STUDY REPORT
... Aclovate Ointment), a placebo (vehicle lotion), and four other already approved topical corticosteroids of ]mown potency. This study was conducted in 40 asymptomatic, healthy, non-tobacco using female subjects, who had been pre-screened to show a vasoconstrictor response to Aclovatea Cream, 0 .05% ( ...
... Aclovate Ointment), a placebo (vehicle lotion), and four other already approved topical corticosteroids of ]mown potency. This study was conducted in 40 asymptomatic, healthy, non-tobacco using female subjects, who had been pre-screened to show a vasoconstrictor response to Aclovatea Cream, 0 .05% ( ...
Solubility enhancement technique for an anti-malarial
... Optimised solid dispersions were further evaluated by XRD, DSC, and SEM. The release rate for pure Atovaquone was found to be 46.7% in 2 hours. This release rate was increased by using amino acid that is arginine in ratio 1:1:1 to 1:1:4. By keeping Arginine constant and only increasing polymer the d ...
... Optimised solid dispersions were further evaluated by XRD, DSC, and SEM. The release rate for pure Atovaquone was found to be 46.7% in 2 hours. This release rate was increased by using amino acid that is arginine in ratio 1:1:1 to 1:1:4. By keeping Arginine constant and only increasing polymer the d ...
gargantuan - American Academy of Dermatology
... Systemic absorption of clindamycin has been demonstrated following topical use of clindamycin. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin. If significant diarrhea occurs, ONEXTON Gel should be discon ...
... Systemic absorption of clindamycin has been demonstrated following topical use of clindamycin. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin. If significant diarrhea occurs, ONEXTON Gel should be discon ...
our guide to drug detox.
... because of the support you receive from the structure of the medical program, as well as the use of detox medications to help reduce the effects of withdrawal. Some people do attempt detox at home, although it’s important to understand that withdrawal symptoms for various drugs can be dangerous. It’ ...
... because of the support you receive from the structure of the medical program, as well as the use of detox medications to help reduce the effects of withdrawal. Some people do attempt detox at home, although it’s important to understand that withdrawal symptoms for various drugs can be dangerous. It’ ...
BENICAR HCT Prescribing Information
... incidence of adverse events similar to that of placebo. Adverse reactions were generally mild, transient and not dependent on the dose of olmesartan medoxomil and hydrochlorothiazide. The rate of withdrawals for adverse events in all trials of hypertensive patients was 2.0% (25/1243) on olmesartan m ...
... incidence of adverse events similar to that of placebo. Adverse reactions were generally mild, transient and not dependent on the dose of olmesartan medoxomil and hydrochlorothiazide. The rate of withdrawals for adverse events in all trials of hypertensive patients was 2.0% (25/1243) on olmesartan m ...
Roger`s Phat Pharm Notes II
... factors VII, IX, and X) of the intrinsic and extrinsic systems and of protein C. Actual mechanism is to block regeneration of KH2 (active hydroquinone form of Vit K) by an epoxide reductase. Delayed onset of action depending on drug pharmK and t1/2 of the 4 Vit K dep clotting factors, which must be ...
... factors VII, IX, and X) of the intrinsic and extrinsic systems and of protein C. Actual mechanism is to block regeneration of KH2 (active hydroquinone form of Vit K) by an epoxide reductase. Delayed onset of action depending on drug pharmK and t1/2 of the 4 Vit K dep clotting factors, which must be ...
Definition of Hazardous Drugs
... both; a carcinogen. The International Agency for Research on Cancer (IARC) classifies agents as carcinogens if they are capable of increasing the incidence of cancers, reducing the latency period before cancer development, or increasing the severity of growth of a malignancy. In some cases, an agent ...
... both; a carcinogen. The International Agency for Research on Cancer (IARC) classifies agents as carcinogens if they are capable of increasing the incidence of cancers, reducing the latency period before cancer development, or increasing the severity of growth of a malignancy. In some cases, an agent ...
The Safety of Stimulants
... The stimulants used to treat ADHD include methylphenidate, mixed salts of amphetamine (Adderall), dextroamphetamine sulfate (Dexedrine, Dextrostat) and, to a much lesser extent, pemoline (Cylert). The methylphenidates and amphetamines are available in short- and long-acting versions. In late 2002, E ...
... The stimulants used to treat ADHD include methylphenidate, mixed salts of amphetamine (Adderall), dextroamphetamine sulfate (Dexedrine, Dextrostat) and, to a much lesser extent, pemoline (Cylert). The methylphenidates and amphetamines are available in short- and long-acting versions. In late 2002, E ...
Schedule Y(ammended version)
... for humans shalls be described according to the animal models and species used. Wherever possible, doseresponse relationships and ED 50s shall be submitted. Special studies conducted to elucidate mode of action shall also be described (Appendix IV); (b) general pharmacological actions as prescribe ...
