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Investigator brochure or IMP dossier
Investigator brochure or IMP dossier

... SmPC – for products with a Marketing Authorisation in an EU member state, the Summary of Product Characteristics (SmPC) may be provided instead of an IMPD as long as the product is being used for the same indication and in accordance with the marketing authorisation. 3. Format of information 3.1 Ful ...
draft - Natural Products Association
draft - Natural Products Association

... and contaminant testing on all ingredients, with additional testing requirements for finished products. As of June 2010, all manufacturers fall under Good Manufacturing Practice (GMP) regulations and the FDA has begun conducting extensive cGMP inspections to ensure compliance. Manufacturers can only ...
Highlights of FDA Activities - College of Pharmacy
Highlights of FDA Activities - College of Pharmacy

Slide 1
Slide 1

... rather than type of evidence or data required  CPC has drafted its own guidance ►Will shift to developing questions and case studies ...
SOCIAL PHARMACOLOGY - Keluarga IKMA FKMUA 2010 | …
SOCIAL PHARMACOLOGY - Keluarga IKMA FKMUA 2010 | …

... . Research (clinical and social) in to the “real life” of drug in the community and . Its consequenses for society, the goverment health authorities, health care services and drug manufactures ...
7100 Software Test System
7100 Software Test System

... Product must contain a CE mark Must have a quality system Product must meet a list of essential ...
“513(g)s” Requests for Information
“513(g)s” Requests for Information

... in intended use, dosage form, strength, route of administration, or significant change in dose; or • (4) Any investigational drug, device, or biological product packaged separately that according to its proposed labeling is for use only with another individually specified investigational drug, devic ...
Food Drug and Cosmetic Act (Federal)
Food Drug and Cosmetic Act (Federal)

... “Drug” means: (A) articles recognized in the official United States Pharmacopoeia, official Homoeopathic Pharmacopoeia of the United States, or official National Formulary, or any supplement to any of them; and (B) articles intended for use in the diagnosis, cure, mitigation, treatment, or preventi ...
Novel Low Molecular Weight Lignins for use as an Anticoagulant
Novel Low Molecular Weight Lignins for use as an Anticoagulant

... binding serine proteases. Instead they are highly selective inhibitors of plasmin. This selectivity can significantly reduce medical risks and side-effects associated with the use of heparin. These compounds can be readily synthesized, in few high-yield inexpensive steps and do not need to be isolat ...
January 2017 - WSU College of Pharmacy
January 2017 - WSU College of Pharmacy

Treatment + research activism in India Challenges and opportunities
Treatment + research activism in India Challenges and opportunities

01_Barbisch Drug Development
01_Barbisch Drug Development

... • Phase 2 Clinical Studies IND • Emphasis is on effectiveness (50-300) • Obtain preliminary data on whether drug works in people with disease or condition – Controlled trials [active drug vs. inactive substance (placebo) or different drug] ...
New Drug Application(NDA)
New Drug Application(NDA)

... drug product in dosage form, strength, route of administration, quality and performance characteristics, and intended use” It termed "abbreviated" because they generally not required to include preclinical (animal) and clinical (human) data to establish safety and effectiveness. Basic Generic Drug R ...
view presentation - Pacira Pharmaceuticals, Inc.
view presentation - Pacira Pharmaceuticals, Inc.

... markets and acute care medical needs • Technology provides advantages over existing therapies to create high end innovative products – Currently developing products with significant market potential for Pacira and Partners ...
JUL 2 5  2007
JUL 2 5 2007

... added to a conventional food must be used in accordance with a food additive regulation unless it is generally recognized as safe '(GRAS) among qualified experts for its intended use in food. Use of a food ingredient that is not GRAS or an approved food additive causes a food #o be adulterated under ...
ovember 15, 2001 Docket No. 98N-0337 Faad and Drug A~i~strati~~
ovember 15, 2001 Docket No. 98N-0337 Faad and Drug A~i~strati~~

... In a letter from Dr. Charles Ganley to e ~Q~s~er ~eal~~ar~ ~~d~~ts Ass~~~ati~~ August 9* 1999, it was re~~~e~ded NDA holders submit a request for al in those cases where the reference llste g has not received approval for cling in the Drug Facts format in sufficient time to aflaw conversion of the A ...
Public Assessment Report
Public Assessment Report

