem cell activity through parallel regulatory
... mutants (Sarkar et al., 2007). WOX5 is closely related to WUSCHEL (WUS), which is expressed in the shoot meristem organizing centre and moves into over-lying cells (Yadav et al., 2011, 2013). As WUS and WOX5 are functionally interchangeable (Sarkar et al., 2007), WOX5 may also be a mobile QC-derived ...
... mutants (Sarkar et al., 2007). WOX5 is closely related to WUSCHEL (WUS), which is expressed in the shoot meristem organizing centre and moves into over-lying cells (Yadav et al., 2011, 2013). As WUS and WOX5 are functionally interchangeable (Sarkar et al., 2007), WOX5 may also be a mobile QC-derived ...
Biological Activity of Withanolides
... treatment by activating the immune response as it caused a striking proliferation of macrophages in the peritoneal cavity and clustering of acid phosphatase rich macrophages around EAC .WA cured mice exhibited complete tumour regression after reinoculation of EAC. The observations that W A acts by i ...
... treatment by activating the immune response as it caused a striking proliferation of macrophages in the peritoneal cavity and clustering of acid phosphatase rich macrophages around EAC .WA cured mice exhibited complete tumour regression after reinoculation of EAC. The observations that W A acts by i ...
Cell Structure Lesson: Vacuole
... special Cytoskeleton type of vacuole known as a contractile vacuole. ...
... special Cytoskeleton type of vacuole known as a contractile vacuole. ...
3-Deazaguanine: Inhibition of Initiation of Translation in L1210 Cells1
... heximide, which inhibited [3H]leucine incorporation into pro teins by 80% (16), prevented the analog-induced shift towards monosomes and returned the polysome fraction of DG-treated cells back toward that of control cells (Chart 5). In addition, although the relative size distribution of polysomes w ...
... heximide, which inhibited [3H]leucine incorporation into pro teins by 80% (16), prevented the analog-induced shift towards monosomes and returned the polysome fraction of DG-treated cells back toward that of control cells (Chart 5). In addition, although the relative size distribution of polysomes w ...
The histone deacetylase inhibitor LBH589 enhances the anti
... tumors and detectable levels of serum hIgG 7 days post-implantation [30]. At this time, animals were randomized into treatment groups (n = 8 mice/group), including control (vehicle alone), LBH589 (1 mg/kg daily, Monday to Friday), melphalan (1 mg/kg, once weekly), PLD (1 mg/kg, on three consecutive ...
... tumors and detectable levels of serum hIgG 7 days post-implantation [30]. At this time, animals were randomized into treatment groups (n = 8 mice/group), including control (vehicle alone), LBH589 (1 mg/kg daily, Monday to Friday), melphalan (1 mg/kg, once weekly), PLD (1 mg/kg, on three consecutive ...
Bacterial Cell Morphogenesis Does Not Require a Preexisting
... gene into D18::tet L-forms by PCR (Figure 3D, lane 4). These results demonstrated that cells that have been propagated for a long period of time (at least 3 months; the proliferating L-form culture was maintained by diluting into fresh medium once per week) in a state in which they are unable to syn ...
... gene into D18::tet L-forms by PCR (Figure 3D, lane 4). These results demonstrated that cells that have been propagated for a long period of time (at least 3 months; the proliferating L-form culture was maintained by diluting into fresh medium once per week) in a state in which they are unable to syn ...
Cellular Senescence and the Biology of Aging, Disease, and Frailty
... is an attractive approach given senescent cells are a major source of tissue inflammation, which, in turn, is a fundamental component of several age-related diseases and frailty. Moreover, the SASP could theoretically be disrupted without interfering with the anti-oncogenic pathways activated in sen ...
... is an attractive approach given senescent cells are a major source of tissue inflammation, which, in turn, is a fundamental component of several age-related diseases and frailty. Moreover, the SASP could theoretically be disrupted without interfering with the anti-oncogenic pathways activated in sen ...
Phosphorylation of initiation factor2 is required for
... protein, eIF4E, during differentiation. However, it remained of interest to determine eIF2a phosphorylation status during differentiation and to ascertain whether phosphorylation of eIF2a is involved in IRES activation. In this study we show that: (a) not only are differentiation conditions permissi ...
... protein, eIF4E, during differentiation. However, it remained of interest to determine eIF2a phosphorylation status during differentiation and to ascertain whether phosphorylation of eIF2a is involved in IRES activation. In this study we show that: (a) not only are differentiation conditions permissi ...
Complementary action of the PGC-1 coactivators in mitochondrial
... basal condition, but no increase in UCP1 protein expression was observed after dbcAMP treatment. The induction of several mRNAs encoded by other genes involved in thermogenesis was either severely impaired in KO cells (C/EBPb) or was even completely blunted (deiodinase D2, cytochrome C) after dbcAMP ...
