Patent Protection for the Protein Products of Recombinant DNA
... Because of the tremendous investments of labor and capital required to produce "first-generation" recombinant proteins1 4 - those resulting from the identification, isolation, and expression of a native cellular gene- it is not surprising that the biotechnology industry has ag15 gressively sought pa ...
... Because of the tremendous investments of labor and capital required to produce "first-generation" recombinant proteins1 4 - those resulting from the identification, isolation, and expression of a native cellular gene- it is not surprising that the biotechnology industry has ag15 gressively sought pa ...
Statistical analysis of DNA microarray data
... The term threading was first coined by Jones, Taylor and Thornton in 1992, and originally referred specifically to the use of a full 3-D structure atomic representation of the protein template in fold recognition. Today, the terms threading and fold recognition are frequently (though somewhat incorr ...
... The term threading was first coined by Jones, Taylor and Thornton in 1992, and originally referred specifically to the use of a full 3-D structure atomic representation of the protein template in fold recognition. Today, the terms threading and fold recognition are frequently (though somewhat incorr ...
Chromosome Theory
... Syndrome, extra chromosome 21, tends to be the most viable Down’s Syndrome is more common in children of mothers who gave birth after age 40 ©1999 Timothy G. Standish ...
... Syndrome, extra chromosome 21, tends to be the most viable Down’s Syndrome is more common in children of mothers who gave birth after age 40 ©1999 Timothy G. Standish ...
Gene Expression Programming: A New Adaptive
... are composed of one or more genes of equal length. Therefore the length of a gene is also fixed. Thus, in GEP, what varies is not the length of genes (which is constant) but the length of the ORFs. Indeed, the length of an ORF may be equal to or less than the length of the gene. In the first case, t ...
... are composed of one or more genes of equal length. Therefore the length of a gene is also fixed. Thus, in GEP, what varies is not the length of genes (which is constant) but the length of the ORFs. Indeed, the length of an ORF may be equal to or less than the length of the gene. In the first case, t ...
A Single Amino Acid Change in the SPRY Domain of Human Trim5
... OMK Trim5␣ (V6), which contained the owl monkey SPRY domain in place of CypA, was inactive against both HIV-1 and MLV [20]. To further probe the role of SPRY in CA recognition and binding, we asked if the SPRY domain from rhesus Trim5␣ could rescue the restriction activity of OMK Trim5 V6. Replacing ...
... OMK Trim5␣ (V6), which contained the owl monkey SPRY domain in place of CypA, was inactive against both HIV-1 and MLV [20]. To further probe the role of SPRY in CA recognition and binding, we asked if the SPRY domain from rhesus Trim5␣ could rescue the restriction activity of OMK Trim5 V6. Replacing ...
Determination of free amino acids in cheeses from the Czech market
... Derivatising the calibration standard – The derivatisation procedure involved preheating of the heating block to 55°C and tube mixing of 10 µl of the calibration standard + 70 µl AccQ•Fluor Borate Buffer in a tube, then mixeing the mixture with Vortex briefly, the addition of 20 µl, reconstituted Ac ...
... Derivatising the calibration standard – The derivatisation procedure involved preheating of the heating block to 55°C and tube mixing of 10 µl of the calibration standard + 70 µl AccQ•Fluor Borate Buffer in a tube, then mixeing the mixture with Vortex briefly, the addition of 20 µl, reconstituted Ac ...
EXTENDED CONCEPT OF KNOWLEDGE FOR EVOLUTIONARY
... If a gene cannot simply be identified with some DNA-string, the idea of genetic reductionism becomes muddled. However, it is not at all clear what kind of 'meaning' associated within a DNA-string makes it a gene, and what or who could be that 'somebody' (and in what sense). There is a real danger to ...
... If a gene cannot simply be identified with some DNA-string, the idea of genetic reductionism becomes muddled. However, it is not at all clear what kind of 'meaning' associated within a DNA-string makes it a gene, and what or who could be that 'somebody' (and in what sense). There is a real danger to ...
Technical standards and guidelines for spinal muscular atrophy testing
... affected patients, whereas the remaining patients have nonsense, frameshift, or missense mutations within the gene.16 Based on Hardy-Weinberg equilibrium, the remaining patients (with the smaller types of mutations) are virtually all assumed to be hemizygous for the SMN1 deletion. The absence of SMN ...
... affected patients, whereas the remaining patients have nonsense, frameshift, or missense mutations within the gene.16 Based on Hardy-Weinberg equilibrium, the remaining patients (with the smaller types of mutations) are virtually all assumed to be hemizygous for the SMN1 deletion. The absence of SMN ...
