- bioRxiv
... In contrast to work with single cell organisms, the impact of gene dosage on expression variability in metazoans is less well studied. However, a full understanding of the effect of gene copy deletions is fundamental for better understanding of diseases that originate from gene copy number changes. ...
... In contrast to work with single cell organisms, the impact of gene dosage on expression variability in metazoans is less well studied. However, a full understanding of the effect of gene copy deletions is fundamental for better understanding of diseases that originate from gene copy number changes. ...
Exploring HLA Diversity in Brazil
... EC: We’re conducting two different research studies. The first study is an evaluation of HLA genetics from a population point of view. For this study, we are using normal, healthy individuals. No one has performed deep sequencing of the HLA region on such a mixed population, and the available databa ...
... EC: We’re conducting two different research studies. The first study is an evaluation of HLA genetics from a population point of view. For this study, we are using normal, healthy individuals. No one has performed deep sequencing of the HLA region on such a mixed population, and the available databa ...
ppt - Chair of Computational Biology
... (A) In the process of GeneMarkS training there is no division of the coding sequence into two clusters. However, in applying the GeneMark.hmm 2.0 program, the model of coding region derived by GeneMarkS can be used as the Typical model along with a heuristic model used as the Atypical model . (B) In ...
... (A) In the process of GeneMarkS training there is no division of the coding sequence into two clusters. However, in applying the GeneMark.hmm 2.0 program, the model of coding region derived by GeneMarkS can be used as the Typical model along with a heuristic model used as the Atypical model . (B) In ...
Doubling Down on Genomes: Polyploidy and Crop Plants
... Using Brassica (cabbages) allopolyploids, a landmark study detailed the loss and gain of restriction fragments in newly synthesized allopolyploids mimicking natural B. rapa and B. juncea (Song et al., 1995). This study was important as Song and colleagues (1995) were able to use the precise progenit ...
... Using Brassica (cabbages) allopolyploids, a landmark study detailed the loss and gain of restriction fragments in newly synthesized allopolyploids mimicking natural B. rapa and B. juncea (Song et al., 1995). This study was important as Song and colleagues (1995) were able to use the precise progenit ...
Genetic and Epigenetic Aspects of Polyploid Evolution in Plants
... chromosome pairing and segregation, especially the formation of multivalents, which creates the prospect of unequal segregation of chromosomes into daughter cells. In addition, polyploidy has been shown to coincide with structural genomic changes that can involve whole chromosomes or chromosome segm ...
... chromosome pairing and segregation, especially the formation of multivalents, which creates the prospect of unequal segregation of chromosomes into daughter cells. In addition, polyploidy has been shown to coincide with structural genomic changes that can involve whole chromosomes or chromosome segm ...
Human Germline Gene Therapy1
... “poses no new ethical problems” (6), and is not morally different from, for instance, organ transplantation. Because safety and efficacy in humans is not fully established, somatic cell gene therapy is currently employed only under strict criteria (2); an example of a current protocol yielding encou ...
... “poses no new ethical problems” (6), and is not morally different from, for instance, organ transplantation. Because safety and efficacy in humans is not fully established, somatic cell gene therapy is currently employed only under strict criteria (2); an example of a current protocol yielding encou ...
American College of Medical Genetics and Genomics
... Because recombination during meiosis is a somewhat random process, the variation from the theoretical value increases with each meiosis7 such that third cousins may share more DNA sequences than second cousins. Even among the progeny of first cousins, in whom the average percentage of the genome tha ...
... Because recombination during meiosis is a somewhat random process, the variation from the theoretical value increases with each meiosis7 such that third cousins may share more DNA sequences than second cousins. Even among the progeny of first cousins, in whom the average percentage of the genome tha ...
PDF
... Replication, Recombination, and DNA Repair sequence, TLR028 (3565-bp in length), is composed of two Genes for the primary replication machinery, the DNA polydifferent transposases flanking a hypothetical protein. The merase III complex in T. tengcongensis, are similar to those of most abundant one, ...
... Replication, Recombination, and DNA Repair sequence, TLR028 (3565-bp in length), is composed of two Genes for the primary replication machinery, the DNA polydifferent transposases flanking a hypothetical protein. The merase III complex in T. tengcongensis, are similar to those of most abundant one, ...
Genome Biology and
... – The number of introns is roughly the same as in human • Both gain and loss of introns in the Fugu lineage are observed ...
... – The number of introns is roughly the same as in human • Both gain and loss of introns in the Fugu lineage are observed ...
