File - Tactical Hazmat
... • Only one known species, has two names Stachybotrys atra or Stachybotrys chartarum – labelled by media as “Black Mould” • Produces tricothecene, one of the more deadly mycotoxins, potential biological agent; toxin present in spores; in high enough dose potential to cause bleeding of the lungs and k ...
... • Only one known species, has two names Stachybotrys atra or Stachybotrys chartarum – labelled by media as “Black Mould” • Produces tricothecene, one of the more deadly mycotoxins, potential biological agent; toxin present in spores; in high enough dose potential to cause bleeding of the lungs and k ...
MARCH 6 Society of Toxicology Annual Meeting NTP Presentations
... Analysis of Myelin Loss Using Scanning Electron Microscopy (SEM) under Fully Hydrated Conditions: Validation in a Mouse Model of Experimental Autoimmune Encephalitis Stimulatory and Inhibitory Effects of Genistein on Uterine Leiomyoma Cell Growth In Vitro is Determined by Dose Transplacental Toxicok ...
... Analysis of Myelin Loss Using Scanning Electron Microscopy (SEM) under Fully Hydrated Conditions: Validation in a Mouse Model of Experimental Autoimmune Encephalitis Stimulatory and Inhibitory Effects of Genistein on Uterine Leiomyoma Cell Growth In Vitro is Determined by Dose Transplacental Toxicok ...
effects of copper nanoparticles in mytilus galloprovincialis
... been determined in the aquatic environment. In the preset study, these compounds were examined in the laboratory with regard on acute and chronic toxicity towards five species Vibrio fisheri (Proteobacteria), Selenastrum capricornotum (Clorophyta), Isochrysis galbana (Haptophyta), Paracentrotus livi ...
... been determined in the aquatic environment. In the preset study, these compounds were examined in the laboratory with regard on acute and chronic toxicity towards five species Vibrio fisheri (Proteobacteria), Selenastrum capricornotum (Clorophyta), Isochrysis galbana (Haptophyta), Paracentrotus livi ...
2007 ecotoxicology under
... • In general the higher the clay and/or organic matter content and pH, the more firmly bound are the metals and the longer is their residence time in soil • Acid rain helps in leaching nutrient (magnesium in European soil) from top to lower soil (inaccessible to root system) ...
... • In general the higher the clay and/or organic matter content and pH, the more firmly bound are the metals and the longer is their residence time in soil • Acid rain helps in leaching nutrient (magnesium in European soil) from top to lower soil (inaccessible to root system) ...
Exposure
... locally. Most substances that are not highly reactive are absorbed and distributed around the affected organism causing systemic injury at a target organ or tissue distinct from the absorption site. The target organ is not necessarily the organ of greatest accumulation. For example, adipose (fatty) ...
... locally. Most substances that are not highly reactive are absorbed and distributed around the affected organism causing systemic injury at a target organ or tissue distinct from the absorption site. The target organ is not necessarily the organ of greatest accumulation. For example, adipose (fatty) ...
Orphenadrine
... The range of toxicity is variable and unpredictable. The therapeutic daily dose is up to 300 mg as the hydrochloride or citrate salt. Among the central nervous system (CNS) symptoms and signs are epileptiform seizures, tremor, mydriasis, nystagmus, shock, and coma. Cardiotoxicity can include disturb ...
... The range of toxicity is variable and unpredictable. The therapeutic daily dose is up to 300 mg as the hydrochloride or citrate salt. Among the central nervous system (CNS) symptoms and signs are epileptiform seizures, tremor, mydriasis, nystagmus, shock, and coma. Cardiotoxicity can include disturb ...
Chemicals and Human Health - virtualpharmtox.pharmacy.arizona.edu
... • Measured in mg of chemical/kg or lb of ...
... • Measured in mg of chemical/kg or lb of ...
Aluminium Arsenic Cadmium Fluoride Compounds Lead
... listed, as well as their known and implicated effects on human health. Advice is also given for natural ways to aid the body in detoxification and chelation. ...
... listed, as well as their known and implicated effects on human health. Advice is also given for natural ways to aid the body in detoxification and chelation. ...
Pharmacology/Toxicology information to submit an IND
... Biostatistics (usually not at the initial IND stage) ...
... Biostatistics (usually not at the initial IND stage) ...
Case 5 - Tripod.com
... treated with LGT experienced sig. improvement One study found that LGT have a powerful suppressive effect on human immune responses for tx of RA mech : inhibition of PG E2 secretion from monocytes & inhibited IL1, IL6 , IL8 & TNF) ...
