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Utilisation et l`intérêt clinique des anticorps monoclonaux
Utilisation et l`intérêt clinique des anticorps monoclonaux

... Benlysta (belimumab): anti-BAFF in SLE • Seropositive SLE patients (ie, antinuclear antibody positive and/or anti-DNA positive) without active nephritis or active central nervous system disease were enrolled in two phase II/III studies (BLISS-52 and BLISS-76) and treated with placebo, 1 mg/kg of an ...
Jubilant HollisterStier, LLC 11/27/13
Jubilant HollisterStier, LLC 11/27/13

... investigators from the U.S. Food and Drug Administration (FDA) identified significant violations of current good manufacturing practice (CGMP) regulations for finished pharmaceuticals, Title 21, Code of Federal Regulations, Parts 210 and 211. These violations cause your drug products to be adulterat ...
Contact: Immune Pharmaceuticals Inc. 430 East 29th Street, suite
Contact: Immune Pharmaceuticals Inc. 430 East 29th Street, suite

... About Immune Pharmaceuticals Immune Pharmaceuticals Inc. applies a personalized approach to treating and, developing novel, highly-targeted antibody therapeutics to improve the lives of patients with inflammatory diseases and cancer. The Company's lead product candidate, bertilimumab, is in clinical ...
Antidepressants and suicide
Antidepressants and suicide

... and SSRIs and were very similar for 37 of 42 identified symptoms. However, they were not described as dependence for SSRIs. To define similar problems as “dependence” for benzodiazepines and as “withdrawal reactions” for SSRIs is irrational. For patients, the symptoms are just the same; it can be ve ...
Drug Metabolism
Drug Metabolism

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Pharmacy Newsletter - Gold Coast Health Plan
Pharmacy Newsletter - Gold Coast Health Plan

... GCHP recently approved The American Diabetes Assn. Standards of Medical Care in Diabetes-2015 as the guideline to be used for diabetes care of GCHP members. This publication includes comprehensive guidelines for the use of medications in the treatment of diabetics. Click here to access all clinical ...
Herbal Medicines: Are they really safe?
Herbal Medicines: Are they really safe?

Pharmaceutical Promotion in Interactive Media – How the Statute
Pharmaceutical Promotion in Interactive Media – How the Statute

... market with DTCA.3 Currently, the DTCA guidelines of broadcasting and print media encourage the consumers to visit the drug websites for further information about the product.4 Today, pharmaceutical companies take fully advantage of the online platforms and use more diverse approaches to reach consu ...
Clinical Terminologies 1
Clinical Terminologies 1

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FDA Requests Boxed Warnings on Older Class of Antipsychotic Drugs
FDA Requests Boxed Warnings on Older Class of Antipsychotic Drugs

... The U.S. Food and Drug Administration last week exercised its new authority under the Food and Drug Administration Amendments Act of 2007 (FDAAA) to require manufacturers of “conventional” antipsychotic drugs to make safety-related changes to prescribing information, or labeling, to warn about an in ...
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No Slide Title

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DEPARTMENT OF HEALTH AND HUMAN ...

... Federal Food, Drug, and Cosmetic Act (the Act)) was filed by the Food and Drug Administration (FDA) on September7,2004. Your notification concernsthe substancecalled “N-Acetyl-LHydroxyproline” that you intend to market as a new dietary ingredient. The notification informs FDA that Kyowa Hakko Kogyo ...
Bionomics to present anti-anxiety drug treatment trial results and
Bionomics to present anti-anxiety drug treatment trial results and

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Overview - science of addiction
Overview - science of addiction

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Realizing Prescription Drug Value in an Environment of Market

... Formulary drug is prescribed 98 percent of the time Incorporates clinical review of generics Sequencing of concerns -- clinical then cost -- is critical Open exception process ...
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Exane BNP Paribas Pharma Conference
Exane BNP Paribas Pharma Conference

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What`s Changing on the Prescription Drug List?

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What is SierraSil

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PHARMACOKINETICS

... ADMET ...
n MANUFACTURERS NATIONALASSOCIATION OF PHARMACUT}
n MANUFACTURERS NATIONALASSOCIATION OF PHARMACUT}

... produces a drug substance with low impurity levels and another manufacturer of the same drug substance with higher impurity levels will be held to different impurity specifications based on their manufacturing process. For example, a situation could arise where the USI? specification for a known imp ...
youngs 3-25 - Iowa State University
youngs 3-25 - Iowa State University

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More Foundations (not in your book
More Foundations (not in your book

...  Sleep Aids - Most contain antihistamine to cause drowsiness. Should not be taken with a CNS depressant due to additive effects. *Can cause CNS stimulation in small children and elderly OTC Drugs  Weight-Control Drugs - Many on the market. Contraindicated for clients with heart disease, Hypertensi ...
Full Prescribing Information
Full Prescribing Information

... HOW SUPPLIED: Nicomide® Tablets are white-colored, oval-shaped tablets debossed on one side with “342”, and are supplied in bottles of 60 tablets (75854-343-60). The listed product number is not a National Drug CONTRAINDICATIONS: This product is contraindicated Code. Instead, Avion has assigned a pr ...
SPARC Investor Presentation - sun pharma advanced research
SPARC Investor Presentation - sun pharma advanced research

... medication, by day and night time asthma symptoms, and by global impression of change rated by subjects and investigators ...
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Biosimilar

A biosimilar (also known as follow-on biologic or subsequent entry biologic) is a biologic medical product which is a copy of an original product that is manufactured by a different company. Biosimilars are officially approved versions of original ""innovator"" products, and can be manufactured when the original product's patent expires. Reference to the innovator product is an integral component of the approval.Unlike the more common small-molecule drugs, biologics generally exhibit high molecular complexity, and may be quite sensitive to changes in manufacturing processes. Follow-on manufacturers do not have access to the originator's molecular clone and original cell bank, nor to the exact fermentation and purification process, nor to the active drug substance. They do have access to the commercialized innovator product.Drug related authorities such as European Medicines Agency (EMA), Food and Drug Administration (FDA), and Health Canada hold their own guidance on requirements for demonstration of the similar nature of two biological products in terms of safety and efficacy. According to them, analytical studies that demonstrate that the biological product is highly similar to the reference product notwithstanding minor differences in clinically inactive components; animal studies (including the assessment of toxicity); and a clinical study or studies (including the assessment of immunogenicity and pharmacokinetics or pharmacodynamics) that are sufficient to demonstrate safety, purity, and potency in one or more appropriate conditions of use for which the reference product is licensed and intended to be used and for which licensure is sought for the biological product.In case of a monoclonal antibody-containing medicinal product, such as Remsima, extensive physicochemical and biological characterization for it and its reference product Remicade was conducted in order to demonstrate their highly similar properties. Consequently, EMA have granted a marketing authorisation for only a few numbers of biosimilars since 2006 including a monoclonal antibody which is recently approved. Meanwhile, on March 6, 2015, the FDA approved the United States's first biosimilar product, the biosimilar filgrastim Zarxio.
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