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AVAPRO (irbesartan) tablets
AVAPRO (irbesartan) tablets

... differences in effectiveness or safety were observed between these subjects and younger subjects, but greater sensitivity of some older individuals cannot be ruled out. [See Clinical Pharmacology (12.3) and Clinical Studies (14.1).] 10 OVERDOSAGE No data are available in regard to overdosage in huma ...
Potent inhibition of thrombin with a monoclonal
Potent inhibition of thrombin with a monoclonal

... patients in each dose group and, provided that enrolment could be modified, or additional dose tiers were added, based upon review by the Safety Committee. Such decisions were based upon deliberation by the Committee after assessment of all available clinical and safety data. There was no formal stop ...
Brodil Levo
Brodil Levo

... with caution with levosalbutamol. If additional adrenergic drugs are to be administered by any route, they should be used with caution to avoid deleterious cardiovascular effects. Beta-blockers: Beta-adrenergic receptor blocking agents not only block the pulmonary effect of beta-agonists such as lev ...
Treatment of Peptic Ulcer Disease
Treatment of Peptic Ulcer Disease

... The PPIs are a remarkably safe and well-tolerated group of agents. The most commonly reported side effects are headache and diarrhea, yet the rate at which patients experience these symptoms does not differ significantly from that for patients treated with placebo.[42] Drug Interactions The elevati ...
DECANOL – 25mg./50mg. INJ.
DECANOL – 25mg./50mg. INJ.

... Nandrolone Decanoate is an anabolic steroid. It has both androgenic as well as anabolic properties. Anabolic steroids are synthetic derivatives of testosterone. Nandrolone Decanoate has a pretty long release period, about 3-4 weeks. It may not be so for single injection, when the release time is abo ...
Late cardiotoxicity
Late cardiotoxicity

... •For late dysfunction, angiotensin-converting enzyme inhibitors and βblockers form the basis of treatment. Angiotensin-converting enzyme inhibitors have been shown to slow the progression of left ventricular dysfunction in patients undergoing high-dose ...
Rivaroxaban prescribing guidance 2016
Rivaroxaban prescribing guidance 2016

... surveillance is recommended throughout the treatment period in line with good anticoagulation practice. All patients prescribed rivaroxaban should be reviewed regularly to assess benefits and risks of on-going therapy weighing the risk of ischaemic events against the bleeding risks. Side effects (fo ...
Bronchial Asthma: Use of Inhalant Glucocorticoids and
Bronchial Asthma: Use of Inhalant Glucocorticoids and

... salbutamol or terbutalin. However, due to their chemical modification by introduction of a long side chain binding to the receptor is much longer compared to short acting drugs. Prolonged action was convincingly shown, for instance, by the work of Taylor et al. (1997) and Boulet et al. (1998). In th ...
ZUCLOPENTHIXOL tab, drops , amp: Class: Typical antipsychotic
ZUCLOPENTHIXOL tab, drops , amp: Class: Typical antipsychotic

... -Acute psychosis: Initial: 10-50 mg/day in 2-3 divided doses; may titrate dose upward by 10-20 mg every 2-3 days; usual dosage range: 20-60 mg/day; maximum dose: 100 mg/day -Maintenance therapy: Maintain lowest effective dose; usual maintenance dose: 20-40 mg/day; may be given as a single dose -Acut ...
Morphine vs Hydromorphone vs Oxycodone vs the Patch
Morphine vs Hydromorphone vs Oxycodone vs the Patch

... Fentanyl: Transdermal (Duragesic) and parenteral formulations are available. · high lipid solubility · 50­100 time more potent than morphine · Transdermal patch convenient in patients with stable pain control. Caution advised in uncontrolled pain  syndromes (not suitable for rapid titration) · Possi ...
Chemo and endocrine
Chemo and endocrine

... Breast cancer is a major health concern in the geriatric population. Patients with breast cancer over age 65 to 70 years should be screened for geriatric syndromes using a brief tool. The treatment approach to medically fit older women with newly diagnosed non-metastatic breast cancer is similar to ...
Adlyxin
Adlyxin

... Pfeffer, M.A., et al. N Engl J Med 2015; 373:2247-2257 ...
Bleeding and Blood Transfusion Issues Among Patients with Acute
Bleeding and Blood Transfusion Issues Among Patients with Acute

