Two novel heterozygous mutations of EVC2 cause a mild phenotype
... only associated with the last exon of EVC2 [Ye et al., 2006; Valencia et al., 2009]. This exclusive association with exon 22 of EVC2 suggests specific residues encoded by this exon are a key part of the protein, and the Weyer variants may be related to a negative effect on Hedgehog signaling. Protei ...
... only associated with the last exon of EVC2 [Ye et al., 2006; Valencia et al., 2009]. This exclusive association with exon 22 of EVC2 suggests specific residues encoded by this exon are a key part of the protein, and the Weyer variants may be related to a negative effect on Hedgehog signaling. Protei ...
Journal of Bacteriology
... strain induced similar plant responses. However, it was not shown whether the same or different factors were produced at high and low bacterial concentrations (2). The substitution of exudate by the single compound naringenin allows us to control Tsr factor synthesis more precisely and to start the ...
... strain induced similar plant responses. However, it was not shown whether the same or different factors were produced at high and low bacterial concentrations (2). The substitution of exudate by the single compound naringenin allows us to control Tsr factor synthesis more precisely and to start the ...
Positive and Negative Selection on Noncoding
... For our data set, given that we sequenced both chromosomes of each of the 15 M. m. castaneus individuals, the sampled number of alleles (n) was 30 if the sequencing was successful for every individual. However, due to sequencing failures, our data set did not contain 30 sequenced alleles for each si ...
... For our data set, given that we sequenced both chromosomes of each of the 15 M. m. castaneus individuals, the sampled number of alleles (n) was 30 if the sequencing was successful for every individual. However, due to sequencing failures, our data set did not contain 30 sequenced alleles for each si ...
Cloning and sequencing of the kedarcidin biosynthetic
... ATCC 53650 cosmid library, resulting in the isolation of cosmid pBS16002. Iterations of chromosomal walking from pBS16002 using probe-2, -3, -4, and -5 afforded the four additional overlapping cosmids pBS16003, pBS16004, pBS16005, and pBS16006. Together, the five overlapping cosmids cover 135 kb of c ...
... ATCC 53650 cosmid library, resulting in the isolation of cosmid pBS16002. Iterations of chromosomal walking from pBS16002 using probe-2, -3, -4, and -5 afforded the four additional overlapping cosmids pBS16003, pBS16004, pBS16005, and pBS16006. Together, the five overlapping cosmids cover 135 kb of c ...
- Journal of Clinical Neurology
... gradually progressed over 10 years, and he found it very difficult to stand or to climb stairs. ...
... gradually progressed over 10 years, and he found it very difficult to stand or to climb stairs. ...
DNA Methylation Analysis
... resolution focused on 144 established cancer genes that have shown differential methylation patterns. To ensure the most important loci were represented, Illumina designed markers to cover nearly 1,000 cancer-related genes described in published literature. Of all genes represented on the HumanMethy ...
... resolution focused on 144 established cancer genes that have shown differential methylation patterns. To ensure the most important loci were represented, Illumina designed markers to cover nearly 1,000 cancer-related genes described in published literature. Of all genes represented on the HumanMethy ...
Osmoadaptation mechanisms in prokaryotes
... Summary. Microorganisms respond to osmotic stress mostly by accumulating compatible solutes, either by uptake from the medium or by de novo synthesis. These osmotically active molecules preserve the positive turgor pressure required for cell division. The diversity of compatible solutes is large but ...
... Summary. Microorganisms respond to osmotic stress mostly by accumulating compatible solutes, either by uptake from the medium or by de novo synthesis. These osmotically active molecules preserve the positive turgor pressure required for cell division. The diversity of compatible solutes is large but ...
Support Vector Machine-based classification of protein folds using
... their accuracies remain low. This can be attributed to insufficient exploitation of fold discriminatory features. Results: We have developed a new method for protein fold recognition using structural information of amino acid residues and amino acid residue pairs. Since protein fold recognition can ...
... their accuracies remain low. This can be attributed to insufficient exploitation of fold discriminatory features. Results: We have developed a new method for protein fold recognition using structural information of amino acid residues and amino acid residue pairs. Since protein fold recognition can ...
Highly Recurrent RET Mutations and Novel Mutations in
... we generated new pairs of primers (Table 1). PCR products were sequenced using an ABI PRISM® Big DyeTM Terminator, Ver. 2.0, Cycle sequencing assay (Applied Biosystems) and an ABI 3100 automated sequencer (Applied Biosystems). For those samples in which a DNA sequence variation was observed, PCR amp ...
... we generated new pairs of primers (Table 1). PCR products were sequenced using an ABI PRISM® Big DyeTM Terminator, Ver. 2.0, Cycle sequencing assay (Applied Biosystems) and an ABI 3100 automated sequencer (Applied Biosystems). For those samples in which a DNA sequence variation was observed, PCR amp ...
A Physical Gene Map of the Bacteriophage P22 Late
... DNA (5.22 kb; Fiers et al., 1978) or pBR322 form II dimer (8.72 kb; Sutcliffe, 1978) DNA was present in all samples as -an internal length standard. Recombination and complementation of P22 mutants with cloned fragments of P22 DNA. Plasmid DNA containing cloned P22 fragments was isolated from E. col ...
... DNA (5.22 kb; Fiers et al., 1978) or pBR322 form II dimer (8.72 kb; Sutcliffe, 1978) DNA was present in all samples as -an internal length standard. Recombination and complementation of P22 mutants with cloned fragments of P22 DNA. Plasmid DNA containing cloned P22 fragments was isolated from E. col ...
