Biochemical and Biophysical Research Communications
... germicidal activity to gram-positive bacteria such as Staphylococcus aureus [3,4]. In addition, they have antifungal activity against Leptosphaeria maculans, which causes black root rot of canola [5]. The amino acid chain of fusaricidin is not ribosomally synthesized by encoding, as are other genera ...
... germicidal activity to gram-positive bacteria such as Staphylococcus aureus [3,4]. In addition, they have antifungal activity against Leptosphaeria maculans, which causes black root rot of canola [5]. The amino acid chain of fusaricidin is not ribosomally synthesized by encoding, as are other genera ...
Primers BSHG06 - National Genetics Reference Laboratories
... We have developed a prototype specification for validated primer design and optimisation and have demonstrated its utility in the context of a fully automated sample processing system. We have also implemented an automated optimisation pipeline that will expedite the development of new primer set ...
... We have developed a prototype specification for validated primer design and optimisation and have demonstrated its utility in the context of a fully automated sample processing system. We have also implemented an automated optimisation pipeline that will expedite the development of new primer set ...
Ch. 25
... Because most biological oxidations involve the loss of hydrogen atoms, they are called dehydrogenation reactions. • When a substance is oxidized, the liberated hydrogen atoms do not remain free in the cell but are transferred immediately by coenzymes to another compound. • Reduction is the opposite ...
... Because most biological oxidations involve the loss of hydrogen atoms, they are called dehydrogenation reactions. • When a substance is oxidized, the liberated hydrogen atoms do not remain free in the cell but are transferred immediately by coenzymes to another compound. • Reduction is the opposite ...
Congenital adrenal hyperplasia syndrome and testicular
... Partial androgen insensitivity syndrome (PAIS): mildly virilized female external genitalia (clitorimegaly without other external anomalies) to mildly undervirilized male external genitalia (hypospadias and/or diminished penile size) ...
... Partial androgen insensitivity syndrome (PAIS): mildly virilized female external genitalia (clitorimegaly without other external anomalies) to mildly undervirilized male external genitalia (hypospadias and/or diminished penile size) ...
The Evolution of Populations
... is adaptive (and even less often, both adaptive and dominant or codominant), i.e., novel functions or novel expression of old functions "On rare occasions, however, a mutant allele may actually fit its bearer to the environment better and enhance the reproductive success of the individual. This is ...
... is adaptive (and even less often, both adaptive and dominant or codominant), i.e., novel functions or novel expression of old functions "On rare occasions, however, a mutant allele may actually fit its bearer to the environment better and enhance the reproductive success of the individual. This is ...
No Evidence of Neandertal mtDNA Contribution to Early Modern
... and 40 early modern human fossils (Table S1). Several important Neandertal fossils, such as La Ferrassie and Krapina, as well as important modern human fossils, such as Veternica, proved to be too poorly preserved to be likely to allow DNA retrieval. Thus, further destructive sampling of these speci ...
... and 40 early modern human fossils (Table S1). Several important Neandertal fossils, such as La Ferrassie and Krapina, as well as important modern human fossils, such as Veternica, proved to be too poorly preserved to be likely to allow DNA retrieval. Thus, further destructive sampling of these speci ...
The degenerate Y chromosome – can
... of two damaged chromosomes. In the Y chromosome, the non-recombining MSY region therefore undergoes mutation, deletion, insertion of retroposons and amplification of repetitive sequences (Charlesworth 1991). It rapidly degrades, losing active genes. It might be expected that selection would preserve ...
... of two damaged chromosomes. In the Y chromosome, the non-recombining MSY region therefore undergoes mutation, deletion, insertion of retroposons and amplification of repetitive sequences (Charlesworth 1991). It rapidly degrades, losing active genes. It might be expected that selection would preserve ...
Crystallization and X-Ray Crystallographic Studies of Wild
... P21 with unit cell dimensions (Table 1), and gave a better defined diffraction pattern than the wild-type crystals. The asymmetric unit contained two molecules of αTS, giving a crystal volume per protein mass (Vm) of 2.15 Å3 Da−1 and a solvent content of 42.95% for the wild-type. The P28L/Y173F crys ...
... P21 with unit cell dimensions (Table 1), and gave a better defined diffraction pattern than the wild-type crystals. The asymmetric unit contained two molecules of αTS, giving a crystal volume per protein mass (Vm) of 2.15 Å3 Da−1 and a solvent content of 42.95% for the wild-type. The P28L/Y173F crys ...
