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Biology 303 EXAM II 3/14/00 NAME
Biology 303 EXAM II 3/14/00 NAME

... Trisomy 21, or Down syndrome, occurs when there is a normal diploid chromosomal complement of 46 chromosomes plus one (extra) chromosome #21. Such individuals therefore have 47 chromosomes. While there is impaired fertility of both sexes, females are more likely to be fertile than males. Assume that ...
Get ready for gene editing
Get ready for gene editing

... acronym means is not important, but it is critical to understand what this technology can do. Just about all of the variability we see in nature or on the farm comes from differences in gene sequence. The differences in DNA are reflected in differences in traits. Traditional plant breeding relies on ...
(a) p 1 - Biology Department | UNC Chapel Hill
(a) p 1 - Biology Department | UNC Chapel Hill

... • Becoming more common • Most species only partially characterized • Usefulness also compromised by sparse synteny ...
Genetics, Technology, Society
Genetics, Technology, Society

... Scientists can alter the genes of many different organisms in order to improve their use to people. Example: COWS! Cows can have their genes modified in order to produce more milk, and ...
File
File

... A defective protein is replaced with a good one, eliminating the symptoms of the disease. Insertion of a new “healthy” gene into the organism to provide needed (usually) proteins, hormones etc. Gene is carried into the host by a viral vector (like the flu virus) that has been disabled. Can provide r ...
$doc.title

Document
Document

... any blood types not possible for his/her children? Why? ...
chapter 20: dna technology and genomics
chapter 20: dna technology and genomics

... This is simply the tool that will carry the gene of interest. b) It is usually DNA that will carry the new or foreign gene into whatever cell we want the gene to be expressed. ...
The_RAY_Manual
The_RAY_Manual

... E. coli as well as ES-cells, permitting a selection for the recombination product in E.coli. Cotransformed yeast colonies are pooled, extrachromosomal DNA is prepared and electroporated into E. coli. Bacterial transformants containing the recombination product are selected on plates containing kana ...
Fact Sheet 2 | VARIATIONS IN THE GENETIC CODE DNA stands for
Fact Sheet 2 | VARIATIONS IN THE GENETIC CODE DNA stands for

... gene product may be critical. So in these cases, even though only one copy of the gene has a mutation, and the other is working, a health problem may still occur. These are known as dominant gene mutations. ...
Ch 13 RNA and Protein Synthesis
Ch 13 RNA and Protein Synthesis

... 1 Explain What is a frameshift mutation and give an example Infer The effects of a mutation are not always visible. Choose a species and explain how a biologist might determine whether a mutation has occurred and, if so, what type of mutation it is 2 Review List four effect mutations can have on gen ...
Chapter 13
Chapter 13

... Many copies of a desired gene can be cloned and its product harvested This is accomplished by using a cloning vector – an organism that contains the desired gene and can multiply rapidly – this organism is usually a bacterium Vector = carrier http://www.bioteach.ubc.ca/TeachingResources/Appl ication ...
13.3_Mutations
13.3_Mutations

... 1 Explain What is a frameshift mutation and give an example Infer The effects of a mutation are not always visible. Choose a species and explain how a biologist might determine whether a mutation has occurred and, if so, what type of mutation it is 2 Review List four effect mutations can have on gen ...
BIO/CS 251 Bioinformatics final project Spring 2006
BIO/CS 251 Bioinformatics final project Spring 2006

... http://www.broad.mit.edu/annotation/fungi/histoplasma_capsulatum/ This site is designed in much the same way as the Aspergillus nidulans website that you worked with in Laboratory 9 (http://www.broad.mit.edu/annotation/fungi/aspergillus_nidulans/). Refer to this lab exercise for general information ...
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File

Genetics SHOW
Genetics SHOW

... the recipe (mRNA). The amino acids fold together to make the protein. The protein moves to the needed area in the body. ...
Transcription – Part II
Transcription – Part II

... 1. What are the components of a eukaryotic promoter? What are the functions of a promoter? Understand what is meant by Upstream and Downstream from a Promoter. What are UASs? 2. What is the role of the Generalized Transcription Factors? 3. Describe initiation of transcription in eukaryotes. Be sure ...
here - CMBI
here - CMBI

... • First group in-paralogs in every species • Find bi-directional best hits between inparalogous groups • Join in-paralogs to orthologous groups – Link all pairs of in-paralogous groups – Only if link is confirmed by third species (triangle) ...
speciation (formation of new species)
speciation (formation of new species)

... Substitution mutations: replacement of one nucleotide with another. The effects of substitution are usually minor, with little or no effect on the organism (silent or neutral mutations). Substitution will have a more serious effect if the ‘new’ amino acid is in a critical position in the protein (mi ...
retinitis pigmentosa - Foundation Fighting Blindness
retinitis pigmentosa - Foundation Fighting Blindness

... or too much protein. (Cells need the proper amount of particular proteins in order to function properly.) Mutations in dozens of genes have been linked to RP. Genetic mutations can be passed from parent to offspring through one of three genetic inheritance patterns — autosomal recessive, autosomal d ...
Human and murine PTX1/Ptx1 gene maps to the region for Treacher
Human and murine PTX1/Ptx1 gene maps to the region for Treacher

... PTX1, like its murine and chick homologs, possesses a homeodomain with a bicoid-class third helix. The homeodomain is highly conserved between mouse and human (100%), as are the Cand N- termini (88 and 97% respectively; Fig. 3a,b). This conservation is also evident at the level of gene structure as ...
Guide to Genome Island
Guide to Genome Island

... There is no fixed pathway for moving through the various activities to be found on Genome Island. In the sections that follow, each activity is treated as an independent entity. You may want to start with Mendelian genetics in the Abbey or with DNA in the Tower. The Human Chromosome Gallery in Towe ...
Genetics Review Questions
Genetics Review Questions

... 2. What is the basic unit of heredity? genes 3. Who studied the inheritance patterns of pea plants and is the “Father of Genetics”? Mendel 4. A gene that masks or hides other genes is called dominant. 5. Recessive traits are not expressed unless the offspring inherit a recessive gene from each paren ...
BIO101 Objectives Unit 2 1 Chapter 14 1. Describe the work of
BIO101 Objectives Unit 2 1 Chapter 14 1. Describe the work of

... 12. Explain why male cats are either black, or orange, but not calico (or tortishell) 13. Contrast linked and unlinked genes and why unlinked genes assort independently into gametes 14. Explain why males have 24 linkage groups while human females exhibit 23 groups 15. Understand that linkage maps ha ...
L26_ABPG2014
L26_ABPG2014

... molecules aiding the process, according to new research. This discovery could explain how similar genes find each other and group together in order to perform key processes involved in the evolution of species. •Although the capacity for single complementary strands of DNA to attract each other is p ...
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Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
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