• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Unit D Review
Unit D Review

... Traits can be determined by one ___________ or several __________. Traits can also be affected by __________________. Nature vs. nurture (______________ vs. _________________) – genes and environment affect traits. ...
Gene duplication
Gene duplication

... Michael Ashburner told that gene Adh of D. melanogaster was a pseudogene. Long found that almost all of the mutation occur at the third site of a codon. Means it may be a real gene rather than a pseudogene. Long confirmed the complex processes of the origination of this gene and named it Jingwei. ...
HGSS Chapter 23: Schizophrenia and Psychopathology
HGSS Chapter 23: Schizophrenia and Psychopathology

... From 7 meta-analyses on European or mostly European Ancestry ...
Eye Color PPT
Eye Color PPT

... functional melanin genes? • How do you get little melanin in the eyes, but plenty elsewhere? • You need to be able to turn the gene off in the eyes. • REGULATORY GENE! From: Eiburg et al 2008 ...
E: Acronyms and Glossary
E: Acronyms and Glossary

... helix held together by weak bonds between base pairs of nucleotides. DNA: See deoxyribonucleic acid. Dominant: In genetics, referring to a situation where only one copy of an allele is necessary for the effect (e.g., disease) to be expressed. Genetic counseling: A clinical service involving educatio ...
The Unseen Genome: Beyond DNA
The Unseen Genome: Beyond DNA

... methyl-adding enzymes in embryonic stem cells. With the methyl guard lowered, many transposons became active. The rate of DNA mutations in the cells shot up 10-fold. Such experiments raised an intriguing possibility: Could epigenetic abnormalities accelerate—perhaps even initiate—the genetic chaos t ...
Document
Document

... Impacts, Issues: The Color of Skin  Skin color comes from the pigment melanin • Produced by melanocytes in skin cells • More than 100 genes directly or indirectly influence amount of melanin in an individual’s skin • Lead to many variations in skin color ...
Chapter 12: Genetic Engineering
Chapter 12: Genetic Engineering

... The combined DNA formed by fusing a DNA fragment and a plasmid consists of parts from ____________________________________________ ...
Supporting Information
Supporting Information

... 5. Guldener U, Heck S, Fielder T, Beinhauer J, Hegemann JH (1996) A new efficient gene disruption cassette for repeated use in budding yeast. Nucleic Acids Res 24: 2519-2524. ...
course: bio 201
course: bio 201

... virtually every cell in the body. These mutations are also called germ line mutations because they are present in the parent’s egg or sperm cells, which are also called germ cells. When an egg and a sperm cell unite, the resulting fertilized egg cell receives DNA from both parents. If this DNA has a ...
Copy number variation in livestock and companion animals A
Copy number variation in livestock and companion animals A

... deletions, with sizes between 50 bp and several Mb, that are polymorphic amongst individuals of a given species. • CNVs can have effects on phenotypes by altering the expression or the structure of transcripts encoded by genes located within or nearby them. • Studies carried out in Drosophila sugges ...
Part I: Multiple Choice ______1. A haploid cell is a cell a. in which
Part I: Multiple Choice ______1. A haploid cell is a cell a. in which

... ______33. In cocker spaniels, black color (B) is dominant over red (b), and solid color (S) is dominant over spotted (s). If the genes are unlinked, and the offspring of BBss and bbss individuals are mated with each other, and then two of the F1 generation are mated with each other, what fraction o ...
Experimental Gene Therapy Use On Humans
Experimental Gene Therapy Use On Humans

... Genes enter the body of a patient through a carrier molecule called a vector. Vectors are usually viruses that have been modified so that they don’t harm the patient. Common viruses used as vectors: retrovirus, adenovirus, adeno-associated virus, herpes simplex virus, and poxvirus. Vectors are eithe ...
File
File

... can replicate independently of the main chromosomes of bacteria. The plasmid can be cleaved with restriction enzymes. If the plasmid and the foreign DNA have been cleaved with the same restriction enzyme, the sticky ends of each will match and they will join, reconnecting the plasmid ring. The forei ...
Mutation PPT
Mutation PPT

... • Because mRNA is read as a series of nucleotide triplets during translation, the insertion or deletion may alter the reading frame (triplet grouping) of the gene • All the nucleotides that are downstream of the deletion or ...
Classification of DNA sequences using Bloom Filters
Classification of DNA sequences using Bloom Filters

... Classification of DNA sequences using Bloom Filters • New generation sequencing technologies – Complex datasets – New efficient, specialized sequence analysis algorithms ...
Lecture_note_463BI
Lecture_note_463BI

... 60 to 90 tRNA isoacceptors (Lin and Agris, 1980). The studies by McBride et al. (1989) as well as studies by others (see, e.g., 180620, 189930, 189920, 180640, 189880) indicated that tRNA genes and pseudogenes are dispersed on at least 7 human chromosomes and suggested that these sequences would pro ...
Real Cats Wear Pink
Real Cats Wear Pink

... To show that the gene went where it was supposed to go, the researchers settled on one that would glow. The gene “is just a marker,” said Leslie Lyons, an assistant professor of population health and reproduction at the School of Veterinary Medicine at the University of California, Davis, who is fam ...
Resources15 Reading resources
Resources15 Reading resources

... nudge, wink, wink, whether we ever go out with the same bloke. The answer, by the way, is no. Then there are those who enquire if my sister and I are telepathic. Again, no. Still, up to now, I may have been a freak, but I was regarded as a benevolent one. Now, thanks to a mad doctor working for an e ...
Notes for The Longevity Seekers
Notes for The Longevity Seekers

... Kennedy went off to Switzerland to study Sir proteins. He found that the gene product was acting in the nucleolus of the cell nucleus. Another MIT student, David Sinclair, discovered that during aging, cell accumulation of ribosomal DNA circles caused a toxic effect. California biotech company Geron ...
ss_tn_biol_04_using_variation
ss_tn_biol_04_using_variation

... The use of selective breeding to improve crop yields and to develop stronger or more productive animals such as cows. How genetic modification is an extension of selective breeding. Life-saving benefits of genetic engineering/genetic modification, such as producing insulin to treat diabetes. How gen ...
7th Grade Science Notes
7th Grade Science Notes

... Humans have a wide variety of phenotypes (how we look) because of the many ways genes can combine (our genotypes) on our 46 chromosomes. The first 22 pairs of chromosomes are called “autosomal” chromosomes. All autosomal traits are either controlled by single genes or multiple genes. Single gene tra ...
File - Lucinda Supernavage
File - Lucinda Supernavage

... - No migration: immigrants can change the frequency of an allele by bringing in new alleles to a population. - No net mutations: if alleles change from one to another, this will change the frequency of those alleles. - Random mating: if certain traits are more desirable, then individuals with those ...
DNA cloning
DNA cloning

... Concept 20.1: DNA cloning yields multiple copies of a gene or other DNA segment • To work directly with specific genes, scientists prepare well-defined segments of DNA in identical copies, a process called DNA cloning ...
熊本大学学術リポジトリ Kumamoto University Repository System
熊本大学学術リポジトリ Kumamoto University Repository System

< 1 ... 951 952 953 954 955 956 957 958 959 ... 1288 >

Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report