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Anabolic Steroids
Anabolic Steroids

... Anabolic steroids are a diverse group of drugs that mimic, to varying degrees, the actions of endogenous testosterone. For the last 50 years the use of these drugs within elite sport (along with a diverse number of other performance-enhancing substances) has been a concern for sports authorities. In ...
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complete IDD M Pharm Syllabus
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... E. Papaverini hydrochloridum 18. Which drug decreases the demand in oxygen due to the blockade of the sympathetic innervation? A. Molsidomin B. * Atenolol C. Pentoxiphylline D. Papaverinum E. Nitroglycerine 19. An efficiency of beta-adrenoblockers at angina pectoris is explained by A. * The removal ...
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... Humans have been using drugs of all kinds and sorts for more than thousands of years. At first, newly discovered substances were unregulated and drugs were freely prescribed by doctors and physicians. Sometimes the drugs were used as medicine but the drugs were often taken for nonmedical reasons. Wh ...
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Orphan drug

An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.In the US and EU it is easier to gain marketing approval for an orphan drug, and there may be other financial incentives, such as extended exclusivity periods, all intended to encourage the development of drugs which might otherwise lack a sufficient profit motive. The assignment of orphan status to a disease and to any drugs developed to treat it is a matter of public policy in many countries, and has resulted in medical breakthroughs that may not have otherwise been achieved due to the economics of drug research and development.According to Thomson Reuters in their 2012 publication ""The Economic Power of Orphan Drugs"", there has been increased investing in orphan drug Research and Development partly due to the U. S. Orphan Drug Act (ODA) 1983 and similar Acts in other regions of the world and also driven by ""high-profile philanthropic funding."" The period between 2001 to 2011 was the ""most productive period in the history of orphan drug development, in terms of average annual orphan drug designations and orphan drug approvals."" For the same decade the compound annual growth rate (CAGR) of the orphan drugs was an ""impressive 25.8 percent, compared to only 20.1 percent for a matched control group of non-orphan drugs."" By 2012 the market for orphan drugs was worth USD$637 million compared to the USD$638 million matched control group of non-orphan drugs, Thomson Reuters.By 2012, ""the revenue-generating potential of orphan drugs [was] as great as for non-orphan drugs, even though patient populations for rare diseases are significantly smaller. Moreover, we suggest that orphan drugs have greater profitability when considered in the full context of developmental drivers including government financial incentives, smaller clinical trial sizes, shorter clinical trial times and higher rates of regulatory success.""
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