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... Population Distribution Urbanization is one of the most profound of global changes (see e.g. 39). In 1950 only New York, London, and Shanghai had populations of over 10 million. By the start of the twenty-first century, 23 cities will have surpassed that number, and more than half of all human being ...
AUTOIMMUNE DISEASES Systemic VS Organ
AUTOIMMUNE DISEASES Systemic VS Organ

... which are protein molecules capable of reacting with and destroying their intended bodily cells. As an example, antinuclear antibodies (ANA), which are seen in several different autoimmune disorders, react with the cell nucleus of specific tissue cells found within the skin, lungs, kidneys, and hear ...
LECTURE 8 Immunopathologic processes Theme 11. Immune
LECTURE 8 Immunopathologic processes Theme 11. Immune

... At various organs and tissues transplantation graft-versus-host reaction often develop. At that graft antigens induce specific antibodies creation and sensibilized erythrocytes production, infiltrating graft and causing its destruction and rejection by the way of direct cytotoxic action or by the wa ...
Stakeholders in Infection Prevention
Stakeholders in Infection Prevention

... Test strips packaged in vials can become contaminated with bacteria during routine use in the hospital ...
1 - Jennifer Horne
1 - Jennifer Horne

... after MMR vaccination when their children had started to become ill and in many cases the number of days quoted were consistent with the incubation period of the vaccine viruses given. Many of the symptoms described were listed in the vaccine manufacturers' own product sheets. The parents reported t ...
Using Diet to Manage Immune and Autoimmune Diseases Sarah
Using Diet to Manage Immune and Autoimmune Diseases Sarah

... – Control of T cell differentiation and activation. – Reduces cytokine production by Th1 and Th17 cells. ...
vaccines
vaccines

... The HIV-1 pandemic has been estimated to have according with WHO/UNAIDS reports been spread globally and infected individuals exist in all countries in the world. So far, only a few experimental vaccine studies have shown promising and protective results in clinical trials. Thus there is a continued ...
IMMUNOREGULATION OF HEPATITIS B VIRUS INFECTION
IMMUNOREGULATION OF HEPATITIS B VIRUS INFECTION

... Chronic liver diseases associated with chronic HBV infection are serious public health problems worldwide. It is estimated that 370 million people are chronically infected with HBV, and that up to 1.2 million people die every year due to the complications of HBV-related chronic liver diseases, such ...
Document
Document

... What are some white blood cells that protect the body? • An antigen is a substance that stimulates a response by the immune system. • T cells can coordinate the body’s immune response and attack infected cells. • Helper T cells activate killer T cells, which attack infected body cells. ...
PPS - Doctor of the Future
PPS - Doctor of the Future

... shallow answers that leave them puzzled with the mystery of “Why is this happening to me?” and “ What can I do about it?” • Trends research over 10 years ago identified a number of factors essential to being successful in the nutritional field – one of those was establishing yourself as an expert ...
BD is a multisystem inflammatory disease characterised by recurrent
BD is a multisystem inflammatory disease characterised by recurrent

... Disease patients; however the function of these cells has not been addressed so far. One problem is that the CD4+CD25+ phenotype found on Treg cells can also been found on a population of T effector lymphocytes and studies with more specific markers, including FoxP3, and CD27 should be carried out i ...
Table 6-11. Calculating a Life Table
Table 6-11. Calculating a Life Table

... We found that a cohort of patients with lung cancer first treated in 1977 had higher six-month survival rates for the total group and for subgroups in each of the three main TNM stages (tumor, nodes, and metastases) than a cohort treated between 1953 and 1964 at the same institutions. The more recen ...
Bacteria Virus Protist Review
Bacteria Virus Protist Review

... Antibody: Protein, build by your own immune system, which destroys pathogens Antibiotic: A chemical prescribed by a physician, to kill a pathogen 16. Why do we say that your immune system has a “memory”? The immune system has a memory. If you survive an infection, the body can quickly produce antibo ...
Clinical features and pathobiology of Ebolavirus
Clinical features and pathobiology of Ebolavirus

... assay and an end point titration assay (TCID50) have also been developed to detect and quantitate filoviruses for use in pre-clinical studies [14,15]. 5. Pathogenic mechanisms The clinical outcome of Ebolavirus infection as stated above is varied in humans. In a minority of the cases the infection re ...
Report on cases of adverse reactions to medicinal products
Report on cases of adverse reactions to medicinal products

... Table 1001. Cumulative data about cases of adverse reactions (AR) to medicinal products, vaccines, tuberculin and/or lack of efficacy (LE) of medicinal products and/or adverse events following immunization (AEFI)/tuberculin diagnostics at health facilities of administrative territorial unit Number o ...
Achievements in genetic engineering and their influence on
Achievements in genetic engineering and their influence on

... Subunit vaccines for papova, adeno and herpes viruses will be discussed together owing to similarities in their replication pathways and the ability to initiate infection from their isolated ds D N A s . For papovaviruses, the clo­ ning of human wart virus D N A has been reported to be in progress f ...
Alzheimer`s Disease of the Immune System A New Variant of
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... and long-term immunological memory against re-infection. Once thought to work independently, recent research shows a complex interaction and integration of innate and adaptive immunity. The cases described here presented us with 3 common findings. Previously, we suggested that atopy may be one facto ...
Full Text PDF - CSC Journals
Full Text PDF - CSC Journals

