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MetroGel® (metronidazole topical gel) Topical Gel, 0.75% Rx Only
MetroGel® (metronidazole topical gel) Topical Gel, 0.75% Rx Only

... months. However, no excess chromosomal aberrations in circulating human lymphocytes have been observed in patients treated for 8 months. Pregnancy Teratogenic effects Pregnancy category B: There has been no experience to date with the use of METROGEL® (metronidazole topical gel) Topical Gel in preg ...
Prescribing Information
Prescribing Information

... oppositional behaviour and anger) were more frequently observed in clinical trials among children and adolescents treated with antidepressants compared to those treated with placebo. If, based on clinical need, a decision to treat is nevertheless taken, the patient should be carefully monitored for ...
CONCERTATM methylphenidate HCl QUALITATIVE AND
CONCERTATM methylphenidate HCl QUALITATIVE AND

... Although a causal relationship has not been established, suppression of growth (i.e., weight gain, and/or height) has been reported with the long-term use of stimulants in children. Therefore, patients requiring long-term therapy should be carefully monitored. Patients who are not growing or gaining ...
Calcium channel blockers in hypertension
Calcium channel blockers in hypertension

... Diltiazem is effective in most forms of angina and the longer-acting formulation is also used in hypertension. Verapamil is used for the treatment of angina, hypertension and arrhythmias.7 Some postmarketing surveillance data has reported a reduced incidence of ankle oedema in patients treated with ...
PRODUCT INFORMATION
PRODUCT INFORMATION

... Citalopram in the dose range 20-80mg/day is more effective than placebo in the treatment of depression in the majority of trials, including relapse prevention trials. In the doubleblind, placebo-controlled trials a total of 1083 patients received citalopram and 486 received placebo. There were three ...
EVALUATION OF HEPATO PROTECTIVE ACTIVITY OF ETHANOLIC ROOT EXTRACT OF
EVALUATION OF HEPATO PROTECTIVE ACTIVITY OF ETHANOLIC ROOT EXTRACT OF

... hepatotoxicity in rats and mice as they virtually mimic any form of naturally occurring liver disease. Liver damage is associated with cellular necrosis, increase in tissue lipid peroxidation and depletion in the tissue GSH levels. In addition serum levels of many biochemical markers like SGOT, SGPT ...
Preparation : Vials contain 250mg aminophylline in 10mL
Preparation : Vials contain 250mg aminophylline in 10mL

... Aminophylline Monitoring and Adverse Effects  Requires ECG, blood pressure and electrolyte monitoring.  Therapeutic drug level monitoring required to prevent toxicity (see below).  Rapid administration may cause hypotension, headache, anxiety, arrhythmias, insomnia and convulsions.  Other possib ...
Sebaceous-disorders-I
Sebaceous-disorders-I

... dosages as low as 0.1 mg/kg per day. However, with such dosages, the incidence of relapses after therapy is greater • Isotretinoin is usually given for 20 weeks, but the length of the course of treatment is not absolute; in patients who have not shown an adequate response, therapy can be ...
Anticoagulation Management Policy
Anticoagulation Management Policy

... Patients at Harris Regional Hospital and Swain Community Hospital who are prescribed anticoagulation will be reviewed by the pharmacy clinical service. All patients on anticoagulation therapy will be tracked for appropriate dosing based on renal function and we will assure that PT/INR is ordered pri ...
1. NAME OF THE MEDICINAL PRODUCT Dompicare 20 mg, film
1. NAME OF THE MEDICINAL PRODUCT Dompicare 20 mg, film

... 4.6. Fertility, pregnancy and lactation Fertility There are no data on the effects of domperidone on human fertility. Pregnancy There are limited post-marketing data on the use of domperidone in pregnant women. A study in rats has shown reproductive toxicity at a high, maternally toxic dose. The pot ...
NUROFEN NUROFEN FORTE NUROFEN FOR CHILDREN
NUROFEN NUROFEN FORTE NUROFEN FOR CHILDREN

... especially in patients with documented hepatic or renal function impairment. The same monitoring may also be required in patients known or suspected to be at risk for renal function impairment, patients taking diuretics concurrently, and in patients in whom signs of possible renal toxicity occur, su ...
novinky v léčbě chronického srdečního selhání na prahu
novinky v léčbě chronického srdečního selhání na prahu

... • fluid retention (heart failure, pulmonary congestion, edemas, ascites, hydrothorax) • hypertension • Main clinical effects: • in heart failure they improve the quality of life, but we do not have enough information about their influence on the life prognosis • In hypertension they decrease the inc ...
Memorandum
Memorandum

