Is long-term treatment with inhaled ... in adults hazardous? * J.
... doses and that these effects arc dose-dependent. The fact that the prevalence of easy bruising increased with treatment time is noteworthy and indicates that long-term treatment with inhaled steroids may be more hazardous than previously assumed. At present, inhaled steroids are used in an increasin ...
... doses and that these effects arc dose-dependent. The fact that the prevalence of easy bruising increased with treatment time is noteworthy and indicates that long-term treatment with inhaled steroids may be more hazardous than previously assumed. At present, inhaled steroids are used in an increasin ...
Table 2. Pain Relief
... and 2 ketoprofen). Table 3 shows pain relief before and after the second dose. The mean onset time of analgesia ranged from 39.8 min for diclofenac sodium, 40.04 min for ketoprofen, 46.33 min for hyoscine N-butyl bromide, to 50.12 min for spasmaverine. A statistically significant difference (p<0.025 ...
... and 2 ketoprofen). Table 3 shows pain relief before and after the second dose. The mean onset time of analgesia ranged from 39.8 min for diclofenac sodium, 40.04 min for ketoprofen, 46.33 min for hyoscine N-butyl bromide, to 50.12 min for spasmaverine. A statistically significant difference (p<0.025 ...
Retrospective Cohort Study of Diabetes Mellitus and
... treated with atypical antipsychotics are less common.15 Nevertheless, an issue has been raised recently regarding the safety of both conventional and atypical antipsychotics, as it has been suggested that their use could be associated with induction of insulin resistance and an increased risk of typ ...
... treated with atypical antipsychotics are less common.15 Nevertheless, an issue has been raised recently regarding the safety of both conventional and atypical antipsychotics, as it has been suggested that their use could be associated with induction of insulin resistance and an increased risk of typ ...
COX-2-selective NSAIDs: New wonder drugs?
... for some of the toxicity of these agents. The most frequent complications associated with NSAID usage are those involving the gastrointestinal tract (GIT). GI bleeding, ulceration and perforation are a significant cause of morbidity and mortality in patients who are treated with these agents. A new ...
... for some of the toxicity of these agents. The most frequent complications associated with NSAID usage are those involving the gastrointestinal tract (GIT). GI bleeding, ulceration and perforation are a significant cause of morbidity and mortality in patients who are treated with these agents. A new ...
digoxin - DavisPlus
... more susceptible to digitalis toxicity. Pedi: Neonates may have falsely elevated serum digoxin concentrations due to a naturally occurring substance chemically similar to digoxin.Geri: Older adults may be toxic even when serum concentrations are within normal range; assess for clinical symptoms of t ...
... more susceptible to digitalis toxicity. Pedi: Neonates may have falsely elevated serum digoxin concentrations due to a naturally occurring substance chemically similar to digoxin.Geri: Older adults may be toxic even when serum concentrations are within normal range; assess for clinical symptoms of t ...
Combination therapy: Synergism between natural plant extracts and
... Antibiotics are one of the most important weapons in fighting bacterial infections and have greatly benefited the health‐related quality of human life since their introduction. However, over the past few decades these health benefits are under threat as many commonly used antibiotics have become les ...
... Antibiotics are one of the most important weapons in fighting bacterial infections and have greatly benefited the health‐related quality of human life since their introduction. However, over the past few decades these health benefits are under threat as many commonly used antibiotics have become les ...
Prescribing Information
... surgery by constricting the iris sphincter independently of cholinergic mechanisms. In clinical studies, flurbiprofen sodium ophthalmic solution 0.03% has been shown to inhibit the miosis induced during the course of cataract surgery. Results from clinical studies indicate that flurbiprofen sodium h ...
... surgery by constricting the iris sphincter independently of cholinergic mechanisms. In clinical studies, flurbiprofen sodium ophthalmic solution 0.03% has been shown to inhibit the miosis induced during the course of cataract surgery. Results from clinical studies indicate that flurbiprofen sodium h ...
Hyoscyamine Sulfate Tablets, USP
... visceral spasm and hypermotility in spastic colitis, spastic bladder, cystitis, pylorospasm, and associated abdominal cramps. May be used in functional intestinal disorders to reduce symptoms such as those seen in mild dysenteries, diverticulitis, and acute enterocolitis. For use as adjunctive thera ...
... visceral spasm and hypermotility in spastic colitis, spastic bladder, cystitis, pylorospasm, and associated abdominal cramps. May be used in functional intestinal disorders to reduce symptoms such as those seen in mild dysenteries, diverticulitis, and acute enterocolitis. For use as adjunctive thera ...
