CFTR Mutations in Congenital Absence of Vas Deferens
... found that the partial penetrance can be explained by another genetic factor, namely the polymorphic TGm locus in front of the Tn locus (11). Different alleles can be found depending on the number of TG repeats found at this locus. The higher number of TG repeats, the less efficient exon 9 splicing ...
... found that the partial penetrance can be explained by another genetic factor, namely the polymorphic TGm locus in front of the Tn locus (11). Different alleles can be found depending on the number of TG repeats found at this locus. The higher number of TG repeats, the less efficient exon 9 splicing ...
Genetics: Mendelian Genetics (1) Patterns of Inheritance
... A Few Genetics Terms Gene – function unit codes some trait. Alleles - one of alternative forms of a particular ...
... A Few Genetics Terms Gene – function unit codes some trait. Alleles - one of alternative forms of a particular ...
Loss of Hox-A1 (Hox-1.6) function results in the
... with 20 µg/ml proteinase K for 7.5 minutes, acetylated, and hybridized under conditions described by Frohman et al. (1990). The probe used was a 35S-labeled antisense RNA probe complementary to the DNA sequence of the hox-B1 gene encompassing nucleotides 889-1173 (Frohman et al., 1990). This sequenc ...
... with 20 µg/ml proteinase K for 7.5 minutes, acetylated, and hybridized under conditions described by Frohman et al. (1990). The probe used was a 35S-labeled antisense RNA probe complementary to the DNA sequence of the hox-B1 gene encompassing nucleotides 889-1173 (Frohman et al., 1990). This sequenc ...
Adenosine triphosphate Adenosine triphosphate Adenosine
... does not involve molecular oxygen, it is an obligately aerobic process because O2 is needed to recycle the reduced NADH and FADH2 to their oxidized states. In the absence of oxygen the citric acid cycle will cease to function due to the lack of available NAD+ and FAD.[23] The generation of ATP by th ...
... does not involve molecular oxygen, it is an obligately aerobic process because O2 is needed to recycle the reduced NADH and FADH2 to their oxidized states. In the absence of oxygen the citric acid cycle will cease to function due to the lack of available NAD+ and FAD.[23] The generation of ATP by th ...
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... Prior to sequencing, RNA amount and quality were quantified by capillary electrophoresis on a microchip device (BioAnalyzer 2100, Agilent). Samples with the RNA integrity number (RIN) of at least nine were chosen for further analysis. RNA sequencing was carried out at the Institute of Applied Genomi ...
... Prior to sequencing, RNA amount and quality were quantified by capillary electrophoresis on a microchip device (BioAnalyzer 2100, Agilent). Samples with the RNA integrity number (RIN) of at least nine were chosen for further analysis. RNA sequencing was carried out at the Institute of Applied Genomi ...
Characterization of an Immuno-dominant Variable Surface
... genomic AZAPII clones as described previously (41) . Phage DNA and plasmid DNA were purified by standard methods (42) . Sequence Analysis. With the exception of the first 207 bp, the entire sequence of gene M17 presented in Fig. 3 was determined on both strands in genomic clone pBSgM17-1 and on one ...
... genomic AZAPII clones as described previously (41) . Phage DNA and plasmid DNA were purified by standard methods (42) . Sequence Analysis. With the exception of the first 207 bp, the entire sequence of gene M17 presented in Fig. 3 was determined on both strands in genomic clone pBSgM17-1 and on one ...
biolsci.org - International Journal of Biological Sciences
... ThiE catalyzes the THZ-P and HMP-PP to yield ThMP. The solved ThiE crystal structures of B. subtilis and M. tuberculosis (http://hdl.handle.net/1813/ 13623) have similar structure [58]. It is dimer and has an α/β structure with a TIM barrel fold and a core of eight β-strands flanked by eight α-helic ...
... ThiE catalyzes the THZ-P and HMP-PP to yield ThMP. The solved ThiE crystal structures of B. subtilis and M. tuberculosis (http://hdl.handle.net/1813/ 13623) have similar structure [58]. It is dimer and has an α/β structure with a TIM barrel fold and a core of eight β-strands flanked by eight α-helic ...
COMPUTATIONAL MODELING OF CHARGE TRANSFER IN NUCLEOBASE-AROMATIC AMINO ACID COMPLEXES Cristina BUTCHOSA ROBLES
... states are also called electron ”holes”. Electron holes can migrate long distances through the nucleobases stack, due to conductivity properties of DNA. Finally, the cationic charge could be trapped and most probably a mutagenic lesion will be initiated. However, if DNA interacts with a protein or p ...
