• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
MultiBac Expression System User Manual
MultiBac Expression System User Manual

... multigene applications. We present a modified recipient baculovirus DNA for these transfer vectors engineered for improved protein production, and a simple and rapid method to integrate genes via two access sites (attTn7 and LoxP) into this baculoviral DNA in E. coli cells tailored for this purpose. ...
DNA as Videotape: Introductory Fact Sheet
DNA as Videotape: Introductory Fact Sheet

... DNA is a tape--it's linear. • It carries information--genetic information. • The information is encoded. • The information has to be translated. • Cells translate the information on DNA. • The information on DNA makes traits.– genes • Cells can copy DNA. • DNA can be edited--for example, we can take ...
Updated BioI_Unit3_Voc
Updated BioI_Unit3_Voc

... 14 type of cancer in blood-forming tissues causing the uncontrolled production of white blood cells 15 type of tumor that grow in the tissues of the lymphatic system 16 the spread of cancer cells beyond their original site 17 a gene that can cause uncontrolled cell proliferation 18 region of DNA tha ...
G 10 20 30 40 50 40 30 20 10 G
G 10 20 30 40 50 40 30 20 10 G

... phenylalanine. What does this experiment indicate? 33. Which of these would most likely cause a mutation? 34. The human disease sickle cell anemia is caused by a change in one codon in a gene from GAA to GUA. This disease is the result of what natural process? 35. Although there are a limited number ...
Estimating the Number of Mouse Genes and the Duplicated Regions
Estimating the Number of Mouse Genes and the Duplicated Regions

... information has been shown in our WWW page [4]. Average % identity of gene pairs located on all duplicated regions was 42.4%. Average overlapped length of two amino acids sequences was 432.1. Seven procollagen genes, three Hox gene clusters, six integrin genes, three fibroblast growth factor recepto ...
Heredity Unit Notes (1)
Heredity Unit Notes (1)

... (5) WHAT HAPPENS IN MEIOSIS? • Meiosis is only used to make more sex cells. ...
Electrophoresis literally means “the condition of
Electrophoresis literally means “the condition of

... tightly wound into 46 chromosomes. Each chromosome has many sections that are called genes. Each gene codes for a protein and the proteins that they code for determine an individual’s ...
Genome Sequencing Using a Mapping Approach
Genome Sequencing Using a Mapping Approach

... Shotgun Approach 1. The shotgun approach obtains a genomic sequence by breaking the genome into overlapping fragments for cloning and sequencing. 2. A computer is then used to assemble the genomic sequence. 3. Advances that have made this approach practical for large genomes include: a. Better compu ...
Lan Mai - New Treatments of Cancers using Gene Expression and Regulation
Lan Mai - New Treatments of Cancers using Gene Expression and Regulation

... expression of all genes in a cell or tissue (Berg 152). This method is the use of high-density arrays of oligonucleotides called DNA microarrays or DNA chips. These microarrays are constructed to detect variations in how often specific genes are expressed and have been used by scientists to better u ...
Lecture 8
Lecture 8

... 50map units is independent assortment. 2 genes can be so far apart that they don’t show linkage, but can belong to a linkage group, by virtue of their distance relative to other closer genes. ...
Glossary - Heart UK
Glossary - Heart UK

... of genes shared by two blood relatives. First degree relatives (parents, siblings, children) share ½ (or 50%) of their genes, Second degree relatives (uncles, aunts, nephews, nieces, grandparents, grandchildren and halfsiblings) share ¼ (or 25%) of their genes, and third degree relatives (first cous ...
Genetics Part 2B 2015
Genetics Part 2B 2015

... similar genes • Eg. hemoglobin: -globin and -globin gene families ...
Unit 5 REVISION NOTES: Cell Division and Genetics
Unit 5 REVISION NOTES: Cell Division and Genetics

... Haploid ...
File
File

... ”C” can only join with a base _____. 12. The human genome consists of _______________ base pairs (pg.129) on _____ chromosomes. 13. The order of the bases in the DNA is called the genetic ____________ and this order of bases in each gene (long section of DNA) directs the cell to form a certain _____ ...
File - Mr. Lambdin`s Biology
File - Mr. Lambdin`s Biology

... ____________genetic variation of ______________ in the population Mutations can help an organism _________________ survive and reproduce Provide a way for species to change over time (evolution) ...
Chromatin Impacts on Human Genetics
Chromatin Impacts on Human Genetics

... activation of a suite of genes, whose identity is not yet known. • When Rsk2 is not functional, expression of the target genes is repressed, thus leading to disease. ...
DNA - heredity2
DNA - heredity2

... • The other ~95% is non-coding or ‘junk’ DNA which varies greatly between individuals • In this ‘junk’ there are sections which have repeated patterns • These repeated patterns are what is used to identify an individual when doing DNA profiling • a match of 10 sites across multiple chromosomes are r ...
BB30055: Genes and genomes
BB30055: Genes and genomes

... • Haplotype is a set of single nucleotide polymorphisms (SNPs) on a single chromatid that are statistically associated. • Haplotypes are generally shared between populations but their frequency can vary International HapMap Project (www.hapmap.org) – identifying common haplotypes in four populations ...
Study Guide
Study Guide

... Copyright © McDougal Littell/Houghton Mifflin Company. ...
Test Review Answers - Northwest ISD Moodle
Test Review Answers - Northwest ISD Moodle

... • 18. Traits acquired during your lifetime are not passed on as inherited traits. Must be in gamete DNA! • 19. At the point that a newer population is no longer able to breed with its parent population yielding plenty of fertile children, if members were brought together. • 20. The pesticide decreas ...
3-5 mutations F11
3-5 mutations F11

... What characteristics of cancer cells distinguish them from normal cells? Why do cancer cells form tumors? Why did they do a CT scan of the liver and chest? Why would the doctor recommend both surgery and chemotherapy? ...
New gene-therapy techniques show potential
New gene-therapy techniques show potential

... muscular dystrophy—both of which stem from defects in large genes—may also make good targets for these new technologies, he says. In gene therapy until now, "everybody was forced to work within certain gene size limitations," says Richard Jude Samulski, a molecular virologist at the University of No ...
Genome evolution: a sequence
Genome evolution: a sequence

... Element proliferation appears in evolutionary bursts. ...
Creating Transgenic Mice
Creating Transgenic Mice

... Genetically modified organisms (GMO) or genetically engineered organisms (GEO) are plants, animals, bacteria or viruses that have been altered through the transfer of new genes into or deletion of genes from that organism. These changes can be produced by a number of different methods depending on t ...
Introduction to your genome
Introduction to your genome

... • If you want to do that, order ASAP, it takes several weeks to get the data back. • Your grade does not depend in any way on whether you analyze your own genome. • You do not need to tell me if you analyze your own genome. • We cannot offer to pay for the test, or provide any counseling ...
< 1 ... 1169 1170 1171 1172 1173 1174 1175 1176 1177 ... 1288 >

Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report