The Amino Acid Sequence Contains Leucine-Rich
... terminal sequences of seven K peptides (Kl-7), eight M peptides (Ml-8), and two Th peptides (Thl and 2) are shown in Table 3. The link of K5 to K6 was established by analysis of M2. Peptide M8 was considered to be included within the sequence of K5. Peptides M3 and M4 were initially isolated as a mi ...
... terminal sequences of seven K peptides (Kl-7), eight M peptides (Ml-8), and two Th peptides (Thl and 2) are shown in Table 3. The link of K5 to K6 was established by analysis of M2. Peptide M8 was considered to be included within the sequence of K5. Peptides M3 and M4 were initially isolated as a mi ...
D:\My Documents\WordPerfect\WordPerfect 8.0\2001Report
... phenotype and reviewed the sensitivity of individuals with such genetic diseases to radiation-induced cancers. The material contained in Annex G, “Hereditary effects of radiation”, and Annex E, “Mechanisms of radiation oncogenesis”, of the UNSCEAR 1993 Report broadly defines the scope of this Annex ...
... phenotype and reviewed the sensitivity of individuals with such genetic diseases to radiation-induced cancers. The material contained in Annex G, “Hereditary effects of radiation”, and Annex E, “Mechanisms of radiation oncogenesis”, of the UNSCEAR 1993 Report broadly defines the scope of this Annex ...
Gene Codon Composition Determines Differentiation
... further that KCs substantially change their tRNA profiles upon differentiation. Aminoacyl-tRNAs from differentiated KCs but not undifferentiated KCs enhanced the translation of authentic L1 mRNA, suggesting that differentiation-associated change to tRNA profiles enhances L1 expression in differentia ...
... further that KCs substantially change their tRNA profiles upon differentiation. Aminoacyl-tRNAs from differentiated KCs but not undifferentiated KCs enhanced the translation of authentic L1 mRNA, suggesting that differentiation-associated change to tRNA profiles enhances L1 expression in differentia ...
Medical Genetics
... The A allele codes for an enzyme that adds N-acetylgalactosamine to the precursor H A antigen. The O allele codes for a mutant version of the transferase that lacks transferase activity, does not detectably affect H substance at all. ...
... The A allele codes for an enzyme that adds N-acetylgalactosamine to the precursor H A antigen. The O allele codes for a mutant version of the transferase that lacks transferase activity, does not detectably affect H substance at all. ...
RNAi in Plants: An Argonaute-Centered View
... proteins (Wu et al., 2009), following the 59 nucleotide-directed loading rule. However, regardless of the identities of their 59 nucleotides, DCL3-dependent lmiRNAs are recruited by AGO4 clade proteins. The specificity of sRNA sorting between AGO1 and AGO4 clade proteins is unlikely to be determined ...
... proteins (Wu et al., 2009), following the 59 nucleotide-directed loading rule. However, regardless of the identities of their 59 nucleotides, DCL3-dependent lmiRNAs are recruited by AGO4 clade proteins. The specificity of sRNA sorting between AGO1 and AGO4 clade proteins is unlikely to be determined ...
Ingenuity Pathway Analysis of metabolomics data including cross
... intermediates of metabolism, signaling molecules or endogenous metabolites altered by phase 1 and phase 2 transformations, or exogenous metabolites from the diet, environment, gut micro-flora or ingestion of drugs. Metabolomics is the study of some or all of these molecules (21, 36, 37, 73). For the ...
... intermediates of metabolism, signaling molecules or endogenous metabolites altered by phase 1 and phase 2 transformations, or exogenous metabolites from the diet, environment, gut micro-flora or ingestion of drugs. Metabolomics is the study of some or all of these molecules (21, 36, 37, 73). For the ...
Nutrient Metabolism
... ABSTRACT A restricted protein diet supplemented with amino acids and fat may reduce the acidogenic effects of exercise. Twelve Arabian horses were assigned to a 2 ⫻ 2 factorial experiment: two fat levels: 0 or 10 g/100 g added corn oil and two crude protein levels: 7.5 g/100 g (supplemented with 0.5 ...
... ABSTRACT A restricted protein diet supplemented with amino acids and fat may reduce the acidogenic effects of exercise. Twelve Arabian horses were assigned to a 2 ⫻ 2 factorial experiment: two fat levels: 0 or 10 g/100 g added corn oil and two crude protein levels: 7.5 g/100 g (supplemented with 0.5 ...