Phase I Trials
... Karim’s study: DLT will be defined as any one of the following attributed to AZD5363/AZD1208 during course 1: grade 4 neutropenia ≥ 1 week; febrile neutropenia; grade 4 thrombocytopenia; grade 3 thrombocytopenia with bleeding; QTcF prolongation to > 500 msec, or an increase of > 60 msec from baselin ...
... Karim’s study: DLT will be defined as any one of the following attributed to AZD5363/AZD1208 during course 1: grade 4 neutropenia ≥ 1 week; febrile neutropenia; grade 4 thrombocytopenia; grade 3 thrombocytopenia with bleeding; QTcF prolongation to > 500 msec, or an increase of > 60 msec from baselin ...
Treatment of Metastatic Renal Cell Carcinoma
... Given the results of these two trials, high-dose IL-2 appears to be more active than lower dose regimens. The lack of a survival benefit for high-dose therapy in these trials may be explained by the relatively small size of the group responding to treatment which would require much larger trials to ...
... Given the results of these two trials, high-dose IL-2 appears to be more active than lower dose regimens. The lack of a survival benefit for high-dose therapy in these trials may be explained by the relatively small size of the group responding to treatment which would require much larger trials to ...
The pharmacokinetic profile of fesoterodine
... increases in Cmax and AUC. In spite of these modest genetic influences and food effects on the pharmacokinetics of fesoterodine, the overall interindividual variability in Cmax levels was relatively little compared to previously published reports using tolterodine. Conclusions: Due to the esterase-m ...
... increases in Cmax and AUC. In spite of these modest genetic influences and food effects on the pharmacokinetics of fesoterodine, the overall interindividual variability in Cmax levels was relatively little compared to previously published reports using tolterodine. Conclusions: Due to the esterase-m ...
Theophylline Revisited
... ↓ poly(ADP-ribose)polymerase-1 (inhibits cell death) ↑ Histone deacetylase activity (↑ efficacy of steroids) ...
... ↓ poly(ADP-ribose)polymerase-1 (inhibits cell death) ↑ Histone deacetylase activity (↑ efficacy of steroids) ...
Levetiracetam for the treatment of epilepsy in children
... Levetiracetam DESITIN minitablets*), containing a new levetiracetam preparation with special galenics, are available from May 2011 onward for the treatment of epilepsy. Levetiracetam DESITIN® is available in different dosage strengths. Each of these is marked on the package in a different colour. Th ...
... Levetiracetam DESITIN minitablets*), containing a new levetiracetam preparation with special galenics, are available from May 2011 onward for the treatment of epilepsy. Levetiracetam DESITIN® is available in different dosage strengths. Each of these is marked on the package in a different colour. Th ...
JAMA. 2000
... Results For all patients, the annualized incidence rates of upper GI ulcer complications alone and combined with symptomatic ulcers for celecoxib vs NSAIDs were 0.76% vs 1.45% (P=.09) and 2.08% vs 3.54% (P=.02), respectively. For patients not taking aspirin, the annualized incidence rates of upper G ...
... Results For all patients, the annualized incidence rates of upper GI ulcer complications alone and combined with symptomatic ulcers for celecoxib vs NSAIDs were 0.76% vs 1.45% (P=.09) and 2.08% vs 3.54% (P=.02), respectively. For patients not taking aspirin, the annualized incidence rates of upper G ...
Ibrutinib
... and anaphylactoid reactions) to ibrutinib or to the excipients in its formulation. Use of preparations containing St. John’s Wort is contraindicated in patients treated with IMBRUVICA. ...
... and anaphylactoid reactions) to ibrutinib or to the excipients in its formulation. Use of preparations containing St. John’s Wort is contraindicated in patients treated with IMBRUVICA. ...
Pharmacological Management of Pediatric Patients With Sepsis
... and soft tissue.5,7 If the primary site of infection is known when a patient presents with sepsis, antimicrobial therapy should be directed at the pathogens most likely to arise from the primary site. However, the primary site of infection is often not known when the patient first presents. Because ...
... and soft tissue.5,7 If the primary site of infection is known when a patient presents with sepsis, antimicrobial therapy should be directed at the pathogens most likely to arise from the primary site. However, the primary site of infection is often not known when the patient first presents. Because ...
Medicines Over the Counter and Dosing
... expectorants. These medications are sold over-the-counter and are frequently given to children as young as 2 years old. Most alarmingly, a recent study of hospital emergency department cases seen between 2004 and 2005, conducted by the US Centers for Disease Control and Prevention. The CDC found tha ...
... expectorants. These medications are sold over-the-counter and are frequently given to children as young as 2 years old. Most alarmingly, a recent study of hospital emergency department cases seen between 2004 and 2005, conducted by the US Centers for Disease Control and Prevention. The CDC found tha ...
