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From Mendel to DNA
From Mendel to DNA

... Sequence of bases forms the genetic code G ...
Biotechnology
Biotechnology

... genes & organisms, then you need a set of tools to work with this unit is a survey of those tools… ...
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... Genes on the sex-chromosomes (the X and Y chromosomes in many species) are sex-linked genes. In mammals, including humans, and some other animals, XX individuals are female and XY individuals are male. Because males have only one copy of each sex chromosome, all of the genes on each chromosome will ...
Clustering
Clustering

... Dr Peter Smooker, peter.smooker@rmit.edu.au ...
How Evolution Works
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... Norm Most traits are polygenic  The normal trait is the average or mean in the population  Selection changes the mean, usually lowers variation  Selection will adjust mean ...
Chapter 1. Introduction
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... Comparative genomics is a subdiscipline of genomic biology in which the genomic features of different organisms are compared. Genomic features may include the DNA sequence, genes and gene order, regulatory sequences, and other genomic structural features. In this branch of genomics, whole or large p ...
sex chromosomes
sex chromosomes

... • Chromosomes are made up of _____ genes which are made up of ____ DNA & ______ protein • Organisms’ chromosomes come in Homologous _______________ pairs (one from mom, one from dad) • Homologous pairs are evident during meiosis ______, where they then separate. • The location of a gene on the chr ...
Plant Molecular Biology
Plant Molecular Biology

... 1. These mutants show evidence of leaf development in darkness: they have expanded cotyledons, plastids that resemble chloroplasts, and chlorophyll protein genes turned on. 2. In the dark, these genes repress photomorphogenesis –related genes in all tissues. 3. In the light, they repress them only i ...
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... Rick Young, a geneticist at the Whitehead Institute in Cambridge, Massachusetts, says that when he first started teaching as a young professor two decades ago, it took him about two hours to teach fresh-faced undergraduates what a gene was and the nuts and bolts of how it worked. Today, he and his c ...
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... 1. EVOLUTION – Mutation is the ultimate source of genetic variation that is required for evolutionary change. (Each zygote has approximately 100 new base pair combinations not present in the genome of either parent.) ...
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... 15. List the types of macrolesions. 16. Gene duplications are generally unstable. True or false. Explain. 17. What is a deletion macrolesion? 18. Which of the macrolesions is most important in evolution. Explain your answer. 19. Distinguish between duplications and insertions. 20. List the types of ...
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... New hybrid vectors have features of BACs and PACs combined. c. Yeast artificial chromosomes Can accommodate megabase (1000-2000 kb) fragments. Contain the critical elements of a yeast chromosome, including a centromere, two telomeres and autonomously replicating sequences (ARS), important for replic ...
Genetic Changes = Mutations
Genetic Changes = Mutations

... 5. Similarities: both involve DNA Both might result in either positive or negative Differences: Body cell DNA mutations affect the individual Sex cell DNA mutations affect the next generation 6. cancer … uncontrolled cell division 7. Point mutation: a change in a single N-base pair in DNA a. End res ...
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Glia and Genetic

... e. Anticipation = severity of a genetic disorder increases with each generation i. That is, children of parents w/ HD inherit longer TNRs and develop HD at an earlier age f. Other TNR diseases (PNS: Table 3-1, p. 55) Prion Diseases a. Definition: i. Fatal infectious diseases characterized by spongif ...
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Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
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