Powerpoint - ChemConnections
... archived in DNA. •Hundreds of amino acids link together with amide (peptide) bonds to form proteins, which are the machinery for the chemistry of life. •There are less than 20,000 total proteins produced from humans’ entire genome, each coded by a specific gene in DNA’s ~3 billion genetic bases. ...
... archived in DNA. •Hundreds of amino acids link together with amide (peptide) bonds to form proteins, which are the machinery for the chemistry of life. •There are less than 20,000 total proteins produced from humans’ entire genome, each coded by a specific gene in DNA’s ~3 billion genetic bases. ...
Epigenetic changes in the estrogen receptor α gene
... accumulating evidence suggests that rapid non-genomic actions of ERα initiated at the plasma membrane through induction of protein phosphorylation-mediated signal transduction pathways are also crucial in estrogenic responses (Vasudevan and Pfaff, 2008; Sakamoto et al., 2012). These characteristics ...
... accumulating evidence suggests that rapid non-genomic actions of ERα initiated at the plasma membrane through induction of protein phosphorylation-mediated signal transduction pathways are also crucial in estrogenic responses (Vasudevan and Pfaff, 2008; Sakamoto et al., 2012). These characteristics ...
CH Zinc Fingers As DNA Binding Domains
... Data are taken from Pfam 9.0 a t Washington Uninversity i n St. Louis. *The number is f o r proteins containing two C2C2 fingers. finger proteins can be divided into four classes (Fig. 2), (A) single C2H2, (B) triple C2H2, (C) multiple-adjacent C2H2, and (D) separated-paired C2H2 zinc finger protein ...
... Data are taken from Pfam 9.0 a t Washington Uninversity i n St. Louis. *The number is f o r proteins containing two C2C2 fingers. finger proteins can be divided into four classes (Fig. 2), (A) single C2H2, (B) triple C2H2, (C) multiple-adjacent C2H2, and (D) separated-paired C2H2 zinc finger protein ...
ppt - Chair of Computational Biology
... Enzymes that catalyze more than one reaction Genome predictions usually assign a single enzymatic function. However, E.coli is known to contain many multifunctional enzymes. Of the 607 E.coli enzymes, 100 are multifunctional, either having the same active site and different substrate specificities ...
... Enzymes that catalyze more than one reaction Genome predictions usually assign a single enzymatic function. However, E.coli is known to contain many multifunctional enzymes. Of the 607 E.coli enzymes, 100 are multifunctional, either having the same active site and different substrate specificities ...
Large-Scale Chromosomal Changes
... b. Cytologically, duplications lead to longer chromosomes and, depending on the type, unique pairing structures during meiosis when heterozygous. These may be simple unpaired loops or more complicated twisted loop structures. Genetically, duplications can lead to asymmetric pairing and unequal cross ...
... b. Cytologically, duplications lead to longer chromosomes and, depending on the type, unique pairing structures during meiosis when heterozygous. These may be simple unpaired loops or more complicated twisted loop structures. Genetically, duplications can lead to asymmetric pairing and unequal cross ...
ANALYSIS OF MULTIPLE RESTRICTION FRAGMENT LENGTH
... probes and containing an insert of 14 .5 kb, termed XGSB 16.1, was restriction mapped (Fig. 1 B) . The Pvu II-Bam HI fragment, GB2PE, which contained neither human repeats nor CRI-1- and CRI-4-like sequences, hybridized to the 14.5-kb Bam HI fragment characteristic ofan S allele and to nonallelic fr ...
... probes and containing an insert of 14 .5 kb, termed XGSB 16.1, was restriction mapped (Fig. 1 B) . The Pvu II-Bam HI fragment, GB2PE, which contained neither human repeats nor CRI-1- and CRI-4-like sequences, hybridized to the 14.5-kb Bam HI fragment characteristic ofan S allele and to nonallelic fr ...
Cambridge Workshop November 2008
... What is ‘Community Curation’? – Annotation/revision of data in FlyBase by fly researchers ...
... What is ‘Community Curation’? – Annotation/revision of data in FlyBase by fly researchers ...
Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin
... homolog of the viral oncogene v-mpl present in the rnyeloof the porcine TPO gene were isolated by screening a pig genomic proliferative leukemia virus (MPLV).’ The receptor bears library (EMBL3; Clontech Inc, Palo Alto, CA) with pR45, a previously described oligonucleotide probe? This probe was deri ...
... homolog of the viral oncogene v-mpl present in the rnyeloof the porcine TPO gene were isolated by screening a pig genomic proliferative leukemia virus (MPLV).’ The receptor bears library (EMBL3; Clontech Inc, Palo Alto, CA) with pR45, a previously described oligonucleotide probe? This probe was deri ...
Computational Tools For Protein Modeling
... A multiple sequence alignment aligns several sequences to obtain the best commonality among them. It is the foundation for identification of functionally important regions, building sequence profile for further sequence search, protein family classification, phylogenetic reconstruction, etc. The con ...
... A multiple sequence alignment aligns several sequences to obtain the best commonality among them. It is the foundation for identification of functionally important regions, building sequence profile for further sequence search, protein family classification, phylogenetic reconstruction, etc. The con ...
Scheme I Supplementary Material Available: Detailed
... make an efficient stereospecific synthesis of these analogues highly desirable. Most previous syntheses of 1 have involved reduction of a-diazo ester^,^ nitrosation and reduction of a-amino acids,1° Hofmann rearrangement of a-ureido acids,*," or treatment of a-halo carboxylic acids with hydrazine.I2 ...
... make an efficient stereospecific synthesis of these analogues highly desirable. Most previous syntheses of 1 have involved reduction of a-diazo ester^,^ nitrosation and reduction of a-amino acids,1° Hofmann rearrangement of a-ureido acids,*," or treatment of a-halo carboxylic acids with hydrazine.I2 ...