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... Once the amide nitrogen in compounds 1 or 4 gets deprotonated (Scheme 2) its nucleophilicity seems to be high and the formed five-membered ring is energetically favoured. As the chlorine in acyl chlorides 4 represents a good leaving group the reaction demands conditions only slightly above room temp ...
... Once the amide nitrogen in compounds 1 or 4 gets deprotonated (Scheme 2) its nucleophilicity seems to be high and the formed five-membered ring is energetically favoured. As the chlorine in acyl chlorides 4 represents a good leaving group the reaction demands conditions only slightly above room temp ...
The role of Dby mRNA in early development of male mouse zygotes
... Sigma (St. Louis, MO, USA). To inactivate the RNase, glasswares were autoclaved and baked, whereas plastic containers and solutions were treated with diethylpyrocarbonate (DEPC). The capacitated spermatozoa of C57BL/6j mice were first spread on polylysine-coated glass slides at 37ºC for 1 h. The sli ...
... Sigma (St. Louis, MO, USA). To inactivate the RNase, glasswares were autoclaved and baked, whereas plastic containers and solutions were treated with diethylpyrocarbonate (DEPC). The capacitated spermatozoa of C57BL/6j mice were first spread on polylysine-coated glass slides at 37ºC for 1 h. The sli ...
- Journal of Clinical Investigation
... He noted that the embryos of the zebrafish are transparent, and that fertilization is external, so that all stages of development are accessible. Development is rapid, with a heart beating by the end of the first day and most organs, or at least their primordia, in place by five days after fertiliza ...
... He noted that the embryos of the zebrafish are transparent, and that fertilization is external, so that all stages of development are accessible. Development is rapid, with a heart beating by the end of the first day and most organs, or at least their primordia, in place by five days after fertiliza ...
INTERMEDIARY METABOLISM
... From these studies it was concluded that purines are synthesized de novo not as free purines but first as the nucleotide inosinic acid (hypoxanthine-ribose-5'-phosphate), which is then converted into the adenine and guanine nucleotides. ...
... From these studies it was concluded that purines are synthesized de novo not as free purines but first as the nucleotide inosinic acid (hypoxanthine-ribose-5'-phosphate), which is then converted into the adenine and guanine nucleotides. ...
The phosphopantetheinyl transferases
... defects in YejM, a membrane protein with unknown function. Even more baffling, AcpT did not need to be a catalytically active enzyme to rescue the yejM-defective E. coli strain (see Section 3.1).17 More broadly, in family II PPTases, the genes encoding the PPTase oen reside in close proximity to, or ...
... defects in YejM, a membrane protein with unknown function. Even more baffling, AcpT did not need to be a catalytically active enzyme to rescue the yejM-defective E. coli strain (see Section 3.1).17 More broadly, in family II PPTases, the genes encoding the PPTase oen reside in close proximity to, or ...
Patent constraints
... Stanford University and an early organizer of the sequencing project. 2 "Our goal — and I say we're going to reach it in the next decade — is to understand plants like little machines. And we're going to use it to do real engineering.” I guess he meant patent applications… 2 Also co-founder, Directo ...
... Stanford University and an early organizer of the sequencing project. 2 "Our goal — and I say we're going to reach it in the next decade — is to understand plants like little machines. And we're going to use it to do real engineering.” I guess he meant patent applications… 2 Also co-founder, Directo ...
unexpected consequences for sense codon reassignment
... Modification of tRNA is widespread and essential for the proper functioning of the translational apparatus in all kingdoms of life. In Escherichia coli (E. coli), one of the three model systems for which the full extent of modifications has been mapped, the 46 tRNA species contain an average of 7.5 ...
... Modification of tRNA is widespread and essential for the proper functioning of the translational apparatus in all kingdoms of life. In Escherichia coli (E. coli), one of the three model systems for which the full extent of modifications has been mapped, the 46 tRNA species contain an average of 7.5 ...
CHAPTER 12 Chromosomal Basis of Inheritance, Sex linkage
... a. Metacentric means the centromere is approximately in the center of the chromosome, producing two equal arms. b. Submetacentric means one arm is somewhat longer than the other. c. Acrocentric chromosomes have one long arm and a short stalk and often a bulb (satellite) as the other arm. ...
... a. Metacentric means the centromere is approximately in the center of the chromosome, producing two equal arms. b. Submetacentric means one arm is somewhat longer than the other. c. Acrocentric chromosomes have one long arm and a short stalk and often a bulb (satellite) as the other arm. ...