First-Line Treatment of Advanced Renal Cell Carcinoma with
... dysfunction (e.g., fatigue, weight gain, fluid retention) TSH monitoring should be done for cycles 1-4 and repeated every 2-3 months thereafter in all patients. Minor TSH elevation (up to 20 mU/L) with no symptoms can be observed, provided the patient has no pre-existing heart disease Thyroid hormon ...
... dysfunction (e.g., fatigue, weight gain, fluid retention) TSH monitoring should be done for cycles 1-4 and repeated every 2-3 months thereafter in all patients. Minor TSH elevation (up to 20 mU/L) with no symptoms can be observed, provided the patient has no pre-existing heart disease Thyroid hormon ...
What is the most appropriate antidepressant to use?
... Fluoxetine should be avoided in patients with unstable seizure disorders and patients with controlled epilepsy should be monitored (17). It is a potent CYP2D6 enzyme inhibitor and can cause changes in blood levels of phenytoin such that cases of phenytoin toxicity have been reported (7;17;22). The l ...
... Fluoxetine should be avoided in patients with unstable seizure disorders and patients with controlled epilepsy should be monitored (17). It is a potent CYP2D6 enzyme inhibitor and can cause changes in blood levels of phenytoin such that cases of phenytoin toxicity have been reported (7;17;22). The l ...
5 Calcium Antagonists (Calcium Channel Blockers)
... all calcium antagonists because they cause relaxation of the lower esophageal sphincter. A rebound increase in angina sometimes, but rarely, occurs on sudden discontinuation of nifedipine or other calcium antagonists, especially in patients with coronary artery spasm (5). Slow withdrawal with the ad ...
... all calcium antagonists because they cause relaxation of the lower esophageal sphincter. A rebound increase in angina sometimes, but rarely, occurs on sudden discontinuation of nifedipine or other calcium antagonists, especially in patients with coronary artery spasm (5). Slow withdrawal with the ad ...
SUBLIMAZE Injection
... Sublimaze should be administered with additional caution in obese patients. Obese patients should be observed carefully for signs of fentanyl toxicity. ...
... Sublimaze should be administered with additional caution in obese patients. Obese patients should be observed carefully for signs of fentanyl toxicity. ...
DIPHENHYDRAMINE HYDROCHLORIDE
... MAO inhibitors prolong and intensify the anticholinergic (drying) effects of antihistamines. Carcinogenes is , Mutagenes is , Impairment of Fertility Long-term studies in animals to determine mutagenic and carcinogenic potential have not been performed. Pregnancy Pregnancy Category B Reproduction st ...
... MAO inhibitors prolong and intensify the anticholinergic (drying) effects of antihistamines. Carcinogenes is , Mutagenes is , Impairment of Fertility Long-term studies in animals to determine mutagenic and carcinogenic potential have not been performed. Pregnancy Pregnancy Category B Reproduction st ...
61570-10 Lipitor (Master)
... low HDL-C levels and small LDL particles, as well as in association with non-lipid metabolic risk factors for coronary heart disease. As such, total plasma TG has not consistently been shown to be an independent risk factor for CHD. Furthermore, the independent effect of raising HDL or lowering TG o ...
... low HDL-C levels and small LDL particles, as well as in association with non-lipid metabolic risk factors for coronary heart disease. As such, total plasma TG has not consistently been shown to be an independent risk factor for CHD. Furthermore, the independent effect of raising HDL or lowering TG o ...
Version 1
... the AUC of oral oxycodone. On average, the AUC was approximately 50% lower (range 37-57%). Rifampicin, a CYP3A4 inducer, administered as 600 mg once-daily for seven days, reduced the AUC of oral oxycodone. On average, the AUC was approximately 86% lower Drugs that inhibit CYP2D6 activity, such as ...
... the AUC of oral oxycodone. On average, the AUC was approximately 50% lower (range 37-57%). Rifampicin, a CYP3A4 inducer, administered as 600 mg once-daily for seven days, reduced the AUC of oral oxycodone. On average, the AUC was approximately 86% lower Drugs that inhibit CYP2D6 activity, such as ...
Aspirin Aspirin is acetylsalicylic acid. It is rapidly converted in the
... Normally, only 1/10th is excreted as free salicylic acid, but this can be increased by alkalinization. The plasma t½ of aspirin as such is 15–20 min, but taken together with that of released salicylic acid, it is 3–5 hours. However, metabolic processes get saturated over the therapeutic range; t½ of ...
... Normally, only 1/10th is excreted as free salicylic acid, but this can be increased by alkalinization. The plasma t½ of aspirin as such is 15–20 min, but taken together with that of released salicylic acid, it is 3–5 hours. However, metabolic processes get saturated over the therapeutic range; t½ of ...
Ofloxacin
Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.