... basal condition, but no increase in UCP1 protein expression was observed after dbcAMP treatment. The induction of several mRNAs encoded by other genes involved in thermogenesis was either severely impaired in KO cells (C/EBPb) or was even completely blunted (deiodinase D2, cytochrome C) after dbcAMP ...
Biological and Biochemical Effects of
... the addition of 0.5 ml of medium, metaboliles, and/or drug. Cell number was determined with a Couller counter (Coul CT3(NSC5159), an antibiotic produced by Streptomyces ler Electronics, Hialeah, Fla.). Three days later, after incu chartreusis (10), was recently found to be active against balion at 3 ...
... the addition of 0.5 ml of medium, metaboliles, and/or drug. Cell number was determined with a Couller counter (Coul CT3(NSC5159), an antibiotic produced by Streptomyces ler Electronics, Hialeah, Fla.). Three days later, after incu chartreusis (10), was recently found to be active against balion at 3 ...
New insights into the evolutionary history of photoreceptor cells
... evolutionary history. Recent papers by Arendt et al. and Panda et al. provide one such reminder. They illustrate that the two classes of animal photoreceptors, ciliary and rhabdomeric photoreceptors, are likely to share an ancient common ancestor and have been evolving in parallel since their duplic ...
... evolutionary history. Recent papers by Arendt et al. and Panda et al. provide one such reminder. They illustrate that the two classes of animal photoreceptors, ciliary and rhabdomeric photoreceptors, are likely to share an ancient common ancestor and have been evolving in parallel since their duplic ...
Molecular sieving properties of the cytoplasm of Escherichia coli and
... (Fig. 2B). These areas of the cytoplasm had a lower concentration of GFP, which co-localized with a region stained with the DNA-binding fluorophore Draq-5. In contrast to the non-stressed cells, GFP seemed partially excluded from the regions stained by Draq-5 (Fig. 2B, compare subpanels 1–3 vs. 5–7) ...
... (Fig. 2B). These areas of the cytoplasm had a lower concentration of GFP, which co-localized with a region stained with the DNA-binding fluorophore Draq-5. In contrast to the non-stressed cells, GFP seemed partially excluded from the regions stained by Draq-5 (Fig. 2B, compare subpanels 1–3 vs. 5–7) ...
hypersensitivity reactions
... T lymphocytes injure tissues either by triggering inflammation or by directly killing target cells ...
... T lymphocytes injure tissues either by triggering inflammation or by directly killing target cells ...
Orexin 1 Receptor Reporter Assay Kit
... 600241) from the freezer and allow to equilibrate to room temperature. Clean the bag with 70% alcohol before opening the bag. Place the plate in the hood and remove from the bag. NOTE: If you are not using the whole plate at one time for your experiment, remove the number of strips needed, put the r ...
... 600241) from the freezer and allow to equilibrate to room temperature. Clean the bag with 70% alcohol before opening the bag. Place the plate in the hood and remove from the bag. NOTE: If you are not using the whole plate at one time for your experiment, remove the number of strips needed, put the r ...
10 Years of Intracoronary and Intramyocardial Bone Marrow Stem
... other therapeutic regimens. Stem cell therapy also represents an ultimate approach in advanced cardiac failure. For acute myocardial infarction and chronic ischemia, long-term mortality after 1 and 5 years, respectively, is significantly reduced. A few studies also indicate beneficial effects for ch ...
... other therapeutic regimens. Stem cell therapy also represents an ultimate approach in advanced cardiac failure. For acute myocardial infarction and chronic ischemia, long-term mortality after 1 and 5 years, respectively, is significantly reduced. A few studies also indicate beneficial effects for ch ...
1st Quarter CRT Review Game
... What keeps the cytoplasm inside and allows nutrients in and waste products out? A. cell membrane B. chloroplast C. nucleus D. mitochondria ...
... What keeps the cytoplasm inside and allows nutrients in and waste products out? A. cell membrane B. chloroplast C. nucleus D. mitochondria ...
A critical role for citrate metabolism in LPS signalling
... is not fully known, although it has been suggested that it might be a way to preserve ATP levels during an immune response [3]. One function for this ATP has been to maintain the mitochondrial membrane potential and prevent apoptosis [4]. The second reason is to generate the biosynthetic intermediat ...
... is not fully known, although it has been suggested that it might be a way to preserve ATP levels during an immune response [3]. One function for this ATP has been to maintain the mitochondrial membrane potential and prevent apoptosis [4]. The second reason is to generate the biosynthetic intermediat ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.