Taste Blind? - URMC - University of Rochester
... Collected DNA samples from each member of the family (1-10) shown in the pedigree on the previous page. Used a special laboratory technique called PCR (polymerase chain reaction) to make copies of the PTC alleles for each family member. Placed these PTC gene allele copies into different wells ...
... Collected DNA samples from each member of the family (1-10) shown in the pedigree on the previous page. Used a special laboratory technique called PCR (polymerase chain reaction) to make copies of the PTC alleles for each family member. Placed these PTC gene allele copies into different wells ...
Integration of omics data with biochemical reaction
... Printing: Háskólaprent, Fálkagata 2, 107 Reykjavik Reykjavik, Iceland, June 2014 ...
... Printing: Háskólaprent, Fálkagata 2, 107 Reykjavik Reykjavik, Iceland, June 2014 ...
Towards Programmable Molecular Machines
... due to its small size and “combinatorial” nature – you can change the sequence of a DNA molecule without affecting its double helical structure. Many nano-machines based on DNA have been proposed and demonstrated [16, 2, 6, 7, 10, 14, 13]. We believe theoretical techniques and algorithmic analysis c ...
... due to its small size and “combinatorial” nature – you can change the sequence of a DNA molecule without affecting its double helical structure. Many nano-machines based on DNA have been proposed and demonstrated [16, 2, 6, 7, 10, 14, 13]. We believe theoretical techniques and algorithmic analysis c ...
meiosis - juan
... Three events are unique to meiosis, and all three occur in meiosis l – Synapsis and crossing over in prophase I: Homologous chromosomes physically connect and exchange genetic information – At the metaphase plate, there are paired homologous chromosomes (tetrads), instead of individual replicated ch ...
... Three events are unique to meiosis, and all three occur in meiosis l – Synapsis and crossing over in prophase I: Homologous chromosomes physically connect and exchange genetic information – At the metaphase plate, there are paired homologous chromosomes (tetrads), instead of individual replicated ch ...
M2 RNA Pol Ⅰ genes
... linked gene from the correct start site. • activate transcription when placed in either orientation with respect to linked genes • Able to function over long distances of more than 1 kb whether from an upstream or downstream position relative to the start site. • Exert preferential stimulation of th ...
... linked gene from the correct start site. • activate transcription when placed in either orientation with respect to linked genes • Able to function over long distances of more than 1 kb whether from an upstream or downstream position relative to the start site. • Exert preferential stimulation of th ...
Biology: Concepts and Connections, 6e
... 47) A scientist suspects that the food in an ecosystem may have been contaminated with radioactive nitrogen over a period of months. Which of the following substances could be examined for radioactivity to test the hypothesis? A) the cell walls of plants growing in the ecosystem B) the hair produced ...
... 47) A scientist suspects that the food in an ecosystem may have been contaminated with radioactive nitrogen over a period of months. Which of the following substances could be examined for radioactivity to test the hypothesis? A) the cell walls of plants growing in the ecosystem B) the hair produced ...
Complete
... In microfluidic approaches for manipulating biological molecules, the conventional test tubes and pipettes are replaced by miniaturized plumbing channels (with 0.1- to 100µm dimensions) etched into the surface of a wafer using methods borrowed from the integrated circuit industry, such as photolitho ...
... In microfluidic approaches for manipulating biological molecules, the conventional test tubes and pipettes are replaced by miniaturized plumbing channels (with 0.1- to 100µm dimensions) etched into the surface of a wafer using methods borrowed from the integrated circuit industry, such as photolitho ...
Genetics WWTBAM 1
... carrier of the recessive haemophilia gene, which is sex-linked. What proportion of their offspring could have the condition? ...
... carrier of the recessive haemophilia gene, which is sex-linked. What proportion of their offspring could have the condition? ...
Gene Section NQO1 (NAD(P)H dehydrogenase, quinone 1) Atlas of Genetics and Cytogenetics
... NQO1 in certain tumors, this has led to an interest in designing compounds which can be efficiently bioactivated by NQO1 as antitumor agents. ...
... NQO1 in certain tumors, this has led to an interest in designing compounds which can be efficiently bioactivated by NQO1 as antitumor agents. ...
sex chromosomes in flowering plants
... (Maloisel and Rossignol, 2006). Suppression of genetic recombination has been documented for primitive and advanced sex chromosomes (Westergaard, 1958; Ohno, 1967; Ma et al., 2004). The papaya sex locus has been genetically mapped to linkage group 1 (Sondur et al., 1996). In a recently constructed h ...