Development of triplet repeat primed PCR (TP
... 14q32.1 (normal alleles - 12 to 44 CAG repeats, mutated alleles - above 52 CAG repeats). This late onset disorder, the most common from its group, presents a high prevalence in the Azores, especially in Flores Island. MJD molecular testing is based on PCR and automated capillary electrophoresis. How ...
... 14q32.1 (normal alleles - 12 to 44 CAG repeats, mutated alleles - above 52 CAG repeats). This late onset disorder, the most common from its group, presents a high prevalence in the Azores, especially in Flores Island. MJD molecular testing is based on PCR and automated capillary electrophoresis. How ...
CHAPTER 14
... for oxygen is greatly enhanced. This phenomenon, called cooperativity, makes hemoglobin a particularly suitable substance for the uptake of oxygen in the lungs. By the same token, once a fully oxygenated hemoglobin molecule releases an oxygen molecule (to myoglobin in the tissues), the other three o ...
... for oxygen is greatly enhanced. This phenomenon, called cooperativity, makes hemoglobin a particularly suitable substance for the uptake of oxygen in the lungs. By the same token, once a fully oxygenated hemoglobin molecule releases an oxygen molecule (to myoglobin in the tissues), the other three o ...
AAV-mediated Gene Therapy Restores Cone Function In A Rat With
... at capsid position 733 (AAV8-733) with the same promoter driving a rat M-opsin cDNA. One microliter of each vector containing 1010 vector genomes was subretinally injected into one eye of a cohort of 30 mutant rats, respectively at postnatal day 14 (P14). At 2 months posttreatment the therapeutic ef ...
... at capsid position 733 (AAV8-733) with the same promoter driving a rat M-opsin cDNA. One microliter of each vector containing 1010 vector genomes was subretinally injected into one eye of a cohort of 30 mutant rats, respectively at postnatal day 14 (P14). At 2 months posttreatment the therapeutic ef ...
Mcp7, a meiosis-specific coiled-coil protein of fission yeast
... mnd1-null mutant arrests in meiotic prophase with most DSBs unrepaired and homolog pairing severely reduced (23). Mnd1 is suggested to be involved in strand invasion since mnd1-1 mutant cells initiated recombination but did not form heteroduplex DNA or Holliday junctions (24). We report here the fun ...
... mnd1-null mutant arrests in meiotic prophase with most DSBs unrepaired and homolog pairing severely reduced (23). Mnd1 is suggested to be involved in strand invasion since mnd1-1 mutant cells initiated recombination but did not form heteroduplex DNA or Holliday junctions (24). We report here the fun ...
Krebs Cycle
... Because most biological oxidations involve the loss of hydrogen atoms, they are called dehydrogenation reactions. • When a substance is oxidized, the liberated hydrogen atoms do not remain free in the cell but are transferred immediately by coenzymes to another compound. • Reduction is the opposite ...
... Because most biological oxidations involve the loss of hydrogen atoms, they are called dehydrogenation reactions. • When a substance is oxidized, the liberated hydrogen atoms do not remain free in the cell but are transferred immediately by coenzymes to another compound. • Reduction is the opposite ...
Opposite deletions/duplications of the X chromosome: two
... factor VIII, of the IDS gene and of the FLN1/emerin region, all resulting from misalignment of inverted repeats, and double recombination. Most of these inversions are of paternal origin possibly because the X chromosome at male meiosis is free to refold into itself for most of its length. We report ...
... factor VIII, of the IDS gene and of the FLN1/emerin region, all resulting from misalignment of inverted repeats, and double recombination. Most of these inversions are of paternal origin possibly because the X chromosome at male meiosis is free to refold into itself for most of its length. We report ...
A rare and atypical female pseudohermaphroditism with phallic
... Adrenal tumor, ingestion of the virilizing progestine compounds, ovarian tumor, and luteoma of pregnancy (an ovarian pseudotumor which disappears after pregnancy) are some of the factors which cause increased level of androgens in the mother during gestation leading to female pseudohermaphroditism[8 ...
... Adrenal tumor, ingestion of the virilizing progestine compounds, ovarian tumor, and luteoma of pregnancy (an ovarian pseudotumor which disappears after pregnancy) are some of the factors which cause increased level of androgens in the mother during gestation leading to female pseudohermaphroditism[8 ...
Arabidopsis is a model for seed plants (Angiosperms)
... 1989. Cloning of first gene by insertional mutagenesis. T-DNA of Agrobacterium tumefaciens as the mutagen. 1992. First Arabidopsis genes isolated by positional cloning. ...
... 1989. Cloning of first gene by insertional mutagenesis. T-DNA of Agrobacterium tumefaciens as the mutagen. 1992. First Arabidopsis genes isolated by positional cloning. ...
