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CHAPTER 2
CHAPTER 2

... described by adefinite volume and concentration of drug contained in that volume. In pharmacokinetics , experimental data are explained by fitting them to compartmental models. • Central compartment; the sum of all body regions( organs and tissue) in which the drug concentration is in instantaneous ...
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... Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling ...
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Designer Drugs
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... • HU-210 - because it is structurally similar to THC, Schedule 1 controlled substance • HU-211, CP 47,497, JWH-018 and JWH-073 - not currently controlled under the CSA ...
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Cardiology, Respiratory, Urology
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APPENDIX The Cytochrome P450 System
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Lecture 01 - Cal State LA

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... 3) Fasting plasma glucose level or hemoglobin A1c – before initiating a new antipsychotic, then yearly. If a patient has significant risk factors for diabetes and for those that are gaining weight – before initiating a new antipsychotic, 4 months after starting an antipsychotic, and then yearly. 4) ...
Chapter 2 - Test Bank Mango
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... A barbiturate may be prescribed for a variety of reasons, the list is extensive, but the most common use today is as an anesthesia for surgery. This form is hardly ever abused because they cause almost immediate unconsciousness. Other forms like Phenobarbital are used in treating various seizure dis ...
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... and results were expressed in DDDs/1000 inhabitants/day. The most frequently prescribed drug in 2003 and 2004 was enalapril (31.16 and 41.71DDDs/1000 inhabitants/day, respectively). The consumption of other ACE inhibitors was much less (7.36 and 10.83 DDDs/1000 inhabitants/ day, respectively). The n ...
REFERENCES
REFERENCES

... that ‘‘Linezolid could have played a key role’’. However, in our opinion, conclusions on the role of a single agent, such as linezolid, are difficult to draw from a series of cases without controls, in which every patient received linezolid in addition to an injectable antimycobacterial agent and a ...
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User`s ​​​Guide - BC Cancer Agency

... The Cancer Drug Manual provides concise, evaluative drug information on drugs used in an oncology setting. The first edition of the Cancer Drug Manual was published by BCCA in 1990, followed by a complete revision in 1994. Since 2001, the Cancer Drug Manual has become a continuously updated BCCA web ...
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Orphan drug

An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.In the US and EU it is easier to gain marketing approval for an orphan drug, and there may be other financial incentives, such as extended exclusivity periods, all intended to encourage the development of drugs which might otherwise lack a sufficient profit motive. The assignment of orphan status to a disease and to any drugs developed to treat it is a matter of public policy in many countries, and has resulted in medical breakthroughs that may not have otherwise been achieved due to the economics of drug research and development.According to Thomson Reuters in their 2012 publication ""The Economic Power of Orphan Drugs"", there has been increased investing in orphan drug Research and Development partly due to the U. S. Orphan Drug Act (ODA) 1983 and similar Acts in other regions of the world and also driven by ""high-profile philanthropic funding."" The period between 2001 to 2011 was the ""most productive period in the history of orphan drug development, in terms of average annual orphan drug designations and orphan drug approvals."" For the same decade the compound annual growth rate (CAGR) of the orphan drugs was an ""impressive 25.8 percent, compared to only 20.1 percent for a matched control group of non-orphan drugs."" By 2012 the market for orphan drugs was worth USD$637 million compared to the USD$638 million matched control group of non-orphan drugs, Thomson Reuters.By 2012, ""the revenue-generating potential of orphan drugs [was] as great as for non-orphan drugs, even though patient populations for rare diseases are significantly smaller. Moreover, we suggest that orphan drugs have greater profitability when considered in the full context of developmental drivers including government financial incentives, smaller clinical trial sizes, shorter clinical trial times and higher rates of regulatory success.""
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