Biopharmaceuticals
Biopharmaceuticals

... statements and forecasts involve risk and uncertainty because they relate to events and depend on circumstances that will occur in the future. There are a number of factors that could cause actual results and developments to differ materially from that expressed or implied by these forward-looking s ...
Read more. - Griffin Discoveries
Read more. - Griffin Discoveries

... pharmacology tools that allow histamine receptors to be studied at an unprecedented level of details. No other company has these capabilities.  30% of all marketed drugs target GPCRs while histamine receptor drugs are among the industries favorites; they are safe and reached blockbuster status.  O ...
PCPC-US-Claims-Labeling-2015
PCPC-US-Claims-Labeling-2015

... • must be on the bottom 30% of the PDP in lines generally parallel to the base. 8 fl oz (236 mL) ...
Abstract
Abstract

... The SNOMED CT relationship data is a powerful data set. However, it can also be very complex which means it is often underused, with vendors and implementers opting for the standard and simple lookup/search integration rather than a rich hierarchical one. Traversing this hierarchical data set in rea ...
A Healthy Prognosis For Some Stocks: Drugs and Robots
A Healthy Prognosis For Some Stocks: Drugs and Robots

... some real issues, namely high capital costs. Biosimilars are harder and more expensive to manufacture than generic pharmaceuticals — a manufacturing plant and equipment costs perhaps $100 million — and the clinical trials can be more complicated. Our biosimilar play is South Korea’s Celltrion [06827 ...
Using FTA Side Letters and Congressional Letters to
Using FTA Side Letters and Congressional Letters to

... concerning cases such as* HIV/AIDS, tuberculosis, malaria, and other epidemic as well as circumstances of extreme urgency or national emergency.” – “[The Patent Chapter] does not prevent the effective utilization of the [Aug. 30] TRIPS/health solution.” – “[T]he references [in this Understanding] in ...
Hospira
Hospira

... The petitioner is not aware of any documentation which establish that the originally approved formulation for Carbocaine° Injection was discontinued for safety or efficacy reasons. The formula comparison of the originally approved innovator's product (including the proposed generic product which is ...
Slide 1
Slide 1

... markets and acute care medical needs • Technology provides advantages over existing therapies to create high end innovative products – Currently developing products with significant market potential for Pacira and Partners ...
< 1 ... 178 179 180 181 182 183 184 185 186 ... 193 >

Biosimilar

A biosimilar (also known as follow-on biologic or subsequent entry biologic) is a biologic medical product which is a copy of an original product that is manufactured by a different company. Biosimilars are officially approved versions of original ""innovator"" products, and can be manufactured when the original product's patent expires. Reference to the innovator product is an integral component of the approval.Unlike the more common small-molecule drugs, biologics generally exhibit high molecular complexity, and may be quite sensitive to changes in manufacturing processes. Follow-on manufacturers do not have access to the originator's molecular clone and original cell bank, nor to the exact fermentation and purification process, nor to the active drug substance. They do have access to the commercialized innovator product.Drug related authorities such as European Medicines Agency (EMA), Food and Drug Administration (FDA), and Health Canada hold their own guidance on requirements for demonstration of the similar nature of two biological products in terms of safety and efficacy. According to them, analytical studies that demonstrate that the biological product is highly similar to the reference product notwithstanding minor differences in clinically inactive components; animal studies (including the assessment of toxicity); and a clinical study or studies (including the assessment of immunogenicity and pharmacokinetics or pharmacodynamics) that are sufficient to demonstrate safety, purity, and potency in one or more appropriate conditions of use for which the reference product is licensed and intended to be used and for which licensure is sought for the biological product.In case of a monoclonal antibody-containing medicinal product, such as Remsima, extensive physicochemical and biological characterization for it and its reference product Remicade was conducted in order to demonstrate their highly similar properties. Consequently, EMA have granted a marketing authorisation for only a few numbers of biosimilars since 2006 including a monoclonal antibody which is recently approved. Meanwhile, on March 6, 2015, the FDA approved the United States's first biosimilar product, the biosimilar filgrastim Zarxio.
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