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Today's biomedical innovation: lost in translation
Today's biomedical innovation: lost in translation

... to compare one experiment to another • Little insight into sources of variability of treatment response, even current therapies • As a result, most clinical development programs are “brute force” empirical efforts: extremely costly and time-consuming ...
View Dr. Liu`s presentation file.
View Dr. Liu`s presentation file.

...  Schizophrenia: 40 to 160 mg once a day  Bipolar depression: 20 to 120 mg once a day  Take with food (min of 350 calories) to increase ...
press release
press release

... NicOx granted IND status for clinical testing of HCT 1026 in the US Sophia Antipolis – France, January 7, 2002- NicOx S.A. (Nouveau Marché: NICOX) today announced that its Investigational New Drug application (IND)* has been accepted by the US Food and Drug Administration (FDA) for the clinical test ...
REGULATORY REQUIREMENTS FOR PREFORMULATION STUDIES
REGULATORY REQUIREMENTS FOR PREFORMULATION STUDIES

PUBLIC ASSESSMENT REPORT of the Medicines Evaluation Board
PUBLIC ASSESSMENT REPORT of the Medicines Evaluation Board

... This report is intended for all those involved with the safe and proper use of the medicinal product, i.e. healthcare professionals, patients and their family and carers. Some knowledge of medicines and diseases is expected of the latter category as the language in this report may be difficult for l ...
Consumer Updates > How to Dispose of Unused Medicines
Consumer Updates > How to Dispose of Unused Medicines

... and in some community drinking water supplies. “The main way drug residues enter water systems is by people taking medicines and then naturally passing them through their bodies,” says Raanan Bloom, Ph.D., an environmental assessment expert at FDA. “Many drugs are not completely absorbed or metaboli ...
Unlicensed Medicines - Neonatal and Paediatric Pharmacists Group
Unlicensed Medicines - Neonatal and Paediatric Pharmacists Group

... Import licensed medicine from QC approved country ...
high potency processing
high potency processing

EU Marketing Authorisation Procedures Registration Dossier
EU Marketing Authorisation Procedures Registration Dossier

... Patent protection • After synthesis (etc.), new innovations (e.g. drug entities) may be patented • As a rule, 20 years • („Bolar provision” permits the same drug development, clinical trials, registration underpatent protection, but not marketing!) ...
1-100, How vigilant were you to avoid GM food when eating out?
1-100, How vigilant were you to avoid GM food when eating out?

... They recommended testing every GM food “before it enters the marketplace.” Division of Food Chemistry and Technology ...
TRIAL PHASES:
TRIAL PHASES:

... All studies performed after the drug has been authorized by the regulator for the market, and related to the authorized indication. These studies are often important for optimizing the drug's use. They may be of any type but must have valid scientific objectives. Commonly conducted studies include s ...
GUIDANCE MANUAL FOR ASSURING QUALITY OF TRASTUZUMAB NATIONAL INSTITUTE OF BIOLOGICALS
GUIDANCE MANUAL FOR ASSURING QUALITY OF TRASTUZUMAB NATIONAL INSTITUTE OF BIOLOGICALS

... The innovator product of trastuzumab is a humanized IgGl kappa monoclonal antibody that selectively binds with high affinity to the extracellular domain of the human epidermal growth factor receptor 2 protein, HER2 (Figure – 2). Trastuzumab is produced by recombinant DNA technology in a mammalian ce ...
Dockets  Management  Branch  (HFA-305)
Dockets Management Branch (HFA-305)

... that present “‘demonstrable difficulties for compounding that reasonably demonstrate an adverse effect on the safety or effectiveness of that drug product.” FDA wants to include both specific drug products and categories of products that are grouped by relevant factors (e.g., specific drug delivery ...
When Do Consumer Products Become Medicine?
When Do Consumer Products Become Medicine?