... Buckshee cites Bromont’s 1985 toxicological dossier, which states that there was no toxicity and no change in fertility or reproductive function in mice at doses 35 times greater than the therapeutic dose during 26 weeks of treatment with Diosmin Complex.’ Tests on bacteria, human lymphocytes, mouse ...
Managing Hyperkalemia Caused by Inhibitors of the Renin
Managing Hyperkalemia Caused by Inhibitors of the Renin

... ngiotensin-converting–enzyme (ace) inhibitors and angiotensin-receptor blockers are used commonly in clinical practice to treat hypertension and decrease cardiovascular events in high-risk patients. A side effect of such therapy is the development of hyperkalemia. Hyperkalemia has been attributed to ...
invega sustenna
invega sustenna

... with oral paliperidone in subjects with moderate hepatic impairment (Child-Pugh Class B), no dose adjustment is required in patients with mild or moderate hepatic impairment (see DOSAGE AND ADMINISTRATION). In the study with oral paliperidone in subjects with moderate hepatic impairment (Child-Pugh ...
Paracetamol self poisoning_ahd (Specific toxin)
Paracetamol self poisoning_ahd (Specific toxin)

... By what mechanism does paracetamol cause problems in overdose? Why does the body produce “toxic metabolites” How can you estimate her risk of hepatic damage? What is the relevance of alcohol ingestion to the risk of hepatotoxicity? ...
SEROXAT™ CR Paroxetine hydrochloride QUALITATIVE AND
SEROXAT™ CR Paroxetine hydrochloride QUALITATIVE AND

... tremor, confusion, sweating, headache, diarrhoea have been reported. Generally these symptoms are mild to moderate, however, in some patients they may be severe in intensity. They usually occur within the first few days of discontinuing treatment, but there have been very rare reports of such sympto ...
Antibiotic-Decongestant Antibiotic Antibiotic Antibiotic 8250 Décarie
Antibiotic-Decongestant Antibiotic Antibiotic Antibiotic 8250 Décarie

... accompanying the common cold and for post-operative care of patients who have undergone intranasal or sinus surgery. Prophylactic use, for reduction of nasal carriage of staphylococci. Skin Ointment: For local use in the treatment of infections caused by pyogenic organisms, in particular S. aureus, ...
Zetia - Merck.com
Zetia - Merck.com

... ZETIA®, administered alone, is indicated as adjunctive therapy to diet for the reduction of elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and nonhigh-density lipoprotein cholesterol (non-HDL-C) in patients with primary (heterozygous fami ...
The rise and fall of the COX-2 inhibitors
The rise and fall of the COX-2 inhibitors

... patients aged over 65 years, patients who are taking other medicines which increase the risk of gastrointestinal effects, patients who are debilitated or those receiving long-term treatment with maximal doses of standard NSAIDs) and always after an assessment of cardiovascular risk. • MHRA Guideline ...
Presentazione standard di PowerPoint
Presentazione standard di PowerPoint

... NSAIDs are also associated with a relatively high incidence of renal adverse drug reactions (ADRs). The mechanism of these renal ADRs is due to changes in renal haemodynamics (kidney blood flow), ordinarily mediated by prostaglandins, which are affected by NSAIDs. Prostaglandins normally cause vasod ...
Guidlies for the diagnosis and management of
Guidlies for the diagnosis and management of

... Dyslipidemia is a powerful risk factor for coronary heart disease (CHD). Clinical trials conclusively have demonstrated that treatment of lipid disorders can reduce CHD morbidity and mortality. Treatment of lipid disorders also helps prevent stroke and peripheral arterial disease. 1. Basic principl ...
Prevention and Treatment of VTE
Prevention and Treatment of VTE

... • Less than 10% absorbed; relatively high rate of GI side effects • Crosses the placenta – do not use during pregnancy • Drug may degrade over time after exposure to air – must be kept in original packaging Unused tablets should be discarded after 90 days * Not FDA-approved indication ...
Ocular Surface Disease
Ocular Surface Disease

... All patients were treated with latanoprost monotherapy once daily in the evening for at least 4 weeks prior to the baseline visit. – Patients on IOP-lowering medications at screening underwent a 4-week washout of all medications other than latanoprost. – Patients not on latanoprost at screening were ...
March - Behavioral Health Care Services
March - Behavioral Health Care Services

... After a single intramuscular (IM) injection of long-acting risperdone, there is a small initial release of the drug followed by a lag time of three weeks. The main release of the drug starts from three weeks onward, is maintained for four to six weeks, and subsides by seven weeks following the IM in ...
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Ofloxacin



Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.
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