... treated with LGT experienced sig. improvement One study found that LGT have a powerful suppressive effect on human immune responses for tx of RA mech : inhibition of PG E2 secretion from monocytes & inhibited IL1, IL6 , IL8 & TNF) ...
Are GMOs Safe?
... producing corn sustained liver and kidney damage. (13, 14) Other harmful effects were also noticed in the heart, adrenal glands, spleen and hematopoietic system of these GM corn-fed rats. Bt toxin has also been demonstrated to reduce fertility in mice, with fewer offspring being produced than by mic ...
... producing corn sustained liver and kidney damage. (13, 14) Other harmful effects were also noticed in the heart, adrenal glands, spleen and hematopoietic system of these GM corn-fed rats. Bt toxin has also been demonstrated to reduce fertility in mice, with fewer offspring being produced than by mic ...
6.2.3 Liver
... may be the only response as after exposure tohydrazine, ethionine, and tetracycline, or it may occur in combination with necrosis as with carbon tetrachloride. It is normally a reversible response, which does not usually lead to cell death, although it can be very serious as is the case with tetrac ...
... may be the only response as after exposure tohydrazine, ethionine, and tetracycline, or it may occur in combination with necrosis as with carbon tetrachloride. It is normally a reversible response, which does not usually lead to cell death, although it can be very serious as is the case with tetrac ...
Chemical Toxicology - NC State University
... Long-term exposure to irritants can result in increased mucous secretions and chronic bronchitis. A primary irritant exerts no systemic toxic action either because the products formed on the tissue of the respiratory tract are non-toxic or because the irritant action is far in excess of any systemic ...
... Long-term exposure to irritants can result in increased mucous secretions and chronic bronchitis. A primary irritant exerts no systemic toxic action either because the products formed on the tissue of the respiratory tract are non-toxic or because the irritant action is far in excess of any systemic ...
BIOCHEMICAL EFFECTS OF ENDOSULFAN IN LIVER OF ALBINO RATS Research Article
... Endosulfan a nonsystemic contact organochlorine insecticide and acaricide is used extensively for pest control. There is some indication that endosulfan can have adverse effect on the immune system at low level of exposure2. In India about 1000 metric tons of endosulfan and its formulations have bee ...
... Endosulfan a nonsystemic contact organochlorine insecticide and acaricide is used extensively for pest control. There is some indication that endosulfan can have adverse effect on the immune system at low level of exposure2. In India about 1000 metric tons of endosulfan and its formulations have bee ...
2061-2008 ecotoxicology under
... Bioavailabiltiy The fraction of a chemical that is in an available form to an organism e.g. fish: food, absorption from water Bioconcentration - where the chemical concentration in an organism exceeds the concentration in the surrounding media (i.e. aquatic environment) as a result of exposure thro ...
... Bioavailabiltiy The fraction of a chemical that is in an available form to an organism e.g. fish: food, absorption from water Bioconcentration - where the chemical concentration in an organism exceeds the concentration in the surrounding media (i.e. aquatic environment) as a result of exposure thro ...
Bimm118 Worksheet #3
... 10. What makes Calcium an effective second messenger (in terms of its cellular concentrations)? Cytosolic Ca2+ is very low (100nM) -steep ion gradient allows for rapid diffusion of Ca2+ across membranes -small changes in Ca2+ permeability can have a prominent effect These properties make Ca2+ an id ...
... 10. What makes Calcium an effective second messenger (in terms of its cellular concentrations)? Cytosolic Ca2+ is very low (100nM) -steep ion gradient allows for rapid diffusion of Ca2+ across membranes -small changes in Ca2+ permeability can have a prominent effect These properties make Ca2+ an id ...
Basic Priniciples of Toxicology - virtualpharmtox.pharmacy.arizona
... Dose determines the biological response. Dose-Response curve: The relationship between the dose of a chemical (dependent variable) and the response produced (independent variable) follows a predictable pattern. As the dose of a toxicant increases, so does the response, either in terms of the proport ...
... Dose determines the biological response. Dose-Response curve: The relationship between the dose of a chemical (dependent variable) and the response produced (independent variable) follows a predictable pattern. As the dose of a toxicant increases, so does the response, either in terms of the proport ...
