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Drugs: dilemmas, choices and the law (summary)
Drugs: dilemmas, choices and the law (summary)

... risky behaviour, such as injecting or smoking heroin, is more often linked with neighbourhoods experiencing multiple disadvantage. Drugs may also be easier to obtain and harder to control in areas where there are fewer legitimate ways to make money. While drug choices are shaped by social and econom ...
medicationsstudentvers
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“THERE ARE MANY WAYS OF PRACTICING THE HEALING ART
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Medications That Interact With What Does the Evidence Say?
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E4 Neurotransmitters and synapses trs
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Can psychedelic drugs play a role in palliative care?
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IND Checklist
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... The drug combination has been approved by the FDA for marketing in the United States – i.e., the drug combination has been described as a part of each individual drug’s FDA approved label. ___ Yes ___ No Note: Consultation with the FDA may be needed at the discretion of the IRB, for example, if the ...
Drug Discovery from Plants
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Policy XI.B
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Bioavailability And First-Pass Metabolism
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... usual effective hepatic blood flow is 1.5 L/min, but it may vary from 1 to 2 L/min depending on diet, food intake, physical activity or drug intake For the drug propoxyphene hydrochloride, F' has been calculated from hepatic clearance (990 ml/min) and an assumed liver blood flow of 1.53 L/min: ...
Bioavailability And First-Pass Metabolism
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UV-Spectrophotometric Estimation of Ranitidine
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2016 Aetna Rx Step Program Medicine List
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CHAPTER 2
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... described by adefinite volume and concentration of drug contained in that volume. In pharmacokinetics , experimental data are explained by fitting them to compartmental models. • Central compartment; the sum of all body regions( organs and tissue) in which the drug concentration is in instantaneous ...
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Orphan drug

An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.In the US and EU it is easier to gain marketing approval for an orphan drug, and there may be other financial incentives, such as extended exclusivity periods, all intended to encourage the development of drugs which might otherwise lack a sufficient profit motive. The assignment of orphan status to a disease and to any drugs developed to treat it is a matter of public policy in many countries, and has resulted in medical breakthroughs that may not have otherwise been achieved due to the economics of drug research and development.According to Thomson Reuters in their 2012 publication ""The Economic Power of Orphan Drugs"", there has been increased investing in orphan drug Research and Development partly due to the U. S. Orphan Drug Act (ODA) 1983 and similar Acts in other regions of the world and also driven by ""high-profile philanthropic funding."" The period between 2001 to 2011 was the ""most productive period in the history of orphan drug development, in terms of average annual orphan drug designations and orphan drug approvals."" For the same decade the compound annual growth rate (CAGR) of the orphan drugs was an ""impressive 25.8 percent, compared to only 20.1 percent for a matched control group of non-orphan drugs."" By 2012 the market for orphan drugs was worth USD$637 million compared to the USD$638 million matched control group of non-orphan drugs, Thomson Reuters.By 2012, ""the revenue-generating potential of orphan drugs [was] as great as for non-orphan drugs, even though patient populations for rare diseases are significantly smaller. Moreover, we suggest that orphan drugs have greater profitability when considered in the full context of developmental drivers including government financial incentives, smaller clinical trial sizes, shorter clinical trial times and higher rates of regulatory success.""
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