... for humans shalls be described according to the animal models and species used. Wherever possible, doseresponse relationships and ED 50s shall be submitted. Special studies conducted to elucidate mode of action shall also be described (Appendix IV); (b) general pharmacological actions as prescribe ...
APPLICATION OF UV SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF
... Two simple, sensitive, rapid, accurate and precise simultaneous UV-spectrophotometric methods have been developed and validated for the estimation of ciprofloxacin and tinidazole in bulk and combined tablet dosage form. The first method is based on simultaneous equation, for the determination of sam ...
... Two simple, sensitive, rapid, accurate and precise simultaneous UV-spectrophotometric methods have been developed and validated for the estimation of ciprofloxacin and tinidazole in bulk and combined tablet dosage form. The first method is based on simultaneous equation, for the determination of sam ...
Definitions Related to the Medical Use of Opioids: Evolution
... drug in the body such that increased doses are required to produce the pharmacologic effects initially resulting from smaller doses. Tolerance may be present in addiction, but it can also occur in the absence of addiction, as when drugs are used therapeutically over a period of time. Until recently, ...
... drug in the body such that increased doses are required to produce the pharmacologic effects initially resulting from smaller doses. Tolerance may be present in addiction, but it can also occur in the absence of addiction, as when drugs are used therapeutically over a period of time. Until recently, ...
50 years of oral lipid-based formulations
... In spite of considerable efforts to reduce physicochemical liabilities, and to design-in reasonable ‘developability’ characteristics in prospective drug candidates, discovery programmes continue to identify drugs with low water solubility, limited cellular permeability and high metabolic clearance—p ...
... In spite of considerable efforts to reduce physicochemical liabilities, and to design-in reasonable ‘developability’ characteristics in prospective drug candidates, discovery programmes continue to identify drugs with low water solubility, limited cellular permeability and high metabolic clearance—p ...
MDMA-Like Stimulus Effects of a-Ethyltryptamine and the cz
... rats (Table 1), and at least ce-EtT has been demonstrated to be an amphetamine-like stimulant in several species of animals (8). Taken together, these preliminary studies suggest that ce-EH DOM and ce-EtT may represent agents with varying degrees of DOM-like (possibly hallucinogenic), amphetamine-li ...
... rats (Table 1), and at least ce-EtT has been demonstrated to be an amphetamine-like stimulant in several species of animals (8). Taken together, these preliminary studies suggest that ce-EH DOM and ce-EtT may represent agents with varying degrees of DOM-like (possibly hallucinogenic), amphetamine-li ...
Lorazepam Drug Information
... overnight prior to dose and remained fasting for 3 hours post dose [4]. Venous blood samples were obtained prior to administration of the drug and at 5 min, 0.25, 0.5, 0.75, 1.0, 1.5, 2.0, 2.5, 3, 4, 6, 8, 12, 24, 30, 36 and 48 hr [4]. The table below shows effect of route on lorazepam pharmacokinet ...
... overnight prior to dose and remained fasting for 3 hours post dose [4]. Venous blood samples were obtained prior to administration of the drug and at 5 min, 0.25, 0.5, 0.75, 1.0, 1.5, 2.0, 2.5, 3, 4, 6, 8, 12, 24, 30, 36 and 48 hr [4]. The table below shows effect of route on lorazepam pharmacokinet ...
formulation development and stability studies of vitamin D3
... The term vitamin D actually refers to a pair of biologically inactive precursors of a critical micronutrient. They are vitamin D3, also known as Choleacalciferol, and vitamin D2 also known as Ergocalciferol. Choleacalciferol (D3) is produced in the skin by a photoreaction on exposure to UV light fro ...
... The term vitamin D actually refers to a pair of biologically inactive precursors of a critical micronutrient. They are vitamin D3, also known as Choleacalciferol, and vitamin D2 also known as Ergocalciferol. Choleacalciferol (D3) is produced in the skin by a photoreaction on exposure to UV light fro ...
Antidepressant Drugs - Vendor Drug Program
... The FDA requires that all antidepressant drugs display a black box warning describing the potential for increased suicidal thinking and behavior when prescribed to children and adolescents with MDD and other psychiatric disorders. In short-term clinical trials the suicide risk occurred twice as freq ...
... The FDA requires that all antidepressant drugs display a black box warning describing the potential for increased suicidal thinking and behavior when prescribed to children and adolescents with MDD and other psychiatric disorders. In short-term clinical trials the suicide risk occurred twice as freq ...
Recent advances in natural products from plants for
... to the clinical and provides the chemistry, pharmacology and future aspects, focus on hepatoprotective properties. Following this, it is hoped that as a result of this review, readers will have a greater awareness of the excellent promise that plant-derived natural products and their derivatives sho ...