... states are also called electron ”holes”. Electron holes can migrate long distances through the nucleobases stack, due to conductivity properties of DNA. Finally, the cationic charge could be trapped and most probably a mutagenic lesion will be initiated. However, if DNA interacts with a protein or p ...
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... binding) and an N-terminal, signal peptide (that is required for paracrine secretion) with the prototypical members, FGF1 and 2 (Ornitz and Itoh 2001). During embryonic and fetal development of the mouse, Fgf5 is first expressed in the extraembryonic ectoderm of the epiblast and then restricted to d ...
... binding) and an N-terminal, signal peptide (that is required for paracrine secretion) with the prototypical members, FGF1 and 2 (Ornitz and Itoh 2001). During embryonic and fetal development of the mouse, Fgf5 is first expressed in the extraembryonic ectoderm of the epiblast and then restricted to d ...
International Agency for Research on Cancer (IARC)
... fish. Administration to rats and fish of aflatoxicol, yet another metabolite of aflatoxin B1, induced hepatocellular carcinomas in both species; the tumour incidence was lower than that in animals treated with aflatoxin B1 at the same dose level. A large number of experiments have been carried out i ...
... fish. Administration to rats and fish of aflatoxicol, yet another metabolite of aflatoxin B1, induced hepatocellular carcinomas in both species; the tumour incidence was lower than that in animals treated with aflatoxin B1 at the same dose level. A large number of experiments have been carried out i ...
Modifying the stereochemistry of an enzyme
... here is a growing demand in the chemical and biotechnology industries for reliable and efficient methods for the production of enantiomerically pure compounds. Increasingly, synthetic chemists are exploiting enzymes in the asymmetric and stereoselective synthesis of chiral building blocks (1). Howev ...
... here is a growing demand in the chemical and biotechnology industries for reliable and efficient methods for the production of enantiomerically pure compounds. Increasingly, synthetic chemists are exploiting enzymes in the asymmetric and stereoselective synthesis of chiral building blocks (1). Howev ...
Selection in backcross programmes
... (drought) but the introgression had no visible effect in the absence of stress. Bouchez et al. (2002) performed the introgression of favourable alleles at three QTL for two traits (earliness and yield) between maize elite lines with markerassisted backcrossing. They showed that the use of markers to ...
... (drought) but the introgression had no visible effect in the absence of stress. Bouchez et al. (2002) performed the introgression of favourable alleles at three QTL for two traits (earliness and yield) between maize elite lines with markerassisted backcrossing. They showed that the use of markers to ...
A role for wingless in the segmental gradient of Drosophila?
... metric; in both thorax and abdomen, the denticles of each segment are oriented towards a central mirror plane. The mirror plane runs through the middle of the belt, irrespective of the belt size (compare, for example, T1 with T2 in Fig. 2C). Furthermore, each belt is symmetrical with respect to the ...
... metric; in both thorax and abdomen, the denticles of each segment are oriented towards a central mirror plane. The mirror plane runs through the middle of the belt, irrespective of the belt size (compare, for example, T1 with T2 in Fig. 2C). Furthermore, each belt is symmetrical with respect to the ...
trigger - Bioconductor
... trait) data. exp.pos: A matrix with m rows and 3 columns containing the chromosome number, gene start and gene end for all the genes in the gene expression matrix. The rows of exp.pos should match those of exp. marker: A matrix with p rows and n columns, containing genotyping information. marker.pos ...
... trait) data. exp.pos: A matrix with m rows and 3 columns containing the chromosome number, gene start and gene end for all the genes in the gene expression matrix. The rows of exp.pos should match those of exp. marker: A matrix with p rows and n columns, containing genotyping information. marker.pos ...
Microbiology
... are JN604516–JN604530. A set of supplementary methods, two supplementary figures, showing multiple sequence alignments of OmpLC nucleotide and amino acid sequences from 15 Edwardsiella ictaluri strains, and a supplementary table, listing oligonucleotides used in this study, are available with the on ...
... are JN604516–JN604530. A set of supplementary methods, two supplementary figures, showing multiple sequence alignments of OmpLC nucleotide and amino acid sequences from 15 Edwardsiella ictaluri strains, and a supplementary table, listing oligonucleotides used in this study, are available with the on ...
IMPROVING THE INHIBITORY POTENCY OF PAPAYA CYSTATIN, USING SITE-DIRECTED MUTAGENESIS
... Structural comparisons have shown that plant cystatins range between 11 to 16 kDa in size (but can also be 23 kDa and even up to 87 kDa has been found for multi-domain plant cystatins) (Oliveira et al, 2003; Mosolov and Valueva, 2005). Structural similarities of plant cystatins to some animal cystat ...