... The Ebola Virus Disease, which the World Health Organisation declared an outbreak on 23 March 2014, first occurred in Yambuku, Zaire and surrounding areas in 1976. The disease was spread by close personal contact and by use of contaminated needles and syringes in hospitals/clinics. This outbreak was ...
WHO Meeting on Immunological Endpoints for TB Vaccine Trials
WHO Meeting on Immunological Endpoints for TB Vaccine Trials

... studies of BCG-induced immunity[13,14], and is currently the primary screening assay to test multiple novel TB antigens in large Gates-funded consortiums[15]. Both these applications have involved measuring IFN-γ as the primary endpoint. IFN-γ is an example of a cytokine that is stable in culture an ...
The importance of nutrition in immunity
The importance of nutrition in immunity

... cough and sore throat (43). There is a multitude of data from animal studies supporting these observations in humans (40). Other human trials did not observe immune-stimulating effects, most probably because of the forms of CLA and/or the doses applied (44-46). CONCLUSIONS The relation between nutri ...
Flagellin from Marinobacter algicola and Vibrio vulnificus activates
Flagellin from Marinobacter algicola and Vibrio vulnificus activates

... infectious diseases. However, the majority of vaccines in aquaculture are usually not ...
at Infection - SPICEducation
at Infection - SPICEducation

... Estimated 1.5 million clinical cases of hepatitis A annually worldwide Tens of millions of hepatitis A virus infections occur each year Transition to lower rates of endemic HAV infection occurring on a global scale Universal childhood vaccination effective in countries with varying endemic rates ...
Immune Cells Have Sex and So Should Journal Articles
Immune Cells Have Sex and So Should Journal Articles

... germ-line encoded. For example, innate detection of nucleic acids by pattern recognition receptors differs between the sexes (6, 18). There are differences between the sexes in the induction of genes associated with toll-like receptor (TLR) pathways and antiviral type I interferon (IFN) responses (9 ...
Application of Biophysical techniques in AIDS Vaccine research:
Application of Biophysical techniques in AIDS Vaccine research:

... Amit Anand MOAC, University of Warwick Amit.Anand@warwick.ac.uk 19th January 2005 ...
STAYING HEALTHY - Mullaway Public School
STAYING HEALTHY - Mullaway Public School

... you cough or sneeze, you reduce how far the droplets can travel and stop them from contaminating other surfaces. In the past, people were encouraged to cover their coughs and sneezes with their hands, but if you do not clean your hands immediately, germs stay on your hands and can be transferred to ...
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Vaccination



Vaccination is the administration of antigenic material (a vaccine) to stimulate an individual's immune system to develop adaptive immunity to a pathogen. Vaccines can prevent or ameliorate morbidity from infection. When a sufficiently large percentage of a population has been vaccinated, this results in herd immunity. The effectiveness of vaccination has been widely studied and verified; for example, the influenza vaccine, the HPV vaccine, and the chicken pox vaccine. Vaccination is the most effective method of preventing infectious diseases; widespread immunity due to vaccination is largely responsible for the worldwide eradication of smallpox and the restriction of diseases such as polio, measles, and tetanus from much of the world. The World Health Organization (WHO) reports that licensed vaccines are currently available to prevent or contribute to the prevention and control of twenty-five infections.The active agent of a vaccine may be intact but inactivated (non-infective) or attenuated (with reduced infectivity) forms of the causative pathogens, or purified components of the pathogen that have been found to be highly immunogenic (e.g., outer coat proteins of a virus). Toxoids are produced for immunization against toxin-based diseases, such as the modification of tetanospasmin toxin of tetanus to remove its toxic effect but retain its immunogenic effect.Smallpox was most likely the first disease people tried to prevent by inoculating themselves and was the first disease for which a vaccine was produced. The smallpox vaccine was discovered in 1796 by the British physician Edward Jenner, although at least six people had used the same principles years earlier. Louis Pasteur furthered the concept through his work in microbiology. The immunization was called vaccination because it was derived from a virus affecting cows (Latin: vacca—cow). Smallpox was a contagious and deadly disease, causing the deaths of 20–60% of infected adults and over 80% of infected children. When smallpox was finally eradicated in 1979, it had already killed an estimated 300–500 million people in the 20th century.In common speech, 'vaccination' and 'immunization' have a similar meaning. This distinguishes it from inoculation, which uses unweakened live pathogens, although in common usage either can refer to an immunization. Vaccination efforts have been met with some controversy on scientific, ethical, political, medical safety, and religious grounds. In rare cases, vaccinations can injure people and, in the United States, they may receive compensation for those injuries under the National Vaccine Injury Compensation Program. Early success and compulsion brought widespread acceptance, and mass vaccination campaigns have greatly reduced the incidence of many diseases in numerous geographic regions.
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