Resources: - Real Science
... Since this idea was proposed, researchers have been looking for evidence. This is not easy for a theory about perishable food eaten two million years ago. But in work earlier this year, Dominy and his colleagues found some. They discovered that the 'isotopic signature' of animals that eat tubers and ...
... Since this idea was proposed, researchers have been looking for evidence. This is not easy for a theory about perishable food eaten two million years ago. But in work earlier this year, Dominy and his colleagues found some. They discovered that the 'isotopic signature' of animals that eat tubers and ...
The Genome of Deep-Sea Vent Chemolithoautotroph
... chemolithoautotrophic sulfur-oxidizing bacteria isolated from deep-sea hydrothermal vents. This gammaproteobacterium has a single chromosome (2,427,734 base pairs), and its genome illustrates many of the adaptations that have enabled it to thrive at vents globally. It has 14 methyl-accepting chemota ...
... chemolithoautotrophic sulfur-oxidizing bacteria isolated from deep-sea hydrothermal vents. This gammaproteobacterium has a single chromosome (2,427,734 base pairs), and its genome illustrates many of the adaptations that have enabled it to thrive at vents globally. It has 14 methyl-accepting chemota ...
The vertebrate genome annotation (Vega) database
... chromosome is highlighted with grey shading. Since the original Vega publication in 2005 (2), the number of human gene loci annotated has more than doubled to almost 33 000 (June 2007 release), close to 19 000 of which are predicted to be protein coding. Four chromosomes (2, 4, 5 and 11) remain to b ...
... chromosome is highlighted with grey shading. Since the original Vega publication in 2005 (2), the number of human gene loci annotated has more than doubled to almost 33 000 (June 2007 release), close to 19 000 of which are predicted to be protein coding. Four chromosomes (2, 4, 5 and 11) remain to b ...
Genetic tasks V: GENE INTERACTIONS
... 2. The colour of a feather of a canary is determined by genes A and B. Dominant allele of gene A encodes for red colour, dominant allele of gene B for yellow one. Birds with genotypes aabb and A-B- are white. a) Use colours in Punnet square (or branching method) to differentiate phenotypes resultin ...
... 2. The colour of a feather of a canary is determined by genes A and B. Dominant allele of gene A encodes for red colour, dominant allele of gene B for yellow one. Birds with genotypes aabb and A-B- are white. a) Use colours in Punnet square (or branching method) to differentiate phenotypes resultin ...
Duchenne and Becker Types of Muscular Dystrophy
... We all have 46 chromosomes arranged into 23 pairs. One copy of each pair is inherited from our mother and the other from our father. The first 22 chromosome pairs are numbered and are known as autosomal chromosomes. The 23rd pair is made up of the sex chromosomes called X and Y. Males have an X and ...
... We all have 46 chromosomes arranged into 23 pairs. One copy of each pair is inherited from our mother and the other from our father. The first 22 chromosome pairs are numbered and are known as autosomal chromosomes. The 23rd pair is made up of the sex chromosomes called X and Y. Males have an X and ...
Letter to the Editor
... How reasonable is it to suppose that a toxin and antitoxin may come into linkage disequilibrium? It does appear unlikely that two such genes should appear side by side. However, the very same invasion condition is necessary for other analogous selfish genetic elements, and the required linkage diseq ...
... How reasonable is it to suppose that a toxin and antitoxin may come into linkage disequilibrium? It does appear unlikely that two such genes should appear side by side. However, the very same invasion condition is necessary for other analogous selfish genetic elements, and the required linkage diseq ...
Case Report Section
... and metaphase cells revealing that the break-apart 5'MLL segment is translocated to the derivative X chromosome. The patient achieved a complete hematological remission with chemotherapy one month later. Chromosomal and FISH studies performed in April, June, August and December confirmed the complet ...
... and metaphase cells revealing that the break-apart 5'MLL segment is translocated to the derivative X chromosome. The patient achieved a complete hematological remission with chemotherapy one month later. Chromosomal and FISH studies performed in April, June, August and December confirmed the complet ...
PDF only - at www.arxiv.org.
... drives ATP synthesis. This is similar in nature to the mechanism used by bacterial proteorhodopsin. The haloarchaea are also aerobic and heterotrophic and the ease with which they will grow under laboratory conditions is part of the reason they have been suggested to be ideal candidates for the stud ...
... drives ATP synthesis. This is similar in nature to the mechanism used by bacterial proteorhodopsin. The haloarchaea are also aerobic and heterotrophic and the ease with which they will grow under laboratory conditions is part of the reason they have been suggested to be ideal candidates for the stud ...