... (Maloisel and Rossignol, 2006). Suppression of genetic recombination has been documented for primitive and advanced sex chromosomes (Westergaard, 1958; Ohno, 1967; Ma et al., 2004). The papaya sex locus has been genetically mapped to linkage group 1 (Sondur et al., 1996). In a recently constructed h ...
EVOLUTIONARY GENETICS AND GENETIC VARIATION OF
... with genetic drift or gene flow, the impact may be less. With selection also acting in males, heterozygous advantage in females is neither a necessary nor a sufficient condition for a stable polymorphism. Figure 2a (after 124) gives the example for haplodiploids or X-linked genes where there is hete ...
... with genetic drift or gene flow, the impact may be less. With selection also acting in males, heterozygous advantage in females is neither a necessary nor a sufficient condition for a stable polymorphism. Figure 2a (after 124) gives the example for haplodiploids or X-linked genes where there is hete ...
Unveiling the physiological and molecular basis of Mycobacterium
... presence of dormant populations of non-growing cells that reactivate during host immunosuppression. Bacterial biofilms, described as single or multispecies communities triggered by cell-density dependent Quorum-Sensing (QS) events, exhibit heterogeneous and stress-tolerant populations that thrive un ...
... presence of dormant populations of non-growing cells that reactivate during host immunosuppression. Bacterial biofilms, described as single or multispecies communities triggered by cell-density dependent Quorum-Sensing (QS) events, exhibit heterogeneous and stress-tolerant populations that thrive un ...
Involvement of Endogenous Retroviruses in Prion Diseases
... remains to be elucidated [24–28]. Consequently, many proviral sequences are negatively selected and carry a large number of mutations. Otherwise, they could be partially excised from the genome by a recombinational deletion process [29]. Although a large percentage of ERVs are replication-defective ...
... remains to be elucidated [24–28]. Consequently, many proviral sequences are negatively selected and carry a large number of mutations. Otherwise, they could be partially excised from the genome by a recombinational deletion process [29]. Although a large percentage of ERVs are replication-defective ...
mammalian hibernation: biochemical adaptation
... the fattening period. This suggests that animals remain sensitive to leptin in the prehibernating phase, but the production of leptin has been inhibited or dissociated from the normal signals that indicate rising adiposity probably in response to overriding seasonal controls on body mass set point. ...
... the fattening period. This suggests that animals remain sensitive to leptin in the prehibernating phase, but the production of leptin has been inhibited or dissociated from the normal signals that indicate rising adiposity probably in response to overriding seasonal controls on body mass set point. ...
Chapter 12 Patterns of Inheritance
... of two traits, without blending When Mendel crossed white-flowered and purple-flowered plants, the hybrid offspring he obtained did not have flowers of inter- mediate color, as the hypothesis of blending inheritance would predict. Instead, in every case the flower color of the offspring resembled t ...
... of two traits, without blending When Mendel crossed white-flowered and purple-flowered plants, the hybrid offspring he obtained did not have flowers of inter- mediate color, as the hypothesis of blending inheritance would predict. Instead, in every case the flower color of the offspring resembled t ...
Full-Text PDF
... amino acid metabolism, assembly of Fe/S clusters and gluconeogenesis. They also control stress responses, in particular the oxidative stress response via reactive oxygen species (ROS) and calcium Ca2+ storage (rewiewed in [1] and references therein). They play a central role in aging [2] and are sub ...
... amino acid metabolism, assembly of Fe/S clusters and gluconeogenesis. They also control stress responses, in particular the oxidative stress response via reactive oxygen species (ROS) and calcium Ca2+ storage (rewiewed in [1] and references therein). They play a central role in aging [2] and are sub ...
Consulta: subjectFacets:"Phenotype" Registros recuperados: 25
... Significant advances recently occurred in Coffea canephora research, such as the completion of its full genome sequencing. The information generated can be used in advanced molecular approaches for genetic improvement, like genome-wide selection programs (GWS). The purpose of this study was the phen ...
... Significant advances recently occurred in Coffea canephora research, such as the completion of its full genome sequencing. The information generated can be used in advanced molecular approaches for genetic improvement, like genome-wide selection programs (GWS). The purpose of this study was the phen ...