Legislative Advocacy: The Safety of Over-the
Legislative Advocacy: The Safety of Over-the

... The OTC monograph system needs reform ...
Clinical Trial Process: Overview
Clinical Trial Process: Overview

...  Defining dose administration  Testing drug formulation  Exploring combination therapies  Evaluating effect of therapies on quality of life ...
Clinical Trial Process: Overview
Clinical Trial Process: Overview

...  Defining dose administration  Testing drug formulation  Exploring combination therapies  Evaluating effect of therapies on quality of life ...
Slide 1
Slide 1

... related to any dose should be considered adverse drug reactions. The phrase responses to a medicinal product means that a causal relationship between a medicinal product and an adverse event is at least a reasonable possibility, i.e. the relationship cannot be ruled out. ...
Demystifying FDA`s 505(b)(2) Drug Registration Process
Demystifying FDA`s 505(b)(2) Drug Registration Process

~ Pacific BioLogic
~ Pacific BioLogic

... Government iabeling legislation requires us to print the following on dietary supplement labels: “The statements presented here have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease”. This required statement refers ...
Biologic Response Modifier Agents for Adults with
Biologic Response Modifier Agents for Adults with

Film Coating for Taste-masking of Pediatric Oral Solid
Film Coating for Taste-masking of Pediatric Oral Solid

... Note: In the US, there is also a version of Isentress for oral suspension, which also includes Surelease. This product is licenced for patients at least 4 weeks of age and weighing over 3kg. Further information on the use of Film Coating for Taste-masking applications can be found at: http://www.col ...
FORM – Initial Review - UIC Office of the Vice Chancellor for Research
FORM – Initial Review - UIC Office of the Vice Chancellor for Research

... Complete only if seeking an exemption from the requirements for an IND. Please select the most appropriate exemption category and answer any questions associated with that category.  Category 1: FDA Determination of Exemption Please attach a copy of the FDA determination letter.  Category 2: FDA-a ...
FDA Warns Consumers About Tainted Weight Loss Pills
FDA Warns Consumers About Tainted Weight Loss Pills

Consumer Updates > FDA Warns of Health Risks Posed by E
Consumer Updates > FDA Warns of Health Risks Posed by E

... he Food and Drug Administration (FDA) has joined other health experts to warn consumers about potential health risks associated with electronic cigarettes. Also known as “e-cigarettes,” electronic cigarettes are battery-operated devices designed to look like and to be used in the same manner as conv ...
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Biosimilar

A biosimilar (also known as follow-on biologic or subsequent entry biologic) is a biologic medical product which is a copy of an original product that is manufactured by a different company. Biosimilars are officially approved versions of original ""innovator"" products, and can be manufactured when the original product's patent expires. Reference to the innovator product is an integral component of the approval.Unlike the more common small-molecule drugs, biologics generally exhibit high molecular complexity, and may be quite sensitive to changes in manufacturing processes. Follow-on manufacturers do not have access to the originator's molecular clone and original cell bank, nor to the exact fermentation and purification process, nor to the active drug substance. They do have access to the commercialized innovator product.Drug related authorities such as European Medicines Agency (EMA), Food and Drug Administration (FDA), and Health Canada hold their own guidance on requirements for demonstration of the similar nature of two biological products in terms of safety and efficacy. According to them, analytical studies that demonstrate that the biological product is highly similar to the reference product notwithstanding minor differences in clinically inactive components; animal studies (including the assessment of toxicity); and a clinical study or studies (including the assessment of immunogenicity and pharmacokinetics or pharmacodynamics) that are sufficient to demonstrate safety, purity, and potency in one or more appropriate conditions of use for which the reference product is licensed and intended to be used and for which licensure is sought for the biological product.In case of a monoclonal antibody-containing medicinal product, such as Remsima, extensive physicochemical and biological characterization for it and its reference product Remicade was conducted in order to demonstrate their highly similar properties. Consequently, EMA have granted a marketing authorisation for only a few numbers of biosimilars since 2006 including a monoclonal antibody which is recently approved. Meanwhile, on March 6, 2015, the FDA approved the United States's first biosimilar product, the biosimilar filgrastim Zarxio.
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