Lower Respiratory Tract Infections
... Special media for growth amino acids L-cysteine Ferric ions Cx on buffered media (pH restrictions) SLOW growth (2-5d) ...
... Special media for growth amino acids L-cysteine Ferric ions Cx on buffered media (pH restrictions) SLOW growth (2-5d) ...
Petunia Ap2-like Genes and Their Role in Flower and
... species (Mandel et al., 1992; Weigel and Nilsson, 1995), and B-type mutants have been complemented by the introduction of B-type genes from other species (Samach et al., 1997). No data have been reported that allow a comparison of the function of the homologs of the A-class gene Apetala2 (Ap2) among ...
... species (Mandel et al., 1992; Weigel and Nilsson, 1995), and B-type mutants have been complemented by the introduction of B-type genes from other species (Samach et al., 1997). No data have been reported that allow a comparison of the function of the homologs of the A-class gene Apetala2 (Ap2) among ...
Studying Protein Flexibility in a Statistical Framework: Tools and
... Subunit motions are classified differently as allosteric, non-allosteric, or unclassifiable. Finally, large protein motions which cannot easily be classified as subunit motions are classified as complex movements. For example, the order-to-disorder transition that the headpiece domain undergoes when ...
... Subunit motions are classified differently as allosteric, non-allosteric, or unclassifiable. Finally, large protein motions which cannot easily be classified as subunit motions are classified as complex movements. For example, the order-to-disorder transition that the headpiece domain undergoes when ...
New insight into pathogenesis of medical diseases
... immediate use or other forms that may be used in future. The foods possess stored energy. When we consume these foods, the digestive processes break them down into simple compounds that are absorbed into the body and transported to various cells. Energy in the body is available for immediate use in ...
... immediate use or other forms that may be used in future. The foods possess stored energy. When we consume these foods, the digestive processes break them down into simple compounds that are absorbed into the body and transported to various cells. Energy in the body is available for immediate use in ...
... biochemist, I have taught my subject to both ‘my own’ students, and to those on allied degree schemes and pre-clinical medicine. Of course, the lines so conveniently drawn (for teaching purposes) between the different bio-disciplines are very artificial; there is far more commonality than difference ...
Analysis of vestigial " (yg ): a mutation causing
... It is, however, far more difficult to analyse how growth and pattern formation are regulated in normal Drosophila development. One way of at least finding some of the features involved is to analyse mutations which interfere with either growth, such as mutations causing cell death, or with pattern, ...
... It is, however, far more difficult to analyse how growth and pattern formation are regulated in normal Drosophila development. One way of at least finding some of the features involved is to analyse mutations which interfere with either growth, such as mutations causing cell death, or with pattern, ...
Cytokinesis: Sid signals septation
... Sid1p, Cdc14p and Cdc7p, are associated with the spindle pole body only during mitosis, and in late mitosis with a single spindle pole body rather than both spindle poles [7,19]. Moreover, while the asymmetric spindle pole body localization of, for example, Sid1p and Cdc14p depends on all upstream c ...
... Sid1p, Cdc14p and Cdc7p, are associated with the spindle pole body only during mitosis, and in late mitosis with a single spindle pole body rather than both spindle poles [7,19]. Moreover, while the asymmetric spindle pole body localization of, for example, Sid1p and Cdc14p depends on all upstream c ...
Microarrays - Consortium for Mathematics and its Applications
... four feet tall. A mutation is a permanent change in the genetic material, usually in a single gene that may be transmitted from one generation to the next. Learning which genes may be involved in genetic diseases like dwarfism has many possible benefits for people. Understanding how DNA functions is ...
... four feet tall. A mutation is a permanent change in the genetic material, usually in a single gene that may be transmitted from one generation to the next. Learning which genes may be involved in genetic diseases like dwarfism has many possible benefits for people. Understanding how DNA functions is ...
PPT
... Structural genomics consists in the determination of the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography, NMR spectroscopy or computational approaches such as homology modelling. As opposed to traditional structural biology, the ...
... Structural genomics consists in the determination of the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography, NMR spectroscopy or computational approaches such as homology modelling. As opposed to traditional structural biology, the ...
Point mutation
A point mutation, or single base modification, is a type of mutation that causes a single nucleotide base change, insertion, or deletion of the genetic material, DNA or RNA. The term frameshift mutation indicates the addition or deletion of a base pair. A point mutant is an individual that is affected by a point mutation.Repeat induced point mutations are recurring point mutations, discussed below.