Chapter 1 Introduction
... including deletions, duplications, translocations, inversions and insertions. In 1971, at the Paris Conference, a new system for the classification of chromosomes, based on Q, G, and R banding patterns, was introduced to identify individual chromosomes and chromosome regions (Paris Conference, 1971) ...
... including deletions, duplications, translocations, inversions and insertions. In 1971, at the Paris Conference, a new system for the classification of chromosomes, based on Q, G, and R banding patterns, was introduced to identify individual chromosomes and chromosome regions (Paris Conference, 1971) ...
Microarray expression data
... * the SVM is used then to recognize and classify the genes in the data set to the established groups on the basis of their expression * the SVM can also identify genes in the training set that are outliers or that have been previously assigned to the incorrect class * an application of potentially g ...
... * the SVM is used then to recognize and classify the genes in the data set to the established groups on the basis of their expression * the SVM can also identify genes in the training set that are outliers or that have been previously assigned to the incorrect class * an application of potentially g ...
Exploring the genomic traits of fungus
... numbers of GIs indicate a complex history of gene recombination and horizontal transfer between bacterial relatives. The genomes of all strains contain one to five possible phages, each ranging in size from 7.0 to 59.9 kb. In total, the six genomes have 18 phages with some of the phages falling into ...
... numbers of GIs indicate a complex history of gene recombination and horizontal transfer between bacterial relatives. The genomes of all strains contain one to five possible phages, each ranging in size from 7.0 to 59.9 kb. In total, the six genomes have 18 phages with some of the phages falling into ...
Worksheet 2
... The lowest position no. of these four numbers is: __________________ The highest position no. of these four numbers is: __________________ These two numbers stretch a region of how many nucleotides? __________________ Record the gi-number for this entry: _______________________________________ What ...
... The lowest position no. of these four numbers is: __________________ The highest position no. of these four numbers is: __________________ These two numbers stretch a region of how many nucleotides? __________________ Record the gi-number for this entry: _______________________________________ What ...
Comparative study of overlapping genes in bacteria, with special
... (Table 1). The frequent occurrence of the unidirectional overlapping structure probably reflects the commonest orientation of adjacent genes in the chromosomes, as prokaryotic genes are often organized into operons or clusters of genes that are transcribed together. Since all genes in an operon must ...
... (Table 1). The frequent occurrence of the unidirectional overlapping structure probably reflects the commonest orientation of adjacent genes in the chromosomes, as prokaryotic genes are often organized into operons or clusters of genes that are transcribed together. Since all genes in an operon must ...
Interacting Gene Clusters and the Evolution of the Vertebrate
... We identified interacting pairs and measured the genomic distance between each pair. For distances of 0–10 Mbp, we sorted the gene pairs into groups separated by 0–1, 1–2 2–3 Mbp, etc. (table 1). For each group, we compared the observed number of interacting pairs with the expected numbers, estimate ...
... We identified interacting pairs and measured the genomic distance between each pair. For distances of 0–10 Mbp, we sorted the gene pairs into groups separated by 0–1, 1–2 2–3 Mbp, etc. (table 1). For each group, we compared the observed number of interacting pairs with the expected numbers, estimate ...
The Genetics of Alcohol Metabolism
... moreover, there are variants (i.e., alleles) of some of these genes that encode enzymes with different characteristics and which have different ethnic distributions. Which ADH or ALDH alleles a person carries influence his or her level of alcohol consumption and risk of alcoholism. Researchers to da ...
... moreover, there are variants (i.e., alleles) of some of these genes that encode enzymes with different characteristics and which have different ethnic distributions. Which ADH or ALDH alleles a person carries influence his or her level of alcohol consumption and risk of alcoholism. Researchers to da ...
Copy-number variation
Copy-number variations (CNVs)—a form of structural variation—are alterations of the DNA of a genome that results in the cell having an abnormal or, for certain genes, a normal variation in the number of copies of one or more sections of the DNA. CNVs correspond to relatively large regions of the genome that have been deleted (fewer than the normal number) or duplicated (more than the normal number) on certain chromosomes. For example, the chromosome that normally has sections in order as A-B-C-D might instead have sections A-B-C-C-D (a duplication of ""C"") or A-B-D (a deletion of ""C"").This variation accounts for roughly 13% of human genomic DNA and each variation may range from about one kilobase (1,000 nucleotide bases) to several megabases in size. CNVs contrast with single-nucleotide polymorphisms (SNPs), which affect only one single nucleotide base.