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Text for JBrown 100912
Text for JBrown 100912

... Heart cells die after a heart attack. Most of the dead cells are not replaced (at least not with beating cells). We are interested in finding out what cellular components cause this cell death. Mitochondria are structures within the cell that provide essential energy for fueling each heart beat, but ...
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Print Preview - C:\WINDOWS\TEMP\e3temp_5676\.aptcache

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Programmed cell death



Programmed cell-death (or PCD) is death of a cell in any form, mediated by an intracellular program. PCD is carried out in a regulated process, which usually confers advantage during an organism's life-cycle. For example, the differentiation of fingers and toes in a developing human embryo occurs because cells between the fingers apoptose; the result is that the digits are separate. PCD serves fundamental functions during both plant and metazoa (multicellular animals) tissue development.Apoptosis and autophagy are both forms of programmed cell death, but necrosis is a non-physiological process that occurs as a result of infection or injury.Necrosis is the death of a cell caused by external factors such as trauma or infection and occurs in several different forms. Recently a form of programmed necrosis, called necroptosis, has been recognized as an alternate form of programmed cell death. It is hypothesized that necroptosis can serve as a cell-death backup to apoptosis when the apoptosis signaling is blocked by endogenous or exogenous factors such as viruses or mutations.
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