Site-Specific Integration of Transgenes in
... All events were then evaluated by four constructspecific qPCR analyses (Fig. 1) to check for DNA recombination at the FRT1 site and the presence of the target, donor, and flp DNA (Table II), followed by five border-specific PCR analyses specific to each target line using the 5# border, 3# border, an ...
... All events were then evaluated by four constructspecific qPCR analyses (Fig. 1) to check for DNA recombination at the FRT1 site and the presence of the target, donor, and flp DNA (Table II), followed by five border-specific PCR analyses specific to each target line using the 5# border, 3# border, an ...
Chapter_7
... – If some properties of the sample protein(s) are known (like mass, pI, amino acid composition, species of origin), one can filter database sequences not satisfying these properties – However, using some of these can be risky if it is not taken into account that the database entry can contain other ...
... – If some properties of the sample protein(s) are known (like mass, pI, amino acid composition, species of origin), one can filter database sequences not satisfying these properties – However, using some of these can be risky if it is not taken into account that the database entry can contain other ...
Chapter 3 - GEOCITIES.ws
... C. Proteins and carbohydrates D. DNA and RNA E. None of the above are correct 38. What term means that a molecule does not like to mix with ...
... C. Proteins and carbohydrates D. DNA and RNA E. None of the above are correct 38. What term means that a molecule does not like to mix with ...
Hydrodynamic Studies on the Manganese
... In higher plants, three extrinsic proteins, with apparent molecular masses of 33, 24, and 17 kDa, are required for high rates of oxygen evolution at physiological inorganic cofactor concentrations. In cyanobacteria, only the 33 kDa component is present with the functions of the 23 and 17 kDa protein ...
... In higher plants, three extrinsic proteins, with apparent molecular masses of 33, 24, and 17 kDa, are required for high rates of oxygen evolution at physiological inorganic cofactor concentrations. In cyanobacteria, only the 33 kDa component is present with the functions of the 23 and 17 kDa protein ...
Annex 1
... subsequently to the application, which gives a detailed disclosure of the nucleotide and/or amino acid sequences and other available information; (ii) sequences which are included are any unbranched sequences of four or more amino acids or unbranched sequences of ten or more nucleotides. Branched se ...
... subsequently to the application, which gives a detailed disclosure of the nucleotide and/or amino acid sequences and other available information; (ii) sequences which are included are any unbranched sequences of four or more amino acids or unbranched sequences of ten or more nucleotides. Branched se ...
Extrachromosomal DNA Transformationof Caenorhabditis elegans
... amount of pBR322 hybridization expected for each worm DNA preparation if the plasmid sequences were present in one copy per genome (see Table 2). The percentage of transformed worms in each population was used to derive the copy number per genome per transformant. It should be noted that the copy nu ...
... amount of pBR322 hybridization expected for each worm DNA preparation if the plasmid sequences were present in one copy per genome (see Table 2). The percentage of transformed worms in each population was used to derive the copy number per genome per transformant. It should be noted that the copy nu ...
Analysis of Selection, Mutation and Recombination in Genetic
... De ne a genetic representation of the problem Create an initial population P (0)P= x01 : : : x0N Compute the average tness F = Ni F(xi)=N. Assign each individual the normalized tness value F(xti)=F Assign each xi a probability p(xi t) proportional to its normalized tness. Using this distributi ...
... De ne a genetic representation of the problem Create an initial population P (0)P= x01 : : : x0N Compute the average tness F = Ni F(xi)=N. Assign each individual the normalized tness value F(xti)=F Assign each xi a probability p(xi t) proportional to its normalized tness. Using this distributi ...
lecture - Department of Molecular & Cell Biology
... led him to propose that two "hits" or mutagenic events were necessary for retinoblastoma development. Retinoblastoma occurs sporadically in most cases, but in some families it displays autosomal dominant inheritance. In an individual with the inherited form of the disease, Knudson proposed that the ...
... led him to propose that two "hits" or mutagenic events were necessary for retinoblastoma development. Retinoblastoma occurs sporadically in most cases, but in some families it displays autosomal dominant inheritance. In an individual with the inherited form of the disease, Knudson proposed that the ...
Point mutation
A point mutation, or single base modification, is a type of mutation that causes a single nucleotide base change, insertion, or deletion of the genetic material, DNA or RNA. The term frameshift mutation indicates the addition or deletion of a base pair. A point mutant is an individual that is affected by a point mutation.Repeat induced point mutations are recurring point mutations, discussed below.