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DNA AND PROTEIN SYNTHESIS
DNA AND PROTEIN SYNTHESIS

... (methionine) to the ribosome. • Each tRNA carries one type of amino acid. • The anticodon (three nitrogen bases on tRNA) must complement codon for amino acid to be added to protein chain ...
Structure and Properties of Proteins
Structure and Properties of Proteins

lec07_2013 - Andrew.cmu.edu
lec07_2013 - Andrew.cmu.edu

... free rotation about the bond is not possible since the pz orbitals of oxygen, carbon, and nitrogen form a delocalized system. Rotation about the peptide bond would break the interaction between the pz orbital of the nitrogen and carbon atoms, and is therefore unfavorable. The peptide bond is said to ...
A genetically programmable protein module as
A genetically programmable protein module as

ABC Name: Final Exam Review for the final exam Using your notes
ABC Name: Final Exam Review for the final exam Using your notes

... What does it mean for a compound to be organic? Water is ___________________________ because the electrons are not evenly shared. Provide two properties of water. What is the difference between a monomer and a polymer? Dehydration synthesis is a reaction that ______________________ water to ________ ...
Chapter 3 USU - BEHS Science
Chapter 3 USU - BEHS Science

... Many biological molecules are macromolecules – huge assemblies of atoms. Biological macromolecules are formed by linking together a set of building blocks (monomers) into long chains (a polymer). ...
Active pharmaceutical ingredients and amino acids as building
Active pharmaceutical ingredients and amino acids as building

... properties of ILs, and more recently the chemical properties, the toxicity, a biological property, has been one of the most highly debated topics in this field.1 Indeed, toxicity is also a tunable property of ILs, and given the similarities between many common IL building blocks and active pharmaceu ...
protein
protein

... Important concepts from previous units: • Amino Acids are the building block macromolecules of proteins. • Amino acids are linked together by covalent peptide bonds in a dehydration reaction. • Proteins have to be folded in order to work; this involves hydrogen bonds (2’) and disulfide bridges (3’) ...
General Biology Notes CH 12: TRANSLATION A.K.A. PROTEIN
General Biology Notes CH 12: TRANSLATION A.K.A. PROTEIN

... into a sequence of amino acids that makes up proteins. ...
Click here to go back
Click here to go back

... Three types of RNA  Messenger ...
translation ppt
translation ppt

... specified by the next codon binds to the codon. A peptide bond forms between adjacent amino acids The ribosome moves the tRNA and mRNA. ...
2.22 Protein Synthesis.docx
2.22 Protein Synthesis.docx

... polypeptide. As shown below, this is a fairly involved process. DNA contains the genetic code that is used as a template to create mRNA in a process known as transcription. The mRNA then moves out of the nucleus into the cytoplasm where it serves as the template for translation, where tRNAs bring in ...
All Living things pass on their genetic heritage by common
All Living things pass on their genetic heritage by common

... Transcription of DNA sequences into RNA’s RNA polymerase makes a single stranded RNA transcript from one strand of the unwound DNA helix. Activated A, U, G and C ribonucleotide triphosphates base pair with the DNA and are linked by the RNA polymerase into RNA polynucleotides. RNA transcripts 1. rRNA ...
Translation
Translation

... and polypeptide synthesis ends. - the polypeptide is released from the tRNA. - the tRNA is released from the ribosome, the two ribosomal subunits separate from the mRNA. http://www.phschool.com/science/biology_place/biocoach/translation/term.html ...
File - Ms Hotchin SCSC
File - Ms Hotchin SCSC

... join by amide links these are similar to polyesters in that they can form homopolymers and copolymers. • What is meant by homopolymers and copolymers? And what is the difference between functional groups in these polymers? ...
PPT 2 Biochem
PPT 2 Biochem

... a) They speed the rate at which reactions approach equilibrium` ...
Slide 1
Slide 1

Polypeptide Chain Synthesis: A Paper Simulation
Polypeptide Chain Synthesis: A Paper Simulation

...  Involves a dehydration synthesis.  Involves a chemical reaction that occurs between two specific areas of the amino acid.  Requires an –OH group and an –H from another –OH group ...
Nucleic Acid Notes
Nucleic Acid Notes

... Folding occurs as protein is synthesized, but physical/chemical environment plays a role DENATURATION: = unraveling/ loss of native confirmation • makes proteins biologically inactive ~ Reason high fevers can be fatal • • does NOT break peptide bonds • so primary structure remains intact • may regai ...
Organic Chemistry
Organic Chemistry

... waxes, oils, fats, steroids (cholesterol & sex hormones) important structural component of the cell membrane (phospholipid) Saturated fats contain no double bonds ...
Translation
Translation

... there is also a small 5s rRNA that helps link the subunits (and a 5.8s rRNA in eukaryotes) e, rRNA is coded by multiple genes in the genome the genes are tandomly arrayed, one after the other with a short spacer between (7 copies in E. coli, many copies in eukaryotes where they form the nucleolus). ...
Mass Spectrometry of Peptides
Mass Spectrometry of Peptides

... Arg-X X-Asp Phe-X, Tyr-X, Trp-X, Leu-X X-Phe, X-Leu, X-Ile, X-Met, X-Val, X-Ala ...
Revealing the Genetic Code
Revealing the Genetic Code

... Gene = sequence of nucleotides (bases) Protein = sequence of amino acids Sequence of bases determines  sequence of amino acids (protein’s primary structure) Protein’s primary structure determines  its secondary & tertiary (3D) structures Protein’s 3D structure determines its function!! ...
Chapter 4
Chapter 4

Lecture 4 - Sites@UCI
Lecture 4 - Sites@UCI

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Bottromycin



Bottromycin is a macrocyclic peptide with antibiotic activity. It was first discovered in 1957 as a natural product isolated from Streptomyces bottropensis. It has been shown to inhibit methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) among other Gram-positive bacteria and mycoplasma. Bottromycin is structurally distinct from both vancomycin, a glycopeptide antibiotic, and methicillin, a beta-lactam antibiotic.Bottromycin binds to the A site of the ribosome and blocks the binding of aminoacyl-tRNA, therefore inhibiting bacterial protein synthesis. Although bottromycin exhibits antibacterial activity in vitro, it has not yet been developed as a clinical antibiotic, potentially due to its poor stability in blood plasma. To increase its stability in vivo, some bottromycin derivatives have been explored.The structure of bottromycin contains a macrocyclic amidine as well as a thiazole ring. The absolute stereochemistry at several chiral centers has been determined as of 2009. In 2012, a three-dimensional solution structure of bottromycin was published. The solution structure revealed that several methyl groups are on the same face of the structure.Bottromycin falls within the ribosomally synthesized and post-translationally modified peptide class of natural product.
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