Dose-response relationship
... Thus, the current testing approaches do not fail to identify or establish appropriate NOAELS in the low rose range of exposure, even if not all effects for every chemical are identified. The goal of chemical testing is to identify the potential for hazard after exposure to the xenobiotic of concern, ...
... Thus, the current testing approaches do not fail to identify or establish appropriate NOAELS in the low rose range of exposure, even if not all effects for every chemical are identified. The goal of chemical testing is to identify the potential for hazard after exposure to the xenobiotic of concern, ...
Ch 14 PPT Pt. 2
... and synthetic ones are all harmful • Plants produce toxic chemicals to defend themselves • Most crop plants have had the level of toxic chemicals reduced by artificial selection, but not eliminated • Eating animals may expose us to the plant chemicals they ate • Bioaccumulation ...
... and synthetic ones are all harmful • Plants produce toxic chemicals to defend themselves • Most crop plants have had the level of toxic chemicals reduced by artificial selection, but not eliminated • Eating animals may expose us to the plant chemicals they ate • Bioaccumulation ...
I Number 35 August
... public perceives risks to human health. In the first part of this essay, 1 I discussed several studies by Baruch Fischhoff and colleagues, Decklon Research, Eugene, Oregon. They studied people’s subjective ratings of various risky activities and technologies.2’2,z3 They found that laypeople don’t te ...
... public perceives risks to human health. In the first part of this essay, 1 I discussed several studies by Baruch Fischhoff and colleagues, Decklon Research, Eugene, Oregon. They studied people’s subjective ratings of various risky activities and technologies.2’2,z3 They found that laypeople don’t te ...
Specific Target Organ Toxicity - Society for Chemical Hazard
... A weight of evidence approach is used to classify substances under STOT-SE. This can include human incidents (case studies), epidemiological studies, and acute toxicity studies in experimental animals. In exceptional cases, it may be appropriate to classify a substance in Category 2 on the basis of ...
... A weight of evidence approach is used to classify substances under STOT-SE. This can include human incidents (case studies), epidemiological studies, and acute toxicity studies in experimental animals. In exceptional cases, it may be appropriate to classify a substance in Category 2 on the basis of ...
Mouth Cancers - Druze Victoria
... Heavy alcohol consumption (>3 drinks/day) increases risk by 2-3 times. ...
... Heavy alcohol consumption (>3 drinks/day) increases risk by 2-3 times. ...
Chapter 5 - Health Effects
... Air pollution episodes are periods of elevated pollutant levels that pose immediate health risks to exposed sensitive individuals. 2. Describe differences between acute and chronic health effects. Acute health effects result from short-term, high-level exposures. Symptoms are usually experienced wit ...
... Air pollution episodes are periods of elevated pollutant levels that pose immediate health risks to exposed sensitive individuals. 2. Describe differences between acute and chronic health effects. Acute health effects result from short-term, high-level exposures. Symptoms are usually experienced wit ...
Adrenocortical hormones –outline
... ① Stimulate protein and RNA synthesis in the liver. ② Have catabolic effects in lymphoid and connective tissue, muscle, fat, and skin. ③ Supraphysiologic amounts: lead to decreased muscle mass and weakness. 3. Effects on fat metabolism: ① promote the lipolysis in adipocytes with increased release of ...
... ① Stimulate protein and RNA synthesis in the liver. ② Have catabolic effects in lymphoid and connective tissue, muscle, fat, and skin. ③ Supraphysiologic amounts: lead to decreased muscle mass and weakness. 3. Effects on fat metabolism: ① promote the lipolysis in adipocytes with increased release of ...
Fumonisin B1
Fumonisin B1 is the most prevalent member of a family of toxins, known as fumonisins, produced by several species of Fusarium molds, such as Fusarium verticillioides, which occur mainly in maize (corn), wheat and other cereals. Fumonisin B1 contamination of maize has been reported worldwide at mg/kg levels. Human exposure occurs at levels of micrograms to milligrams per day and is greatest in regions where maize products are the dietary staple.Fumonisin B1 is hepatotoxic and nephrotoxic in all animal species tested. The earliest histological change to appear in either the liver or kidney of fumonisin-treated animals is increased apoptosis followed by regenerative cell proliferation. While the acute toxicity of fumonisin is low, it is the known cause of two diseases which occur in domestic animals with rapid onset: equine leukoencephalomalacia and porcine pulmonary oedema syndrome. Both of these diseases involve disturbed sphingolipid metabolism and cardiovascular dysfunction.