... to the clinical and provides the chemistry, pharmacology and future aspects, focus on hepatoprotective properties. Following this, it is hoped that as a result of this review, readers will have a greater awareness of the excellent promise that plant-derived natural products and their derivatives sho ...
The BC Public Health Opiod Overdose Emergency
... Calls and Paramedic data (BCEHS); Emergency Department (ED) data from three Regional Health Authorities, and BC Coroners Service (BCCS) data on illicit drug deaths. It is important to understand that each data source captures overdose differently. BCCS defines apparent illicit drug overdose deaths a ...
... Calls and Paramedic data (BCEHS); Emergency Department (ED) data from three Regional Health Authorities, and BC Coroners Service (BCCS) data on illicit drug deaths. It is important to understand that each data source captures overdose differently. BCCS defines apparent illicit drug overdose deaths a ...
Antifungal Therapy During Pregnancy
... The azole class of systemic antifungals includes the imidazoles and the more recently introduced triazoles. These drugs have offered a less toxic alternative to amphotericin B for the treatment of many of the fungi that produce deep-seated infection. The azoles are active against a wide array of fun ...
... The azole class of systemic antifungals includes the imidazoles and the more recently introduced triazoles. These drugs have offered a less toxic alternative to amphotericin B for the treatment of many of the fungi that produce deep-seated infection. The azoles are active against a wide array of fun ...
DRUG NAME - BC Cancer Agency
... myelosuppression and has also been associated with the occurrence of secondary malignancies. Approximately 3% of whites and blacks express either a homozygous deletion or mutation of the TPMT gene.14 An estimated 10% of patients may be at increased risk for toxicity due to a heterozygous deletion or ...
... myelosuppression and has also been associated with the occurrence of secondary malignancies. Approximately 3% of whites and blacks express either a homozygous deletion or mutation of the TPMT gene.14 An estimated 10% of patients may be at increased risk for toxicity due to a heterozygous deletion or ...
LSD Psycholog Med final - Spiral
... such cases are rare and largely restricted to recreational use. Evidence does not support the view that psychedelics are harmful to mental health (Hendricks et al., 2015). Indeed, to the contrary, two recent population studies found decreased rates of suicidality and psychological distress among per ...
... such cases are rare and largely restricted to recreational use. Evidence does not support the view that psychedelics are harmful to mental health (Hendricks et al., 2015). Indeed, to the contrary, two recent population studies found decreased rates of suicidality and psychological distress among per ...
Apotex Launches First Generic Plavix®
... the part of Sanofi. Accordingly, Apotex has launched prior to trial so that patients and public and private health care payors can begin benefiting from a quality, low-cost alternative to Plavix® immediately rather than years from now." "There should be no mistaking," Sherman added "that our decisio ...
... the part of Sanofi. Accordingly, Apotex has launched prior to trial so that patients and public and private health care payors can begin benefiting from a quality, low-cost alternative to Plavix® immediately rather than years from now." "There should be no mistaking," Sherman added "that our decisio ...
Drug abuse treatment as an HIV prevention strategy
... as a whole, the trends in the data regarding needlesharing, needle-obtainment, and places of drug use were very similar. Unfortunately for the purposes of this review, the sub-sample was not compared with the sample of only those participants who had been in treatment for a longer period of time. It ...
... as a whole, the trends in the data regarding needlesharing, needle-obtainment, and places of drug use were very similar. Unfortunately for the purposes of this review, the sub-sample was not compared with the sample of only those participants who had been in treatment for a longer period of time. It ...
Non-respiratory functions of the lung
... non-inflammatory immune response against invading pathogens. This results in a reduction in the number and duration of chest infections in chronic obstructive pulmonary disease (COPD) patients.9 Recombinant interferon-g1b administered as an adjuvant along with anti-tuberculosis therapy has been show ...
... non-inflammatory immune response against invading pathogens. This results in a reduction in the number and duration of chest infections in chronic obstructive pulmonary disease (COPD) patients.9 Recombinant interferon-g1b administered as an adjuvant along with anti-tuberculosis therapy has been show ...
Chapter_021
... peripheral tissues Prolongs time that levodopa is available to the brain Increases levodopa availability by inhibiting COMT, which decreases production of levodopa metabolites that compete with levodopa for transport Adverse effects: from increasing levodopa levels ...
... peripheral tissues Prolongs time that levodopa is available to the brain Increases levodopa availability by inhibiting COMT, which decreases production of levodopa metabolites that compete with levodopa for transport Adverse effects: from increasing levodopa levels ...
Pharmaceutical industry
The pharmaceutical industry develops, produces, and markets drugs or pharmaceuticals for use as medications. Pharmaceutical companies may deal in generic or brand medications and medical devices. They are subject to a variety of laws and regulations that govern the patenting, testing, safety, efficacy and marketing of drugs.