... Structural comparisons have shown that plant cystatins range between 11 to 16 kDa in size (but can also be 23 kDa and even up to 87 kDa has been found for multi-domain plant cystatins) (Oliveira et al, 2003; Mosolov and Valueva, 2005). Structural similarities of plant cystatins to some animal cystat ...
Clinical Findings in Chromosome Aberrations
... omphalocele congenital heart defects renal malformations, large bladder due to urethral obstruction, abnormal male genitalia cleft lip and palate holoprosencephaly and other brain malformations hexadactyly, radial hypo-/aplasia ...
... omphalocele congenital heart defects renal malformations, large bladder due to urethral obstruction, abnormal male genitalia cleft lip and palate holoprosencephaly and other brain malformations hexadactyly, radial hypo-/aplasia ...
Gene replacement with the human BRCA1 locus
... tissues of several TgN´BRCA1 lines and examined the expression of human BRCA1 protein. Human BRCA1 protein, is expressed in TgN´BRCA1GEN transgenic mice and responds to ionizing radiation Proteins extracted from the testis were analysed by immuno-precipitation followed by immuno-blotting with specie ...
... tissues of several TgN´BRCA1 lines and examined the expression of human BRCA1 protein. Human BRCA1 protein, is expressed in TgN´BRCA1GEN transgenic mice and responds to ionizing radiation Proteins extracted from the testis were analysed by immuno-precipitation followed by immuno-blotting with specie ...
Dysfunction of Wild-Type Huntingtin in Huntington
... Huntingtin is the protein involved in Huntington disease (HD), an inherited neurodegenerative disease. Research activities have focused on the abnormal functions of mutant huntingtin. However, recent results indicate that wild-type huntingtin has important activities in brain neurons, suggesting tha ...
... Huntingtin is the protein involved in Huntington disease (HD), an inherited neurodegenerative disease. Research activities have focused on the abnormal functions of mutant huntingtin. However, recent results indicate that wild-type huntingtin has important activities in brain neurons, suggesting tha ...
Mosaic: A Position-Effect Variegation Eye
... DNA in polytene chromosomes has been seen ( Karpen and Spradling 1990). In general, no genotypic differences are believed to exist between variegating genes in cell clusters in which the gene is expressed and those in which it is not. Rather the molecular basis of suppression of gene activity is due ...
... DNA in polytene chromosomes has been seen ( Karpen and Spradling 1990). In general, no genotypic differences are believed to exist between variegating genes in cell clusters in which the gene is expressed and those in which it is not. Rather the molecular basis of suppression of gene activity is due ...
06_Metabolism of lipid
... Acetyl CoA carboxylase is switched off by phosphorylation and activated by dephosphorylation Insulin stimulates fatty acid synthesis causing dephosphorylation of carboxylase. Glucagon and epinephrine have the reverse effect (keep the carboxylase in the inactive phosphorylated state). Protein kinase ...
... Acetyl CoA carboxylase is switched off by phosphorylation and activated by dephosphorylation Insulin stimulates fatty acid synthesis causing dephosphorylation of carboxylase. Glucagon and epinephrine have the reverse effect (keep the carboxylase in the inactive phosphorylated state). Protein kinase ...
Nature inspired platforms for production of acetyl
... fertilizers, and pesticides, which burden the environment2. Ethanol has the additional problems of containing ~70% of the energy content of gasoline and is miscible with water, making it difficult to distill from fermentation broth and corrosive to storage and distribution infrastructures3. Advanced ...
... fertilizers, and pesticides, which burden the environment2. Ethanol has the additional problems of containing ~70% of the energy content of gasoline and is miscible with water, making it difficult to distill from fermentation broth and corrosive to storage and distribution infrastructures3. Advanced ...
The Bacterial Toxin RelE Displays Codon
... At a RelE concentration four times less than the concentration of ribosomes that were competent in dipeptide formation (Zavialov et al., 2001; Experimental Procedures), peptide synthesis from the mRNA with UAG as stop codon was completely blocked by the toxin. With twenty times less RelE than active ...
... At a RelE concentration four times less than the concentration of ribosomes that were competent in dipeptide formation (Zavialov et al., 2001; Experimental Procedures), peptide synthesis from the mRNA with UAG as stop codon was completely blocked by the toxin. With twenty times less RelE than active ...