... * Dyspnea was generally mild, transient, and infrequently led to discontinuation ^ Most cases occurred within first 60 days and were asymptomatic; All cases resolved, even when treatment was continued; No Hy’s Law cases. ...
Diosmin/Hesperidin
Diosmin/Hesperidin

... A 2-month, double-blind, placebo-controlled trial of 200 individuals with severe chronic venous insufficiency found that treatment with diosmin/hesperidin significantly improved symptoms as compared to placebo. 11 Another double-blind, placebo-controlled trial of diosmin/hesperidin enrolled 101 indi ...
EFFEXOR XR INSTRUCTION SHEET EFFEXOR XR
EFFEXOR XR INSTRUCTION SHEET EFFEXOR XR

... Partial dosing: During transition, (if less than 37.5 or between 37.5 and 75mg is needed), capsules may be opened and used as a sprinkle form on any soft food. Sprinkled granules remain slow release unless bitten into. PANIC PATIENTS NOTE: This step is especially important in panic disorder where in ...
Fatimah Al-Shehri,journal club presentation of amplfy study NGH
Fatimah Al-Shehri,journal club presentation of amplfy study NGH

... with those of the Apixaban for the Extended Treatment of Deep Vein Thrombosis and Pulmonary Embolism trials , apixaban provided a simple, effective, and safe regimen for the initial and long-term treatment of venous thromboembolism. ...
Diapositiva 1
Diapositiva 1

... Thomas, J. et al. 2008. Methylnaltrexone for Opioid-Induced Constipation in Advanced Illness. NEJM 358(22):2332-2343. Slatkin, N. et al., 2009. Methylnaltrexone for Treatment of Opioid-Induced Constipation in Advanced Illness Patients. J Support Oncol 7(1):39–46. RELISTOR – SmPC ...
docx #19692 - Studybay.com
docx #19692 - Studybay.com

... compared with other NSAIDs because of its irreversible binding characteristic to COX. Other NSAIDs such as diclofenac bind to COX reversibly, therefore, they do not have a higher risk of causing spontaneous bleeding. 3. Mr. Buchanan may develop digoxin toxicity due to the drug interaction between NS ...
Anti-androgenic Therapy Using Oral Spironolactone for Acne
Anti-androgenic Therapy Using Oral Spironolactone for Acne

... Some patients who also suffered from concurrent seborrheic dermatitis on their faces also showed improvement after administration of oral spironolactone. This effect probably results from the inhibitory action of spironolactone on sebum production by blockage of androgen signals at the receptor level. ...
Serratiopeptidase-The-Miracle
Serratiopeptidase-The-Miracle

... more difficult for the body to break up and expel. Antibiotics are also frequently prescribed for these conditions, often with little success. The thick mucus remains intact after antibiotic therapy and provides a breeding ground for more bacteria, and the patient begins an endless cycle of inflamma ...
Prescribing Information
Prescribing Information

... Because clinical trials are conducted under widely varying conditions, the adverse reaction rates observed cannot be directly compared to rates in other clinical trials and may not reflect the rates observed in clinical practice. Safety data on the use of KORLYM are available from 50 patients with C ...
DVT and PE Pharmacotherapy Teaching Slides
DVT and PE Pharmacotherapy Teaching Slides

... • longer duration of UFH or LMWH if massive PE • Should overlap with warfarin for at least 4-5 days. – D/C after 2 consecutive days of therapeutic INR ...
daniels-broiler-3-2
daniels-broiler-3-2

... base exhibited evidence of maternal toxicity including decreased body weight gain and/or body weight loss and a concomitant decrease in food consumption during the first week of dosing. No teratogenic or embryo-fetal effects were observed at doses equivalent to up to 22.5 mg/kg per day rolapitant f ...
Emory`s CNE Sept 13 WORD
Emory`s CNE Sept 13 WORD

... base exhibited evidence of maternal toxicity including decreased body weight gain and/or body weight loss and a concomitant decrease in food consumption during the first week of dosing. No teratogenic or embryo-fetal effects were observed at doses equivalent to up to 22.5 mg/kg per day rolapitant f ...
2120   Sex Hormones and their Modulators
2120 Sex Hormones and their Modulators

... As for progestogens in general (see Progesterone, p.2125). See also under Hormonal Contraceptives, p.2059. Effects on the liver. There were 6 cases of jaundice among 107 patients with breast cancer treated with high-dose norethisterone acetate;1 the jaundice was reversible and of an obstructive type ...
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Dydrogesterone



Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.
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